LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HRS0_LEIIN
TriTrypDb:
LINF_270033890 *
Length:
433

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0016020 membrane 2 3
GO:0110165 cellular anatomical entity 1 3

Expansion

Sequence features

A4HRS0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRS0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 384 388 PF00656 0.616
CLV_NRD_NRD_1 210 212 PF00675 0.458
CLV_NRD_NRD_1 244 246 PF00675 0.497
CLV_NRD_NRD_1 254 256 PF00675 0.491
CLV_NRD_NRD_1 273 275 PF00675 0.651
CLV_NRD_NRD_1 304 306 PF00675 0.526
CLV_NRD_NRD_1 320 322 PF00675 0.542
CLV_NRD_NRD_1 325 327 PF00675 0.522
CLV_NRD_NRD_1 335 337 PF00675 0.414
CLV_NRD_NRD_1 363 365 PF00675 0.457
CLV_NRD_NRD_1 379 381 PF00675 0.439
CLV_PCSK_FUR_1 302 306 PF00082 0.497
CLV_PCSK_FUR_1 318 322 PF00082 0.416
CLV_PCSK_FUR_1 332 336 PF00082 0.461
CLV_PCSK_KEX2_1 142 144 PF00082 0.504
CLV_PCSK_KEX2_1 210 212 PF00082 0.458
CLV_PCSK_KEX2_1 246 248 PF00082 0.534
CLV_PCSK_KEX2_1 256 258 PF00082 0.573
CLV_PCSK_KEX2_1 273 275 PF00082 0.634
CLV_PCSK_KEX2_1 304 306 PF00082 0.526
CLV_PCSK_KEX2_1 318 320 PF00082 0.532
CLV_PCSK_KEX2_1 325 327 PF00082 0.513
CLV_PCSK_KEX2_1 334 336 PF00082 0.435
CLV_PCSK_KEX2_1 363 365 PF00082 0.417
CLV_PCSK_KEX2_1 379 381 PF00082 0.439
CLV_PCSK_PC1ET2_1 142 144 PF00082 0.453
CLV_PCSK_PC1ET2_1 246 248 PF00082 0.517
CLV_PCSK_PC1ET2_1 256 258 PF00082 0.546
CLV_PCSK_PC1ET2_1 334 336 PF00082 0.480
CLV_PCSK_PC7_1 314 320 PF00082 0.424
CLV_PCSK_PC7_1 321 327 PF00082 0.448
CLV_PCSK_PC7_1 375 381 PF00082 0.427
CLV_PCSK_SKI1_1 150 154 PF00082 0.458
CLV_PCSK_SKI1_1 247 251 PF00082 0.500
CLV_PCSK_SKI1_1 273 277 PF00082 0.579
CLV_PCSK_SKI1_1 321 325 PF00082 0.452
CLV_PCSK_SKI1_1 367 371 PF00082 0.372
DEG_APCC_DBOX_1 320 328 PF00400 0.700
DEG_APCC_DBOX_1 45 53 PF00400 0.453
DEG_SPOP_SBC_1 418 422 PF00917 0.634
DOC_CKS1_1 225 230 PF01111 0.633
DOC_CYCLIN_yCln2_LP_2 175 181 PF00134 0.645
DOC_MAPK_gen_1 363 372 PF00069 0.622
DOC_MAPK_gen_1 39 47 PF00069 0.605
DOC_PP2B_LxvP_1 175 178 PF13499 0.643
DOC_USP7_MATH_1 107 111 PF00917 0.570
DOC_USP7_MATH_1 155 159 PF00917 0.678
DOC_USP7_MATH_1 249 253 PF00917 0.727
DOC_USP7_MATH_1 262 266 PF00917 0.699
DOC_USP7_MATH_1 344 348 PF00917 0.701
DOC_USP7_MATH_1 390 394 PF00917 0.704
DOC_USP7_MATH_1 8 12 PF00917 0.274
DOC_USP7_MATH_1 94 98 PF00917 0.543
DOC_USP7_MATH_2 228 234 PF00917 0.649
DOC_WW_Pin1_4 105 110 PF00397 0.665
DOC_WW_Pin1_4 182 187 PF00397 0.670
DOC_WW_Pin1_4 189 194 PF00397 0.695
DOC_WW_Pin1_4 195 200 PF00397 0.701
DOC_WW_Pin1_4 224 229 PF00397 0.631
LIG_14-3-3_CanoR_1 302 308 PF00244 0.606
LIG_14-3-3_CanoR_1 364 372 PF00244 0.641
LIG_14-3-3_CanoR_1 380 390 PF00244 0.678
LIG_14-3-3_CanoR_1 46 50 PF00244 0.274
LIG_14-3-3_CanoR_1 93 103 PF00244 0.563
LIG_Actin_WH2_2 26 44 PF00022 0.554
LIG_Actin_WH2_2 81 98 PF00022 0.377
LIG_BIR_III_2 234 238 PF00653 0.669
LIG_BIR_III_2 387 391 PF00653 0.668
LIG_EVH1_1 224 228 PF00568 0.629
LIG_FHA_1 109 115 PF00498 0.693
LIG_FHA_1 162 168 PF00498 0.721
LIG_FHA_1 172 178 PF00498 0.652
LIG_FHA_1 186 192 PF00498 0.617
LIG_FHA_1 196 202 PF00498 0.630
LIG_FHA_1 248 254 PF00498 0.666
LIG_FHA_1 418 424 PF00498 0.680
LIG_FHA_2 151 157 PF00498 0.728
LIG_FHA_2 198 204 PF00498 0.731
LIG_FHA_2 225 231 PF00498 0.671
LIG_LIR_Gen_1 134 140 PF02991 0.720
LIG_PTAP_UEV_1 339 344 PF05743 0.653
LIG_PTB_Apo_2 129 136 PF02174 0.662
LIG_PTB_Phospho_1 129 135 PF10480 0.664
LIG_SH2_CRK 67 71 PF00017 0.307
LIG_SH2_STAP1 67 71 PF00017 0.324
LIG_SH2_STAT5 67 70 PF00017 0.307
LIG_SH2_STAT5 85 88 PF00017 0.482
LIG_SH3_3 187 193 PF00018 0.657
LIG_SH3_3 222 228 PF00018 0.635
LIG_SH3_3 334 340 PF00018 0.670
LIG_SH3_3 406 412 PF00018 0.653
LIG_SH3_3 97 103 PF00018 0.628
LIG_Sin3_3 54 61 PF02671 0.274
LIG_SUMO_SIM_anti_2 11 16 PF11976 0.274
LIG_SUMO_SIM_par_1 168 174 PF11976 0.642
LIG_TYR_ITIM 65 70 PF00017 0.471
LIG_TYR_ITIM 83 88 PF00017 0.314
LIG_Vh1_VBS_1 3 21 PF01044 0.274
MOD_CDK_SPxxK_3 109 116 PF00069 0.514
MOD_CK1_1 108 114 PF00069 0.516
MOD_CK1_1 185 191 PF00069 0.531
MOD_CK1_1 263 269 PF00069 0.699
MOD_CK1_1 279 285 PF00069 0.695
MOD_CK1_1 330 336 PF00069 0.564
MOD_CK1_1 381 387 PF00069 0.571
MOD_CK1_1 393 399 PF00069 0.628
MOD_CK1_1 48 54 PF00069 0.274
MOD_CK2_1 116 122 PF00069 0.563
MOD_CK2_1 159 165 PF00069 0.562
MOD_CK2_1 197 203 PF00069 0.730
MOD_CK2_1 216 222 PF00069 0.525
MOD_CK2_1 224 230 PF00069 0.549
MOD_GlcNHglycan 124 127 PF01048 0.660
MOD_GlcNHglycan 153 156 PF01048 0.602
MOD_GlcNHglycan 218 221 PF01048 0.561
MOD_GlcNHglycan 277 281 PF01048 0.589
MOD_GlcNHglycan 293 296 PF01048 0.511
MOD_GlcNHglycan 313 317 PF01048 0.469
MOD_GlcNHglycan 340 343 PF01048 0.641
MOD_GlcNHglycan 367 370 PF01048 0.421
MOD_GlcNHglycan 383 386 PF01048 0.570
MOD_GSK3_1 105 112 PF00069 0.491
MOD_GSK3_1 134 141 PF00069 0.612
MOD_GSK3_1 146 153 PF00069 0.609
MOD_GSK3_1 155 162 PF00069 0.585
MOD_GSK3_1 185 192 PF00069 0.657
MOD_GSK3_1 226 233 PF00069 0.515
MOD_GSK3_1 326 333 PF00069 0.568
MOD_GSK3_1 390 397 PF00069 0.693
MOD_GSK3_1 413 420 PF00069 0.579
MOD_NEK2_1 3 8 PF00069 0.375
MOD_NEK2_1 45 50 PF00069 0.274
MOD_NEK2_1 65 70 PF00069 0.396
MOD_NEK2_1 84 89 PF00069 0.299
MOD_NEK2_1 95 100 PF00069 0.427
MOD_NEK2_2 249 254 PF00069 0.625
MOD_NEK2_2 31 36 PF00069 0.415
MOD_OFUCOSY 28 35 PF10250 0.415
MOD_PIKK_1 327 333 PF00454 0.542
MOD_PKA_1 210 216 PF00069 0.555
MOD_PKA_2 210 216 PF00069 0.555
MOD_PKA_2 303 309 PF00069 0.482
MOD_PKA_2 378 384 PF00069 0.564
MOD_PKA_2 45 51 PF00069 0.274
MOD_PKA_2 95 101 PF00069 0.527
MOD_PKB_1 245 253 PF00069 0.572
MOD_Plk_1 133 139 PF00069 0.560
MOD_Plk_1 263 269 PF00069 0.699
MOD_Plk_1 393 399 PF00069 0.546
MOD_Plk_4 263 269 PF00069 0.600
MOD_Plk_4 65 71 PF00069 0.375
MOD_Plk_4 8 14 PF00069 0.274
MOD_ProDKin_1 105 111 PF00069 0.572
MOD_ProDKin_1 182 188 PF00069 0.579
MOD_ProDKin_1 189 195 PF00069 0.615
MOD_ProDKin_1 224 230 PF00069 0.529
MOD_SUMO_for_1 126 129 PF00179 0.664
TRG_DiLeu_BaLyEn_6 110 115 PF01217 0.610
TRG_DiLeu_BaLyEn_6 282 287 PF01217 0.550
TRG_DiLeu_BaLyEn_6 372 377 PF01217 0.552
TRG_ENDOCYTIC_2 135 138 PF00928 0.657
TRG_ENDOCYTIC_2 67 70 PF00928 0.349
TRG_ENDOCYTIC_2 85 88 PF00928 0.315
TRG_ER_diArg_1 210 212 PF00400 0.561
TRG_ER_diArg_1 302 305 PF00400 0.673
TRG_ER_diArg_1 318 321 PF00400 0.549
TRG_ER_diArg_1 324 326 PF00400 0.555
TRG_ER_diArg_1 335 337 PF00400 0.496
TRG_ER_diArg_1 348 351 PF00400 0.500
TRG_ER_diArg_1 362 364 PF00400 0.379
TRG_ER_diArg_1 379 382 PF00400 0.533
TRG_NLS_Bipartite_1 318 338 PF00514 0.538
TRG_NLS_MonoExtN_4 332 338 PF00514 0.567

Homologs

Protein Taxonomy Sequence identity Coverage
E8NHE4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 50% 66%
E8NHE6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E8NHN4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 49% 100%
E9AH09 Leishmania infantum 99% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS