Flagellar associated protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HRU2_LEIIN

TriTrypDb:

LINF_030008000

Length:

1043

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0005929	cilium	4	1
GO:0031514	motile cilium	5	1
GO:0042995	cell projection	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HRU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRU2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	160	164	PF00656	0.549
CLV_C14_Caspase3-7	28	32	PF00656	0.679
CLV_C14_Caspase3-7	754	758	PF00656	0.434
CLV_NRD_NRD_1	1002	1004	PF00675	0.650
CLV_NRD_NRD_1	269	271	PF00675	0.544
CLV_NRD_NRD_1	416	418	PF00675	0.637
CLV_NRD_NRD_1	447	449	PF00675	0.557
CLV_NRD_NRD_1	463	465	PF00675	0.355
CLV_NRD_NRD_1	498	500	PF00675	0.442
CLV_NRD_NRD_1	770	772	PF00675	0.527
CLV_NRD_NRD_1	818	820	PF00675	0.410
CLV_NRD_NRD_1	920	922	PF00675	0.735
CLV_PCSK_FUR_1	496	500	PF00082	0.561
CLV_PCSK_KEX2_1	1001	1003	PF00082	0.649
CLV_PCSK_KEX2_1	269	271	PF00082	0.580
CLV_PCSK_KEX2_1	349	351	PF00082	0.580
CLV_PCSK_KEX2_1	375	377	PF00082	0.546
CLV_PCSK_KEX2_1	447	449	PF00082	0.504
CLV_PCSK_KEX2_1	498	500	PF00082	0.534
CLV_PCSK_KEX2_1	920	922	PF00082	0.735
CLV_PCSK_PC1ET2_1	349	351	PF00082	0.580
CLV_PCSK_PC1ET2_1	375	377	PF00082	0.580
CLV_PCSK_PC7_1	998	1004	PF00082	0.626
CLV_PCSK_SKI1_1	149	153	PF00082	0.565
CLV_PCSK_SKI1_1	181	185	PF00082	0.564
CLV_PCSK_SKI1_1	198	202	PF00082	0.311
CLV_PCSK_SKI1_1	250	254	PF00082	0.564
CLV_PCSK_SKI1_1	287	291	PF00082	0.588
CLV_PCSK_SKI1_1	375	379	PF00082	0.591
CLV_PCSK_SKI1_1	404	408	PF00082	0.560
CLV_PCSK_SKI1_1	514	518	PF00082	0.456
CLV_PCSK_SKI1_1	636	640	PF00082	0.411
CLV_PCSK_SKI1_1	679	683	PF00082	0.433
CLV_PCSK_SKI1_1	688	692	PF00082	0.325
CLV_PCSK_SKI1_1	699	703	PF00082	0.383
CLV_PCSK_SKI1_1	80	84	PF00082	0.472
CLV_Separin_Metazoa	454	458	PF03568	0.548
CLV_Separin_Metazoa	57	61	PF03568	0.486
DEG_APCC_DBOX_1	148	156	PF00400	0.560
DEG_APCC_DBOX_1	698	706	PF00400	0.377
DEG_APCC_DBOX_1	793	801	PF00400	0.483
DEG_SPOP_SBC_1	15	19	PF00917	0.779
DOC_CYCLIN_RxL_1	146	154	PF00134	0.496
DOC_CYCLIN_RxL_1	445	458	PF00134	0.402
DOC_CYCLIN_RxL_1	676	689	PF00134	0.431
DOC_CYCLIN_RxL_1	77	87	PF00134	0.553
DOC_MAPK_gen_1	187	197	PF00069	0.564
DOC_MAPK_gen_1	349	357	PF00069	0.612
DOC_MAPK_gen_1	445	455	PF00069	0.600
DOC_MAPK_gen_1	695	702	PF00069	0.381
DOC_PP1_RVXF_1	590	596	PF00149	0.548
DOC_SPAK_OSR1_1	312	316	PF12202	0.559
DOC_USP7_MATH_1	27	31	PF00917	0.778
DOC_USP7_MATH_1	429	433	PF00917	0.727
DOC_USP7_MATH_1	443	447	PF00917	0.442
DOC_USP7_MATH_1	609	613	PF00917	0.506
DOC_USP7_MATH_1	669	673	PF00917	0.425
DOC_USP7_MATH_1	910	914	PF00917	0.768
DOC_USP7_MATH_1	954	958	PF00917	0.745
DOC_USP7_MATH_1	960	964	PF00917	0.688
