Putative 60S acidic ribosomal protein P2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60s Acidic ribosomal protein - putative

Species:

Leishmania infantum

UniProt:

A4HRV3_LEIIN

TriTrypDb:

LINF_030009000

Length:

112

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	8
GO:0032991	protein-containing complex	1	9
GO:0043226	organelle	2	8
GO:0043228	non-membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043232	intracellular non-membrane-bounded organelle	4	8
GO:0110165	cellular anatomical entity	1	9
GO:1990904	ribonucleoprotein complex	2	9
GO:0005737	cytoplasm	2	1
GO:0015934	large ribosomal subunit	4	1
GO:0022625	cytosolic large ribosomal subunit	5	1
GO:0044391	ribosomal subunit	3	1

Expansion

Sequence features

A4HRV3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRV3

Function

Biological processes
Term	Name	Level	Count
GO:0002181	cytoplasmic translation	5	1
GO:0006412	translation	4	1
GO:0006414	translational elongation	5	7
GO:0006518	peptide metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	7
GO:0009058	biosynthetic process	2	7
GO:0009059	macromolecule biosynthetic process	4	7
GO:0009987	cellular process	1	7
GO:0019538	protein metabolic process	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	7
GO:0043043	peptide biosynthetic process	5	1
GO:0043170	macromolecule metabolic process	3	7
GO:0043603	amide metabolic process	3	1
GO:0043604	amide biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	7
GO:0005198	structural molecule activity	1	7
GO:0005488	binding	1	1
GO:0008047	enzyme activator activity	3	1
GO:0019207	kinase regulator activity	3	1
GO:0019209	kinase activator activity	4	1
GO:0019887	protein kinase regulator activity	4	1
GO:0030234	enzyme regulator activity	2	1
GO:0030295	protein kinase activator activity	5	1
GO:0043021	ribonucleoprotein complex binding	3	1
GO:0044877	protein-containing complex binding	2	1
GO:0098772	molecular function regulator activity	1	1
GO:0140677	molecular function activator activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	99	103	PF00656	0.494
CLV_NRD_NRD_1	65	67	PF00675	0.420
CLV_NRD_NRD_1	68	70	PF00675	0.436
CLV_NRD_NRD_1	77	79	PF00675	0.525
CLV_PCSK_FUR_1	66	70	PF00082	0.426
CLV_PCSK_FUR_1	74	78	PF00082	0.493
CLV_PCSK_KEX2_1	65	67	PF00082	0.420
CLV_PCSK_KEX2_1	68	70	PF00082	0.436
CLV_PCSK_KEX2_1	76	78	PF00082	0.523
CLV_PCSK_PC7_1	61	67	PF00082	0.414
DEG_APCC_DBOX_1	38	46	PF00400	0.527
DOC_MAPK_MEF2A_6	39	46	PF00069	0.560
DOC_USP7_UBL2_3	89	93	PF12436	0.793
LIG_BIR_II_1	1	5	PF00653	0.490
LIG_FHA_1	39	45	PF00498	0.589
LIG_FHA_2	20	26	PF00498	0.581
LIG_Integrin_RGD_1	55	57	PF01839	0.400
LIG_LIR_Apic_2	57	63	PF02991	0.412
LIG_LIR_Gen_1	9	18	PF02991	0.547
LIG_LIR_Nem_3	9	13	PF02991	0.534
LIG_SH2_CRK	10	14	PF00017	0.541
LIG_SH2_STAP1	10	14	PF00017	0.541
LIG_SH3_1	61	67	PF00018	0.414
LIG_SH3_2	64	69	PF14604	0.420
LIG_SH3_3	37	43	PF00018	0.587
LIG_SH3_3	61	67	PF00018	0.449
LIG_WW_3	62	66	PF00397	0.413
LIG_WW_3	71	75	PF00397	0.456
MOD_CK1_1	2	8	PF00069	0.476
MOD_CK2_1	19	25	PF00069	0.587
MOD_GlcNHglycan	1	4	PF01048	0.513
MOD_GlcNHglycan	22	25	PF01048	0.597
MOD_GSK3_1	2	9	PF00069	0.557
MOD_NEK2_1	6	11	PF00069	0.537
MOD_PKA_2	38	44	PF00069	0.599
TRG_ENDOCYTIC_2	10	13	PF00928	0.533
TRG_ER_diArg_1	64	66	PF00400	0.415
TRG_ER_diArg_1	67	69	PF00400	0.430
TRG_ER_diArg_1	73	76	PF00400	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A451EJP5	Leishmania donovani	64%	100%
A4H3L0	Leishmania braziliensis	59%	100%
A4H3L1	Leishmania braziliensis	59%	100%
A4HRV4	Leishmania infantum	64%	100%
E9ACI8	Leishmania major	64%	100%
E9AJS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
E9AJS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	100%
O23095	Arabidopsis thaliana	34%	99%
Q8LCW9	Arabidopsis thaliana	34%	100%
Q8LEQ0	Arabidopsis thaliana	33%	99%