Phosphoglycan beta 1,2 arabinosyltransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphoglycan beta 1 -2 arabinosyltransferase

Species:

Leishmania infantum

UniProt:

A4HRS2_LEIIN

TriTrypDb:

LINF_020007200

Length:

832

Annotations

LeishMANIAdb annotations

A signal-anchored enzyme family expanded in Leishmaniids. Any identification as glycosyltransferase is highly tentative.. Localization: Golgi (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005796	Golgi lumen	5	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2

Expansion

Sequence features

A4HRS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRS2

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	2
GO:0005996	monosaccharide metabolic process	3	2
GO:0006012	galactose metabolic process	5	2
GO:0008152	metabolic process	1	2
GO:0019318	hexose metabolic process	4	2
GO:0044238	primary metabolic process	2	2
GO:0044281	small molecule metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016740	transferase activity	2	10
GO:0008378	galactosyltransferase activity	5	2
GO:0016757	glycosyltransferase activity	3	2
GO:0016758	hexosyltransferase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.342
CLV_C14_Caspase3-7	569	573	PF00656	0.377
CLV_MEL_PAP_1	278	284	PF00089	0.501
CLV_NRD_NRD_1	151	153	PF00675	0.583
CLV_NRD_NRD_1	362	364	PF00675	0.562
CLV_NRD_NRD_1	392	394	PF00675	0.517
CLV_NRD_NRD_1	415	417	PF00675	0.569
CLV_NRD_NRD_1	46	48	PF00675	0.467
CLV_NRD_NRD_1	598	600	PF00675	0.636
CLV_NRD_NRD_1	719	721	PF00675	0.638
CLV_NRD_NRD_1	808	810	PF00675	0.515
CLV_PCSK_FUR_1	413	417	PF00082	0.500
CLV_PCSK_KEX2_1	362	364	PF00082	0.562
CLV_PCSK_KEX2_1	392	394	PF00082	0.517
CLV_PCSK_KEX2_1	415	417	PF00082	0.569
CLV_PCSK_KEX2_1	46	48	PF00082	0.469
CLV_PCSK_KEX2_1	597	599	PF00082	0.612
CLV_PCSK_KEX2_1	719	721	PF00082	0.613
CLV_PCSK_KEX2_1	808	810	PF00082	0.515
CLV_PCSK_SKI1_1	152	156	PF00082	0.592
CLV_PCSK_SKI1_1	224	228	PF00082	0.567
CLV_PCSK_SKI1_1	376	380	PF00082	0.537
DEG_COP1_1	285	293	PF00400	0.394
DEG_Nend_UBRbox_1	1	4	PF02207	0.625
DEG_SCF_FBW7_1	337	344	PF00400	0.273
DOC_CKS1_1	472	477	PF01111	0.388
DOC_CYCLIN_yClb5_NLxxxL_5	427	436	PF00134	0.270
DOC_CYCLIN_yCln2_LP_2	400	406	PF00134	0.339
DOC_MAPK_gen_1	152	161	PF00069	0.394
DOC_MAPK_gen_1	224	232	PF00069	0.351
