Putative cAMP-specific phosphodiesterase

Quick info Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cAMP-specific phosphodiesterase - putative

Species:

Leishmania infantum

UniProt:

A4HRZ8_LEIIN

TriTrypDb:

LINF_040005200

Length:

724

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Phosphorylation

Amastigote: 641
Promastigote: 703
Promastigote/Amastigote: 639

Expansion

Sequence features

A4HRZ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRZ8

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	12
GO:0009987	cellular process	1	12
GO:0050789	regulation of biological process	2	12
GO:0050794	regulation of cellular process	3	12
GO:0065007	biological regulation	1	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004112	cyclic-nucleotide phosphodiesterase activity	6	12
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	7	12
GO:0008081	phosphoric diester hydrolase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0042578	phosphoric ester hydrolase activity	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	338	342	PF00656	0.468
CLV_C14_Caspase3-7	436	440	PF00656	0.633
CLV_C14_Caspase3-7	649	653	PF00656	0.490
CLV_NRD_NRD_1	187	189	PF00675	0.528
CLV_NRD_NRD_1	482	484	PF00675	0.603
CLV_NRD_NRD_1	598	600	PF00675	0.561
CLV_PCSK_KEX2_1	525	527	PF00082	0.768
CLV_PCSK_PC1ET2_1	525	527	PF00082	0.729
CLV_PCSK_SKI1_1	114	118	PF00082	0.530
CLV_PCSK_SKI1_1	157	161	PF00082	0.383
CLV_PCSK_SKI1_1	188	192	PF00082	0.549
CLV_PCSK_SKI1_1	306	310	PF00082	0.369
CLV_PCSK_SKI1_1	413	417	PF00082	0.507
CLV_PCSK_SKI1_1	473	477	PF00082	0.564
CLV_PCSK_SKI1_1	526	530	PF00082	0.583
DEG_APCC_DBOX_1	388	396	PF00400	0.500
DEG_SPOP_SBC_1	95	99	PF00917	0.676
DOC_AGCK_PIF_1	167	172	PF00069	0.402
DOC_CKS1_1	290	295	PF01111	0.423
DOC_CYCLIN_RxL_1	182	192	PF00134	0.465
DOC_CYCLIN_yCln2_LP_2	90	96	PF00134	0.626
DOC_MAPK_gen_1	155	162	PF00069	0.442
DOC_MAPK_MEF2A_6	155	162	PF00069	0.470
DOC_MAPK_MEF2A_6	385	392	PF00069	0.423
DOC_MAPK_MEF2A_6	714	722	PF00069	0.815
DOC_MAPK_NFAT4_5	155	163	PF00069	0.499
DOC_PP1_RVXF_1	180	187	PF00149	0.397
DOC_PP1_RVXF_1	428	434	PF00149	0.579
DOC_PP4_FxxP_1	217	220	PF00568	0.474
DOC_PP4_FxxP_1	290	293	PF00568	0.423
DOC_USP7_MATH_1	246	250	PF00917	0.381
DOC_USP7_MATH_1	259	263	PF00917	0.341
DOC_USP7_MATH_1	317	321	PF00917	0.446
DOC_USP7_MATH_1	353	357	PF00917	0.486
DOC_USP7_MATH_1	358	362	PF00917	0.444
DOC_USP7_MATH_1	440	444	PF00917	0.555
DOC_USP7_MATH_1	493	497	PF00917	0.690
DOC_USP7_MATH_1	552	556	PF00917	0.648
DOC_USP7_MATH_1	571	575	PF00917	0.277
DOC_USP7_MATH_1	636	640	PF00917	0.685
DOC_USP7_MATH_2	293	299	PF00917	0.325
DOC_WW_Pin1_4	104	109	PF00397	0.565
DOC_WW_Pin1_4	14	19	PF00397	0.620
DOC_WW_Pin1_4	289	294	PF00397	0.470
DOC_WW_Pin1_4	491	496	PF00397	0.605
DOC_WW_Pin1_4	544	549	PF00397	0.767
DOC_WW_Pin1_4	681	686	PF00397	0.789
DOC_WW_Pin1_4	700	705	PF00397	0.499
LIG_14-3-3_CanoR_1	157	163	PF00244	0.382
LIG_14-3-3_CanoR_1	188	196	PF00244	0.548
LIG_14-3-3_CanoR_1	336	343	PF00244	0.453
LIG_14-3-3_CanoR_1	389	393	PF00244	0.488
LIG_14-3-3_CanoR_1	551	561	PF00244	0.588
LIG_Actin_WH2_2	113	131	PF00022	0.434
LIG_Actin_WH2_2	17	34	PF00022	0.614
LIG_Actin_WH2_2	458	474	PF00022	0.620
LIG_Actin_WH2_2	52	69	PF00022	0.571
LIG_BRCT_BRCA1_1	213	217	PF00533	0.474
LIG_BRCT_BRCA1_1	355	359	PF00533	0.471
LIG_Clathr_ClatBox_1	253	257	PF01394	0.466
LIG_Clathr_ClatBox_1	656	660	PF01394	0.524
LIG_FHA_1	105	111	PF00498	0.550
LIG_FHA_1	277	283	PF00498	0.380
LIG_FHA_1	417	423	PF00498	0.396
LIG_FHA_1	460	466	PF00498	0.581
LIG_FHA_1	625	631	PF00498	0.545
LIG_FHA_2	290	296	PF00498	0.403
LIG_FHA_2	336	342	PF00498	0.468
LIG_LIR_Apic_2	214	220	PF02991	0.474
LIG_LIR_Gen_1	115	125	PF02991	0.420
LIG_LIR_Gen_1	156	167	PF02991	0.410
LIG_LIR_Gen_1	171	180	PF02991	0.349
LIG_LIR_Gen_1	181	191	PF02991	0.476
LIG_LIR_Gen_1	307	318	PF02991	0.427
LIG_LIR_Gen_1	405	415	PF02991	0.390
LIG_LIR_Gen_1	54	64	PF02991	0.655
LIG_LIR_Gen_1	556	565	PF02991	0.443
LIG_LIR_Gen_1	651	662	PF02991	0.521
LIG_LIR_Nem_3	115	120	PF02991	0.480
LIG_LIR_Nem_3	156	162	PF02991	0.421
LIG_LIR_Nem_3	165	170	PF02991	0.350
LIG_LIR_Nem_3	171	176	PF02991	0.337
LIG_LIR_Nem_3	181	186	PF02991	0.327
LIG_LIR_Nem_3	262	267	PF02991	0.427
LIG_LIR_Nem_3	307	313	PF02991	0.403
LIG_LIR_Nem_3	405	410	PF02991	0.395
LIG_LIR_Nem_3	555	561	PF02991	0.464
LIG_LIR_Nem_3	651	657	PF02991	0.518
LIG_MLH1_MIPbox_1	213	217	PF16413	0.474
LIG_MYND_1	14	18	PF01753	0.540
LIG_PTB_Apo_2	166	173	PF02174	0.382
LIG_REV1ctd_RIR_1	214	219	PF16727	0.474
LIG_SH2_CRK	310	314	PF00017	0.457
LIG_SH2_GRB2like	200	203	PF00017	0.369
LIG_SH2_GRB2like	407	410	PF00017	0.455
LIG_SH2_PTP2	407	410	PF00017	0.474
LIG_SH2_SRC	407	410	PF00017	0.428
LIG_SH2_STAP1	310	314	PF00017	0.453
LIG_SH2_STAT5	130	133	PF00017	0.409
LIG_SH2_STAT5	407	410	PF00017	0.372
LIG_SH2_STAT5	55	58	PF00017	0.686
LIG_SH2_STAT5	558	561	PF00017	0.421
LIG_SH2_STAT5	593	596	PF00017	0.406
LIG_SH2_STAT5	662	665	PF00017	0.508
LIG_SH3_3	240	246	PF00018	0.474
LIG_SH3_3	387	393	PF00018	0.366
LIG_SH3_3	408	414	PF00018	0.438
LIG_SH3_3	684	690	PF00018	0.821
LIG_SUMO_SIM_anti_2	274	280	PF11976	0.474
LIG_SUMO_SIM_anti_2	419	426	PF11976	0.500
LIG_SUMO_SIM_anti_2	462	469	PF11976	0.535
LIG_SUMO_SIM_par_1	237	242	PF11976	0.407
LIG_SUMO_SIM_par_1	252	257	PF11976	0.464
LIG_SUMO_SIM_par_1	274	280	PF11976	0.455
LIG_TRAF2_1	227	230	PF00917	0.438
LIG_WRC_WIRS_1	558	563	PF05994	0.463
LIG_WW_3	46	50	PF00397	0.590
MOD_CDC14_SPxK_1	494	497	PF00782	0.705
MOD_CDC14_SPxK_1	703	706	PF00782	0.756
MOD_CDK_SPK_2	109	114	PF00069	0.598
MOD_CDK_SPxK_1	491	497	PF00069	0.646
MOD_CDK_SPxK_1	700	706	PF00069	0.767
MOD_CDK_SPxxK_3	14	21	PF00069	0.616
MOD_CDK_SPxxK_3	544	551	PF00069	0.755
MOD_CK1_1	171	177	PF00069	0.398
MOD_CK1_1	298	304	PF00069	0.480
MOD_CK1_1	320	326	PF00069	0.463
MOD_CK1_1	463	469	PF00069	0.539
MOD_CK1_1	510	516	PF00069	0.693
MOD_CK1_1	536	542	PF00069	0.776
MOD_CK1_1	69	75	PF00069	0.690
MOD_CK1_1	713	719	PF00069	0.789
MOD_CK1_1	98	104	PF00069	0.621
MOD_CK2_1	109	115	PF00069	0.572
MOD_CK2_1	147	153	PF00069	0.522
MOD_CK2_1	224	230	PF00069	0.353
MOD_CK2_1	289	295	PF00069	0.403
MOD_CK2_1	463	469	PF00069	0.479
MOD_CK2_1	51	57	PF00069	0.672
MOD_CK2_1	616	622	PF00069	0.508
MOD_CK2_1	623	629	PF00069	0.515
MOD_GlcNHglycan	300	303	PF01048	0.408
MOD_GlcNHglycan	325	328	PF01048	0.452
MOD_GlcNHglycan	332	336	PF01048	0.431
MOD_GlcNHglycan	517	520	PF01048	0.806
MOD_GlcNHglycan	521	524	PF01048	0.782
MOD_GlcNHglycan	542	545	PF01048	0.733
MOD_GlcNHglycan	573	576	PF01048	0.551
MOD_GlcNHglycan	60	63	PF01048	0.618
MOD_GlcNHglycan	673	676	PF01048	0.676
MOD_GSK3_1	158	165	PF00069	0.360
MOD_GSK3_1	168	175	PF00069	0.384
MOD_GSK3_1	331	338	PF00069	0.470
MOD_GSK3_1	459	466	PF00069	0.544
MOD_GSK3_1	47	54	PF00069	0.655
MOD_GSK3_1	473	480	PF00069	0.542
MOD_GSK3_1	491	498	PF00069	0.583
MOD_GSK3_1	509	516	PF00069	0.668
MOD_GSK3_1	536	543	PF00069	0.702
MOD_GSK3_1	66	73	PF00069	0.695
MOD_GSK3_1	94	101	PF00069	0.634
MOD_N-GLC_1	168	173	PF02516	0.361
MOD_N-GLC_1	201	206	PF02516	0.438
MOD_N-GLC_1	491	496	PF02516	0.566
