LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Ubiquitin-like domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4HRW5_LEIIN
TriTrypDb:
LINF_030012700
Length:
548

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005929 cilium 4 11
GO:0042995 cell projection 2 11
GO:0043226 organelle 2 11
GO:0043227 membrane-bounded organelle 3 11
GO:0110165 cellular anatomical entity 1 12
GO:0120025 plasma membrane bounded cell projection 3 11
GO:0005737 cytoplasm 2 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1

Expansion

Sequence features

A4HRW5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRW5

Function

Biological processes
Term Name Level Count
GO:0006457 protein folding 2 12
GO:0009987 cellular process 1 12
GO:0000226 microtubule cytoskeleton organization 3 1
GO:0006996 organelle organization 4 1
GO:0007010 cytoskeleton organization 5 1
GO:0007017 microtubule-based process 2 1
GO:0007021 tubulin complex assembly 6 1
GO:0007023 post-chaperonin tubulin folding pathway 3 1
GO:0016043 cellular component organization 3 1
GO:0022607 cellular component assembly 4 1
GO:0043933 protein-containing complex organization 4 1
GO:0065003 protein-containing complex assembly 5 1
GO:0071840 cellular component organization or biogenesis 2 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 12
GO:0005515 protein binding 2 12
GO:0008092 cytoskeletal protein binding 3 12
GO:0015631 tubulin binding 4 12
GO:0043014 alpha-tubulin binding 5 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 14 18 PF00656 0.397
CLV_C14_Caspase3-7 317 321 PF00656 0.384
CLV_C14_Caspase3-7 371 375 PF00656 0.376
CLV_C14_Caspase3-7 392 396 PF00656 0.615
CLV_PCSK_SKI1_1 125 129 PF00082 0.422
CLV_PCSK_SKI1_1 155 159 PF00082 0.357
CLV_PCSK_SKI1_1 300 304 PF00082 0.459
CLV_PCSK_SKI1_1 328 332 PF00082 0.455
CLV_PCSK_SKI1_1 382 386 PF00082 0.518
DEG_APCC_DBOX_1 60 68 PF00400 0.500
DEG_SPOP_SBC_1 147 151 PF00917 0.557
DEG_SPOP_SBC_1 4 8 PF00917 0.580
DEG_SPOP_SBC_1 464 468 PF00917 0.671
DOC_CDC14_PxL_1 120 128 PF14671 0.484
DOC_CDC14_PxL_1 131 139 PF14671 0.519
DOC_CDC14_PxL_1 172 180 PF14671 0.421
DOC_CKS1_1 518 523 PF01111 0.531
DOC_CYCLIN_RxL_1 176 185 PF00134 0.528
DOC_MAPK_gen_1 297 307 PF00069 0.414
DOC_MAPK_gen_1 42 49 PF00069 0.597
DOC_MAPK_gen_1 421 429 PF00069 0.420
DOC_MAPK_gen_1 55 64 PF00069 0.402
DOC_MAPK_MEF2A_6 411 419 PF00069 0.434
DOC_MAPK_MEF2A_6 423 431 PF00069 0.489
DOC_MAPK_MEF2A_6 58 66 PF00069 0.516
DOC_MAPK_MEF2A_6 68 76 PF00069 0.368
DOC_PP2B_LxvP_1 267 270 PF13499 0.498
DOC_PP4_MxPP_1 140 143 PF00568 0.551
DOC_USP7_MATH_1 11 15 PF00917 0.479
DOC_USP7_MATH_1 147 151 PF00917 0.530
DOC_USP7_MATH_1 2 6 PF00917 0.747
DOC_USP7_MATH_1 210 214 PF00917 0.737
DOC_USP7_MATH_1 464 468 PF00917 0.672
DOC_USP7_UBL2_3 421 425 PF12436 0.468
