Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HRW9_LEIIN

TriTrypDb:

LINF_030013100

Length:

1093

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4HRW9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRW9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	65	69	PF00656	0.667
CLV_NRD_NRD_1	1009	1011	PF00675	0.697
CLV_NRD_NRD_1	129	131	PF00675	0.594
CLV_NRD_NRD_1	300	302	PF00675	0.584
CLV_NRD_NRD_1	369	371	PF00675	0.511
CLV_NRD_NRD_1	372	374	PF00675	0.508
CLV_NRD_NRD_1	386	388	PF00675	0.442
CLV_NRD_NRD_1	391	393	PF00675	0.433
CLV_NRD_NRD_1	426	428	PF00675	0.523
CLV_NRD_NRD_1	44	46	PF00675	0.561
CLV_NRD_NRD_1	563	565	PF00675	0.433
CLV_NRD_NRD_1	587	589	PF00675	0.490
CLV_NRD_NRD_1	628	630	PF00675	0.562
CLV_NRD_NRD_1	63	65	PF00675	0.518
CLV_NRD_NRD_1	84	86	PF00675	0.571
CLV_NRD_NRD_1	874	876	PF00675	0.511
CLV_NRD_NRD_1	897	899	PF00675	0.555
CLV_NRD_NRD_1	909	911	PF00675	0.476
CLV_PCSK_FUR_1	370	374	PF00082	0.525
CLV_PCSK_KEX2_1	1009	1011	PF00082	0.697
CLV_PCSK_KEX2_1	129	131	PF00082	0.600
CLV_PCSK_KEX2_1	369	371	PF00082	0.511
CLV_PCSK_KEX2_1	372	374	PF00082	0.508
CLV_PCSK_KEX2_1	386	388	PF00082	0.442
CLV_PCSK_KEX2_1	391	393	PF00082	0.433
CLV_PCSK_KEX2_1	425	427	PF00082	0.530
CLV_PCSK_KEX2_1	562	564	PF00082	0.446
CLV_PCSK_KEX2_1	585	587	PF00082	0.525
CLV_PCSK_KEX2_1	628	630	PF00082	0.562
CLV_PCSK_KEX2_1	63	65	PF00082	0.524
CLV_PCSK_KEX2_1	86	88	PF00082	0.561
CLV_PCSK_KEX2_1	874	876	PF00082	0.511
CLV_PCSK_KEX2_1	897	899	PF00082	0.555
CLV_PCSK_KEX2_1	909	911	PF00082	0.476
CLV_PCSK_PC1ET2_1	585	587	PF00082	0.525
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.539
CLV_PCSK_PC7_1	365	371	PF00082	0.510
CLV_PCSK_PC7_1	387	393	PF00082	0.526
CLV_PCSK_PC7_1	82	88	PF00082	0.535
CLV_PCSK_SKI1_1	1049	1053	PF00082	0.653
CLV_PCSK_SKI1_1	167	171	PF00082	0.522
CLV_PCSK_SKI1_1	426	430	PF00082	0.496
CLV_PCSK_SKI1_1	57	61	PF00082	0.629
CLV_PCSK_SKI1_1	653	657	PF00082	0.623
CLV_PCSK_SKI1_1	708	712	PF00082	0.607
CLV_PCSK_SKI1_1	87	91	PF00082	0.592
DEG_APCC_DBOX_1	425	433	PF00400	0.706
DEG_APCC_DBOX_1	713	721	PF00400	0.770
DEG_Nend_Nbox_1	1	3	PF02207	0.800
DEG_SPOP_SBC_1	237	241	PF00917	0.781
DEG_SPOP_SBC_1	631	635	PF00917	0.776
DOC_ANK_TNKS_1	214	221	PF00023	0.695
DOC_ANK_TNKS_1	44	51	PF00023	0.701
DOC_CKS1_1	206	211	PF01111	0.768
DOC_CKS1_1	461	466	PF01111	0.429
DOC_MAPK_MEF2A_6	1079	1087	PF00069	0.332
DOC_MAPK_MEF2A_6	433	442	PF00069	0.699
DOC_MAPK_MEF2A_6	839	848	PF00069	0.762
DOC_MAPK_MEF2A_6	965	973	PF00069	0.590
DOC_MAPK_RevD_3	884	898	PF00069	0.644
