LeishMANIAdb
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GPR1/FUN34/yaaH family-domain-containing protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
GPR1/FUN34/yaaH family-domain-containing protein
Gene product:
GPR1/FUN34/yaaH family - putative
Species:
Leishmania infantum
UniProt:
A4HRU8_LEIIN
TriTrypDb:
LINF_030008600
Length:
370

Annotations

LeishMANIAdb annotations

Most closely related to Prokaryotic SatP transporters. Especially expanded in the Leptomonas lineage

Annotations by Jardim et al.

Transporters, GPR1/FUN34/yaaH family (acetate Transporter) , putative

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 16
NetGPI no yes: 0, no: 16
Cellular components
Term Name Level Count
GO:0016020 membrane 2 17
GO:0110165 cellular anatomical entity 1 17
GO:0005886 plasma membrane 3 3

Phosphorylation

Promastigote: 3

Expansion

Sequence features

A4HRU8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRU8

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 3
GO:0006811 monoatomic ion transport 4 3
GO:0006820 monoatomic anion transport 5 3
GO:0006835 dicarboxylic acid transport 7 3
GO:0006846 acetate transport 6 3
GO:0009987 cellular process 1 3
GO:0015711 organic anion transport 5 3
GO:0015718 monocarboxylic acid transport 7 3
GO:0015740 C4-dicarboxylate transport 8 3
GO:0015744 succinate transport 6 3
GO:0015849 organic acid transport 5 3
GO:0034220 monoatomic ion transmembrane transport 3 3
GO:0035433 acetate transmembrane transport 5 3
GO:0046942 carboxylic acid transport 6 3
GO:0051179 localization 1 3
GO:0051234 establishment of localization 2 3
GO:0055085 transmembrane transport 2 3
GO:0071422 succinate transmembrane transport 5 3
GO:0071702 organic substance transport 4 3
GO:0098656 monoatomic anion transmembrane transport 4 3
GO:1903825 organic acid transmembrane transport 3 3
GO:1905039 carboxylic acid transmembrane transport 4 3
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 3
GO:0005342 organic acid transmembrane transporter activity 3 3
GO:0008028 monocarboxylic acid transmembrane transporter activity 5 3
GO:0008324 monoatomic cation transmembrane transporter activity 4 3
GO:0008509 monoatomic anion transmembrane transporter activity 4 3
GO:0008514 organic anion transmembrane transporter activity 5 3
GO:0015075 monoatomic ion transmembrane transporter activity 3 3
GO:0015078 proton transmembrane transporter activity 5 3
GO:0015123 acetate transmembrane transporter activity 6 3
GO:0015291 secondary active transmembrane transporter activity 4 3
GO:0015293 symporter activity 5 3
GO:0015294 solute:monoatomic cation symporter activity 5 3
GO:0015295 solute:proton symporter activity 6 3
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 3
GO:0015355 secondary active monocarboxylate transmembrane transporter activity 5 3
GO:0015360 acetate:proton symporter activity 7 3
GO:0022804 active transmembrane transporter activity 3 3
GO:0022853 active monoatomic ion transmembrane transporter activity 4 3
GO:0022857 transmembrane transporter activity 2 3
GO:0022890 inorganic cation transmembrane transporter activity 4 3
GO:0043893 acetate:monoatomic cation symporter activity 6 3
GO:0046943 carboxylic acid transmembrane transporter activity 4 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 118 122 PF00656 0.582
CLV_C14_Caspase3-7 90 94 PF00656 0.626
CLV_NRD_NRD_1 143 145 PF00675 0.313
CLV_NRD_NRD_1 50 52 PF00675 0.466
CLV_NRD_NRD_1 80 82 PF00675 0.468
CLV_PCSK_FUR_1 48 52 PF00082 0.464
CLV_PCSK_KEX2_1 352 354 PF00082 0.346
CLV_PCSK_KEX2_1 50 52 PF00082 0.439
CLV_PCSK_PC1ET2_1 352 354 PF00082 0.335
CLV_PCSK_SKI1_1 31 35 PF00082 0.434
CLV_PCSK_SKI1_1 324 328 PF00082 0.371
DEG_APCC_DBOX_1 323 331 PF00400 0.571
DOC_CYCLIN_yClb5_NLxxxL_5 264 271 PF00134 0.485
DOC_MAPK_DCC_7 144 154 PF00069 0.527
DOC_MAPK_DCC_7 324 332 PF00069 0.550
DOC_MAPK_MEF2A_6 264 273 PF00069 0.511
DOC_MAPK_MEF2A_6 324 332 PF00069 0.571
DOC_USP7_MATH_1 139 143 PF00917 0.438
DOC_USP7_MATH_1 208 212 PF00917 0.411