DOC_WW_Pin1_4 194 199 PF00397 0.646
DOC_WW_Pin1_4 468 473 PF00397 0.531
DOC_WW_Pin1_4 5 10 PF00397 0.657
DOC_WW_Pin1_4 517 522 PF00397 0.514
LIG_14-3-3_CanoR_1 125 130 PF00244 0.476
LIG_14-3-3_CanoR_1 300 305 PF00244 0.454
LIG_14-3-3_CanoR_1 333 343 PF00244 0.375
LIG_14-3-3_CanoR_1 505 509 PF00244 0.487
LIG_14-3-3_CanoR_1 61 65 PF00244 0.505
LIG_deltaCOP1_diTrp_1 41 46 PF00928 0.636
LIG_eIF4E_1 379 385 PF01652 0.503
LIG_FHA_1 126 132 PF00498 0.425
LIG_FHA_1 143 149 PF00498 0.524
LIG_FHA_1 227 233 PF00498 0.359
LIG_FHA_1 282 288 PF00498 0.557
LIG_FHA_1 314 320 PF00498 0.440
LIG_FHA_1 329 335 PF00498 0.237
LIG_FHA_1 356 362 PF00498 0.470
LIG_FHA_1 447 453 PF00498 0.394
LIG_FHA_1 475 481 PF00498 0.514
LIG_FHA_1 61 67 PF00498 0.425
LIG_FHA_2 187 193 PF00498 0.527
LIG_FHA_2 340 346 PF00498 0.521
LIG_FHA_2 518 524 PF00498 0.465
LIG_Integrin_isoDGR_2 347 349 PF01839 0.287
LIG_LIR_Gen_1 335 341 PF02991 0.393
LIG_LIR_Gen_1 41 49 PF02991 0.566
LIG_LIR_Gen_1 444 453 PF02991 0.487
LIG_LIR_LC3C_4 63 66 PF02991 0.496
LIG_LIR_Nem_3 161 166 PF02991 0.486
LIG_LIR_Nem_3 221 227 PF02991 0.430
LIG_LIR_Nem_3 238 243 PF02991 0.341
LIG_LIR_Nem_3 335 339 PF02991 0.393
LIG_LIR_Nem_3 41 47 PF02991 0.579
LIG_LIR_Nem_3 444 448 PF02991 0.525
LIG_LIR_Nem_3 528 534 PF02991 0.465
LIG_LYPXL_yS_3 414 417 PF13949 0.399
LIG_MYND_1 135 139 PF01753 0.517
LIG_PTB_Apo_2 157 164 PF02174 0.461
LIG_SH2_CRK 296 300 PF00017 0.413
LIG_SH2_CRK 336 340 PF00017 0.428
LIG_SH2_NCK_1 458 462 PF00017 0.615
LIG_SH2_PTP2 445 448 PF00017 0.542
LIG_SH2_STAP1 336 340 PF00017 0.387
LIG_SH2_STAP1 458 462 PF00017 0.644
LIG_SH2_STAT5 122 125 PF00017 0.487
LIG_SH2_STAT5 258 261 PF00017 0.471
LIG_SH2_STAT5 298 301 PF00017 0.368
LIG_SH2_STAT5 351 354 PF00017 0.350
LIG_SH2_STAT5 379 382 PF00017 0.372
LIG_SH2_STAT5 445 448 PF00017 0.542
LIG_SH2_STAT5 453 456 PF00017 0.510
LIG_SH2_STAT5 541 544 PF00017 0.526
LIG_SH3_1 118 124 PF00018 0.498
LIG_SH3_3 118 124 PF00018 0.498
LIG_SH3_3 136 142 PF00018 0.381
LIG_SH3_3 170 176 PF00018 0.421
LIG_SH3_3 192 198 PF00018 0.630
LIG_SH3_3 219 225 PF00018 0.586
LIG_SH3_3 289 295 PF00018 0.530
LIG_SH3_3 409 415 PF00018 0.487
LIG_SH3_4 500 507 PF00018 0.536
LIG_SUMO_SIM_anti_2 189 195 PF11976 0.572
LIG_SUMO_SIM_anti_2 358 363 PF11976 0.475
LIG_SUMO_SIM_anti_2 60 66 PF11976 0.518
LIG_SUMO_SIM_par_1 446 451 PF11976 0.497
LIG_SUMO_SIM_par_1 512 520 PF11976 0.503
LIG_TYR_ITIM 334 339 PF00017 0.420
LIG_TYR_ITIM 412 417 PF00017 0.432
LIG_TYR_ITIM 529 534 PF00017 0.391
LIG_UBA3_1 304 308 PF00899 0.484
LIG_WRC_WIRS_1 329 334 PF05994 0.331
MOD_CK1_1 106 112 PF00069 0.536
MOD_CK1_1 151 157 PF00069 0.447
MOD_CK1_1 201 207 PF00069 0.709
MOD_CK1_1 3 9 PF00069 0.728
MOD_CK1_1 467 473 PF00069 0.406
MOD_CK1_1 482 488 PF00069 0.238
