LeishMANIAdb
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FYVE-type domain-containing protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
FYVE-type domain-containing protein
Gene product:
Apolipoprotein A1/A4/E domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4HRT8_LEIIN
TriTrypDb:
LINF_030007500 *
Length:
2143

Annotations

LeishMANIAdb annotations

A family of very long coiled-coil proteins, likely performing cytoskeletal functions.. Two varieties have evolved, one with an N-terminal FYVE domain (Non-TM) and another with a C-terminal PDZ domain (might be TM)

Annotations by Jardim et al.

Lipid Metabolism, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0005576 extracellular region 2 5
GO:0110165 cellular anatomical entity 1 5
GO:0000795 synaptonemal complex 3 1
GO:0099086 synaptonemal structure 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HRT8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRT8

Function

Biological processes
Term Name Level Count
GO:0006807 nitrogen compound metabolic process 2 5
GO:0006810 transport 3 5
GO:0006869 lipid transport 5 5
GO:0008152 metabolic process 1 5
GO:0019538 protein metabolic process 3 5
GO:0042157 lipoprotein metabolic process 4 5
GO:0043170 macromolecule metabolic process 3 5
GO:0044238 primary metabolic process 2 5
GO:0051179 localization 1 5
GO:0051234 establishment of localization 2 5
GO:0071702 organic substance transport 4 5
GO:0071704 organic substance metabolic process 2 5
GO:1901564 organonitrogen compound metabolic process 3 5
GO:0006996 organelle organization 4 1
GO:0007130 synaptonemal complex assembly 4 1
GO:0009987 cellular process 1 2
GO:0016043 cellular component organization 3 1
GO:0022402 cell cycle process 2 1
GO:0022414 reproductive process 1 1
GO:0022607 cellular component assembly 4 1
GO:0051276 chromosome organization 5 1
GO:0070192 chromosome organization involved in meiotic cell cycle 3 1
GO:0070193 synaptonemal complex organization 6 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:1903046 meiotic cell cycle process 2 1
GO:0007017 microtubule-based process 2 1
GO:0007018 microtubule-based movement 3 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 6
GO:0008289 lipid binding 2 5
GO:0043167 ion binding 2 6
GO:0043169 cation binding 3 5
GO:0046872 metal ion binding 4 5
GO:0000166 nucleotide binding 3 1
GO:0003774 cytoskeletal motor activity 1 1
GO:0003777 microtubule motor activity 2 1
GO:0005515 protein binding 2 1
GO:0005524 ATP binding 5 1
GO:0008017 microtubule binding 5 1
GO:0008092 cytoskeletal protein binding 3 1
GO:0015631 tubulin binding 4 1
GO:0017076 purine nucleotide binding 4 1