DOC_USP7_MATH_1 230 234 PF00917 0.374
DOC_USP7_MATH_1 49 53 PF00917 0.610
DOC_USP7_MATH_1 9 13 PF00917 0.766
DOC_WW_Pin1_4 64 69 PF00397 0.606
LIG_14-3-3_CanoR_1 200 205 PF00244 0.571
LIG_14-3-3_CanoR_1 31 39 PF00244 0.816
LIG_14-3-3_CanoR_1 353 360 PF00244 0.525
LIG_14-3-3_CanoR_1 51 57 PF00244 0.636
LIG_Actin_RPEL_3 317 336 PF02755 0.507
LIG_BIR_II_1 1 5 PF00653 0.699
LIG_BRCT_BRCA1_1 239 243 PF00533 0.322
LIG_deltaCOP1_diTrp_1 197 204 PF00928 0.552
LIG_FHA_1 1 7 PF00498 0.663
LIG_FHA_1 159 165 PF00498 0.357
LIG_FHA_1 174 180 PF00498 0.363
LIG_FHA_1 230 236 PF00498 0.319
LIG_FHA_1 273 279 PF00498 0.410
LIG_FHA_1 331 337 PF00498 0.617
LIG_FHA_1 34 40 PF00498 0.644
LIG_FHA_1 355 361 PF00498 0.531
LIG_FHA_1 97 103 PF00498 0.617
LIG_FHA_2 346 352 PF00498 0.555
LIG_LIR_Gen_1 203 214 PF02991 0.360
LIG_LIR_Gen_1 255 263 PF02991 0.403
LIG_LIR_Gen_1 277 288 PF02991 0.410
LIG_LIR_Gen_1 55 62 PF02991 0.634
LIG_LIR_Nem_3 203 209 PF02991 0.366
LIG_LIR_Nem_3 210 215 PF02991 0.396
LIG_LIR_Nem_3 240 246 PF02991 0.317
LIG_LIR_Nem_3 255 259 PF02991 0.334
LIG_LIR_Nem_3 277 283 PF02991 0.352
LIG_LIR_Nem_3 55 59 PF02991 0.632
LIG_MLH1_MIPbox_1 239 243 PF16413 0.352
LIG_NRP_CendR_1 369 370 PF00754 0.414
LIG_SH2_CRK 56 60 PF00017 0.699
LIG_SH2_SRC 91 94 PF00017 0.624
LIG_SH2_STAP1 56 60 PF00017 0.678
LIG_SH2_STAT5 206 209 PF00017 0.418
LIG_SH2_STAT5 242 245 PF00017 0.395
LIG_SH2_STAT5 247 250 PF00017 0.398
LIG_SH2_STAT5 311 314 PF00017 0.358
LIG_SH2_STAT5 58 61 PF00017 0.702
LIG_SH2_STAT5 91 94 PF00017 0.700
LIG_SH3_3 17 23 PF00018 0.661
LIG_SH3_3 325 331 PF00018 0.521
LIG_SUMO_SIM_anti_2 255 262 PF11976 0.324
LIG_SUMO_SIM_anti_2 275 280 PF11976 0.418
LIG_WRC_WIRS_1 253 258 PF05994 0.418
MOD_CK1_1 100 106 PF00069 0.671
MOD_CK1_1 287 293 PF00069 0.263
MOD_CK1_1 361 367 PF00069 0.718
MOD_CK1_1 52 58 PF00069 0.795
MOD_CK2_1 21 27 PF00069 0.688
MOD_GlcNHglycan 121 124 PF01048 0.366
MOD_GlcNHglycan 290 293 PF01048 0.544
MOD_GlcNHglycan 363 366 PF01048 0.385
MOD_GSK3_1 115 122 PF00069 0.729
MOD_GSK3_1 168 175 PF00069 0.263
MOD_GSK3_1 225 232 PF00069 0.285
MOD_GSK3_1 283 290 PF00069 0.408
MOD_GSK3_1 354 361 PF00069 0.578
MOD_GSK3_1 60 67 PF00069 0.732
MOD_GSK3_1 81 88 PF00069 0.774
MOD_GSK3_1 96 103 PF00069 0.765
MOD_N-GLC_1 353 358 PF02516 0.378
MOD_N-GLC_1 96 101 PF02516 0.483
MOD_N-GLC_2 70 72 PF02516 0.421
MOD_NEK2_1 157 162 PF00069 0.350
MOD_NEK2_1 166 171 PF00069 0.356
MOD_NEK2_1 215 220 PF00069 0.358
MOD_NEK2_1 259 264 PF00069 0.367
MOD_NEK2_1 274 279 PF00069 0.366
MOD_NEK2_1 283 288 PF00069 0.369
MOD_PIKK_1 330 336 PF00454 0.552
MOD_PIKK_1 345 351 PF00454 0.634
MOD_PIKK_1 358 364 PF00454 0.556
MOD_PKA_1 81 87 PF00069 0.712
MOD_PKA_2 354 360 PF00069 0.567
MOD_PKA_2 49 55 PF00069 0.729
MOD_PKA_2 97 103 PF00069 0.701
MOD_Plk_1 322 328 PF00069 0.550
MOD_Plk_1 9 15 PF00069 0.641
MOD_Plk_4 158 164 PF00069 0.355
MOD_Plk_4 173 179 PF00069 0.306
MOD_Plk_4 215 221 PF00069 0.369
MOD_Plk_4 274 280 PF00069 0.422
MOD_ProDKin_1 64 70 PF00069 0.609
TRG_ENDOCYTIC_2 206 209 PF00928 0.370
TRG_ENDOCYTIC_2 212 215 PF00928 0.344
TRG_ENDOCYTIC_2 247 250 PF00928 0.344
TRG_ENDOCYTIC_2 300 303 PF00928 0.391
TRG_ENDOCYTIC_2 311 314 PF00928 0.391
TRG_ENDOCYTIC_2 56 59 PF00928 0.700
TRG_ER_diArg_1 368 370 PF00400 0.614
TRG_ER_diArg_1 47 50 PF00400 0.718

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PAF6 Leptomonas seymouri 58% 100%
A0A3S5H538 Leishmania donovani 99% 100%
A0A3S5H540 Leishmania donovani 97% 100%
A0A451EJN9 Leishmania donovani 23% 100%
A4H3K6 Leishmania braziliensis 70% 100%
A4H3K7 Leishmania braziliensis 64% 100%
A4HRU7 Leishmania infantum 23% 100%
A4HRV0 Leishmania infantum 97% 100%
E9ACI2 Leishmania major 27% 100%
E9ACI3 Leishmania major 91% 100%
E9ACI5 Leishmania major 82% 100%
E9AJS1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9AJS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 80% 100%
E9AJS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
V5BCC6 Trypanosoma cruzi 35% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS