DNA-directed RNA polymerase III subunit RPC3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HRS6_LEIIN

TriTrypDb:

LINF_270033500

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0000428	DNA-directed RNA polymerase complex	4	4
GO:0005666	RNA polymerase III complex	4	4
GO:0030880	RNA polymerase complex	3	4
GO:0032991	protein-containing complex	1	4
GO:0055029	nuclear DNA-directed RNA polymerase complex	3	4
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	4
GO:0140513	nuclear protein-containing complex	2	4
GO:0140535	intracellular protein-containing complex	2	4
GO:1902494	catalytic complex	2	4
GO:1990234	transferase complex	3	4

Expansion

Sequence features

A4HRS6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRS6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	4
GO:0003677	DNA binding	4	4
GO:0003697	single-stranded DNA binding	5	4
GO:0005488	binding	1	4
GO:0097159	organic cyclic compound binding	2	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	64	68	PF00656	0.552
CLV_NRD_NRD_1	26	28	PF00675	0.543
CLV_NRD_NRD_1	55	57	PF00675	0.579
CLV_PCSK_KEX2_1	25	27	PF00082	0.558
CLV_PCSK_KEX2_1	55	57	PF00082	0.576
CLV_PCSK_PC7_1	22	28	PF00082	0.503
CLV_PCSK_SKI1_1	116	120	PF00082	0.706
CLV_PCSK_SKI1_1	15	19	PF00082	0.437
CLV_PCSK_SKI1_1	159	163	PF00082	0.545
CLV_PCSK_SKI1_1	187	191	PF00082	0.577
CLV_PCSK_SKI1_1	213	217	PF00082	0.644
CLV_PCSK_SKI1_1	237	241	PF00082	0.546
CLV_PCSK_SKI1_1	306	310	PF00082	0.475
CLV_PCSK_SKI1_1	320	324	PF00082	0.325
CLV_Separin_Metazoa	203	207	PF03568	0.641
DEG_APCC_DBOX_1	14	22	PF00400	0.478
DEG_APCC_DBOX_1	186	194	PF00400	0.574
DEG_Nend_UBRbox_2	1	2	PF02207	0.555
DEG_SIAH_1	261	269	PF03145	0.489
DEG_SPOP_SBC_1	69	73	PF00917	0.681
DOC_CYCLIN_RxL_1	317	326	PF00134	0.453
DOC_CYCLIN_yCln2_LP_2	84	90	PF00134	0.685
DOC_MAPK_gen_1	213	221	PF00069	0.613
DOC_MAPK_gen_1	235	244	PF00069	0.552
DOC_MAPK_MEF2A_6	152	160	PF00069	0.566
DOC_MAPK_MEF2A_6	320	327	PF00069	0.463
DOC_USP7_MATH_1	176	180	PF00917	0.552
DOC_USP7_MATH_1	205	209	PF00917	0.674
DOC_USP7_MATH_1	215	219	PF00917	0.445
DOC_USP7_MATH_1	271	275	PF00917	0.644
DOC_USP7_MATH_1	37	41	PF00917	0.525
DOC_USP7_MATH_1	70	74	PF00917	0.649
DOC_USP7_MATH_1	98	102	PF00917	0.766
DOC_WW_Pin1_4	103	108	PF00397	0.766
DOC_WW_Pin1_4	266	271	PF00397	0.642
LIG_14-3-3_CanoR_1	15	21	PF00244	0.547
LIG_14-3-3_CanoR_1	237	243	PF00244	0.547
LIG_AP2alpha_1	194	198	PF02296	0.597
LIG_BRCT_BRCA1_1	105	109	PF00533	0.778
LIG_Clathr_ClatBox_1	322	326	PF01394	0.454
LIG_FHA_1	113	119	PF00498	0.742
LIG_FHA_1	205	211	PF00498	0.686
LIG_FHA_1	239	245	PF00498	0.552
LIG_FHA_1	33	39	PF00498	0.554
LIG_FHA_1	49	55	PF00498	0.607