DOC_PP2B_LxvP_1	841	844	PF13499	0.766
DOC_PP4_FxxP_1	461	464	PF00568	0.540
DOC_USP7_MATH_1	1004	1008	PF00917	0.580
DOC_USP7_MATH_1	1032	1036	PF00917	0.622
DOC_USP7_MATH_1	1044	1048	PF00917	0.580
DOC_USP7_MATH_1	114	118	PF00917	0.785
DOC_USP7_MATH_1	136	140	PF00917	0.753
DOC_USP7_MATH_1	161	165	PF00917	0.705
DOC_USP7_MATH_1	186	190	PF00917	0.707
DOC_USP7_MATH_1	285	289	PF00917	0.824
DOC_USP7_MATH_1	403	407	PF00917	0.796
DOC_USP7_MATH_1	447	451	PF00917	0.466
DOC_USP7_MATH_1	490	494	PF00917	0.532
DOC_USP7_MATH_1	53	57	PF00917	0.813
DOC_USP7_MATH_1	609	613	PF00917	0.750
DOC_USP7_MATH_1	631	635	PF00917	0.797
DOC_USP7_MATH_1	690	694	PF00917	0.769
DOC_USP7_MATH_1	835	839	PF00917	0.695
DOC_USP7_MATH_1	902	906	PF00917	0.643
DOC_WW_Pin1_4	1025	1030	PF00397	0.568
DOC_WW_Pin1_4	122	127	PF00397	0.734
DOC_WW_Pin1_4	205	210	PF00397	0.728
DOC_WW_Pin1_4	273	278	PF00397	0.705
DOC_WW_Pin1_4	293	298	PF00397	0.744
DOC_WW_Pin1_4	460	465	PF00397	0.426
DOC_WW_Pin1_4	492	497	PF00397	0.539
DOC_WW_Pin1_4	662	667	PF00397	0.786
DOC_WW_Pin1_4	770	775	PF00397	0.813
DOC_WW_Pin1_4	96	101	PF00397	0.800
LIG_14-3-3_CanoR_1	1009	1018	PF00244	0.578
LIG_14-3-3_CanoR_1	426	435	PF00244	0.696
LIG_14-3-3_CanoR_1	63	72	PF00244	0.677
LIG_14-3-3_CanoR_1	708	717	PF00244	0.782
LIG_14-3-3_CanoR_1	721	725	PF00244	0.706
LIG_14-3-3_CanoR_1	789	796	PF00244	0.770
LIG_14-3-3_CanoR_1	93	97	PF00244	0.794
LIG_BIR_III_2	920	924	PF00653	0.758
LIG_BRCT_BRCA1_1	653	657	PF00533	0.813
LIG_BRCT_BRCA1_1	94	98	PF00533	0.757
LIG_CSL_BTD_1	1	4	PF09270	0.738
LIG_CtBP_PxDLS_1	152	156	PF00389	0.736
LIG_deltaCOP1_diTrp_1	555	565	PF00928	0.689
LIG_deltaCOP1_diTrp_1	989	999	PF00928	0.500
LIG_DLG_GKlike_1	716	724	PF00625	0.710
LIG_eIF4E_1	1067	1073	PF01652	0.330
LIG_eIF4E_1	516	522	PF01652	0.513
LIG_eIF4E_1	529	535	PF01652	0.266
LIG_FHA_1	1078	1084	PF00498	0.346
LIG_FHA_1	15	21	PF00498	0.795
LIG_FHA_1	197	203	PF00498	0.770
LIG_FHA_1	206	212	PF00498	0.795
LIG_FHA_1	237	243	PF00498	0.819
LIG_FHA_1	394	400	PF00498	0.771
LIG_FHA_1	461	467	PF00498	0.429
LIG_FHA_1	657	663	PF00498	0.806
LIG_FHA_1	699	705	PF00498	0.764
LIG_FHA_1	799	805	PF00498	0.695
LIG_FHA_1	946	952	PF00498	0.724
LIG_FHA_1	985	991	PF00498	0.483
LIG_FHA_2	27	33	PF00498	0.809
LIG_FHA_2	493	499	PF00498	0.540
LIG_FHA_2	63	69	PF00498	0.763
LIG_FHA_2	755	761	PF00498	0.762
LIG_FHA_2	974	980	PF00498	0.466
LIG_Integrin_RGD_1	822	824	PF01839	0.496
LIG_Integrin_RGD_1	898	900	PF01839	0.522
LIG_LIR_Apic_2	458	464	PF02991	0.667
LIG_LIR_Gen_1	667	674	PF02991	0.714