DOC_USP7_MATH_1	969	973	PF00917	0.738
DOC_USP7_MATH_1	984	988	PF00917	0.546
DOC_USP7_UBL2_3	286	290	PF12436	0.552
DOC_USP7_UBL2_3	349	353	PF12436	0.557
DOC_USP7_UBL2_3	768	772	PF12436	0.528
DOC_WW_Pin1_4	16	21	PF00397	0.724
DOC_WW_Pin1_4	41	46	PF00397	0.575
DOC_WW_Pin1_4	925	930	PF00397	0.742
LIG_14-3-3_CanoR_1	156	166	PF00244	0.506
LIG_14-3-3_CanoR_1	376	383	PF00244	0.569
LIG_14-3-3_CanoR_1	386	391	PF00244	0.527
LIG_14-3-3_CanoR_1	417	423	PF00244	0.623
LIG_14-3-3_CanoR_1	496	505	PF00244	0.557
LIG_14-3-3_CanoR_1	530	537	PF00244	0.434
LIG_14-3-3_CanoR_1	60	68	PF00244	0.578
LIG_14-3-3_CanoR_1	920	929	PF00244	0.631
LIG_14-3-3_CanoR_1	942	947	PF00244	0.649
LIG_Actin_WH2_2	603	620	PF00022	0.531
LIG_BIR_II_1	1	5	PF00653	0.732
LIG_CaM_IQ_9	296	312	PF13499	0.568
LIG_FHA_1	167	173	PF00498	0.626
LIG_FHA_1	261	267	PF00498	0.566
LIG_FHA_1	329	335	PF00498	0.561
LIG_FHA_1	422	428	PF00498	0.558
LIG_FHA_1	561	567	PF00498	0.544
LIG_FHA_1	645	651	PF00498	0.391
LIG_FHA_1	711	717	PF00498	0.473
LIG_FHA_1	778	784	PF00498	0.449
LIG_FHA_1	825	831	PF00498	0.547
LIG_FHA_2	138	144	PF00498	0.589
LIG_FHA_2	158	164	PF00498	0.552
LIG_FHA_2	202	208	PF00498	0.534
LIG_FHA_2	239	245	PF00498	0.479
LIG_FHA_2	293	299	PF00498	0.628
LIG_FHA_2	456	462	PF00498	0.584
LIG_FHA_2	538	544	PF00498	0.507
LIG_FHA_2	920	926	PF00498	0.697
LIG_Integrin_isoDGR_2	999	1001	PF01839	0.657
LIG_LIR_Gen_1	52	62	PF02991	0.441
LIG_LIR_Gen_1	74	83	PF02991	0.421
LIG_LIR_Gen_1	787	798	PF02991	0.459
LIG_LIR_Nem_3	52	58	PF02991	0.443
LIG_LIR_Nem_3	74	78	PF02991	0.425
LIG_LIR_Nem_3	787	793	PF02991	0.440
LIG_MYND_1	66	70	PF01753	0.541
LIG_NRBOX	179	185	PF00104	0.572
LIG_NRBOX	77	83	PF00104	0.561
LIG_PCNA_yPIPBox_3	360	373	PF02747	0.534
LIG_PCNA_yPIPBox_3	676	685	PF02747	0.525
LIG_RPA_C_Fungi	721	733	PF08784	0.553
LIG_RPA_C_Plants	198	209	PF08784	0.357
LIG_SH2_CRK	790	794	PF00017	0.496
LIG_SH2_STAP1	624	628	PF00017	0.500
LIG_SH2_STAT3	469	472	PF00017	0.581
LIG_SH2_STAT5	179	182	PF00017	0.505
LIG_SH2_STAT5	707	710	PF00017	0.523
LIG_SH3_3	1015	1021	PF00018	0.605
LIG_SH3_3	9	15	PF00018	0.570
LIG_SH3_3	944	950	PF00018	0.738
LIG_Sin3_3	403	410	PF02671	0.409
LIG_SUMO_SIM_anti_2	653	661	PF11976	0.498
LIG_TRAF2_1	295	298	PF00917	0.511
LIG_TRAF2_1	398	401	PF00917	0.510
LIG_TRAF2_1	44	47	PF00917	0.365
LIG_TRAF2_1	504	507	PF00917	0.594
LIG_TRAF2_1	553	556	PF00917	0.535
LIG_TRAF2_1	805	808	PF00917	0.640
LIG_TRAF2_1	833	836	PF00917	0.510
LIG_WW_3	995	999	PF00397	0.626
MOD_CDC14_SPxK_1	19	22	PF00782	0.561
MOD_CDK_SPxK_1	16	22	PF00069	0.557
MOD_CK1_1	18	24	PF00069	0.789
MOD_CK1_1	41	47	PF00069	0.415
MOD_CK1_1	524	530	PF00069	0.463
MOD_CK1_1	560	566	PF00069	0.545
MOD_CK1_1	672	678	PF00069	0.460
MOD_CK1_1	747	753	PF00069	0.595
MOD_CK1_1	913	919	PF00069	0.702
MOD_CK2_1	137	143	PF00069	0.592
MOD_CK2_1	238	244	PF00069	0.566
MOD_CK2_1	292	298	PF00069	0.498
MOD_CK2_1	41	47	PF00069	0.658
MOD_CK2_1	430	436	PF00069	0.653
MOD_CK2_1	455	461	PF00069	0.556
MOD_CK2_1	537	543	PF00069	0.424
MOD_CK2_1	550	556	PF00069	0.410
MOD_CK2_1	602	608	PF00069	0.512
MOD_CK2_1	826	832	PF00069	0.546
MOD_Cter_Amidation	999	1002	PF01082	0.657
MOD_GlcNHglycan	2	5	PF01048	0.688
MOD_GlcNHglycan	359	363	PF01048	0.524
MOD_GlcNHglycan	62	65	PF01048	0.622
MOD_GlcNHglycan	671	674	PF01048	0.517
MOD_GlcNHglycan	882	885	PF01048	0.557
MOD_GlcNHglycan	893	896	PF01048	0.671
MOD_GlcNHglycan	898	901	PF01048	0.707
MOD_GlcNHglycan	912	915	PF01048	0.744
MOD_GlcNHglycan	929	932	PF01048	0.735
MOD_GlcNHglycan	933	936	PF01048	0.711
MOD_GlcNHglycan	942	945	PF01048	0.618
MOD_GlcNHglycan	956	959	PF01048	0.582
MOD_GlcNHglycan	971	974	PF01048	0.731
MOD_GlcNHglycan	976	979	PF01048	0.715
MOD_GlcNHglycan	982	985	PF01048	0.719
MOD_GlcNHglycan	986	989	PF01048	0.681
MOD_GSK3_1	14	21	PF00069	0.703
MOD_GSK3_1	166	173	PF00069	0.568
MOD_GSK3_1	382	389	PF00069	0.581
MOD_GSK3_1	423	430	PF00069	0.636
MOD_GSK3_1	443	450	PF00069	0.355
MOD_GSK3_1	891	898	PF00069	0.708
MOD_GSK3_1	921	928	PF00069	0.736
MOD_GSK3_1	954	961	PF00069	0.738
MOD_GSK3_1	976	983	PF00069	0.702
MOD_N-GLC_1	201	206	PF02516	0.556
MOD_N-GLC_1	991	996	PF02516	0.689
MOD_NEK2_1	1010	1015	PF00069	0.723
MOD_NEK2_1	151	156	PF00069	0.631
MOD_NEK2_1	358	363	PF00069	0.554
MOD_NEK2_1	455	460	PF00069	0.493
MOD_NEK2_1	463	468	PF00069	0.495
MOD_NEK2_1	522	527	PF00069	0.558
MOD_NEK2_1	722	727	PF00069	0.543
MOD_NEK2_1	81	86	PF00069	0.549
MOD_NEK2_1	826	831	PF00069	0.508
MOD_NEK2_2	123	128	PF00069	0.502
MOD_PIKK_1	114	120	PF00454	0.486
MOD_PIKK_1	216	222	PF00454	0.480
MOD_PIKK_1	644	650	PF00454	0.377
MOD_PIKK_1	720	726	PF00454	0.524
MOD_PIKK_1	942	948	PF00454	0.664
MOD_PK_1	253	259	PF00069	0.560
MOD_PK_1	386	392	PF00069	0.563
MOD_PKA_1	375	381	PF00069	0.559
MOD_PKA_1	447	453	PF00069	0.409
MOD_PKA_2	260	266	PF00069	0.515
MOD_PKA_2	375	381	PF00069	0.527
MOD_PKA_2	416	422	PF00069	0.667
MOD_PKA_2	447	453	PF00069	0.596
MOD_PKA_2	463	469	PF00069	0.431
MOD_PKA_2	497	503	PF00069	0.560
MOD_PKA_2	537	543	PF00069	0.506
MOD_PKA_2	669	675	PF00069	0.471
MOD_PKA_2	919	925	PF00069	0.667
MOD_PKB_1	548	556	PF00069	0.489
MOD_Plk_1	253	259	PF00069	0.560
MOD_Plk_1	325	331	PF00069	0.605
MOD_Plk_2-3	396	402	PF00069	0.569
MOD_Plk_4	325	331	PF00069	0.577
MOD_Plk_4	463	469	PF00069	0.500
MOD_ProDKin_1	16	22	PF00069	0.728
MOD_ProDKin_1	41	47	PF00069	0.569
MOD_ProDKin_1	925	931	PF00069	0.742
MOD_SUMO_for_1	348	351	PF00179	0.582
MOD_SUMO_for_1	561	564	PF00179	0.547
