LeishMANIAdb
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WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
WD_REPEATS_REGION domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HRQ7_LEIIN
TriTrypDb:
LINF_020011500
Length:
567

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HRQ7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRQ7

Function

Biological processes
Term Name Level Count
GO:0006417 regulation of translation 6 1
GO:0006448 regulation of translational elongation 7 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009058 biosynthetic process 2 1
GO:0009889 regulation of biosynthetic process 4 1
GO:0009987 cellular process 1 1
GO:0010468 regulation of gene expression 5 1
GO:0010556 regulation of macromolecule biosynthetic process 5 1
GO:0010608 post-transcriptional regulation of gene expression 6 1
GO:0017182 peptidyl-diphthamide metabolic process 7 1
GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine 4 1
GO:0018193 peptidyl-amino acid modification 5 1
GO:0018202 peptidyl-histidine modification 6 1
GO:0019222 regulation of metabolic process 3 1
GO:0019538 protein metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031326 regulation of cellular biosynthetic process 5 1
GO:0034248 regulation of amide metabolic process 5 1
GO:0036211 protein modification process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044249 cellular biosynthetic process 3 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051246 regulation of protein metabolic process 5 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0071704 organic substance metabolic process 2 1
GO:0080090 regulation of primary metabolic process 4 1
GO:1900247 regulation of cytoplasmic translational elongation 8 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:2000112 obsolete regulation of cellular macromolecule biosynthetic process 6 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0016787 hydrolase activity 2 1
GO:0016788 hydrolase activity, acting on ester bonds 3 1
GO:0052689 carboxylic ester hydrolase activity 4 1
GO:0061685 diphthine methylesterase activity 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 106 110 PF00656 0.766
CLV_C14_Caspase3-7 171 175 PF00656 0.564
CLV_C14_Caspase3-7 282 286 PF00656 0.736
CLV_C14_Caspase3-7 342 346 PF00656 0.502
CLV_C14_Caspase3-7 510 514 PF00656 0.513
CLV_C14_Caspase3-7 527 531 PF00656 0.372
CLV_NRD_NRD_1 145 147 PF00675 0.553
CLV_NRD_NRD_1 37 39 PF00675 0.363
CLV_NRD_NRD_1 432 434 PF00675 0.565
CLV_NRD_NRD_1 553 555 PF00675 0.449
CLV_PCSK_KEX2_1 145 147 PF00082 0.553
CLV_PCSK_KEX2_1 37 39 PF00082 0.430
CLV_PCSK_KEX2_1 432 434 PF00082 0.652
CLV_PCSK_KEX2_1 437 439 PF00082 0.672
CLV_PCSK_KEX2_1 553 555 PF00082 0.425
CLV_PCSK_PC1ET2_1 437 439 PF00082 0.721
CLV_PCSK_PC7_1 428 434 PF00082 0.507
CLV_PCSK_SKI1_1 241 245 PF00082 0.484
CLV_PCSK_SKI1_1 392 396 PF00082 0.453
CLV_PCSK_SKI1_1 80 84 PF00082 0.545
DEG_APCC_DBOX_1 79 87 PF00400 0.603
DEG_SCF_TRCP1_1 399 405 PF00400 0.625
DEG_SPOP_SBC_1 94 98 PF00917 0.600
DOC_CKS1_1 219 224 PF01111 0.341
DOC_CKS1_1 42 47 PF01111 0.456
DOC_CYCLIN_RxL_1 389 399 PF00134 0.468
DOC_MAPK_gen_1 389 397 PF00069 0.508
DOC_MAPK_gen_1 77 85 PF00069 0.594
