GPR1/FUN34/yaaH family-domain-containing protein

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GPR1/FUN34/yaaH family - putative

Species:

Leishmania infantum

UniProt:

A4HRV0_LEIIN

TriTrypDb:

LINF_030008700

Length:

303

Annotations

LeishMANIAdb annotations

Most closely related to Prokaryotic SatP transporters. Especially expanded in the Leptomonas lineage

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16
GO:0005886	plasma membrane	3	2

Phosphorylation

Amastigote: 39

Expansion

Sequence features

A4HRV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRV0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006811	monoatomic ion transport	4	2
GO:0006820	monoatomic anion transport	5	2
GO:0006835	dicarboxylic acid transport	7	2
GO:0006846	acetate transport	6	2
GO:0009987	cellular process	1	2
GO:0015711	organic anion transport	5	2
GO:0015718	monocarboxylic acid transport	7	2
GO:0015740	C4-dicarboxylate transport	8	2
GO:0015744	succinate transport	6	2
GO:0015849	organic acid transport	5	2
GO:0034220	monoatomic ion transmembrane transport	3	2
GO:0035433	acetate transmembrane transport	5	2
GO:0046942	carboxylic acid transport	6	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0055085	transmembrane transport	2	2
GO:0071422	succinate transmembrane transport	5	2
GO:0071702	organic substance transport	4	2
GO:0098656	monoatomic anion transmembrane transport	4	2
GO:1903825	organic acid transmembrane transport	3	2
GO:1905039	carboxylic acid transmembrane transport	4	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	2
GO:0005342	organic acid transmembrane transporter activity	3	2
GO:0008028	monocarboxylic acid transmembrane transporter activity	5	2
GO:0008324	monoatomic cation transmembrane transporter activity	4	2
GO:0008509	monoatomic anion transmembrane transporter activity	4	2
GO:0008514	organic anion transmembrane transporter activity	5	2
GO:0015075	monoatomic ion transmembrane transporter activity	3	2
GO:0015078	proton transmembrane transporter activity	5	2
GO:0015123	acetate transmembrane transporter activity	6	2
GO:0015291	secondary active transmembrane transporter activity	4	2
GO:0015293	symporter activity	5	2
GO:0015294	solute:monoatomic cation symporter activity	5	2
GO:0015295	solute:proton symporter activity	6	2
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	2
GO:0015355	secondary active monocarboxylate transmembrane transporter activity	5	2
GO:0015360	acetate:proton symporter activity	7	2
GO:0022804	active transmembrane transporter activity	3	2
GO:0022853	active monoatomic ion transmembrane transporter activity	4	2
GO:0022857	transmembrane transporter activity	2	2
GO:0022890	inorganic cation transmembrane transporter activity	4	2
GO:0043893	acetate:monoatomic cation symporter activity	6	2
GO:0046943	carboxylic acid transmembrane transporter activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	62	64	PF00675	0.382
CLV_NRD_NRD_1	66	68	PF00675	0.364
CLV_NRD_NRD_1	85	87	PF00675	0.308
CLV_PCSK_KEX2_1	66	68	PF00082	0.395
CLV_PCSK_KEX2_1	85	87	PF00082	0.320
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.420
CLV_PCSK_SKI1_1	265	269	PF00082	0.342
CLV_PCSK_SKI1_1	63	67	PF00082	0.280
DEG_APCC_DBOX_1	264	272	PF00400	0.563
DEG_APCC_DBOX_1	66	74	PF00400	0.574
DOC_CYCLIN_yClb5_NLxxxL_5	205	212	PF00134	0.523
DOC_MAPK_DCC_7	265	273	PF00069	0.563
DOC_MAPK_DCC_7	85	95	PF00069	0.486
DOC_MAPK_MEF2A_6	205	214	PF00069	0.491
DOC_MAPK_MEF2A_6	265	273	PF00069	0.563
DOC_USP7_MATH_1	149	153	PF00917	0.318
DOC_USP7_MATH_1	15	19	PF00917	0.771
DOC_USP7_MATH_1	171	175	PF00917	0.283
DOC_USP7_MATH_1	287	291	PF00917	0.675
DOC_USP7_UBL2_3	64	68	PF12436	0.601
DOC_WW_Pin1_4	280	285	PF00397	0.656
LIG_14-3-3_CanoR_1	141	146	PF00244	0.473