MOD_SUMO_rev_2	279	289	PF00179	0.503
MOD_SUMO_rev_2	346	355	PF00179	0.565
MOD_SUMO_rev_2	396	403	PF00179	0.506
MOD_SUMO_rev_2	500	505	PF00179	0.527
TRG_DiLeu_BaEn_1	192	197	PF01217	0.556
TRG_DiLeu_BaEn_1	368	373	PF01217	0.577
TRG_DiLeu_BaEn_1	654	659	PF01217	0.375
TRG_DiLeu_BaEn_1	686	691	PF01217	0.423
TRG_DiLeu_BaEn_1	778	783	PF01217	0.439
TRG_DiLeu_BaEn_4	192	198	PF01217	0.580
TRG_DiLeu_BaEn_4	506	512	PF01217	0.458
TRG_DiLeu_BaEn_4	849	855	PF01217	0.512
TRG_DiLeu_BaLyEn_6	77	82	PF01217	0.433
TRG_DiLeu_BaLyEn_6	88	93	PF01217	0.407
TRG_ENDOCYTIC_2	236	239	PF00928	0.456
TRG_ENDOCYTIC_2	75	78	PF00928	0.418
TRG_ENDOCYTIC_2	790	793	PF00928	0.448
TRG_ER_diArg_1	1001	1003	PF00400	0.693
TRG_ER_diArg_1	268	270	PF00400	0.553
TRG_ER_diArg_1	447	449	PF00400	0.600
TRG_ER_diArg_1	495	498	PF00400	0.558
TRG_ER_diArg_1	547	550	PF00400	0.532
TRG_ER_diArg_1	592	595	PF00400	0.525
TRG_ER_diArg_1	696	699	PF00400	0.393
TRG_ER_diArg_1	703	706	PF00400	0.427
TRG_ER_diArg_1	726	729	PF00400	0.532
TRG_NES_CRM1_1	694	709	PF08389	0.507
TRG_NES_CRM1_1	754	766	PF08389	0.540
TRG_NLS_Bipartite_1	498	518	PF00514	0.555
TRG_Pf-PMV_PEXEL_1	125	130	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	269	273	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	280	284	PF00026	0.580
TRG_Pf-PMV_PEXEL_1	304	308	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	332	336	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	447	452	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	535	539	PF00026	0.419
TRG_Pf-PMV_PEXEL_1	580	585	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	594	598	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	60	65	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	682	686	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	688	693	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	730	734	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	91	95	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2V1	Leptomonas seymouri	62%	100%
A0A0S4JMK5	Bodo saltans	33%	100%
A0A0S4KGN1	Bodo saltans	25%	100%
A0A1X0P9K9	Trypanosomatidae	40%	100%
A0A381MLP4	Leishmania infantum	24%	100%
A0A3Q8IAS8	Leishmania donovani	24%	100%
A0A3R7L4Y2	Trypanosoma rangeli	38%	100%
A0A3S5H534	Leishmania donovani	100%	100%
A0A451EJK4	Leishmania donovani	24%	100%
A4H3K2	Leishmania braziliensis	78%	96%
A8HUA1	Chlamydomonas reinhardtii	27%	100%
B2RW38	Mus musculus	28%	100%
C9ZJ55	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
D0A240	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9ACH7	Leishmania major	93%	99%
E9AJR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	97%
Q5T655	Homo sapiens	27%	100%
V5BCD1	Trypanosoma cruzi	39%	100%