Vesicle transport protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Got1/Sft2-like family - putative

Species:

Leishmania infantum

UniProt:

A4HRX8_LEIIN

TriTrypDb:

LINF_030014300

Length:

218

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	23
GO:0110165	cellular anatomical entity	1	23

Expansion

Sequence features

A4HRX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRX8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	23
GO:0008104	protein localization	4	23
GO:0009987	cellular process	1	23
GO:0015031	protein transport	4	23
GO:0016192	vesicle-mediated transport	4	23
GO:0033036	macromolecule localization	2	23
GO:0045184	establishment of protein localization	3	23
GO:0051179	localization	1	23
GO:0051234	establishment of localization	2	23
GO:0051641	cellular localization	2	23
GO:0070727	cellular macromolecule localization	3	23
GO:0071702	organic substance transport	4	23
GO:0071705	nitrogen compound transport	4	23

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.609
CLV_PCSK_SKI1_1	127	131	PF00082	0.270
CLV_PCSK_SKI1_1	188	192	PF00082	0.480
DOC_CYCLIN_RxL_1	30	41	PF00134	0.536
DOC_MAPK_MEF2A_6	184	191	PF00069	0.671
DOC_USP7_MATH_1	200	204	PF00917	0.375
DOC_WW_Pin1_4	196	201	PF00397	0.314
LIG_14-3-3_CanoR_1	184	188	PF00244	0.639
LIG_Actin_WH2_2	173	190	PF00022	0.477
LIG_BRCT_BRCA1_1	114	118	PF00533	0.275
LIG_BRCT_BRCA1_1	194	198	PF00533	0.381
LIG_eIF4E_1	32	38	PF01652	0.530
LIG_FHA_1	114	120	PF00498	0.341
LIG_FHA_1	184	190	PF00498	0.558
LIG_FHA_1	44	50	PF00498	0.748
LIG_FHA_1	69	75	PF00498	0.596
LIG_FHA_2	126	132	PF00498	0.584
LIG_GBD_Chelix_1	145	153	PF00786	0.230
LIG_GBD_Chelix_1	169	177	PF00786	0.257
LIG_LIR_Gen_1	192	201	PF02991	0.506
LIG_LIR_Gen_1	75	86	PF02991	0.334
LIG_LIR_Nem_3	178	182	PF02991	0.343
LIG_LIR_Nem_3	195	201	PF02991	0.357
LIG_NRBOX	85	91	PF00104	0.257
LIG_PCNA_PIPBox_1	147	156	PF02747	0.246
LIG_SH2_CRK	32	36	PF00017	0.589
LIG_SH2_SRC	141	144	PF00017	0.257
LIG_SH2_STAP1	175	179	PF00017	0.283
LIG_SH2_STAP1	193	197	PF00017	0.459
LIG_SH2_STAP1	70	74	PF00017	0.575
LIG_SH2_STAT3	182	185	PF00017	0.644
LIG_SH2_STAT3	26	29	PF00017	0.626
LIG_SH2_STAT5	141	144	PF00017	0.374
LIG_SH2_STAT5	179	182	PF00017	0.337
LIG_SH2_STAT5	70	73	PF00017	0.631
LIG_Sin3_3	163	170	PF02671	0.207
LIG_SxIP_EBH_1	173	184	PF03271	0.362
LIG_UBA3_1	149	158	PF00899	0.381
MOD_CK1_1	192	198	PF00069	0.432
MOD_CK1_1	36	42	PF00069	0.659
MOD_CK1_1	63	69	PF00069	0.615
MOD_CK2_1	125	131	PF00069	0.430
MOD_GlcNHglycan	150	153	PF01048	0.372
MOD_GlcNHglycan	202	205	PF01048	0.196
MOD_GlcNHglycan	5	8	PF01048	0.514
MOD_GSK3_1	141	148	PF00069	0.335
MOD_GSK3_1	192	199	PF00069	0.477
MOD_GSK3_1	68	75	PF00069	0.614
MOD_GSK3_1	99	106	PF00069	0.258
MOD_N-GLC_2	210	212	PF02516	0.207
MOD_NEK2_1	103	108	PF00069	0.348
MOD_NEK2_1	113	118	PF00069	0.366
MOD_NEK2_1	3	8	PF00069	0.677
MOD_NEK2_1	68	73	PF00069	0.578
MOD_NEK2_2	183	188	PF00069	0.633
MOD_PIKK_1	25	31	PF00454	0.639
MOD_PIKK_1	68	74	PF00454	0.633
MOD_PKA_1	99	105	PF00069	0.334
MOD_PKA_2	183	189	PF00069	0.625
MOD_PKA_2	72	78	PF00069	0.534
MOD_Plk_1	66	72	PF00069	0.595
MOD_Plk_4	113	119	PF00069	0.339
MOD_Plk_4	145	151	PF00069	0.315
MOD_Plk_4	175	181	PF00069	0.386
MOD_Plk_4	192	198	PF00069	0.520
MOD_Plk_4	33	39	PF00069	0.580
MOD_ProDKin_1	196	202	PF00069	0.314
MOD_SUMO_rev_2	17	23	PF00179	0.538
TRG_ENDOCYTIC_2	193	196	PF00928	0.502
TRG_ENDOCYTIC_2	32	35	PF00928	0.563

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5I1	Leptomonas seymouri	69%	99%
A0A0N1I3M5	Leptomonas seymouri	31%	100%
A0A0S4JF33	Bodo saltans	33%	100%
A0A1X0P315	Trypanosomatidae	31%	100%
A0A1X0P7F6	Trypanosomatidae	30%	100%
A0A1X0P987	Trypanosomatidae	44%	100%
A0A3Q8IBK0	Leishmania donovani	39%	100%
A0A3S5H567	Leishmania donovani	100%	100%
A0A3S5H5K3	Leishmania donovani	39%	100%
A0A422N175	Trypanosoma rangeli	45%	100%
A4H3Q4	Leishmania braziliensis	86%	100%
A4HDV3	Leishmania braziliensis	40%	100%
A4HSK3	Leishmania infantum	39%	100%
A4I148	Leishmania infantum	39%	100%
C9ZKI8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	78%
E9ACN7	Leishmania major	95%	100%
E9AJX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9AKI7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AX82	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
Q4QA90	Leishmania major	40%	100%
Q4QJC1	Leishmania major	39%	100%