LIG_FHA_1	64	70	PF00498	0.713
LIG_FHA_2	172	178	PF00498	0.588
LIG_FHA_2	62	68	PF00498	0.541
LIG_GBD_Chelix_1	16	24	PF00786	0.435
LIG_LIR_Gen_1	106	117	PF02991	0.769
LIG_LIR_Gen_1	182	190	PF02991	0.494
LIG_LIR_Gen_1	243	252	PF02991	0.561
LIG_LIR_Gen_1	40	49	PF02991	0.454
LIG_LIR_Nem_3	126	131	PF02991	0.559
LIG_LIR_Nem_3	151	156	PF02991	0.587
LIG_LIR_Nem_3	182	186	PF02991	0.508
LIG_LIR_Nem_3	243	249	PF02991	0.560
LIG_LIR_Nem_3	40	44	PF02991	0.458
LIG_NRBOX	317	323	PF00104	0.454
LIG_PCNA_yPIPBox_3	306	319	PF02747	0.460
LIG_PDZ_Class_3	323	328	PF00595	0.415
LIG_Pex14_2	194	198	PF04695	0.597
LIG_SH2_CRK	153	157	PF00017	0.564
LIG_SH2_PTP2	183	186	PF00017	0.502
LIG_SH2_SRC	11	14	PF00017	0.487
LIG_SH2_STAP1	34	38	PF00017	0.556
LIG_SH2_STAP1	91	95	PF00017	0.599
LIG_SH2_STAT5	183	186	PF00017	0.595
LIG_SH2_STAT5	220	223	PF00017	0.558
LIG_SH2_STAT5	34	37	PF00017	0.555
LIG_SH3_3	256	262	PF00018	0.482
LIG_SH3_4	121	128	PF00018	0.596
LIG_SUMO_SIM_par_1	320	326	PF11976	0.454
LIG_TRAF2_1	40	43	PF00917	0.465
LIG_WRC_WIRS_1	38	43	PF05994	0.478
MOD_CK1_1	108	114	PF00069	0.660
MOD_CK1_1	179	185	PF00069	0.560
MOD_CK1_1	275	281	PF00069	0.549
MOD_CK1_1	32	38	PF00069	0.550
MOD_CK2_1	171	177	PF00069	0.587
MOD_CK2_1	37	43	PF00069	0.483
MOD_CK2_1	69	75	PF00069	0.672
MOD_GlcNHglycan	100	103	PF01048	0.701
MOD_GlcNHglycan	207	210	PF01048	0.695
MOD_GlcNHglycan	212	216	PF01048	0.582
MOD_GlcNHglycan	226	229	PF01048	0.282
MOD_GlcNHglycan	256	259	PF01048	0.517
MOD_GlcNHglycan	278	281	PF01048	0.566
MOD_GlcNHglycan	31	34	PF01048	0.541
MOD_GlcNHglycan	57	61	PF01048	0.611
MOD_GSK3_1	103	110	PF00069	0.785
MOD_GSK3_1	211	218	PF00069	0.626
MOD_GSK3_1	222	229	PF00069	0.382
MOD_GSK3_1	271	278	PF00069	0.624
MOD_GSK3_1	306	313	PF00069	0.471
MOD_N-GLC_1	276	281	PF02516	0.535
MOD_NEK2_1	16	21	PF00069	0.477
MOD_NEK2_1	224	229	PF00069	0.537
MOD_NEK2_1	238	243	PF00069	0.349
MOD_NEK2_2	215	220	PF00069	0.606
MOD_PIKK_1	121	127	PF00454	0.600
MOD_PKA_2	205	211	PF00069	0.686
MOD_Plk_1	171	177	PF00069	0.587
MOD_Plk_2-3	171	177	PF00069	0.587
MOD_Plk_4	16	22	PF00069	0.480
MOD_Plk_4	179	185	PF00069	0.607
MOD_Plk_4	215	221	PF00069	0.600
MOD_Plk_4	226	232	PF00069	0.401
MOD_Plk_4	314	320	PF00069	0.450
MOD_ProDKin_1	103	109	PF00069	0.759
MOD_ProDKin_1	266	272	PF00069	0.644
TRG_DiLeu_BaLyEn_6	317	322	PF01217	0.449
TRG_ENDOCYTIC_2	153	156	PF00928	0.572
TRG_ENDOCYTIC_2	183	186	PF00928	0.502
TRG_ER_diArg_1	24	27	PF00400	0.553
TRG_ER_diArg_1	54	56	PF00400	0.576
TRG_NES_CRM1_1	188	203	PF08389	0.589
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	296	300	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H3F9	Leishmania braziliensis	84%	100%
E9ACE2	Leishmania major	92%	100%