MOD_N-GLC_1	513	518	PF02516	0.784
MOD_N-GLC_2	143	145	PF02516	0.359
MOD_NEK2_1	103	108	PF00069	0.665
MOD_NEK2_1	139	144	PF00069	0.485
MOD_NEK2_1	158	163	PF00069	0.225
MOD_NEK2_1	172	177	PF00069	0.356
MOD_NEK2_1	196	201	PF00069	0.535
MOD_NEK2_1	276	281	PF00069	0.460
MOD_NEK2_1	288	293	PF00069	0.170
MOD_NEK2_1	461	466	PF00069	0.570
MOD_NEK2_1	616	621	PF00069	0.596
MOD_NEK2_1	66	71	PF00069	0.676
MOD_NEK2_1	96	101	PF00069	0.674
MOD_NEK2_2	124	129	PF00069	0.523
MOD_NEK2_2	168	173	PF00069	0.436
MOD_NEK2_2	259	264	PF00069	0.474
MOD_PIKK_1	358	364	PF00454	0.453
MOD_PIKK_1	495	501	PF00454	0.691
MOD_PKA_1	483	489	PF00069	0.559
MOD_PKA_2	320	326	PF00069	0.410
MOD_PKA_2	335	341	PF00069	0.410
MOD_PKA_2	388	394	PF00069	0.457
MOD_PKA_2	66	72	PF00069	0.725
MOD_Plk_1	168	174	PF00069	0.373
MOD_Plk_1	196	202	PF00069	0.558
MOD_Plk_1	453	459	PF00069	0.659
MOD_Plk_2-3	295	301	PF00069	0.325
MOD_Plk_4	147	153	PF00069	0.524
MOD_Plk_4	162	168	PF00069	0.272
MOD_Plk_4	211	217	PF00069	0.404
MOD_Plk_4	259	265	PF00069	0.401
MOD_Plk_4	271	277	PF00069	0.420
MOD_Plk_4	320	326	PF00069	0.445
MOD_Plk_4	463	469	PF00069	0.527
MOD_Plk_4	51	57	PF00069	0.631
MOD_Plk_4	650	656	PF00069	0.477
MOD_Plk_4	98	104	PF00069	0.678
MOD_ProDKin_1	104	110	PF00069	0.556
MOD_ProDKin_1	14	20	PF00069	0.619
MOD_ProDKin_1	289	295	PF00069	0.470
MOD_ProDKin_1	491	497	PF00069	0.616
MOD_ProDKin_1	544	550	PF00069	0.762
MOD_ProDKin_1	681	687	PF00069	0.788
MOD_ProDKin_1	700	706	PF00069	0.506
MOD_SUMO_for_1	524	527	PF00179	0.629
MOD_SUMO_rev_2	479	486	PF00179	0.546
TRG_DiLeu_BaEn_1	271	276	PF01217	0.474
TRG_DiLeu_BaEn_1	613	618	PF01217	0.485
TRG_ENDOCYTIC_2	310	313	PF00928	0.457
TRG_ENDOCYTIC_2	407	410	PF00928	0.388
TRG_ENDOCYTIC_2	558	561	PF00928	0.439
TRG_ER_diArg_1	29	32	PF00400	0.550
TRG_ER_diArg_1	318	321	PF00400	0.369
TRG_ER_diArg_1	718	721	PF00400	0.789
TRG_NES_CRM1_1	229	242	PF08389	0.474
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3J8	Leptomonas seymouri	65%	97%
A0A0S4J2W3	Bodo saltans	27%	100%
A0A1X0NMW5	Trypanosomatidae	37%	100%
A0A3R7NEI4	Trypanosoma rangeli	36%	100%
A0A3S5H571	Leishmania donovani	100%	100%
C9ZXZ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AI20	Leishmania braziliensis	84%	100%
E9AJY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q95Z92	Leishmania major	96%	100%
V5BDS9	Trypanosoma cruzi	37%	100%