GO:0030554 adenyl nucleotide binding 5 1
GO:0032553 ribonucleotide binding 3 1
GO:0032555 purine ribonucleotide binding 4 1
GO:0032559 adenyl ribonucleotide binding 5 1
GO:0035639 purine ribonucleoside triphosphate binding 4 1
GO:0036094 small molecule binding 2 1
GO:0043168 anion binding 3 1
GO:0097159 organic cyclic compound binding 2 1
GO:0097367 carbohydrate derivative binding 2 1
GO:0140657 ATP-dependent activity 1 1
GO:1901265 nucleoside phosphate binding 3 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 149 153 PF00656 0.471
CLV_C14_Caspase3-7 1506 1510 PF00656 0.192
CLV_C14_Caspase3-7 1588 1592 PF00656 0.393
CLV_C14_Caspase3-7 1733 1737 PF00656 0.425
CLV_C14_Caspase3-7 2139 2143 PF00656 0.435
CLV_NRD_NRD_1 1469 1471 PF00675 0.382
CLV_NRD_NRD_1 1595 1597 PF00675 0.433
CLV_NRD_NRD_1 1750 1752 PF00675 0.390
CLV_NRD_NRD_1 1878 1880 PF00675 0.531
CLV_NRD_NRD_1 1904 1906 PF00675 0.481
CLV_NRD_NRD_1 1983 1985 PF00675 0.557
CLV_NRD_NRD_1 2109 2111 PF00675 0.442
CLV_NRD_NRD_1 2128 2130 PF00675 0.381
CLV_PCSK_KEX2_1 1469 1471 PF00082 0.382
CLV_PCSK_KEX2_1 1595 1597 PF00082 0.433
CLV_PCSK_KEX2_1 1750 1752 PF00082 0.390
CLV_PCSK_KEX2_1 1878 1880 PF00082 0.531
CLV_PCSK_KEX2_1 1904 1906 PF00082 0.493
CLV_PCSK_KEX2_1 1983 1985 PF00082 0.557
CLV_PCSK_KEX2_1 2109 2111 PF00082 0.442
CLV_PCSK_KEX2_1 2128 2130 PF00082 0.381
CLV_PCSK_SKI1_1 1026 1030 PF00082 0.382
CLV_PCSK_SKI1_1 1065 1069 PF00082 0.392
CLV_PCSK_SKI1_1 1104 1108 PF00082 0.392
CLV_PCSK_SKI1_1 1143 1147 PF00082 0.392
CLV_PCSK_SKI1_1 1182 1186 PF00082 0.402
CLV_PCSK_SKI1_1 1221 1225 PF00082 0.392
CLV_PCSK_SKI1_1 1260 1264 PF00082 0.402
CLV_PCSK_SKI1_1 1299 1303 PF00082 0.392
CLV_PCSK_SKI1_1 1338 1342 PF00082 0.392
CLV_PCSK_SKI1_1 1377 1381 PF00082 0.382
CLV_PCSK_SKI1_1 1416 1420 PF00082 0.398
CLV_PCSK_SKI1_1 1470 1474 PF00082 0.383
CLV_PCSK_SKI1_1 1720 1724 PF00082 0.339
CLV_PCSK_SKI1_1 178 182 PF00082 0.440
CLV_PCSK_SKI1_1 1925 1929 PF00082 0.468
CLV_PCSK_SKI1_1 2048 2052 PF00082 0.388
CLV_PCSK_SKI1_1 207 211 PF00082 0.407
CLV_PCSK_SKI1_1 2095 2099 PF00082 0.394
CLV_PCSK_SKI1_1 246 250 PF00082 0.402
CLV_PCSK_SKI1_1 285 289 PF00082 0.402
CLV_PCSK_SKI1_1 324 328 PF00082 0.499
CLV_PCSK_SKI1_1 363 367 PF00082 0.402
CLV_PCSK_SKI1_1 402 406 PF00082 0.421
CLV_PCSK_SKI1_1 441 445 PF00082 0.402
CLV_PCSK_SKI1_1 480 484 PF00082 0.409
CLV_PCSK_SKI1_1 519 523 PF00082 0.392
CLV_PCSK_SKI1_1 558 562 PF00082 0.402
CLV_PCSK_SKI1_1 597 601 PF00082 0.402
CLV_PCSK_SKI1_1 636 640 PF00082 0.382
CLV_PCSK_SKI1_1 675 679 PF00082 0.392
CLV_PCSK_SKI1_1 714 718 PF00082 0.402
CLV_PCSK_SKI1_1 753 757 PF00082 0.402
CLV_PCSK_SKI1_1 792 796 PF00082 0.402
CLV_PCSK_SKI1_1 831 835 PF00082 0.402
CLV_PCSK_SKI1_1 870 874 PF00082 0.402
CLV_PCSK_SKI1_1 909 913 PF00082 0.392
CLV_PCSK_SKI1_1 948 952 PF00082 0.402
CLV_PCSK_SKI1_1 987 991 PF00082 0.392
CLV_Separin_Metazoa 2016 2020 PF03568 0.594
DEG_APCC_DBOX_1 1639 1647 PF00400 0.369
DEG_APCC_DBOX_1 2094 2102 PF00400 0.390
DEG_SCF_FBW7_1 98 105 PF00400 0.531
DEG_SIAH_1 125 133 PF03145 0.506
DEG_SPOP_SBC_1 93 97 PF00917 0.544
DOC_ANK_TNKS_1 1850 1857 PF00023 0.484
DOC_CKS1_1 1 6 PF01111 0.504
DOC_CKS1_1 1969 1974 PF01111 0.592
DOC_MAPK_gen_1 1844 1852 PF00069 0.462
DOC_MAPK_gen_1 1921 1930 PF00069 0.472
DOC_MAPK_gen_1 2128 2134 PF00069 0.335
DOC_MIT_MIM_1 1638 1646 PF04212 0.409
DOC_USP7_MATH_1 102 106 PF00917 0.512
DOC_USP7_MATH_1 111 115 PF00917 0.506
DOC_USP7_MATH_1 1472 1476 PF00917 0.182
DOC_USP7_MATH_1 1495 1499 PF00917 0.192
DOC_USP7_MATH_1 179 183 PF00917 0.232
DOC_USP7_MATH_1 1804 1808 PF00917 0.524
DOC_USP7_MATH_1 1814 1818 PF00917 0.514
DOC_USP7_MATH_1 1887 1891 PF00917 0.560
DOC_USP7_MATH_1 1900 1904 PF00917 0.499
DOC_USP7_MATH_1 196 200 PF00917 0.258
DOC_USP7_MATH_1 1989 1993 PF00917 0.549
DOC_USP7_MATH_1 2003 2007 PF00917 0.524
DOC_USP7_MATH_1 83 87 PF00917 0.458
DOC_WW_Pin1_4 120 125 PF00397 0.558
DOC_WW_Pin1_4 128 133 PF00397 0.533
DOC_WW_Pin1_4 1968 1973 PF00397 0.594
DOC_WW_Pin1_4 1978 1983 PF00397 0.547
DOC_WW_Pin1_4 2008 2013 PF00397 0.613
DOC_WW_Pin1_4 85 90 PF00397 0.517
DOC_WW_Pin1_4 98 103 PF00397 0.491
LIG_14-3-3_CanoR_1 1695 1705 PF00244 0.420
LIG_14-3-3_CanoR_1 1720 1725 PF00244 0.397
LIG_14-3-3_CanoR_1 1789 1798 PF00244 0.485
LIG_14-3-3_CanoR_1 1801 1808 PF00244 0.485
LIG_14-3-3_CanoR_1 1878 1886 PF00244 0.528
LIG_14-3-3_CanoR_1 1951 1959 PF00244 0.526
LIG_14-3-3_CanoR_1 2039 2047 PF00244 0.447
LIG_14-3-3_CanoR_1 2073 2080 PF00244 0.508
LIG_14-3-3_CanoR_1 2084 2091 PF00244 0.345
LIG_Actin_WH2_2 1774 1791 PF00022 0.441
LIG_APCC_ABBA_1 1537 1542 PF00400 0.415
LIG_APCC_ABBA_1 1703 1708 PF00400 0.413
LIG_BIR_II_1 1 5 PF00653 0.538
LIG_Clathr_ClatBox_1 1815 1819 PF01394 0.499
LIG_CtBP_PxDLS_1 1856 1862 PF00389 0.473
LIG_FHA_1 1698 1704 PF00498 0.425
LIG_FHA_1 1953 1959 PF00498 0.554
LIG_FHA_1 198 204 PF00498 0.246
LIG_FHA_1 2080 2086 PF00498 0.508
LIG_FHA_1 53 59 PF00498 0.352
LIG_FHA_2 149 155 PF00498 0.507
LIG_FHA_2 187 193 PF00498 0.245
LIG_FHA_2 1993 1999 PF00498 0.529
LIG_FHA_2 2028 2034 PF00498 0.550
LIG_LIR_Gen_1 2049 2056 PF02991 0.399
LIG_LIR_Nem_3 2044 2050 PF02991 0.408
LIG_LIR_Nem_3 2125 2130 PF02991 0.389
LIG_REV1ctd_RIR_1 32 42 PF16727 0.270
LIG_SH2_GRB2like 63 66 PF00017 0.282
LIG_SH2_SRC 2052 2055 PF00017 0.401
LIG_SH2_STAP1 2052 2056 PF00017 0.396
LIG_SH2_STAP1 63 67 PF00017 0.228
LIG_SH2_STAT5 2070 2073 PF00017 0.466
LIG_SH2_STAT5 91 94 PF00017 0.592
LIG_SH3_1 104 110 PF00018 0.556
LIG_SH3_1 1983 1989 PF00018 0.535
LIG_SH3_2 2014 2019 PF14604 0.582
LIG_SH3_3 104 110 PF00018 0.570
LIG_SH3_3 1894 1900 PF00018 0.515
LIG_SH3_3 1966 1972 PF00018 0.592
LIG_SH3_3 1983 1989 PF00018 0.501
LIG_SH3_3 2011 2017 PF00018 0.597
LIG_SUMO_SIM_par_1 1813 1819 PF11976 0.496
LIG_SxIP_EBH_1 51 65 PF03271 0.282
LIG_TRAF2_1 1670 1673 PF00917 0.437
LIG_TRAF2_1 1710 1713 PF00917 0.416
LIG_TRAF2_1 189 192 PF00917 0.230
LIG_TRAF2_1 2100 2103 PF00917 0.382
LIG_TRAF2_1 2118 2121 PF00917 0.322
LIG_TYR_ITIM 2050 2055 PF00017 0.404
LIG_WW_3 2016 2020 PF00397 0.585
MOD_CDK_SPK_2 1978 1983 PF00069 0.551
MOD_CDK_SPxK_1 1978 1984 PF00069 0.593
MOD_CDK_SPxK_1 98 104 PF00069 0.557
MOD_CDK_SPxxK_3 2008 2015 PF00069 0.610
MOD_CK1_1 1803 1809 PF00069 0.518
MOD_CK1_1 1890 1896 PF00069 0.502
MOD_CK1_1 1992 1998 PF00069 0.546
MOD_CK1_1 54 60 PF00069 0.253
MOD_CK2_1 1472 1478 PF00069 0.186
MOD_CK2_1 1547 1553 PF00069 0.402
MOD_CK2_1 1696 1702 PF00069 0.408
MOD_CK2_1 186 192 PF00069 0.264
MOD_CK2_1 1878 1884 PF00069 0.547
MOD_CK2_1 1992 1998 PF00069 0.532
MOD_CK2_1 2027 2033 PF00069 0.581
MOD_GlcNHglycan 1658 1661 PF01048 0.370
MOD_GlcNHglycan 1742 1745 PF01048 0.482
MOD_GlcNHglycan 1802 1805 PF01048 0.515
MOD_GlcNHglycan 181 184 PF01048 0.282
MOD_GlcNHglycan 1812 1815 PF01048 0.513
MOD_GlcNHglycan 1821 1824 PF01048 0.529
MOD_GlcNHglycan 1991 1994 PF01048 0.572
MOD_GlcNHglycan 2000 2003 PF01048 0.521
MOD_GlcNHglycan 2006 2009 PF01048 0.542
MOD_GlcNHglycan 2075 2078 PF01048 0.567
MOD_GlcNHglycan 2085 2088 PF01048 0.396
MOD_GlcNHglycan 2134 2137 PF01048 0.356
MOD_GlcNHglycan 98 101 PF01048 0.533
MOD_GSK3_1 116 123 PF00069 0.609
MOD_GSK3_1 142 149 PF00069 0.541
MOD_GSK3_1 1740 1747 PF00069 0.465
MOD_GSK3_1 1789 1796 PF00069 0.475
MOD_GSK3_1 1800 1807 PF00069 0.457
MOD_GSK3_1 1810 1817 PF00069 0.517
MOD_GSK3_1 1887 1894 PF00069 0.501
MOD_GSK3_1 1953 1960 PF00069 0.554
MOD_GSK3_1 1964 1971 PF00069 0.566
MOD_GSK3_1 2004 2011 PF00069 0.589
MOD_GSK3_1 2029 2036 PF00069 0.526
MOD_GSK3_1 2079 2086 PF00069 0.515
MOD_GSK3_1 92 99 PF00069 0.713
MOD_N-GLC_2 1719 1721 PF02516 0.375
MOD_NEK2_1 1802 1807 PF00069 0.521
MOD_NEK2_1 2085 2090 PF00069 0.368
MOD_NEK2_1 2105 2110 PF00069 0.445
MOD_NEK2_1 34 39 PF00069 0.447
MOD_PIKK_1 1067 1073 PF00454 0.228
MOD_PIKK_1 1106 1112 PF00454 0.214
MOD_PIKK_1 111 117 PF00454 0.538
MOD_PIKK_1 1223 1229 PF00454 0.228
MOD_PIKK_1 1340 1346 PF00454 0.228
MOD_PIKK_1 1457 1463 PF00454 0.214
MOD_PIKK_1 1557 1563 PF00454 0.355
MOD_PIKK_1 1891 1897 PF00454 0.557
MOD_PIKK_1 2033 2039 PF00454 0.495
MOD_PIKK_1 2079 2085 PF00454 0.474
MOD_PIKK_1 248 254 PF00454 0.214
