Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HRW7_LEIIN

TriTrypDb:

LINF_030012900

Length:

435

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HRW7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRW7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	186	190	PF00656	0.507
CLV_C14_Caspase3-7	289	293	PF00656	0.696
CLV_C14_Caspase3-7	315	319	PF00656	0.686
CLV_C14_Caspase3-7	409	413	PF00656	0.515
CLV_NRD_NRD_1	22	24	PF00675	0.536
CLV_NRD_NRD_1	241	243	PF00675	0.464
CLV_NRD_NRD_1	250	252	PF00675	0.522
CLV_PCSK_FUR_1	20	24	PF00082	0.538
CLV_PCSK_KEX2_1	20	22	PF00082	0.544
CLV_PCSK_KEX2_1	241	243	PF00082	0.463
CLV_PCSK_KEX2_1	249	251	PF00082	0.530
CLV_PCSK_SKI1_1	382	386	PF00082	0.644
DEG_Nend_UBRbox_3	1	3	PF02207	0.632
DEG_SPOP_SBC_1	359	363	PF00917	0.605
DOC_CKS1_1	330	335	PF01111	0.641
DOC_CYCLIN_RxL_1	379	389	PF00134	0.659
DOC_CYCLIN_yCln2_LP_2	330	336	PF00134	0.610
DOC_PP2B_LxvP_1	252	255	PF13499	0.657
DOC_USP7_MATH_1	103	107	PF00917	0.492
DOC_USP7_MATH_1	112	116	PF00917	0.402
DOC_USP7_MATH_1	133	137	PF00917	0.661
DOC_USP7_MATH_1	187	191	PF00917	0.530
DOC_USP7_MATH_1	307	311	PF00917	0.791
DOC_USP7_MATH_1	360	364	PF00917	0.703
DOC_USP7_MATH_1	380	384	PF00917	0.634
DOC_USP7_MATH_1	63	67	PF00917	0.704
DOC_USP7_MATH_1	95	99	PF00917	0.629
DOC_WW_Pin1_4	110	115	PF00397	0.585
DOC_WW_Pin1_4	143	148	PF00397	0.666
DOC_WW_Pin1_4	153	158	PF00397	0.653
DOC_WW_Pin1_4	261	266	PF00397	0.667
DOC_WW_Pin1_4	329	334	PF00397	0.726
DOC_WW_Pin1_4	336	341	PF00397	0.604
DOC_WW_Pin1_4	364	369	PF00397	0.737
DOC_WW_Pin1_4	5	10	PF00397	0.601
LIG_14-3-3_CanoR_1	151	160	PF00244	0.567
LIG_14-3-3_CanoR_1	300	308	PF00244	0.690
LIG_14-3-3_CanoR_1	382	391	PF00244	0.616
LIG_14-3-3_CanoR_1	72	77	PF00244	0.637
LIG_BIR_III_4	318	322	PF00653	0.781
LIG_CSL_BTD_1	252	255	PF09270	0.520
LIG_EH1_1	215	223	PF00400	0.425
LIG_FHA_1	105	111	PF00498	0.518
LIG_FHA_1	330	336	PF00498	0.715
LIG_FHA_2	154	160	PF00498	0.561
LIG_FHA_2	184	190	PF00498	0.555
LIG_FHA_2	313	319	PF00498	0.710
LIG_FHA_2	9	15	PF00498	0.508
LIG_LIR_Gen_1	164	171	PF02991	0.714
LIG_LIR_Gen_1	198	209	PF02991	0.475
LIG_LIR_LC3C_4	116	121	PF02991	0.618
LIG_LIR_Nem_3	14	19	PF02991	0.534
LIG_LIR_Nem_3	164	170	PF02991	0.711
LIG_LIR_Nem_3	198	204	PF02991	0.452
LIG_LIR_Nem_3	403	408	PF02991	0.447
LIG_NRBOX	118	124	PF00104	0.613
LIG_PCNA_yPIPBox_3	12	26	PF02747	0.508
LIG_SH2_CRK	16	20	PF00017	0.514
LIG_SH2_CRK	167	171	PF00017	0.731
LIG_SH2_CRK	201	205	PF00017	0.467
LIG_SH2_STAP1	167	171	PF00017	0.570
LIG_SH2_STAP1	201	205	PF00017	0.439
LIG_SH2_STAT3	371	374	PF00017	0.703
LIG_SH2_STAT5	131	134	PF00017	0.482
LIG_SH3_3	157	163	PF00018	0.498
LIG_SH3_3	256	262	PF00018	0.774
LIG_SH3_3	392	398	PF00018	0.444
LIG_SUMO_SIM_par_1	118	125	PF11976	0.480
LIG_SUMO_SIM_par_1	332	337	PF11976	0.569
LIG_TRAF2_1	217	220	PF00917	0.420
LIG_TRFH_1	34	38	PF08558	0.623
MOD_CDK_SPK_2	153	158	PF00069	0.653
MOD_CK1_1	106	112	PF00069	0.488
MOD_CK1_1	113	119	PF00069	0.468
MOD_CK1_1	165	171	PF00069	0.569
MOD_CK1_1	275	281	PF00069	0.758
MOD_CK1_1	367	373	PF00069	0.745
MOD_CK1_1	383	389	PF00069	0.492
MOD_CK1_1	5	11	PF00069	0.594
MOD_CK1_1	68	74	PF00069	0.558
MOD_CK1_1	75	81	PF00069	0.619
MOD_CK1_1	98	104	PF00069	0.693
MOD_CK2_1	314	320	PF00069	0.621
MOD_CK2_1	383	389	PF00069	0.621
MOD_CK2_1	8	14	PF00069	0.516
MOD_GlcNHglycan	141	144	PF01048	0.604
MOD_GlcNHglycan	176	179	PF01048	0.675
MOD_GlcNHglycan	183	186	PF01048	0.579
MOD_GlcNHglycan	277	280	PF01048	0.742
MOD_GlcNHglycan	309	312	PF01048	0.837
MOD_GlcNHglycan	61	64	PF01048	0.686
MOD_GlcNHglycan	65	68	PF01048	0.728
MOD_GlcNHglycan	85	88	PF01048	0.703
MOD_GlcNHglycan	97	100	PF01048	0.582
MOD_GSK3_1	106	113	PF00069	0.567
MOD_GSK3_1	139	146	PF00069	0.578
MOD_GSK3_1	161	168	PF00069	0.633
MOD_GSK3_1	170	177	PF00069	0.708
MOD_GSK3_1	183	190	PF00069	0.546
MOD_GSK3_1	266	273	PF00069	0.765
MOD_GSK3_1	325	332	PF00069	0.775
MOD_GSK3_1	360	367	PF00069	0.813
MOD_GSK3_1	59	66	PF00069	0.601
MOD_GSK3_1	68	75	PF00069	0.708
MOD_N-GLC_1	133	138	PF02516	0.689
MOD_N-GLC_1	275	280	PF02516	0.754
MOD_N-GLC_1	325	330	PF02516	0.784
MOD_NEK2_1	139	144	PF00069	0.639
MOD_NEK2_1	196	201	PF00069	0.579
MOD_NEK2_1	267	272	PF00069	0.679
MOD_NEK2_1	40	45	PF00069	0.606
MOD_NEK2_1	77	82	PF00069	0.587
MOD_PIKK_1	299	305	PF00454	0.697
MOD_PK_1	72	78	PF00069	0.641
MOD_PKA_2	299	305	PF00069	0.794
MOD_Plk_1	124	130	PF00069	0.458
MOD_Plk_1	133	139	PF00069	0.389
MOD_Plk_1	325	331	PF00069	0.704
MOD_Plk_2-3	314	320	PF00069	0.621
MOD_Plk_4	106	112	PF00069	0.503
MOD_Plk_4	124	130	PF00069	0.458
MOD_Plk_4	134	140	PF00069	0.660
MOD_Plk_4	162	168	PF00069	0.560
MOD_Plk_4	187	193	PF00069	0.516
MOD_Plk_4	72	78	PF00069	0.672
MOD_ProDKin_1	110	116	PF00069	0.577
MOD_ProDKin_1	143	149	PF00069	0.669
MOD_ProDKin_1	153	159	PF00069	0.649
MOD_ProDKin_1	261	267	PF00069	0.671
MOD_ProDKin_1	329	335	PF00069	0.719
MOD_ProDKin_1	336	342	PF00069	0.601
MOD_ProDKin_1	364	370	PF00069	0.729
MOD_ProDKin_1	5	11	PF00069	0.594
MOD_SUMO_for_1	281	284	PF00179	0.771
TRG_DiLeu_BaEn_1	14	19	PF01217	0.531
TRG_DiLeu_BaEn_1	389	394	PF01217	0.577
TRG_DiLeu_BaLyEn_6	330	335	PF01217	0.574
TRG_DiLeu_BaLyEn_6	403	408	PF01217	0.454
TRG_ENDOCYTIC_2	16	19	PF00928	0.519
TRG_ENDOCYTIC_2	167	170	PF00928	0.731
TRG_ENDOCYTIC_2	201	204	PF00928	0.457
TRG_ENDOCYTIC_2	405	408	PF00928	0.459
TRG_ER_diArg_1	150	153	PF00400	0.638
TRG_ER_diArg_1	19	22	PF00400	0.536
TRG_ER_diArg_1	240	242	PF00400	0.462
TRG_ER_diArg_1	248	251	PF00400	0.526
TRG_Pf-PMV_PEXEL_1	382	387	PF00026	0.673
TRG_Pf-PMV_PEXEL_1	406	410	PF00026	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3J3	Leptomonas seymouri	47%	95%
A0A3S5H559	Leishmania donovani	100%	100%
A4H3P0	Leishmania braziliensis	71%	97%
E9ACM4	Leishmania major	94%	100%
E9AJW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%