DNA-directed RNA polymerase III subunit RPC3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania infantum

UniProt:

A4HRR3_LEIIN

TriTrypDb:

LINF_020012100

Length:

192

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0000428	DNA-directed RNA polymerase complex	4	4
GO:0005666	RNA polymerase III complex	4	4
GO:0030880	RNA polymerase complex	3	4
GO:0032991	protein-containing complex	1	4
GO:0055029	nuclear DNA-directed RNA polymerase complex	3	4
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	4
GO:0140513	nuclear protein-containing complex	2	4
GO:0140535	intracellular protein-containing complex	2	4
GO:1902494	catalytic complex	2	4
GO:1990234	transferase complex	3	4

Expansion

Sequence features

A4HRR3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRR3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	4
GO:0003677	DNA binding	4	4
GO:0003697	single-stranded DNA binding	5	4
GO:0005488	binding	1	4
GO:0097159	organic cyclic compound binding	2	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	124	128	PF00082	0.474
CLV_PCSK_SKI1_1	150	154	PF00082	0.481
CLV_PCSK_SKI1_1	174	178	PF00082	0.427
CLV_PCSK_SKI1_1	53	57	PF00082	0.503
CLV_PCSK_SKI1_1	96	100	PF00082	0.514
CLV_Separin_Metazoa	140	144	PF03568	0.447
DEG_APCC_DBOX_1	123	131	PF00400	0.384
DEG_SPOP_SBC_1	6	10	PF00917	0.487
DOC_CYCLIN_yCln2_LP_2	21	27	PF00134	0.453
DOC_MAPK_gen_1	150	158	PF00069	0.422
DOC_MAPK_gen_1	172	181	PF00069	0.361
DOC_MAPK_MEF2A_6	89	97	PF00069	0.376
DOC_USP7_MATH_1	113	117	PF00917	0.372
DOC_USP7_MATH_1	142	146	PF00917	0.576
DOC_USP7_MATH_1	152	156	PF00917	0.515
DOC_USP7_MATH_1	35	39	PF00917	0.563
DOC_USP7_MATH_1	7	11	PF00917	0.441
DOC_WW_Pin1_4	40	45	PF00397	0.566
LIG_14-3-3_CanoR_1	174	180	PF00244	0.506
LIG_AP2alpha_1	131	135	PF02296	0.403
LIG_BRCT_BRCA1_1	42	46	PF00533	0.560
LIG_FHA_1	1	7	PF00498	0.556
LIG_FHA_1	142	148	PF00498	0.508
LIG_FHA_1	176	182	PF00498	0.369
LIG_FHA_1	50	56	PF00498	0.544
LIG_FHA_2	109	115	PF00498	0.398
LIG_LIR_Gen_1	119	127	PF02991	0.379
LIG_LIR_Gen_1	180	189	PF02991	0.375
LIG_LIR_Gen_1	43	54	PF02991	0.561
LIG_LIR_Nem_3	119	123	PF02991	0.393
LIG_LIR_Nem_3	180	186	PF02991	0.371
LIG_LIR_Nem_3	63	68	PF02991	0.599
LIG_LIR_Nem_3	88	93	PF02991	0.395
LIG_Pex14_2	131	135	PF04695	0.403
LIG_SH2_CRK	90	94	PF00017	0.374
LIG_SH2_PTP2	120	123	PF00017	0.387
LIG_SH2_STAP1	28	32	PF00017	0.513
LIG_SH2_STAT5	120	123	PF00017	0.405
LIG_SH2_STAT5	157	160	PF00017	0.368
LIG_SH3_4	58	65	PF00018	0.466
MOD_CK1_1	116	122	PF00069	0.494
MOD_CK1_1	45	51	PF00069	0.536
MOD_CK2_1	108	114	PF00069	0.396
MOD_CK2_1	6	12	PF00069	0.643
MOD_GlcNHglycan	144	147	PF01048	0.601
MOD_GlcNHglycan	149	153	PF01048	0.578
MOD_GlcNHglycan	163	166	PF01048	0.359
MOD_GlcNHglycan	37	40	PF01048	0.673
MOD_GSK3_1	148	155	PF00069	0.581
MOD_GSK3_1	159	166	PF00069	0.386
MOD_GSK3_1	40	47	PF00069	0.568
MOD_NEK2_1	161	166	PF00069	0.342
MOD_NEK2_1	175	180	PF00069	0.358
MOD_NEK2_2	152	157	PF00069	0.415
MOD_PIKK_1	58	64	PF00454	0.469
MOD_PKA_2	142	148	PF00069	0.494
MOD_Plk_1	108	114	PF00069	0.396
MOD_Plk_2-3	108	114	PF00069	0.396
MOD_Plk_4	116	122	PF00069	0.415
MOD_Plk_4	152	158	PF00069	0.410
MOD_Plk_4	163	169	PF00069	0.315
MOD_ProDKin_1	40	46	PF00069	0.564
TRG_ENDOCYTIC_2	120	123	PF00928	0.562
TRG_ENDOCYTIC_2	90	93	PF00928	0.381
TRG_NES_CRM1_1	125	140	PF08389	0.397
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.387

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H514	Leishmania donovani	99%	100%
E9AJN0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	99%