Ammonia transport outward protein 2

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GPR1/FUN34/yaaH family - putative

Species:

Leishmania infantum

UniProt:

A4HRU7_LEIIN

TriTrypDb:

LINF_030008500

Length:

310

Annotations

LeishMANIAdb annotations

Most closely related to Prokaryotic SatP transporters. Especially expanded in the Leptomonas lineage

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13
GO:0005886	plasma membrane	3	3

Expansion

Sequence features

A4HRU7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRU7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	3
GO:0006811	monoatomic ion transport	4	3
GO:0006820	monoatomic anion transport	5	3
GO:0006835	dicarboxylic acid transport	7	3
GO:0006846	acetate transport	6	3
GO:0009987	cellular process	1	3
GO:0015711	organic anion transport	5	3
GO:0015718	monocarboxylic acid transport	7	3
GO:0015740	C4-dicarboxylate transport	8	3
GO:0015744	succinate transport	6	3
GO:0015849	organic acid transport	5	3
GO:0034220	monoatomic ion transmembrane transport	3	3
GO:0035433	acetate transmembrane transport	5	3
GO:0046942	carboxylic acid transport	6	3
GO:0051179	localization	1	3
GO:0051234	establishment of localization	2	3
GO:0055085	transmembrane transport	2	3
GO:0071422	succinate transmembrane transport	5	3
GO:0071702	organic substance transport	4	3
GO:0098656	monoatomic anion transmembrane transport	4	3
GO:1903825	organic acid transmembrane transport	3	3
GO:1905039	carboxylic acid transmembrane transport	4	3

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	3
GO:0005342	organic acid transmembrane transporter activity	3	3
GO:0008028	monocarboxylic acid transmembrane transporter activity	5	3
GO:0008324	monoatomic cation transmembrane transporter activity	4	3
GO:0008509	monoatomic anion transmembrane transporter activity	4	3
GO:0008514	organic anion transmembrane transporter activity	5	3
GO:0015075	monoatomic ion transmembrane transporter activity	3	3
GO:0015078	proton transmembrane transporter activity	5	3
GO:0015123	acetate transmembrane transporter activity	6	3
GO:0015291	secondary active transmembrane transporter activity	4	3
GO:0015293	symporter activity	5	3
GO:0015294	solute:monoatomic cation symporter activity	5	3
GO:0015295	solute:proton symporter activity	6	3
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	3
GO:0015355	secondary active monocarboxylate transmembrane transporter activity	5	3
GO:0015360	acetate:proton symporter activity	7	3
GO:0022804	active transmembrane transporter activity	3	3
GO:0022853	active monoatomic ion transmembrane transporter activity	4	3
GO:0022857	transmembrane transporter activity	2	3
GO:0022890	inorganic cation transmembrane transporter activity	4	3
GO:0043893	acetate:monoatomic cation symporter activity	6	3
GO:0046943	carboxylic acid transmembrane transporter activity	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	106	108	PF00675	0.461
CLV_NRD_NRD_1	48	50	PF00675	0.506
CLV_PCSK_KEX2_1	106	108	PF00082	0.566
CLV_PCSK_KEX2_1	303	305	PF00082	0.414
CLV_PCSK_PC1ET2_1	303	305	PF00082	0.364
CLV_PCSK_SKI1_1	294	298	PF00082	0.367
DEG_APCC_DBOX_1	293	301	PF00400	0.607
DOC_MAPK_DCC_7	120	129	PF00069	0.502
DOC_MAPK_gen_1	44	53	PF00069	0.677
DOC_MAPK_MEF2A_6	294	301	PF00069	0.605
DOC_PP4_FxxP_1	198	201	PF00568	0.337
DOC_PP4_FxxP_1	233	236	PF00568	0.491
DOC_PP4_FxxP_1	244	247	PF00568	0.337
DOC_USP7_MATH_1	201	205	PF00917	0.292
DOC_USP7_MATH_1	27	31	PF00917	0.676
DOC_WW_Pin1_4	112	117	PF00397	0.746
DOC_WW_Pin1_4	120	125	PF00397	0.492
DOC_WW_Pin1_4	232	237	PF00397	0.515
DOC_WW_Pin1_4	74	79	PF00397	0.606
LIG_14-3-3_CanoR_1	176	180	PF00244	0.511
LIG_14-3-3_CanoR_1	234	244	PF00244	0.456
LIG_Actin_WH2_2	275	291	PF00022	0.337
LIG_APCC_ABBA_1	5	10	PF00400	0.650
LIG_BRCT_BRCA1_1	225	229	PF00533	0.432
LIG_BRCT_BRCA1_1	253	257	PF00533	0.275
LIG_EH1_1	131	139	PF00400	0.268
LIG_FHA_1	133	139	PF00498	0.319
LIG_FHA_1	151	157	PF00498	0.371
LIG_FHA_1	162	168	PF00498	0.337
LIG_FHA_1	192	198	PF00498	0.315
LIG_FHA_1	266	272	PF00498	0.369
LIG_FHA_1	29	35	PF00498	0.623
LIG_FHA_2	285	291	PF00498	0.532
LIG_LIR_Apic_2	231	236	PF02991	0.447
LIG_LIR_Gen_1	235	245	PF02991	0.492
LIG_LIR_Nem_3	184	190	PF02991	0.322
LIG_Pex14_2	166	170	PF04695	0.323
LIG_Pex14_2	217	221	PF04695	0.288
LIG_Pex14_2	229	233	PF04695	0.303
LIG_SH2_STAT5	205	208	PF00017	0.267
LIG_SH2_STAT5	270	273	PF00017	0.361
LIG_SH2_STAT5	281	284	PF00017	0.299
LIG_SH2_STAT5	307	310	PF00017	0.592
LIG_SH2_STAT5	55	58	PF00017	0.708
LIG_SH3_2	91	96	PF14604	0.569
LIG_SH3_3	10	16	PF00018	0.718
LIG_SH3_3	110	116	PF00018	0.734
LIG_SH3_3	88	94	PF00018	0.697
LIG_TRAF2_1	78	81	PF00917	0.624
LIG_UBA3_1	296	303	PF00899	0.560
MOD_CK1_1	232	238	PF00069	0.459
MOD_CK1_1	74	80	PF00069	0.703
MOD_CK2_1	201	207	PF00069	0.245
MOD_CK2_1	55	61	PF00069	0.635
MOD_CK2_1	74	80	PF00069	0.680
MOD_DYRK1A_RPxSP_1	112	116	PF00069	0.613
MOD_GSK3_1	175	182	PF00069	0.480
MOD_GSK3_1	18	25	PF00069	0.688
MOD_GSK3_1	224	231	PF00069	0.446
MOD_GSK3_1	72	79	PF00069	0.821
MOD_N-GLC_1	23	28	PF02516	0.429
MOD_N-GLC_1	71	76	PF02516	0.556
MOD_N-GLC_2	145	147	PF02516	0.436
MOD_NEK2_1	132	137	PF00069	0.332
MOD_NEK2_1	179	184	PF00069	0.364
MOD_NEK2_1	224	229	PF00069	0.325
MOD_NEK2_1	251	256	PF00069	0.339
MOD_NEK2_1	284	289	PF00069	0.504
MOD_NEK2_2	37	42	PF00069	0.602
MOD_PIKK_1	161	167	PF00454	0.323
MOD_PKA_2	175	181	PF00069	0.494
MOD_Plk_1	201	207	PF00069	0.244
MOD_Plk_4	132	138	PF00069	0.322
MOD_Plk_4	201	207	PF00069	0.332
MOD_Plk_4	224	230	PF00069	0.282
MOD_Plk_4	277	283	PF00069	0.318
MOD_ProDKin_1	112	118	PF00069	0.743
MOD_ProDKin_1	120	126	PF00069	0.492
MOD_ProDKin_1	232	238	PF00069	0.515
MOD_ProDKin_1	74	80	PF00069	0.604
MOD_SUMO_rev_2	77	85	PF00179	0.602
TRG_DiLeu_BaEn_4	80	86	PF01217	0.639
TRG_ENDOCYTIC_2	187	190	PF00928	0.354
TRG_ENDOCYTIC_2	270	273	PF00928	0.359
TRG_ENDOCYTIC_2	281	284	PF00928	0.273
TRG_ER_diArg_1	304	307	PF00400	0.597
TRG_ER_diArg_1	41	44	PF00400	0.742

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0C8	Leptomonas seymouri	59%	97%
A0A3R7M294	Trypanosoma rangeli	35%	100%
A0A3R7MT82	Trypanosoma rangeli	30%	100%
A0A3S5H540	Leishmania donovani	26%	100%
A0A451EJN9	Leishmania donovani	99%	100%
A4HRU8	Leishmania infantum	23%	84%
A4HRV0	Leishmania infantum	26%	100%
E9ACI2	Leishmania major	88%	100%
E9ACI3	Leishmania major	24%	100%
E9ACI5	Leishmania major	26%	100%
E9AJS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%