LIG_Actin_RPEL_3	258	277	PF02755	0.504
LIG_APCC_ABBA_1	26	31	PF00400	0.504
LIG_BIR_II_1	1	5	PF00653	0.688
LIG_BRCT_BRCA1_1	180	184	PF00533	0.346
LIG_deltaCOP1_diTrp_1	138	145	PF00928	0.546
LIG_FHA_1	100	106	PF00498	0.312
LIG_FHA_1	115	121	PF00498	0.272
LIG_FHA_1	171	177	PF00498	0.323
LIG_FHA_1	214	220	PF00498	0.346
LIG_FHA_1	272	278	PF00498	0.586
LIG_FHA_2	20	26	PF00498	0.542
LIG_LIR_Gen_1	144	155	PF02991	0.326
LIG_LIR_Gen_1	196	204	PF02991	0.359
LIG_LIR_Gen_1	218	229	PF02991	0.444
LIG_LIR_Nem_3	144	150	PF02991	0.317
LIG_LIR_Nem_3	151	156	PF02991	0.289
LIG_LIR_Nem_3	181	187	PF02991	0.263
LIG_LIR_Nem_3	196	200	PF02991	0.287
LIG_LIR_Nem_3	218	224	PF02991	0.360
LIG_MLH1_MIPbox_1	180	184	PF16413	0.346
LIG_SH2_STAT5	147	150	PF00017	0.310
LIG_SH2_STAT5	183	186	PF00017	0.313
LIG_SH2_STAT5	188	191	PF00017	0.313
LIG_SH2_STAT5	252	255	PF00017	0.316
LIG_SH2_STAT5	27	30	PF00017	0.639
LIG_SH3_3	266	272	PF00018	0.478
LIG_SUMO_SIM_anti_2	196	203	PF11976	0.396
LIG_SUMO_SIM_anti_2	216	221	PF11976	0.306
LIG_WRC_WIRS_1	194	199	PF05994	0.385
MOD_CDC14_SPxK_1	283	286	PF00782	0.568
MOD_CDK_SPxK_1	280	286	PF00069	0.565
MOD_CK1_1	2	8	PF00069	0.681
MOD_CK1_1	228	234	PF00069	0.258
MOD_CK2_1	54	60	PF00069	0.579
MOD_GlcNHglycan	17	20	PF01048	0.347
MOD_GlcNHglycan	231	234	PF01048	0.496
MOD_GlcNHglycan	289	292	PF01048	0.493
MOD_GlcNHglycan	4	7	PF01048	0.479
MOD_GSK3_1	109	116	PF00069	0.367
MOD_GSK3_1	15	22	PF00069	0.743
MOD_GSK3_1	166	173	PF00069	0.297
MOD_GSK3_1	224	231	PF00069	0.443
MOD_GSK3_1	54	61	PF00069	0.639
MOD_N-GLC_1	36	41	PF02516	0.430
MOD_NEK2_1	107	112	PF00069	0.287
MOD_NEK2_1	156	161	PF00069	0.350
MOD_NEK2_1	200	205	PF00069	0.314
MOD_NEK2_1	215	220	PF00069	0.345
MOD_NEK2_1	224	229	PF00069	0.323
MOD_NEK2_1	58	63	PF00069	0.504
MOD_NEK2_1	98	103	PF00069	0.328
MOD_PIKK_1	271	277	PF00454	0.525
MOD_PIKK_1	36	42	PF00454	0.738
MOD_PKA_2	58	64	PF00069	0.600
MOD_Plk_1	263	269	PF00069	0.544
MOD_Plk_4	114	120	PF00069	0.264
MOD_Plk_4	156	162	PF00069	0.319
MOD_Plk_4	215	221	PF00069	0.385
MOD_Plk_4	99	105	PF00069	0.319
MOD_ProDKin_1	280	286	PF00069	0.660
TRG_ENDOCYTIC_2	147	150	PF00928	0.324
TRG_ENDOCYTIC_2	153	156	PF00928	0.333
TRG_ENDOCYTIC_2	188	191	PF00928	0.350
TRG_ENDOCYTIC_2	241	244	PF00928	0.353
TRG_ENDOCYTIC_2	252	255	PF00928	0.284
TRG_ER_diArg_1	67	70	PF00400	0.558
TRG_ER_diArg_1	84	86	PF00400	0.520
TRG_NLS_MonoCore_2	65	70	PF00514	0.493
TRG_NLS_MonoExtC_3	62	67	PF00514	0.499
TRG_NLS_MonoExtN_4	63	70	PF00514	0.509
TRG_Pf-PMV_PEXEL_1	56	60	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.389

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1I5	Leptomonas seymouri	49%	77%
A0A0N1PAF6	Leptomonas seymouri	66%	83%
A0A1X0P9Q6	Trypanosomatidae	52%	100%
A0A3R7M294	Trypanosoma rangeli	37%	100%
A0A3R7MT82	Trypanosoma rangeli	46%	100%
A0A3S5H538	Leishmania donovani	90%	82%
A0A3S5H540	Leishmania donovani	100%	100%
A0A451EJN9	Leishmania donovani	25%	98%
A4H3K6	Leishmania braziliensis	70%	100%
A4H3K7	Leishmania braziliensis	72%	85%
A4HRU7	Leishmania infantum	26%	100%
A4HRU8	Leishmania infantum	97%	82%
B0YBR5	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	27%	100%
E9ACI2	Leishmania major	27%	100%
E9ACI3	Leishmania major	92%	82%
E9ACI5	Leishmania major	92%	100%
E9AJS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AJS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	81%
E9AJS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	97%
P32907	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
P41943	Yarrowia lipolytica (strain CLIB 122 / E 150)	31%	100%
Q24JP1	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	27%	100%
Q460G9	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	24%	100%
Q5B2K4	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	34%	100%