Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HRS8_LEIIN

TriTrypDb:

LINF_030006500

Length:

191

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HRS8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRS8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	70	74	PF00656	0.822
CLV_C14_Caspase3-7	84	88	PF00656	0.541
CLV_PCSK_KEX2_1	159	161	PF00082	0.675
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.675
CLV_PCSK_SKI1_1	24	28	PF00082	0.464
DOC_CDC14_PxL_1	172	180	PF14671	0.665
DOC_PP2B_LxvP_1	173	176	PF13499	0.533
DOC_USP7_MATH_1	75	79	PF00917	0.713
DOC_USP7_MATH_1	80	84	PF00917	0.608
DOC_WW_Pin1_4	139	144	PF00397	0.668
DOC_WW_Pin1_4	3	8	PF00397	0.699
DOC_WW_Pin1_4	62	67	PF00397	0.700
DOC_WW_Pin1_4	76	81	PF00397	0.560
LIG_BIR_II_1	1	5	PF00653	0.801
LIG_CtBP_PxDLS_1	166	170	PF00389	0.773
LIG_FHA_1	47	53	PF00498	0.785
LIG_FHA_1	96	102	PF00498	0.510
LIG_GBD_Chelix_1	22	30	PF00786	0.462
LIG_LIR_Apic_2	2	8	PF02991	0.739
LIG_LIR_Nem_3	48	53	PF02991	0.787
LIG_MYND_1	176	180	PF01753	0.558
LIG_SH2_CRK	5	9	PF00017	0.712
LIG_SH2_SRC	100	103	PF00017	0.670
LIG_SH2_STAT5	100	103	PF00017	0.670
LIG_SH3_2	4	9	PF14604	0.603
LIG_SH3_3	1	7	PF00018	0.741
LIG_SUMO_SIM_anti_2	25	30	PF11976	0.600
LIG_TRAF2_1	45	48	PF00917	0.779
LIG_WW_3	6	10	PF00397	0.607
MOD_CDC14_SPxK_1	6	9	PF00782	0.609
MOD_CDK_SPxK_1	139	145	PF00069	0.670
MOD_CDK_SPxK_1	3	9	PF00069	0.599
MOD_CK1_1	3	9	PF00069	0.764
MOD_CK1_1	65	71	PF00069	0.709
MOD_CK1_1	83	89	PF00069	0.548
MOD_CK1_1	92	98	PF00069	0.684
MOD_GlcNHglycan	121	124	PF01048	0.628
MOD_GlcNHglycan	153	156	PF01048	0.681
MOD_GlcNHglycan	67	70	PF01048	0.785
MOD_GSK3_1	151	158	PF00069	0.695
MOD_GSK3_1	58	65	PF00069	0.804
MOD_GSK3_1	76	83	PF00069	0.491
MOD_GSK3_1	85	92	PF00069	0.635
MOD_N-GLC_1	35	40	PF02516	0.726
MOD_PKA_2	119	125	PF00069	0.726
MOD_PKA_2	75	81	PF00069	0.820
MOD_Plk_1	24	30	PF00069	0.560
MOD_Plk_4	24	30	PF00069	0.506
MOD_Plk_4	92	98	PF00069	0.672
MOD_ProDKin_1	139	145	PF00069	0.670
MOD_ProDKin_1	3	9	PF00069	0.702
MOD_ProDKin_1	62	68	PF00069	0.702
MOD_ProDKin_1	76	82	PF00069	0.560
TRG_ENDOCYTIC_2	53	56	PF00928	0.753
TRG_NES_CRM1_1	25	39	PF08389	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A451EJM2	Leishmania donovani	99%	99%
A4H3I9	Leishmania braziliensis	62%	100%
E9ACG4	Leishmania major	84%	100%
E9AJQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%