DOC_MAPK_MEF2A_6 27 36 PF00069 0.530
DOC_MAPK_MEF2A_6 77 85 PF00069 0.524
DOC_PP2B_LxvP_1 456 459 PF13499 0.358
DOC_PP2B_LxvP_1 52 55 PF13499 0.551
DOC_USP7_MATH_1 295 299 PF00917 0.698
DOC_USP7_MATH_1 402 406 PF00917 0.651
DOC_USP7_MATH_1 410 414 PF00917 0.663
DOC_USP7_MATH_1 450 454 PF00917 0.523
DOC_USP7_MATH_1 494 498 PF00917 0.632
DOC_USP7_MATH_1 546 550 PF00917 0.460
DOC_USP7_MATH_1 67 71 PF00917 0.750
DOC_USP7_MATH_1 95 99 PF00917 0.670
DOC_WW_Pin1_4 194 199 PF00397 0.581
DOC_WW_Pin1_4 218 223 PF00397 0.462
DOC_WW_Pin1_4 269 274 PF00397 0.649
DOC_WW_Pin1_4 335 340 PF00397 0.435
DOC_WW_Pin1_4 350 355 PF00397 0.469
DOC_WW_Pin1_4 372 377 PF00397 0.339
DOC_WW_Pin1_4 41 46 PF00397 0.499
DOC_WW_Pin1_4 54 59 PF00397 0.469
LIG_14-3-3_CanoR_1 145 153 PF00244 0.592
LIG_14-3-3_CanoR_1 27 36 PF00244 0.569
LIG_14-3-3_CanoR_1 296 303 PF00244 0.585
LIG_14-3-3_CanoR_1 37 43 PF00244 0.511
LIG_14-3-3_CanoR_1 432 439 PF00244 0.665
LIG_14-3-3_CanoR_1 473 480 PF00244 0.566
LIG_14-3-3_CanoR_1 93 102 PF00244 0.522
LIG_Actin_WH2_2 79 95 PF00022 0.514
LIG_AP2alpha_2 192 194 PF02296 0.438
LIG_BIR_III_2 174 178 PF00653 0.364
LIG_BRCT_BRCA1_1 160 164 PF00533 0.506
LIG_eIF4E_1 219 225 PF01652 0.333
LIG_FHA_1 145 151 PF00498 0.589
LIG_FHA_1 164 170 PF00498 0.583
LIG_FHA_1 219 225 PF00498 0.523
LIG_FHA_1 228 234 PF00498 0.314
LIG_FHA_1 242 248 PF00498 0.343
LIG_FHA_1 255 261 PF00498 0.428
LIG_FHA_1 297 303 PF00498 0.569
LIG_FHA_1 336 342 PF00498 0.458
LIG_FHA_1 351 357 PF00498 0.353
LIG_FHA_1 450 456 PF00498 0.458
LIG_FHA_1 8 14 PF00498 0.525
LIG_FHA_2 4 10 PF00498 0.620
LIG_FHA_2 508 514 PF00498 0.592
LIG_FHA_2 534 540 PF00498 0.670
LIG_LIR_Gen_1 308 317 PF02991 0.533
LIG_LIR_Gen_1 353 361 PF02991 0.390
LIG_LIR_Nem_3 308 314 PF02991 0.531
LIG_LIR_Nem_3 353 358 PF02991 0.389
LIG_MLH1_MIPbox_1 160 164 PF16413 0.506
LIG_NRBOX 343 349 PF00104 0.372
LIG_NRBOX 419 425 PF00104 0.548
LIG_SH2_CRK 311 315 PF00017 0.532
LIG_SH2_NCK_1 125 129 PF00017 0.472
LIG_SH2_NCK_1 236 240 PF00017 0.477
LIG_SH2_SRC 234 237 PF00017 0.474
LIG_SH2_SRC 361 364 PF00017 0.418
LIG_SH2_STAP1 125 129 PF00017 0.472
LIG_SH2_STAP1 361 365 PF00017 0.367
LIG_SH2_STAP1 470 474 PF00017 0.508
LIG_SH2_STAP1 518 522 PF00017 0.376
LIG_SH2_STAP1 551 555 PF00017 0.504
LIG_SH2_STAP1 90 94 PF00017 0.497
LIG_SH2_STAT5 234 237 PF00017 0.426
LIG_SH2_STAT5 311 314 PF00017 0.532
LIG_SH2_STAT5 355 358 PF00017 0.411
LIG_SH2_STAT5 489 492 PF00017 0.463
LIG_SH3_3 154 160 PF00018 0.466
LIG_SH3_3 17 23 PF00018 0.528
LIG_SH3_3 187 193 PF00018 0.517
LIG_SH3_3 196 202 PF00018 0.529
LIG_SH3_3 264 270 PF00018 0.598
LIG_SH3_3 39 45 PF00018 0.519
LIG_SH3_3 519 525 PF00018 0.474
LIG_SH3_3 52 58 PF00018 0.524
LIG_SH3_3 75 81 PF00018 0.712
LIG_SUMO_SIM_anti_2 362 369 PF11976 0.468
LIG_SUMO_SIM_anti_2 452 459 PF11976 0.470
LIG_SUMO_SIM_par_1 333 338 PF11976 0.442
LIG_SUMO_SIM_par_1 366 372 PF11976 0.518
LIG_TRAF2_1 475 478 PF00917 0.519
LIG_TRFH_1 194 198 PF08558 0.505
LIG_TYR_ITSM 351 358 PF00017 0.454
MOD_CDK_SPK_2 41 46 PF00069 0.387
MOD_CK1_1 11 17 PF00069 0.673
MOD_CK1_1 158 164 PF00069 0.457
MOD_CK1_1 165 171 PF00069 0.574
MOD_CK1_1 227 233 PF00069 0.479
MOD_CK1_1 372 378 PF00069 0.591
MOD_CK1_1 41 47 PF00069 0.414
MOD_CK1_1 444 450 PF00069 0.504
MOD_CK1_1 57 63 PF00069 0.547
MOD_CK1_1 66 72 PF00069 0.737
MOD_CK1_1 97 103 PF00069 0.589
MOD_CK2_1 234 240 PF00069 0.512
MOD_CK2_1 3 9 PF00069 0.618
MOD_CK2_1 357 363 PF00069 0.378
MOD_CK2_1 472 478 PF00069 0.506
MOD_CK2_1 494 500 PF00069 0.601
MOD_CK2_1 546 552 PF00069 0.482
MOD_GlcNHglycan 129 132 PF01048 0.578
MOD_GlcNHglycan 170 173 PF01048 0.623
MOD_GlcNHglycan 226 229 PF01048 0.447
MOD_GlcNHglycan 29 32 PF01048 0.645
MOD_GlcNHglycan 299 302 PF01048 0.450
MOD_GlcNHglycan 304 307 PF01048 0.330
MOD_GlcNHglycan 399 402 PF01048 0.619
MOD_GlcNHglycan 425 428 PF01048 0.528
MOD_GlcNHglycan 446 449 PF01048 0.428
MOD_GlcNHglycan 474 477 PF01048 0.580
MOD_GlcNHglycan 539 543 PF01048 0.586
MOD_GlcNHglycan 65 68 PF01048 0.748
MOD_GlcNHglycan 69 72 PF01048 0.750
MOD_GlcNHglycan 97 100 PF01048 0.735
MOD_GSK3_1 101 108 PF00069 0.672
MOD_GSK3_1 155 162 PF00069 0.531
MOD_GSK3_1 3 10 PF00069 0.619
MOD_GSK3_1 319 326 PF00069 0.592
MOD_GSK3_1 357 364 PF00069 0.391
MOD_GSK3_1 63 70 PF00069 0.715
MOD_GSK3_1 93 100 PF00069 0.587
MOD_N-GLC_1 418 423 PF02516 0.547
MOD_N-GLC_1 450 455 PF02516 0.485
MOD_NEK2_1 163 168 PF00069 0.596
MOD_NEK2_1 210 215 PF00069 0.410
MOD_NEK2_1 224 229 PF00069 0.174
MOD_NEK2_1 302 307 PF00069 0.485
MOD_NEK2_1 397 402 PF00069 0.577
MOD_NEK2_1 423 428 PF00069 0.533
MOD_NEK2_2 546 551 PF00069 0.480
MOD_OFUCOSY 12 18 PF10250 0.528
MOD_PIKK_1 241 247 PF00454 0.515
MOD_PK_1 38 44 PF00069 0.562
MOD_PKA_2 144 150 PF00069 0.596
MOD_PKA_2 295 301 PF00069 0.644
MOD_PKA_2 388 394 PF00069 0.364
MOD_PKA_2 431 437 PF00069 0.558
MOD_PKA_2 472 478 PF00069 0.573
MOD_Plk_1 137 143 PF00069 0.600
MOD_Plk_1 361 367 PF00069 0.482
MOD_Plk_1 418 424 PF00069 0.546
MOD_Plk_1 512 518 PF00069 0.476
MOD_Plk_1 8 14 PF00069 0.622
MOD_Plk_2-3 363 369 PF00069 0.522
MOD_Plk_4 159 165 PF00069 0.546
MOD_Plk_4 229 235 PF00069 0.494
MOD_Plk_4 418 424 PF00069 0.546
MOD_Plk_4 485 491 PF00069 0.528
MOD_Plk_4 512 518 PF00069 0.476
MOD_Plk_4 546 552 PF00069 0.392
MOD_ProDKin_1 194 200 PF00069 0.579
MOD_ProDKin_1 218 224 PF00069 0.454
MOD_ProDKin_1 269 275 PF00069 0.650
MOD_ProDKin_1 335 341 PF00069 0.435
MOD_ProDKin_1 350 356 PF00069 0.464
MOD_ProDKin_1 372 378 PF00069 0.331
MOD_ProDKin_1 41 47 PF00069 0.494
MOD_ProDKin_1 54 60 PF00069 0.481
MOD_SUMO_rev_2 434 439 PF00179 0.609
TRG_DiLeu_BaEn_1 363 368 PF01217 0.393
TRG_DiLeu_BaLyEn_6 81 86 PF01217 0.327
TRG_ENDOCYTIC_2 125 128 PF00928 0.496
TRG_ENDOCYTIC_2 311 314 PF00928 0.532
TRG_ENDOCYTIC_2 355 358 PF00928 0.385
TRG_ER_diArg_1 327 330 PF00400 0.531
TRG_ER_diArg_1 36 38 PF00400 0.385
TRG_ER_diArg_1 553 555 PF00400 0.449
TRG_Pf-PMV_PEXEL_1 204 209 PF00026 0.572
TRG_PTS1 564 567 PF00515 0.486

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IHU3 Leptomonas seymouri 49% 100%
A0A1X0NJL9 Trypanosomatidae 29% 100%
A0A3R7NH89 Trypanosoma rangeli 30% 100%
A0A3S7WNM2 Leishmania donovani 99% 100%
A4H3F3 Leishmania braziliensis 75% 100%
C9ZJ47 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
E9ACD6 Leishmania major 90% 100%
E9AJM4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
V5BER3 Trypanosoma cruzi 29% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS