Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HRW4_LEIIN

TriTrypDb:

LINF_030012600

Length:

317

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HRW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRW4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	194	198	PF00656	0.595
CLV_NRD_NRD_1	278	280	PF00675	0.603
CLV_NRD_NRD_1	54	56	PF00675	0.758
CLV_NRD_NRD_1	88	90	PF00675	0.404
CLV_PCSK_KEX2_1	278	280	PF00082	0.603
CLV_PCSK_KEX2_1	54	56	PF00082	0.706
CLV_PCSK_KEX2_1	87	89	PF00082	0.434
CLV_PCSK_PC7_1	274	280	PF00082	0.515
CLV_PCSK_SKI1_1	10	14	PF00082	0.649
CLV_Separin_Metazoa	268	272	PF03568	0.493
DEG_APCC_DBOX_1	86	94	PF00400	0.396
DEG_Nend_UBRbox_1	1	4	PF02207	0.621
DEG_SPOP_SBC_1	151	155	PF00917	0.573
DEG_SPOP_SBC_1	191	195	PF00917	0.553
DEG_SPOP_SBC_1	43	47	PF00917	0.729
DOC_CYCLIN_yCln2_LP_2	181	187	PF00134	0.437
DOC_MAPK_gen_1	87	94	PF00069	0.384
DOC_MAPK_MEF2A_6	210	219	PF00069	0.347
DOC_MAPK_MEF2A_6	87	94	PF00069	0.384
DOC_PP2B_LxvP_1	181	184	PF13499	0.517
DOC_USP7_MATH_1	12	16	PF00917	0.615
DOC_USP7_MATH_1	151	155	PF00917	0.591
DOC_USP7_MATH_1	163	167	PF00917	0.559
DOC_USP7_MATH_1	187	191	PF00917	0.600
DOC_USP7_MATH_1	42	46	PF00917	0.688
DOC_WW_Pin1_4	166	171	PF00397	0.642
DOC_WW_Pin1_4	45	50	PF00397	0.665
LIG_14-3-3_CanoR_1	114	122	PF00244	0.493
LIG_14-3-3_CanoR_1	2	7	PF00244	0.578
LIG_14-3-3_CanoR_1	260	265	PF00244	0.397
LIG_14-3-3_CanoR_1	54	59	PF00244	0.770
LIG_BRCT_BRCA1_1	115	119	PF00533	0.476
LIG_eIF4E_1	113	119	PF01652	0.427
LIG_EVH1_1	76	80	PF00568	0.616
LIG_FHA_1	11	17	PF00498	0.631
LIG_FHA_1	113	119	PF00498	0.439
LIG_FHA_1	232	238	PF00498	0.450
LIG_FHA_1	259	265	PF00498	0.495
LIG_FHA_2	105	111	PF00498	0.536
LIG_FHA_2	167	173	PF00498	0.735
LIG_Integrin_RGD_1	36	38	PF01839	0.581
LIG_LIR_Gen_1	116	127	PF02991	0.515
LIG_LIR_Nem_3	116	122	PF02991	0.480
LIG_LIR_Nem_3	207	211	PF02991	0.372
LIG_LIR_Nem_3	212	217	PF02991	0.393
LIG_LIR_Nem_3	74	79	PF02991	0.595
LIG_MYND_1	99	103	PF01753	0.461
LIG_NRBOX	265	271	PF00104	0.590
LIG_SH2_PTP2	252	255	PF00017	0.463
LIG_SH2_STAT5	208	211	PF00017	0.469
LIG_SH2_STAT5	242	245	PF00017	0.477
LIG_SH2_STAT5	252	255	PF00017	0.500
LIG_SH2_STAT5	296	299	PF00017	0.411
LIG_SH3_2	49	54	PF14604	0.588
LIG_SH3_3	126	132	PF00018	0.378
LIG_SH3_3	142	148	PF00018	0.366
LIG_SH3_3	181	187	PF00018	0.652
LIG_SH3_3	196	202	PF00018	0.527
LIG_SH3_3	46	52	PF00018	0.657
LIG_SH3_3	74	80	PF00018	0.683
LIG_SUMO_SIM_par_1	260	265	PF11976	0.397
LIG_SxIP_EBH_1	16	26	PF03271	0.537
LIG_TRAF2_1	282	285	PF00917	0.581
LIG_WW_3	58	62	PF00397	0.626
MOD_CK1_1	153	159	PF00069	0.594
MOD_CK1_1	166	172	PF00069	0.517
MOD_CK1_1	189	195	PF00069	0.672
MOD_CK1_1	45	51	PF00069	0.631
MOD_CK1_1	5	11	PF00069	0.534
MOD_CK2_1	251	257	PF00069	0.444
MOD_Cter_Amidation	276	279	PF01082	0.602
MOD_GlcNHglycan	115	118	PF01048	0.479
MOD_GlcNHglycan	155	158	PF01048	0.622
MOD_GlcNHglycan	161	164	PF01048	0.652
MOD_GlcNHglycan	189	192	PF01048	0.582
MOD_GlcNHglycan	56	59	PF01048	0.648
MOD_GSK3_1	113	120	PF00069	0.502
MOD_GSK3_1	159	166	PF00069	0.616
MOD_GSK3_1	185	192	PF00069	0.670
MOD_GSK3_1	43	50	PF00069	0.626
MOD_GSK3_1	8	15	PF00069	0.622
MOD_N-GLC_1	18	23	PF02516	0.608
MOD_NEK2_1	118	123	PF00069	0.324
MOD_NEK2_1	150	155	PF00069	0.677
MOD_NEK2_1	231	236	PF00069	0.461
MOD_NEK2_1	251	256	PF00069	0.502
MOD_NEK2_1	308	313	PF00069	0.538
MOD_PK_1	260	266	PF00069	0.503
MOD_PKA_1	54	60	PF00069	0.710
MOD_PKA_2	113	119	PF00069	0.420
MOD_PKA_2	231	237	PF00069	0.484
MOD_PKA_2	277	283	PF00069	0.491
MOD_PKA_2	53	59	PF00069	0.636
MOD_Plk_1	18	24	PF00069	0.723
MOD_Plk_1	29	35	PF00069	0.607
MOD_Plk_4	118	124	PF00069	0.388
MOD_Plk_4	18	24	PF00069	0.748
MOD_ProDKin_1	166	172	PF00069	0.642
MOD_ProDKin_1	45	51	PF00069	0.666
MOD_SUMO_for_1	282	285	PF00179	0.552
MOD_SUMO_rev_2	281	288	PF00179	0.544
TRG_DiLeu_BaEn_1	265	270	PF01217	0.524
TRG_DiLeu_BaLyEn_6	145	150	PF01217	0.448
TRG_ENDOCYTIC_2	208	211	PF00928	0.469
TRG_ENDOCYTIC_2	252	255	PF00928	0.463
TRG_ER_diArg_1	86	89	PF00400	0.447
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCN8	Leptomonas seymouri	66%	95%
A0A1X0PA92	Trypanosomatidae	39%	100%
A0A3R7KEM6	Trypanosoma rangeli	40%	100%
A0A3S5H557	Leishmania donovani	99%	100%
C9ZKG9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ACM1	Leishmania major	91%	100%
E9AJV9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
V5BC94	Trypanosoma cruzi	42%	100%