MOD_CK1_1 507 513 PF00069 0.306
MOD_CK1_1 535 541 PF00069 0.375
MOD_CK1_1 80 86 PF00069 0.637
MOD_CK2_1 109 115 PF00069 0.441
MOD_CK2_1 339 345 PF00069 0.516
MOD_GlcNHglycan 212 215 PF01048 0.727
MOD_GlcNHglycan 24 27 PF01048 0.595
MOD_GlcNHglycan 402 405 PF01048 0.650
MOD_GlcNHglycan 509 512 PF01048 0.308
MOD_GlcNHglycan 78 82 PF01048 0.686
MOD_GSK3_1 142 149 PF00069 0.543
MOD_GSK3_1 158 165 PF00069 0.404
MOD_GSK3_1 182 189 PF00069 0.493
MOD_GSK3_1 194 201 PF00069 0.649
MOD_GSK3_1 309 316 PF00069 0.458
MOD_GSK3_1 328 335 PF00069 0.182
MOD_GSK3_1 339 346 PF00069 0.395
MOD_GSK3_1 434 441 PF00069 0.636
MOD_GSK3_1 463 470 PF00069 0.627
MOD_GSK3_1 471 478 PF00069 0.299
MOD_GSK3_1 5 12 PF00069 0.702
MOD_N-GLC_1 158 163 PF02516 0.454
MOD_N-GLC_1 186 191 PF02516 0.558
MOD_N-GLC_1 210 215 PF02516 0.636
MOD_N-GLC_1 309 314 PF02516 0.420
MOD_N-GLC_1 343 348 PF02516 0.370
MOD_NEK2_1 148 153 PF00069 0.433
MOD_NEK2_1 158 163 PF00069 0.408
MOD_NEK2_1 313 318 PF00069 0.512
MOD_NEK2_1 332 337 PF00069 0.186
MOD_PIKK_1 252 258 PF00454 0.473
MOD_PIKK_1 472 478 PF00454 0.425
MOD_PKA_2 332 338 PF00069 0.355
MOD_PKA_2 363 369 PF00069 0.532
MOD_PKA_2 504 510 PF00069 0.355
MOD_PKA_2 60 66 PF00069 0.506
MOD_Plk_1 106 112 PF00069 0.430
MOD_Plk_1 186 192 PF00069 0.341
MOD_Plk_1 309 315 PF00069 0.432
MOD_Plk_2-3 27 33 PF00069 0.616
MOD_Plk_4 11 17 PF00069 0.448
MOD_Plk_4 269 275 PF00069 0.475
MOD_Plk_4 300 306 PF00069 0.414
MOD_Plk_4 335 341 PF00069 0.459
MOD_Plk_4 441 447 PF00069 0.614
MOD_Plk_4 448 454 PF00069 0.469
MOD_Plk_4 535 541 PF00069 0.388
MOD_Plk_4 60 66 PF00069 0.506
MOD_ProDKin_1 194 200 PF00069 0.647
MOD_ProDKin_1 468 474 PF00069 0.414
MOD_ProDKin_1 5 11 PF00069 0.648
MOD_ProDKin_1 517 523 PF00069 0.391
TRG_DiLeu_BaEn_1 115 120 PF01217 0.488
TRG_ENDOCYTIC_2 296 299 PF00928 0.368
TRG_ENDOCYTIC_2 336 339 PF00928 0.376
TRG_ENDOCYTIC_2 414 417 PF00928 0.399
TRG_ENDOCYTIC_2 445 448 PF00928 0.542
TRG_ENDOCYTIC_2 531 534 PF00928 0.391
TRG_Pf-PMV_PEXEL_1 164 168 PF00026 0.443
TRG_Pf-PMV_PEXEL_1 170 174 PF00026 0.459
TRG_Pf-PMV_PEXEL_1 382 386 PF00026 0.515

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HTC4 Leptomonas seymouri 62% 100%
A0A0S4JLX2 Bodo saltans 38% 100%
A0A1X0P967 Trypanosomatidae 42% 100%
A0A3S5H558 Leishmania donovani 100% 99%
A0A422NHN6 Trypanosoma rangeli 44% 100%
A4H3N8 Leishmania braziliensis 81% 100%
C9ZKH0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
E9ACM2 Leishmania major 93% 100%
E9AJW0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q15813 Homo sapiens 23% 100%
Q32KS0 Bos taurus 23% 100%
Q5RBD9 Pongo abelii 23% 100%
Q5U508 Xenopus laevis 22% 100%
Q8CIV8 Mus musculus 22% 100%
Q8GRL7 Arabidopsis thaliana 25% 100%
V5C274 Trypanosoma cruzi 42% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS