Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Aminoacyl-tRNA editing domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HRV9_LEIIN

TriTrypDb:

LINF_030012100

Length:

228

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HRV9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRV9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0002161	aminoacyl-tRNA editing activity	5	9
GO:0003824	catalytic activity	1	9
GO:0016787	hydrolase activity	2	9
GO:0016788	hydrolase activity, acting on ester bonds	3	9
GO:0052689	carboxylic ester hydrolase activity	4	9
GO:0140098	catalytic activity, acting on RNA	3	9
GO:0140101	catalytic activity, acting on a tRNA	4	9
GO:0140640	catalytic activity, acting on a nucleic acid	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	132	134	PF00082	0.241
CLV_PCSK_KEX2_1	165	167	PF00082	0.216
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.251
CLV_PCSK_PC1ET2_1	165	167	PF00082	0.236
CLV_PCSK_SKI1_1	129	133	PF00082	0.280
DEG_Nend_UBRbox_2	1	3	PF02207	0.435
DOC_CDC14_PxL_1	9	17	PF14671	0.307
DOC_MAPK_MEF2A_6	157	164	PF00069	0.425
DOC_MAPK_RevD_3	104	119	PF00069	0.471
DOC_PP1_RVXF_1	43	50	PF00149	0.312
DOC_USP7_MATH_1	113	117	PF00917	0.471
DOC_USP7_MATH_1	220	224	PF00917	0.514
DOC_USP7_MATH_1	23	27	PF00917	0.416
DOC_USP7_MATH_1	80	84	PF00917	0.552
DOC_USP7_UBL2_3	114	118	PF12436	0.434
DOC_USP7_UBL2_3	119	123	PF12436	0.400
DOC_USP7_UBL2_3	53	57	PF12436	0.537
DOC_USP7_UBL2_3	61	65	PF12436	0.527
DOC_WW_Pin1_4	86	91	PF00397	0.688
LIG_14-3-3_CanoR_1	85	93	PF00244	0.508
LIG_APCC_ABBA_1	156	161	PF00400	0.409
LIG_BRCT_BRCA1_1	45	49	PF00533	0.317
LIG_deltaCOP1_diTrp_1	197	205	PF00928	0.334
LIG_FHA_1	26	32	PF00498	0.365
LIG_FHA_2	182	188	PF00498	0.471
LIG_GBD_Chelix_1	43	51	PF00786	0.325
LIG_LIR_Gen_1	197	203	PF02991	0.326
LIG_LIR_Nem_3	137	142	PF02991	0.471
LIG_LIR_Nem_3	197	201	PF02991	0.350
LIG_NRBOX	46	52	PF00104	0.366
LIG_SH2_PTP2	169	172	PF00017	0.471
LIG_SH2_SRC	159	162	PF00017	0.483
LIG_SH2_SRC	169	172	PF00017	0.483
LIG_SH2_STAP1	191	195	PF00017	0.437
LIG_SH2_STAT5	139	142	PF00017	0.471
LIG_SH2_STAT5	159	162	PF00017	0.483
LIG_SH2_STAT5	169	172	PF00017	0.483
LIG_SH3_3	87	93	PF00018	0.558
LIG_SH3_4	53	60	PF00018	0.470
MOD_CK1_1	218	224	PF00069	0.550
MOD_CK1_1	25	31	PF00069	0.382
MOD_CK2_1	181	187	PF00069	0.461
MOD_CK2_1	53	59	PF00069	0.513
MOD_GlcNHglycan	115	118	PF01048	0.292
MOD_GlcNHglycan	222	225	PF01048	0.517
MOD_GlcNHglycan	24	28	PF01048	0.358
MOD_GlcNHglycan	76	80	PF01048	0.678
MOD_GlcNHglycan	86	89	PF01048	0.633
MOD_GSK3_1	220	227	PF00069	0.503
MOD_GSK3_1	80	87	PF00069	0.667
MOD_NEK2_1	160	165	PF00069	0.423
MOD_NEK2_1	22	27	PF00069	0.429
MOD_PKA_1	52	58	PF00069	0.410
MOD_PKA_2	84	90	PF00069	0.597
MOD_Plk_1	160	166	PF00069	0.416
MOD_Plk_4	45	51	PF00069	0.350
MOD_ProDKin_1	86	92	PF00069	0.685
MOD_SUMO_for_1	131	134	PF00179	0.433
MOD_SUMO_rev_2	56	62	PF00179	0.521
TRG_ENDOCYTIC_2	139	142	PF00928	0.471
TRG_ENDOCYTIC_2	159	162	PF00928	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U1	Leptomonas seymouri	57%	100%
A0A1X0P8W1	Trypanosomatidae	44%	100%
A0A3R7N573	Trypanosoma rangeli	39%	100%
A0A3S5H554	Leishmania donovani	99%	100%
A4H3N2	Leishmania braziliensis	69%	100%
E9ACL6	Leishmania major	83%	100%
E9AJV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
P71000	Bacillus subtilis (strain 168)	38%	100%