DDRGK_domain_containing_protein_-_putative

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DDRGK domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HRU4_LEIIN

TriTrypDb:

LINF_030008200

Length:

342

Annotations

LeishMANIAdb annotations

Similar to distant Eukaryotic DDRGK proteins. Likely bound to the ER.. Localization: ER (by homology)

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HRU4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRU4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	169	173	PF00656	0.658
CLV_C14_Caspase3-7	63	67	PF00656	0.660
CLV_MEL_PAP_1	322	328	PF00089	0.252
CLV_NRD_NRD_1	137	139	PF00675	0.369
CLV_NRD_NRD_1	150	152	PF00675	0.300
CLV_NRD_NRD_1	177	179	PF00675	0.432
CLV_NRD_NRD_1	194	196	PF00675	0.423
CLV_NRD_NRD_1	229	231	PF00675	0.290
CLV_NRD_NRD_1	58	60	PF00675	0.481
CLV_NRD_NRD_1	84	86	PF00675	0.478
CLV_NRD_NRD_1	94	96	PF00675	0.424
CLV_PCSK_FUR_1	227	231	PF00082	0.211
CLV_PCSK_FUR_1	82	86	PF00082	0.523
CLV_PCSK_FUR_1	92	96	PF00082	0.481
CLV_PCSK_KEX2_1	150	152	PF00082	0.352
CLV_PCSK_KEX2_1	177	179	PF00082	0.432
CLV_PCSK_KEX2_1	194	196	PF00082	0.336
CLV_PCSK_KEX2_1	229	231	PF00082	0.329
CLV_PCSK_KEX2_1	57	59	PF00082	0.458
CLV_PCSK_KEX2_1	82	84	PF00082	0.484
CLV_PCSK_KEX2_1	92	94	PF00082	0.420
CLV_PCSK_PC7_1	225	231	PF00082	0.209
CLV_PCSK_SKI1_1	140	144	PF00082	0.423
CLV_PCSK_SKI1_1	273	277	PF00082	0.228
CLV_PCSK_SKI1_1	304	308	PF00082	0.239
DOC_MAPK_gen_1	321	328	PF00069	0.499
DOC_PP4_FxxP_1	307	310	PF00568	0.499
DOC_USP7_MATH_1	246	250	PF00917	0.617
DOC_USP7_MATH_1	29	33	PF00917	0.661
DOC_USP7_MATH_1	51	55	PF00917	0.734
DOC_USP7_UBL2_3	139	143	PF12436	0.553
DOC_WW_Pin1_4	253	258	PF00397	0.626
LIG_14-3-3_CanoR_1	162	170	PF00244	0.502
LIG_14-3-3_CanoR_1	229	235	PF00244	0.591
LIG_14-3-3_CanoR_1	323	329	PF00244	0.416
LIG_Actin_WH2_2	260	278	PF00022	0.490
LIG_Actin_WH2_2	6	24	PF00022	0.369
LIG_BIR_II_1	1	5	PF00653	0.354
LIG_BIR_III_4	127	131	PF00653	0.620
LIG_FHA_1	118	124	PF00498	0.693
LIG_LIR_Nem_3	311	316	PF02991	0.416
LIG_NRBOX	7	13	PF00104	0.326
LIG_PCNA_PIPBox_1	228	237	PF02747	0.544
LIG_PCNA_yPIPBox_3	225	235	PF02747	0.549
LIG_SH2_PTP2	305	308	PF00017	0.499
LIG_SH2_STAP1	205	209	PF00017	0.542
LIG_SH2_STAT5	305	308	PF00017	0.479
LIG_SUMO_SIM_par_1	264	270	PF11976	0.445
LIG_TRAF2_1	184	187	PF00917	0.599
LIG_TRAF2_1	257	260	PF00917	0.670
LIG_TRAF2_1	278	281	PF00917	0.499
LIG_TRAF2_1	327	330	PF00917	0.499
LIG_WRC_WIRS_1	231	236	PF05994	0.513
MOD_CK1_1	2	8	PF00069	0.423
MOD_CK1_1	255	261	PF00069	0.563
MOD_CK2_1	253	259	PF00069	0.644
MOD_CK2_1	275	281	PF00069	0.381
MOD_CK2_1	324	330	PF00069	0.282
MOD_CK2_1	58	64	PF00069	0.593
MOD_Cter_Amidation	80	83	PF01082	0.711
MOD_GlcNHglycan	1	4	PF01048	0.578
MOD_GlcNHglycan	248	251	PF01048	0.563
MOD_GlcNHglycan	30	34	PF01048	0.684
MOD_GlcNHglycan	51	54	PF01048	0.659
MOD_GSK3_1	45	52	PF00069	0.678
MOD_N-GLC_1	49	54	PF02516	0.684
MOD_N-GLC_1	64	69	PF02516	0.648
MOD_NEK2_1	45	50	PF00069	0.626
MOD_PIKK_1	22	28	PF00454	0.511
MOD_PIKK_1	287	293	PF00454	0.423
MOD_PIKK_1	45	51	PF00454	0.631
MOD_PKA_1	58	64	PF00069	0.665
MOD_PKA_2	324	330	PF00069	0.268
MOD_PKA_2	45	51	PF00069	0.648
MOD_PKA_2	58	64	PF00069	0.407
MOD_Plk_1	111	117	PF00069	0.653
MOD_Plk_2-3	111	117	PF00069	0.653
MOD_Plk_4	2	8	PF00069	0.420
MOD_Plk_4	230	236	PF00069	0.486
MOD_ProDKin_1	253	259	PF00069	0.559
MOD_SUMO_rev_2	179	185	PF00179	0.474
TRG_DiLeu_BaEn_4	215	221	PF01217	0.615
TRG_DiLeu_LyEn_5	311	316	PF01217	0.423
TRG_ENDOCYTIC_2	305	308	PF00928	0.312
TRG_ER_diArg_1	193	195	PF00400	0.581
TRG_ER_diArg_1	227	230	PF00400	0.479
TRG_ER_diArg_1	320	323	PF00400	0.381
TRG_ER_diArg_1	44	47	PF00400	0.660
TRG_ER_diArg_1	56	59	PF00400	0.651
TRG_ER_diArg_1	82	85	PF00400	0.629
TRG_ER_diArg_1	91	94	PF00400	0.556
TRG_NLS_MonoExtN_4	135	142	PF00514	0.568
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1I6	Leptomonas seymouri	55%	100%
A0A3R7MKY1	Trypanosoma rangeli	43%	100%
A0A3S5H536	Leishmania donovani	99%	100%
A4H3K4	Leishmania braziliensis	79%	100%
B0WIW5	Culex quinquefasciatus	28%	100%
D0A242	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	98%
E9ACH9	Leishmania major	92%	100%
E9AJR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5C2C3	Trypanosoma cruzi	41%	100%