LIG_LIR_Nem_3	513	519	PF02991	0.523
LIG_LIR_Nem_3	524	529	PF02991	0.404
LIG_LIR_Nem_3	738	742	PF02991	0.774
LIG_LIR_Nem_3	752	758	PF02991	0.704
LIG_LIR_Nem_3	782	787	PF02991	0.784
LIG_LIR_Nem_3	866	872	PF02991	0.757
LIG_MYND_3	509	513	PF01753	0.494
LIG_NRBOX	450	456	PF00104	0.466
LIG_NRBOX	536	542	PF00104	0.466
LIG_OCRL_FandH_1	954	966	PF00620	0.657
LIG_PCNA_PIPBox_1	410	419	PF02747	0.607
LIG_PDZ_Class_1	1088	1093	PF00595	0.551
LIG_Pex14_2	522	526	PF04695	0.480
LIG_Pex14_2	865	869	PF04695	0.707
LIG_REV1ctd_RIR_1	81	91	PF16727	0.734
LIG_SH2_CRK	784	788	PF00017	0.781
LIG_SH2_NCK_1	419	423	PF00017	0.711
LIG_SH2_NCK_1	546	550	PF00017	0.416
LIG_SH2_SRC	546	549	PF00017	0.416
LIG_SH2_SRC	925	928	PF00017	0.701
LIG_SH2_SRC	957	960	PF00017	0.626
LIG_SH2_STAP1	353	357	PF00017	0.711
LIG_SH2_STAP1	722	726	PF00017	0.746
LIG_SH2_STAT3	332	335	PF00017	0.732
LIG_SH2_STAT3	813	816	PF00017	0.738
LIG_SH2_STAT5	1067	1070	PF00017	0.330
LIG_SH2_STAT5	159	162	PF00017	0.755
LIG_SH2_STAT5	332	335	PF00017	0.732
LIG_SH2_STAT5	434	437	PF00017	0.646
LIG_SH2_STAT5	465	468	PF00017	0.610
LIG_SH2_STAT5	925	928	PF00017	0.796
LIG_SH2_STAT5	957	960	PF00017	0.626
LIG_SH3_3	1013	1019	PF00018	0.575
LIG_SH3_3	120	126	PF00018	0.744
LIG_SH3_3	203	209	PF00018	0.764
LIG_SH3_3	224	230	PF00018	0.811
LIG_SH3_3	330	336	PF00018	0.731
LIG_SH3_3	456	462	PF00018	0.650
LIG_SH3_3	617	623	PF00018	0.701
LIG_SH3_3	771	777	PF00018	0.762
LIG_SH3_3	94	100	PF00018	0.795
LIG_SH3_3	947	953	PF00018	0.717
LIG_SH3_3	958	964	PF00018	0.528
LIG_SH3_CIN85_PxpxPR_1	124	129	PF14604	0.733
LIG_Sin3_3	480	487	PF02671	0.482
LIG_SUMO_SIM_anti_2	450	456	PF11976	0.466
LIG_SUMO_SIM_anti_2	481	487	PF11976	0.483
LIG_SUMO_SIM_anti_2	979	985	PF11976	0.433
LIG_SUMO_SIM_anti_2	987	992	PF11976	0.467
LIG_SUMO_SIM_par_1	453	458	PF11976	0.466
LIG_SUMO_SIM_par_1	538	544	PF11976	0.466
LIG_SUMO_SIM_par_1	973	979	PF11976	0.383
LIG_Vh1_VBS_1	1071	1089	PF01044	0.432
MOD_CDK_SPK_2	770	775	PF00069	0.792
MOD_CDK_SPxxK_3	122	129	PF00069	0.708
MOD_CK1_1	1031	1037	PF00069	0.513
MOD_CK1_1	196	202	PF00069	0.735
MOD_CK1_1	231	237	PF00069	0.812
MOD_CK1_1	288	294	PF00069	0.794
MOD_CK1_1	31	37	PF00069	0.768
MOD_CK1_1	478	484	PF00069	0.524
MOD_CK1_1	603	609	PF00069	0.764
MOD_CK1_1	610	616	PF00069	0.730
MOD_CK1_1	62	68	PF00069	0.747
MOD_CK1_1	633	639	PF00069	0.774
MOD_CK1_1	799	805	PF00069	0.801
MOD_CK1_1	998	1004	PF00069	0.478
MOD_CK2_1	549	555	PF00069	0.659
MOD_CK2_1	64	70	PF00069	0.728
MOD_CK2_1	754	760	PF00069	0.777
MOD_CK2_1	850	856	PF00069	0.757
MOD_CK2_1	973	979	PF00069	0.466
MOD_Cter_Amidation	389	392	PF01082	0.533
MOD_Cter_Amidation	583	586	PF01082	0.538
MOD_DYRK1A_RPxSP_1	205	209	PF00069	0.766
MOD_GlcNHglycan	1000	1003	PF01048	0.772
MOD_GlcNHglycan	1012	1015	PF01048	0.787
MOD_GlcNHglycan	1030	1033	PF01048	0.626
MOD_GlcNHglycan	1034	1037	PF01048	0.720
MOD_GlcNHglycan	1062	1067	PF01048	0.692
MOD_GlcNHglycan	110	113	PF01048	0.637
MOD_GlcNHglycan	116	119	PF01048	0.624
MOD_GlcNHglycan	138	141	PF01048	0.571
MOD_GlcNHglycan	163	166	PF01048	0.499
MOD_GlcNHglycan	182	185	PF01048	0.584
MOD_GlcNHglycan	193	198	PF01048	0.499
MOD_GlcNHglycan	233	236	PF01048	0.613
MOD_GlcNHglycan	278	281	PF01048	0.548
MOD_GlcNHglycan	290	293	PF01048	0.548
MOD_GlcNHglycan	303	306	PF01048	0.505
MOD_GlcNHglycan	382	385	PF01048	0.550
MOD_GlcNHglycan	4	7	PF01048	0.577
MOD_GlcNHglycan	401	404	PF01048	0.434
MOD_GlcNHglycan	405	408	PF01048	0.538
MOD_GlcNHglycan	477	480	PF01048	0.725
MOD_GlcNHglycan	492	495	PF01048	0.598
MOD_GlcNHglycan	609	612	PF01048	0.536
MOD_GlcNHglycan	653	656	PF01048	0.625
MOD_GlcNHglycan	697	701	PF01048	0.561
MOD_GlcNHglycan	732	735	PF01048	0.547
MOD_GlcNHglycan	798	801	PF01048	0.601
MOD_GlcNHglycan	859	862	PF01048	0.572
MOD_GlcNHglycan	905	908	PF01048	0.582
MOD_GSK3_1	1004	1011	PF00069	0.606
MOD_GSK3_1	1027	1034	PF00069	0.553
MOD_GSK3_1	132	139	PF00069	0.808
MOD_GSK3_1	176	183	PF00069	0.785
MOD_GSK3_1	196	203	PF00069	0.644
MOD_GSK3_1	20	27	PF00069	0.769
MOD_GSK3_1	393	400	PF00069	0.751
MOD_GSK3_1	492	499	PF00069	0.515
MOD_GSK3_1	53	60	PF00069	0.790
MOD_GSK3_1	596	603	PF00069	0.794
MOD_GSK3_1	658	665	PF00069	0.802
MOD_GSK3_1	704	711	PF00069	0.781
MOD_GSK3_1	716	723	PF00069	0.692
MOD_GSK3_1	726	733	PF00069	0.733
MOD_GSK3_1	745	752	PF00069	0.615
MOD_GSK3_1	766	773	PF00069	0.815
MOD_GSK3_1	851	858	PF00069	0.731
MOD_GSK3_1	92	99	PF00069	0.791
MOD_N-GLC_1	1025	1030	PF02516	0.780
MOD_N-GLC_1	403	408	PF02516	0.510
MOD_N-GLC_1	490	495	PF02516	0.722
MOD_N-GLC_1	596	601	PF02516	0.500
MOD_NEK2_1	1088	1093	PF00069	0.551
MOD_NEK2_1	20	25	PF00069	0.766
MOD_NEK2_1	26	31	PF00069	0.707
MOD_NEK2_1	428	433	PF00069	0.635
MOD_NEK2_1	455	460	PF00069	0.466
MOD_NEK2_1	521	526	PF00069	0.492
MOD_NEK2_1	541	546	PF00069	0.219
MOD_NEK2_1	59	64	PF00069	0.788
MOD_NEK2_1	656	661	PF00069	0.782
MOD_NEK2_1	670	675	PF00069	0.702
MOD_NEK2_1	696	701	PF00069	0.783
MOD_NEK2_1	704	709	PF00069	0.744
MOD_NEK2_1	720	725	PF00069	0.653
MOD_NEK2_1	726	731	PF00069	0.760
MOD_NEK2_1	735	740	PF00069	0.674
MOD_NEK2_1	796	801	PF00069	0.743
MOD_NEK2_1	855	860	PF00069	0.740
MOD_NEK2_1	937	942	PF00069	0.834
MOD_NEK2_1	945	950	PF00069	0.720
MOD_NEK2_1	973	978	PF00069	0.466
MOD_NEK2_2	658	663	PF00069	0.781
MOD_NEK2_2	817	822	PF00069	0.679
MOD_PIKK_1	1004	1010	PF00454	0.582
MOD_PIKK_1	38	44	PF00454	0.696
MOD_PK_1	596	602	PF00069	0.700
MOD_PKA_1	1009	1015	PF00069	0.494
MOD_PKA_1	301	307	PF00069	0.786
MOD_PKA_1	63	69	PF00069	0.677
MOD_PKA_2	1008	1014	PF00069	0.578
MOD_PKA_2	1032	1038	PF00069	0.621
MOD_PKA_2	108	114	PF00069	0.670
MOD_PKA_2	174	180	PF00069	0.763
MOD_PKA_2	228	234	PF00069	0.810
MOD_PKA_2	38	44	PF00069	0.696
MOD_PKA_2	380	386	PF00069	0.724
MOD_PKA_2	62	68	PF00069	0.742
MOD_PKA_2	642	648	PF00069	0.738
MOD_PKA_2	720	726	PF00069	0.733
MOD_PKA_2	788	794	PF00069	0.765
MOD_PKA_2	92	98	PF00069	0.795
MOD_PKB_1	130	138	PF00069	0.794
MOD_PKB_1	425	433	PF00069	0.621
MOD_PKB_1	714	722	PF00069	0.806
MOD_Plk_1	394	400	PF00069	0.693
MOD_Plk_1	596	602	PF00069	0.700
MOD_Plk_1	851	857	PF00069	0.678
MOD_Plk_1	984	990	PF00069	0.517
MOD_Plk_2-3	984	990	PF00069	0.517
MOD_Plk_4	15	21	PF00069	0.795
MOD_Plk_4	447	453	PF00069	0.533
MOD_Plk_4	529	535	PF00069	0.390
MOD_Plk_4	603	609	PF00069	0.696
MOD_Plk_4	633	639	PF00069	0.798
MOD_Plk_4	766	772	PF00069	0.823
MOD_Plk_4	92	98	PF00069	0.790
MOD_Plk_4	973	979	PF00069	0.416
MOD_Plk_4	995	1001	PF00069	0.446
MOD_ProDKin_1	1025	1031	PF00069	0.569
MOD_ProDKin_1	122	128	PF00069	0.734
MOD_ProDKin_1	205	211	PF00069	0.730
MOD_ProDKin_1	273	279	PF00069	0.705
MOD_ProDKin_1	293	299	PF00069	0.742
MOD_ProDKin_1	460	466	PF00069	0.427
MOD_ProDKin_1	492	498	PF00069	0.539
MOD_ProDKin_1	662	668	PF00069	0.787
MOD_ProDKin_1	770	776	PF00069	0.810
MOD_ProDKin_1	96	102	PF00069	0.800
TRG_ENDOCYTIC_2	516	519	PF00928	0.519
TRG_ENDOCYTIC_2	784	787	PF00928	0.819
TRG_ENDOCYTIC_2	957	960	PF00928	0.626
TRG_ER_diArg_1	128	130	PF00400	0.789
TRG_ER_diArg_1	369	372	PF00400	0.719
TRG_ER_diArg_1	424	427	PF00400	0.709
TRG_ER_diArg_1	562	564	PF00400	0.610
TRG_ER_diArg_1	586	588	PF00400	0.750
TRG_ER_diArg_1	714	717	PF00400	0.771
TRG_ER_diArg_1	84	87	PF00400	0.748
TRG_ER_diArg_1	909	912	PF00400	0.675
TRG_ER_diArg_1	922	925	PF00400	0.631
TRG_NLS_MonoCore_2	584	589	PF00514	0.745
TRG_NLS_MonoExtC_3	584	589	PF00514	0.745
TRG_NLS_MonoExtN_4	82	89	PF00514	0.736
TRG_Pf-PMV_PEXEL_1	564	568	PF00026	0.465
TRG_Pf-PMV_PEXEL_1	76	80	PF00026	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H561	Leishmania donovani	99%	100%
A4H3P3	Leishmania braziliensis	54%	100%
E9ACM6	Leishmania major	86%	98%
E9AJW4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	98%