DOC_MAPK_gen_1	392	399	PF00069	0.324
DOC_MAPK_gen_1	46	55	PF00069	0.578
DOC_MAPK_gen_1	601	610	PF00069	0.398
DOC_MAPK_gen_1	741	750	PF00069	0.349
DOC_MAPK_MEF2A_6	224	232	PF00069	0.351
DOC_PP1_RVXF_1	374	380	PF00149	0.254
DOC_PP2B_LxvP_1	104	107	PF13499	0.451
DOC_PP2B_LxvP_1	400	403	PF13499	0.359
DOC_PP2B_LxvP_1	404	407	PF13499	0.317
DOC_PP2B_LxvP_1	748	751	PF13499	0.301
DOC_PP4_FxxP_1	472	475	PF00568	0.493
DOC_PP4_FxxP_1	526	529	PF00568	0.301
DOC_USP7_MATH_1	13	17	PF00917	0.644
DOC_USP7_MATH_1	138	142	PF00917	0.470
DOC_USP7_MATH_1	327	331	PF00917	0.417
DOC_USP7_MATH_1	341	345	PF00917	0.262
DOC_USP7_MATH_1	445	449	PF00917	0.371
DOC_USP7_MATH_1	545	549	PF00917	0.427
DOC_USP7_MATH_1	665	669	PF00917	0.320
DOC_USP7_MATH_1	74	78	PF00917	0.503
DOC_USP7_MATH_1	751	755	PF00917	0.319
DOC_USP7_MATH_1	81	85	PF00917	0.483
DOC_USP7_UBL2_3	730	734	PF12436	0.334
DOC_USP7_UBL2_3	743	747	PF12436	0.279
DOC_WW_Pin1_4	337	342	PF00397	0.313
DOC_WW_Pin1_4	402	407	PF00397	0.420
DOC_WW_Pin1_4	440	445	PF00397	0.487
DOC_WW_Pin1_4	471	476	PF00397	0.453
DOC_WW_Pin1_4	91	96	PF00397	0.528
LIG_14-3-3_CanoR_1	194	198	PF00244	0.385
LIG_14-3-3_CanoR_1	440	444	PF00244	0.326
LIG_14-3-3_CanoR_1	621	625	PF00244	0.357
LIG_14-3-3_CanoR_1	720	726	PF00244	0.339
LIG_14-3-3_CanoR_1	728	734	PF00244	0.352
LIG_14-3-3_CanoR_1	89	95	PF00244	0.551
LIG_Actin_WH2_2	527	544	PF00022	0.366
LIG_BIR_III_4	506	510	PF00653	0.452
LIG_BIR_III_4	572	576	PF00653	0.383
LIG_BRCT_BRCA1_1	455	459	PF00533	0.377
LIG_BRCT_BRCA1_1	667	671	PF00533	0.380
LIG_CSL_BTD_1	230	233	PF09270	0.328
LIG_FHA_1	120	126	PF00498	0.427
LIG_FHA_1	145	151	PF00498	0.406
LIG_FHA_1	249	255	PF00498	0.445
LIG_FHA_1	275	281	PF00498	0.329
LIG_FHA_1	285	291	PF00498	0.339
LIG_FHA_1	331	337	PF00498	0.372
LIG_FHA_1	4	10	PF00498	0.598
LIG_FHA_1	676	682	PF00498	0.340
LIG_FHA_2	128	134	PF00498	0.389
LIG_FHA_2	161	167	PF00498	0.356
LIG_FHA_2	181	187	PF00498	0.369
LIG_FHA_2	255	261	PF00498	0.417
LIG_FHA_2	287	293	PF00498	0.398
LIG_FHA_2	369	375	PF00498	0.314
LIG_FHA_2	472	478	PF00498	0.409
LIG_FHA_2	766	772	PF00498	0.269
LIG_Integrin_RGD_1	2	4	PF01839	0.439
LIG_LIR_Apic_2	237	241	PF02991	0.380
LIG_LIR_Apic_2	333	337	PF02991	0.356
LIG_LIR_Apic_2	469	475	PF02991	0.483
LIG_LIR_Gen_1	300	307	PF02991	0.371
LIG_LIR_Gen_1	364	375	PF02991	0.324
LIG_LIR_Gen_1	482	491	PF02991	0.382
LIG_LIR_Gen_1	66	76	PF02991	0.681
LIG_LIR_Gen_1	754	765	PF02991	0.289
LIG_LIR_Gen_1	781	792	PF02991	0.290
LIG_LIR_Nem_3	300	306	PF02991	0.368
LIG_LIR_Nem_3	344	350	PF02991	0.314
LIG_LIR_Nem_3	364	370	PF02991	0.293
LIG_LIR_Nem_3	395	399	PF02991	0.339
LIG_LIR_Nem_3	482	487	PF02991	0.405
LIG_LIR_Nem_3	535	541	PF02991	0.375
LIG_LIR_Nem_3	654	659	PF02991	0.327
LIG_LIR_Nem_3	66	72	PF02991	0.447
LIG_LIR_Nem_3	678	683	PF02991	0.340
LIG_LIR_Nem_3	731	736	PF02991	0.387
LIG_LIR_Nem_3	754	760	PF02991	0.352
LIG_LIR_Nem_3	781	787	PF02991	0.336
LIG_LIR_Nem_3	825	831	PF02991	0.369
LIG_MYND_1	402	406	PF01753	0.395
LIG_NRBOX	316	322	PF00104	0.295
LIG_NRBOX	536	542	PF00104	0.365
LIG_PCNA_yPIPBox_3	411	424	PF02747	0.348
LIG_Pex14_1	611	615	PF04695	0.310
LIG_Pex14_2	827	831	PF04695	0.257
LIG_PTB_Apo_2	764	771	PF02174	0.325
LIG_PTB_Phospho_1	764	770	PF10480	0.322
LIG_SH2_CRK	367	371	PF00017	0.305
LIG_SH2_CRK	757	761	PF00017	0.333
LIG_SH2_PTP2	334	337	PF00017	0.298
LIG_SH2_PTP2	396	399	PF00017	0.293
LIG_SH2_PTP2	784	787	PF00017	0.290
LIG_SH2_SRC	770	773	PF00017	0.317
LIG_SH2_SRC	823	826	PF00017	0.304
LIG_SH2_STAP1	555	559	PF00017	0.392
LIG_SH2_STAP1	659	663	PF00017	0.370
LIG_SH2_STAP1	725	729	PF00017	0.405
LIG_SH2_STAP1	757	761	PF00017	0.303
LIG_SH2_STAT3	683	686	PF00017	0.388
LIG_SH2_STAT5	248	251	PF00017	0.407
LIG_SH2_STAT5	334	337	PF00017	0.398
LIG_SH2_STAT5	347	350	PF00017	0.339
LIG_SH2_STAT5	367	370	PF00017	0.194
LIG_SH2_STAT5	396	399	PF00017	0.346
LIG_SH2_STAT5	525	528	PF00017	0.321
LIG_SH2_STAT5	62	65	PF00017	0.304
LIG_SH2_STAT5	622	625	PF00017	0.375
LIG_SH2_STAT5	656	659	PF00017	0.352
LIG_SH2_STAT5	680	683	PF00017	0.392
LIG_SH2_STAT5	784	787	PF00017	0.290
LIG_SH2_STAT5	823	826	PF00017	0.337
LIG_SH3_2	42	47	PF14604	0.632
LIG_SH3_3	192	198	PF00018	0.387
LIG_SH3_3	227	233	PF00018	0.424
LIG_SH3_3	260	266	PF00018	0.418
LIG_SH3_3	39	45	PF00018	0.647
LIG_SH3_3	396	402	PF00018	0.385
LIG_SH3_3	416	422	PF00018	0.353
LIG_SUMO_SIM_anti_2	157	164	PF11976	0.366
LIG_SUMO_SIM_anti_2	56	62	PF11976	0.338
LIG_TRAF2_1	130	133	PF00917	0.409
LIG_TRAF2_1	164	167	PF00917	0.279
LIG_TRAF2_1	183	186	PF00917	0.276
LIG_TRFH_1	525	529	PF08558	0.407
LIG_TYR_ITIM	394	399	PF00017	0.393
LIG_WRC_WIRS_1	336	341	PF05994	0.411
LIG_WRC_WIRS_1	824	829	PF05994	0.356
MOD_CDK_SPxxK_3	91	98	PF00069	0.564
MOD_CK1_1	205	211	PF00069	0.594
MOD_CK1_1	273	279	PF00069	0.480
MOD_CK1_1	330	336	PF00069	0.486
MOD_CK1_1	40	46	PF00069	0.489
MOD_CK1_1	439	445	PF00069	0.417
MOD_CK1_1	5	11	PF00069	0.490
MOD_CK1_1	56	62	PF00069	0.358
MOD_CK1_1	636	642	PF00069	0.405
MOD_CK1_1	643	649	PF00069	0.360
MOD_CK1_1	724	730	PF00069	0.382
MOD_CK1_1	755	761	PF00069	0.357
MOD_CK1_1	800	806	PF00069	0.379
MOD_CK2_1	127	133	PF00069	0.519
MOD_CK2_1	160	166	PF00069	0.352
MOD_CK2_1	17	23	PF00069	0.564
MOD_CK2_1	180	186	PF00069	0.380
MOD_CK2_1	286	292	PF00069	0.508
MOD_CK2_1	368	374	PF00069	0.375
MOD_CK2_1	471	477	PF00069	0.461
MOD_CK2_1	636	642	PF00069	0.450
MOD_CK2_1	648	654	PF00069	0.318
MOD_CK2_1	765	771	PF00069	0.407
MOD_CK2_1	81	87	PF00069	0.752
MOD_DYRK1A_RPxSP_1	440	444	PF00069	0.459
MOD_GlcNHglycan	204	207	PF01048	0.598
MOD_GlcNHglycan	519	522	PF01048	0.383
MOD_GlcNHglycan	543	546	PF01048	0.389
MOD_GlcNHglycan	547	550	PF01048	0.359
MOD_GlcNHglycan	557	560	PF01048	0.339
MOD_GlcNHglycan	650	653	PF01048	0.390
MOD_GlcNHglycan	667	670	PF01048	0.576
MOD_GlcNHglycan	684	689	PF01048	0.516
MOD_GlcNHglycan	737	740	PF01048	0.435
MOD_GlcNHglycan	83	86	PF01048	0.705
MOD_GSK3_1	13	20	PF00069	0.568
MOD_GSK3_1	265	272	PF00069	0.413
MOD_GSK3_1	297	304	PF00069	0.391
MOD_GSK3_1	33	40	PF00069	0.529
MOD_GSK3_1	337	344	PF00069	0.311
MOD_GSK3_1	436	443	PF00069	0.483
MOD_GSK3_1	5	12	PF00069	0.567
MOD_GSK3_1	541	548	PF00069	0.377
MOD_GSK3_1	563	570	PF00069	0.498
MOD_GSK3_1	620	627	PF00069	0.511
MOD_GSK3_1	633	640	PF00069	0.355
MOD_GSK3_1	724	731	PF00069	0.644
MOD_GSK3_1	751	758	PF00069	0.475
MOD_GSK3_1	796	803	PF00069	0.329
MOD_GSK3_1	81	88	PF00069	0.701
MOD_N-GLC_1	144	149	PF02516	0.411
MOD_N-GLC_1	188	193	PF02516	0.548
MOD_N-GLC_1	25	30	PF02516	0.567
MOD_N-GLC_1	330	335	PF02516	0.373
MOD_N-GLC_1	634	639	PF02516	0.393
MOD_N-GLC_1	665	670	PF02516	0.408
MOD_N-GLC_1	711	716	PF02516	0.459
MOD_N-GLC_1	755	760	PF02516	0.502
MOD_N-GLC_1	90	95	PF02516	0.591
MOD_NEK2_1	436	441	PF00069	0.420
MOD_NEK2_1	489	494	PF00069	0.453
MOD_NEK2_1	53	58	PF00069	0.456
MOD_NEK2_1	579	584	PF00069	0.429
MOD_NEK2_1	610	615	PF00069	0.463
MOD_NEK2_1	63	68	PF00069	0.397
MOD_NEK2_1	667	672	PF00069	0.574
MOD_NEK2_1	765	770	PF00069	0.293
MOD_NEK2_1	787	792	PF00069	0.349
MOD_NEK2_1	9	14	PF00069	0.632
MOD_NEK2_2	823	828	PF00069	0.375
MOD_OFUCOSY	51	57	PF10250	0.248
MOD_PIKK_1	27	33	PF00454	0.569
MOD_PK_1	453	459	PF00069	0.419
MOD_PKA_2	13	19	PF00069	0.547
MOD_PKA_2	193	199	PF00069	0.421
MOD_PKA_2	202	208	PF00069	0.550
MOD_PKA_2	254	260	PF00069	0.572
MOD_PKA_2	283	289	PF00069	0.400
MOD_PKA_2	327	333	PF00069	0.479
MOD_PKA_2	40	46	PF00069	0.627
MOD_PKA_2	439	445	PF00069	0.399
MOD_PKA_2	459	465	PF00069	0.404
MOD_PKA_2	541	547	PF00069	0.418
MOD_PKA_2	579	585	PF00069	0.610
MOD_PKA_2	620	626	PF00069	0.426
MOD_PKB_1	597	605	PF00069	0.539
MOD_Plk_1	144	150	PF00069	0.435
MOD_Plk_1	188	194	PF00069	0.427
MOD_Plk_1	330	336	PF00069	0.372
MOD_Plk_1	341	347	PF00069	0.422
MOD_Plk_1	350	356	PF00069	0.254
MOD_Plk_1	532	538	PF00069	0.387
MOD_Plk_1	634	640	PF00069	0.436
MOD_Plk_1	643	649	PF00069	0.402
MOD_Plk_1	755	761	PF00069	0.453
MOD_Plk_2-3	620	626	PF00069	0.435
MOD_Plk_4	274	280	PF00069	0.388
MOD_Plk_4	351	357	PF00069	0.502
MOD_Plk_4	431	437	PF00069	0.384
MOD_Plk_4	453	459	PF00069	0.435
MOD_Plk_4	676	682	PF00069	0.353
MOD_Plk_4	756	762	PF00069	0.450
MOD_Plk_4	765	771	PF00069	0.410
MOD_Plk_4	823	829	PF00069	0.376
MOD_ProDKin_1	337	343	PF00069	0.375
MOD_ProDKin_1	402	408	PF00069	0.512
MOD_ProDKin_1	440	446	PF00069	0.607
MOD_ProDKin_1	471	477	PF00069	0.557
MOD_ProDKin_1	91	97	PF00069	0.664
MOD_SUMO_for_1	155	158	PF00179	0.423
MOD_SUMO_for_1	742	745	PF00179	0.375
TRG_DiLeu_BaEn_4	157	163	PF01217	0.436
TRG_ENDOCYTIC_2	367	370	PF00928	0.293
TRG_ENDOCYTIC_2	396	399	PF00928	0.413
TRG_ENDOCYTIC_2	757	760	PF00928	0.522
TRG_ENDOCYTIC_2	784	787	PF00928	0.459
TRG_ENDOCYTIC_2	828	831	PF00928	0.384
TRG_ER_diArg_1	361	363	PF00400	0.418
TRG_ER_diArg_1	391	393	PF00400	0.530
TRG_ER_diArg_1	413	416	PF00400	0.466
TRG_ER_diArg_1	45	47	PF00400	0.604
TRG_ER_diArg_1	597	599	PF00400	0.519
TRG_ER_diArg_1	718	720	PF00400	0.642
TRG_ER_diArg_1	807	809	PF00400	0.367
TRG_NES_CRM1_1	381	395	PF08389	0.369
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.428

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW42	Leptomonas seymouri	31%	97%
A0A0N1P9X3	Leptomonas seymouri	42%	100%
A0A3Q8IMZ0	Leishmania donovani	33%	92%
A4I9M1	Leishmania infantum	33%	92%
E9AC93	Leishmania major	88%	100%
E9AC97	Leishmania major	88%	100%
E9B4M0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
Q4Q3F6	Leishmania major	34%	100%