C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HRZ9_LEIIN

TriTrypDb:

LINF_040005400

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HRZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRZ9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	415	419	PF00656	0.481
CLV_PCSK_SKI1_1	396	400	PF00082	0.357
CLV_PCSK_SKI1_1	421	425	PF00082	0.448
DEG_Nend_UBRbox_3	1	3	PF02207	0.586
DEG_SPOP_SBC_1	124	128	PF00917	0.656
DEG_SPOP_SBC_1	176	180	PF00917	0.500
DEG_SPOP_SBC_1	413	417	PF00917	0.350
DOC_CKS1_1	432	437	PF01111	0.436
DOC_MAPK_gen_1	130	139	PF00069	0.584
DOC_MAPK_gen_1	182	190	PF00069	0.430
DOC_MAPK_gen_1	312	322	PF00069	0.485
DOC_MAPK_gen_1	366	376	PF00069	0.388
DOC_MAPK_MEF2A_6	267	275	PF00069	0.390
DOC_USP7_MATH_1	124	128	PF00917	0.734
DOC_USP7_MATH_1	183	187	PF00917	0.480
DOC_USP7_MATH_1	244	248	PF00917	0.535
DOC_USP7_MATH_1	401	405	PF00917	0.574
DOC_USP7_MATH_1	413	417	PF00917	0.467
DOC_USP7_MATH_1	72	76	PF00917	0.546
DOC_WW_Pin1_4	113	118	PF00397	0.633
DOC_WW_Pin1_4	423	428	PF00397	0.496
DOC_WW_Pin1_4	431	436	PF00397	0.402
DOC_WW_Pin1_4	61	66	PF00397	0.679
DOC_WW_Pin1_4	88	93	PF00397	0.648
LIG_14-3-3_CanoR_1	182	191	PF00244	0.435
LIG_14-3-3_CanoR_1	218	224	PF00244	0.444
LIG_14-3-3_CanoR_1	366	376	PF00244	0.317
LIG_14-3-3_CanoR_1	421	426	PF00244	0.404
LIG_Actin_WH2_2	351	368	PF00022	0.350
LIG_FHA_1	114	120	PF00498	0.583
LIG_FHA_1	164	170	PF00498	0.419
LIG_FHA_1	279	285	PF00498	0.432
LIG_FHA_1	333	339	PF00498	0.387
LIG_FHA_1	418	424	PF00498	0.458
LIG_FHA_2	339	345	PF00498	0.430
LIG_LIR_Nem_3	33	38	PF02991	0.499
LIG_LIR_Nem_3	353	358	PF02991	0.374
LIG_NRBOX	428	434	PF00104	0.427
LIG_PTB_Apo_2	227	234	PF02174	0.457
LIG_PTB_Phospho_1	227	233	PF10480	0.455
LIG_SH2_GRB2like	172	175	PF00017	0.482
LIG_SH2_SRC	18	21	PF00017	0.589
LIG_SH2_STAP1	172	176	PF00017	0.535
LIG_SH2_STAP1	233	237	PF00017	0.471
LIG_SH2_STAP1	251	255	PF00017	0.406
LIG_SH2_STAT3	213	216	PF00017	0.403
LIG_SH2_STAT3	232	235	PF00017	0.464
LIG_SH2_STAT5	18	21	PF00017	0.589
LIG_SH2_STAT5	213	216	PF00017	0.403
LIG_SH2_STAT5	269	272	PF00017	0.403
LIG_SH2_STAT5	294	297	PF00017	0.406
LIG_SH2_STAT5	367	370	PF00017	0.362
LIG_SH2_STAT5	67	70	PF00017	0.579
LIG_SH3_3	21	27	PF00018	0.507
LIG_SH3_3	9	15	PF00018	0.633
LIG_SUMO_SIM_anti_2	272	277	PF11976	0.537
LIG_SUMO_SIM_anti_2	334	341	PF11976	0.440
LIG_SUMO_SIM_par_1	269	274	PF11976	0.530
LIG_SUMO_SIM_par_1	416	426	PF11976	0.482
LIG_SUMO_SIM_par_1	428	434	PF11976	0.407
LIG_TRAF2_1	341	344	PF00917	0.468
LIG_UBA3_1	429	436	PF00899	0.496
MOD_CDK_SPK_2	423	428	PF00069	0.496
MOD_CDK_SPK_2	431	436	PF00069	0.396