MOD_PIKK_1 287 293 PF00454 0.214
MOD_PIKK_1 365 371 PF00454 0.214
MOD_PIKK_1 443 449 PF00454 0.242
MOD_PIKK_1 482 488 PF00454 0.228
MOD_PIKK_1 560 566 PF00454 0.228
MOD_PIKK_1 716 722 PF00454 0.228
MOD_PIKK_1 794 800 PF00454 0.242
MOD_PIKK_1 833 839 PF00454 0.256
MOD_PIKK_1 950 956 PF00454 0.214
MOD_PIKK_1 989 995 PF00454 0.242
MOD_PKA_1 1878 1884 PF00069 0.530
MOD_PKA_2 1483 1489 PF00069 0.186
MOD_PKA_2 1800 1806 PF00069 0.526
MOD_PKA_2 1877 1883 PF00069 0.536
MOD_PKA_2 1998 2004 PF00069 0.509
MOD_PKA_2 2038 2044 PF00069 0.467
MOD_PKA_2 2072 2078 PF00069 0.489
MOD_PKA_2 2083 2089 PF00069 0.377
MOD_PKA_2 83 89 PF00069 0.516
MOD_Plk_1 1547 1553 PF00069 0.383
MOD_Plk_1 1650 1656 PF00069 0.399
MOD_Plk_1 1891 1897 PF00069 0.522
MOD_Plk_1 2120 2126 PF00069 0.365
MOD_Plk_2-3 1547 1553 PF00069 0.383
MOD_Plk_4 1483 1489 PF00069 0.186
MOD_Plk_4 1794 1800 PF00069 0.488
MOD_Plk_4 1953 1959 PF00069 0.570
MOD_Plk_4 54 60 PF00069 0.376
MOD_ProDKin_1 120 126 PF00069 0.555
MOD_ProDKin_1 128 134 PF00069 0.531
MOD_ProDKin_1 1968 1974 PF00069 0.594
MOD_ProDKin_1 1978 1984 PF00069 0.547
MOD_ProDKin_1 2008 2014 PF00069 0.609
MOD_ProDKin_1 85 91 PF00069 0.522
MOD_ProDKin_1 98 104 PF00069 0.503
MOD_SUMO_for_1 1544 1547 PF00179 0.406
MOD_SUMO_rev_2 1437 1447 PF00179 0.211
MOD_SUMO_rev_2 1623 1627 PF00179 0.424
TRG_DiLeu_BaEn_1 1848 1853 PF01217 0.472
TRG_DiLeu_BaEn_4 1450 1456 PF01217 0.186
TRG_DiLeu_BaEn_4 1553 1559 PF01217 0.389
TRG_DiLeu_BaEn_4 192 198 PF01217 0.284
TRG_DiLeu_LyEn_5 1848 1853 PF01217 0.472
TRG_ENDOCYTIC_2 1706 1709 PF00928 0.424
TRG_ENDOCYTIC_2 2047 2050 PF00928 0.406
TRG_ENDOCYTIC_2 2052 2055 PF00928 0.373
TRG_ENDOCYTIC_2 75 78 PF00928 0.279
TRG_ER_diArg_1 1469 1471 PF00400 0.186
TRG_ER_diArg_1 1639 1642 PF00400 0.374
TRG_ER_diArg_1 1692 1695 PF00400 0.484
TRG_ER_diArg_1 1749 1751 PF00400 0.376
TRG_ER_diArg_1 1862 1865 PF00400 0.462
TRG_ER_diArg_1 1904 1906 PF00400 0.479
TRG_ER_diArg_1 1982 1984 PF00400 0.549
TRG_ER_diArg_1 2018 2021 PF00400 0.594
TRG_ER_diArg_1 2109 2111 PF00400 0.446
TRG_ER_diArg_1 2127 2129 PF00400 0.380
TRG_NES_CRM1_1 1617 1630 PF08389 0.395
TRG_NES_CRM1_1 1848 1861 PF08389 0.481
TRG_Pf-PMV_PEXEL_1 1469 1474 PF00026 0.186
TRG_Pf-PMV_PEXEL_1 1707 1712 PF00026 0.436
TRG_Pf-PMV_PEXEL_1 1751 1755 PF00026 0.392
TRG_Pf-PMV_PEXEL_1 1851 1855 PF00026 0.465
TRG_Pf-PMV_PEXEL_1 1864 1868 PF00026 0.435
TRG_Pf-PMV_PEXEL_1 2099 2103 PF00026 0.415

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S5H530 Leishmania donovani 98% 100%
A4H3J9 Leishmania braziliensis 61% 100%
A4H7R4 Leishmania braziliensis 25% 99%
E9ACH4 Leishmania major 83% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS