Retrotransposon hot spot (RHS) protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania infantum

UniProt:

A4HRU9_LEIIN

TriTrypDb:

LINF_030008650

Length:

256

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HRU9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRU9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	7	9	PF00675	0.500
CLV_NRD_NRD_1	71	73	PF00675	0.503
CLV_PCSK_KEX2_1	7	9	PF00082	0.500
CLV_PCSK_KEX2_1	71	73	PF00082	0.490
CLV_PCSK_SKI1_1	199	203	PF00082	0.418
CLV_Separin_Metazoa	231	235	PF03568	0.543
DEG_Nend_UBRbox_4	1	3	PF02207	0.678
DEG_SCF_FBW7_1	55	62	PF00400	0.693
DEG_SPOP_SBC_1	42	46	PF00917	0.660
DEG_SPOP_SBC_1	59	63	PF00917	0.624
DOC_CYCLIN_yCln2_LP_2	145	151	PF00134	0.432
DOC_CYCLIN_yCln2_LP_2	47	53	PF00134	0.689
DOC_MAPK_DCC_7	89	98	PF00069	0.602
DOC_USP7_MATH_1	60	64	PF00917	0.694
DOC_USP7_MATH_1	67	71	PF00917	0.681
DOC_WW_Pin1_4	138	143	PF00397	0.406
DOC_WW_Pin1_4	144	149	PF00397	0.400
DOC_WW_Pin1_4	212	217	PF00397	0.610
DOC_WW_Pin1_4	24	29	PF00397	0.647
DOC_WW_Pin1_4	55	60	PF00397	0.692
DOC_WW_Pin1_4	63	68	PF00397	0.659
LIG_Clathr_ClatBox_1	151	155	PF01394	0.437
LIG_FHA_1	103	109	PF00498	0.608
LIG_FHA_1	118	124	PF00498	0.272
LIG_FHA_1	14	20	PF00498	0.668
LIG_FHA_1	27	33	PF00498	0.585
LIG_FHA_1	42	48	PF00498	0.667
LIG_FHA_1	50	56	PF00498	0.695
LIG_FHA_2	44	50	PF00498	0.676
LIG_LIR_Gen_1	29	39	PF02991	0.622
LIG_LIR_LC3C_4	16	21	PF02991	0.670
LIG_LIR_Nem_3	196	200	PF02991	0.576
LIG_LIR_Nem_3	29	34	PF02991	0.620
LIG_Pex14_1	31	35	PF04695	0.616
LIG_SH2_PTP2	166	169	PF00017	0.316
LIG_SH2_SRC	166	169	PF00017	0.316
LIG_SH2_STAT5	166	169	PF00017	0.465
LIG_SH3_3	185	191	PF00018	0.612
LIG_SH3_3	214	220	PF00018	0.749
LIG_SUMO_SIM_par_1	14	24	PF11976	0.670
LIG_SUMO_SIM_par_1	146	153	PF11976	0.437
LIG_WW_3	86	90	PF00397	0.483
MOD_CK1_1	143	149	PF00069	0.448
MOD_CK1_1	150	156	PF00069	0.465
MOD_CK1_1	63	69	PF00069	0.697
MOD_CK2_1	43	49	PF00069	0.672
MOD_GSK3_1	112	119	PF00069	0.545
MOD_GSK3_1	140	147	PF00069	0.438
MOD_GSK3_1	153	160	PF00069	0.478
MOD_GSK3_1	20	27	PF00069	0.668
MOD_GSK3_1	41	48	PF00069	0.695
MOD_GSK3_1	55	62	PF00069	0.697
MOD_GSK3_1	63	70	PF00069	0.768
MOD_GSK3_1	76	83	PF00069	0.643
MOD_LATS_1	221	227	PF00433	0.593
MOD_NEK2_1	101	106	PF00069	0.608
MOD_NEK2_1	110	115	PF00069	0.514
MOD_NEK2_1	80	85	PF00069	0.664
MOD_PKA_2	21	27	PF00069	0.662
MOD_Plk_1	14	20	PF00069	0.668
MOD_Plk_4	102	108	PF00069	0.608
MOD_Plk_4	117	123	PF00069	0.272
MOD_Plk_4	140	146	PF00069	0.429
MOD_Plk_4	147	153	PF00069	0.534
MOD_Plk_4	15	21	PF00069	0.671
MOD_ProDKin_1	138	144	PF00069	0.408
MOD_ProDKin_1	212	218	PF00069	0.611
MOD_ProDKin_1	24	30	PF00069	0.642
MOD_ProDKin_1	55	61	PF00069	0.692
MOD_ProDKin_1	63	69	PF00069	0.657
TRG_ENDOCYTIC_2	166	169	PF00928	0.474
TRG_ER_diArg_1	206	209	PF00400	0.611

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H539	Leishmania donovani	99%	100%