MOD_CDK_SPK_2	88	93	PF00069	0.648
MOD_CDK_SPxxK_3	88	95	PF00069	0.653
MOD_CK1_1	101	107	PF00069	0.568
MOD_CK1_1	109	115	PF00069	0.567
MOD_CK1_1	118	124	PF00069	0.585
MOD_CK1_1	178	184	PF00069	0.558
MOD_CK1_1	348	354	PF00069	0.467
MOD_CK1_1	361	367	PF00069	0.318
MOD_CK1_1	416	422	PF00069	0.613
MOD_CK2_1	109	115	PF00069	0.567
MOD_CK2_1	338	344	PF00069	0.409
MOD_CK2_1	347	353	PF00069	0.362
MOD_GlcNHglycan	111	114	PF01048	0.569
MOD_GlcNHglycan	122	125	PF01048	0.603
MOD_GlcNHglycan	246	249	PF01048	0.469
MOD_GlcNHglycan	350	353	PF01048	0.436
MOD_GlcNHglycan	369	372	PF01048	0.301
MOD_GlcNHglycan	403	406	PF01048	0.336
MOD_GlcNHglycan	74	77	PF01048	0.531
MOD_GlcNHglycan	86	89	PF01048	0.581
MOD_GlcNHglycan	98	101	PF01048	0.587
MOD_GSK3_1	109	116	PF00069	0.689
MOD_GSK3_1	120	127	PF00069	0.692
MOD_GSK3_1	163	170	PF00069	0.424
MOD_GSK3_1	334	341	PF00069	0.513
MOD_GSK3_1	343	350	PF00069	0.474
MOD_GSK3_1	412	419	PF00069	0.552
MOD_GSK3_1	57	64	PF00069	0.554
MOD_GSK3_1	84	91	PF00069	0.628
MOD_N-GLC_1	276	281	PF02516	0.385
MOD_N-GLC_1	57	62	PF02516	0.491
MOD_NEK2_1	120	125	PF00069	0.684
MOD_NEK2_1	167	172	PF00069	0.437
MOD_NEK2_1	177	182	PF00069	0.508
MOD_NEK2_1	207	212	PF00069	0.560
MOD_NEK2_1	276	281	PF00069	0.392
MOD_NEK2_1	59	64	PF00069	0.664
MOD_NEK2_1	96	101	PF00069	0.598
MOD_NEK2_2	125	130	PF00069	0.689
MOD_NEK2_2	30	35	PF00069	0.512
MOD_PIKK_1	104	110	PF00454	0.578
MOD_PIKK_1	231	237	PF00454	0.487
MOD_PIKK_1	399	405	PF00454	0.397
MOD_PKA_2	217	223	PF00069	0.438
MOD_PKA_2	344	350	PF00069	0.388
MOD_Plk_1	135	141	PF00069	0.428
MOD_Plk_1	271	277	PF00069	0.496
MOD_Plk_1	361	367	PF00069	0.361
MOD_Plk_1	417	423	PF00069	0.382
MOD_Plk_4	115	121	PF00069	0.746
MOD_Plk_4	135	141	PF00069	0.362
MOD_Plk_4	271	277	PF00069	0.444
MOD_Plk_4	30	36	PF00069	0.565
MOD_Plk_4	334	340	PF00069	0.444
MOD_Plk_4	372	378	PF00069	0.363
MOD_Plk_4	8	14	PF00069	0.564
MOD_ProDKin_1	113	119	PF00069	0.634
MOD_ProDKin_1	423	429	PF00069	0.492
MOD_ProDKin_1	431	437	PF00069	0.409
MOD_ProDKin_1	61	67	PF00069	0.678
MOD_ProDKin_1	88	94	PF00069	0.650
TRG_DiLeu_BaEn_1	115	120	PF01217	0.618
TRG_DiLeu_BaEn_1	266	271	PF01217	0.479
TRG_ENDOCYTIC_2	31	34	PF00928	0.524
TRG_ENDOCYTIC_2	355	358	PF00928	0.375
TRG_ENDOCYTIC_2	67	70	PF00928	0.538
TRG_NES_CRM1_1	272	285	PF08389	0.403
TRG_Pf-PMV_PEXEL_1	340	344	PF00026	0.405

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3X9	Leptomonas seymouri	64%	95%
A0A451EJV0	Leishmania donovani	100%	100%
A4H3S4	Leishmania braziliensis	83%	100%
E9AJY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q95Z91	Leishmania major	93%	100%