TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat/Tetratricopeptide repeat - putative

Species:

Leishmania infantum

UniProt:

A4HRQ4_LEIIN

TriTrypDb:

LINF_020011200

Length:

524

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HRQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRQ4

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	10
GO:0009987	cellular process	1	10

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0030544	Hsp70 protein binding	4	10
GO:0031072	heat shock protein binding	3	10
GO:0051879	Hsp90 protein binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	276	278	PF00675	0.550
CLV_NRD_NRD_1	286	288	PF00675	0.620
CLV_NRD_NRD_1	392	394	PF00675	0.751
CLV_NRD_NRD_1	444	446	PF00675	0.646
CLV_NRD_NRD_1	468	470	PF00675	0.688
CLV_NRD_NRD_1	516	518	PF00675	0.502
CLV_PCSK_FUR_1	274	278	PF00082	0.380
CLV_PCSK_KEX2_1	242	244	PF00082	0.372
CLV_PCSK_KEX2_1	276	278	PF00082	0.554
CLV_PCSK_KEX2_1	286	288	PF00082	0.625
CLV_PCSK_KEX2_1	444	446	PF00082	0.646
CLV_PCSK_KEX2_1	467	469	PF00082	0.707
CLV_PCSK_KEX2_1	518	520	PF00082	0.504
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.372
CLV_PCSK_PC1ET2_1	518	520	PF00082	0.643
CLV_PCSK_PC7_1	272	278	PF00082	0.385
CLV_PCSK_SKI1_1	101	105	PF00082	0.718
CLV_PCSK_SKI1_1	381	385	PF00082	0.713
CLV_PCSK_SKI1_1	398	402	PF00082	0.672
CLV_PCSK_SKI1_1	48	52	PF00082	0.736
CLV_PCSK_SKI1_1	519	523	PF00082	0.548
CLV_PCSK_SKI1_1	7	11	PF00082	0.516
DEG_SPOP_SBC_1	172	176	PF00917	0.521
DEG_SPOP_SBC_1	307	311	PF00917	0.770
DEG_SPOP_SBC_1	96	100	PF00917	0.688
DOC_CKS1_1	104	109	PF01111	0.619
DOC_MAPK_gen_1	276	285	PF00069	0.622
DOC_PP1_RVXF_1	106	113	PF00149	0.713
DOC_PP4_FxxP_1	104	107	PF00568	0.746
DOC_PP4_FxxP_1	486	489	PF00568	0.679
DOC_USP7_MATH_1	130	134	PF00917	0.630
DOC_USP7_MATH_1	187	191	PF00917	0.284
DOC_USP7_MATH_1	19	23	PF00917	0.678
DOC_USP7_MATH_1	307	311	PF00917	0.774
DOC_USP7_MATH_1	321	325	PF00917	0.661
DOC_USP7_MATH_1	377	381	PF00917	0.609
DOC_USP7_MATH_1	402	406	PF00917	0.697
DOC_USP7_MATH_1	409	413	PF00917	0.527
DOC_USP7_MATH_1	416	420	PF00917	0.672
DOC_USP7_MATH_1	457	461	PF00917	0.715
DOC_USP7_MATH_1	503	507	PF00917	0.664
DOC_USP7_MATH_1	55	59	PF00917	0.751
DOC_USP7_MATH_1	97	101	PF00917	0.702
DOC_USP7_MATH_2	497	503	PF00917	0.536
DOC_USP7_UBL2_3	394	398	PF12436	0.627
DOC_WW_Pin1_4	103	108	PF00397	0.620
DOC_WW_Pin1_4	381	386	PF00397	0.745
DOC_WW_Pin1_4	448	453	PF00397	0.755
DOC_WW_Pin1_4	470	475	PF00397	0.667
DOC_WW_Pin1_4	51	56	PF00397	0.711
DOC_WW_Pin1_4	86	91	PF00397	0.673
LIG_14-3-3_CanoR_1	101	107	PF00244	0.744
LIG_14-3-3_CanoR_1	219	224	PF00244	0.439
LIG_14-3-3_CanoR_1	260	265	PF00244	0.520
LIG_14-3-3_CanoR_1	290	299	PF00244	0.574
LIG_14-3-3_CanoR_1	422	431	PF00244	0.647
LIG_14-3-3_CanoR_1	467	474	PF00244	0.749
LIG_Actin_WH2_2	71	88	PF00022	0.637
LIG_BIR_II_1	1	5	PF00653	0.602
LIG_FHA_1	163	169	PF00498	0.403
LIG_FHA_1	218	224	PF00498	0.511
LIG_FHA_1	294	300	PF00498	0.650
LIG_FHA_1	41	47	PF00498	0.674
LIG_FHA_1	80	86	PF00498	0.705
LIG_FHA_2	1	7	PF00498	0.543
LIG_FHA_2	15	21	PF00498	0.481
LIG_FHA_2	309	315	PF00498	0.765
LIG_FHA_2	327	333	PF00498	0.732
LIG_FHA_2	356	362	PF00498	0.653
LIG_FHA_2	425	431	PF00498	0.645
LIG_FHA_2	483	489	PF00498	0.485
LIG_FHA_2	82	88	PF00498	0.786
LIG_LIR_Apic_2	485	489	PF02991	0.578
LIG_LIR_Nem_3	225	231	PF02991	0.415
LIG_LIR_Nem_3	236	241	PF02991	0.330
LIG_MYND_1	462	466	PF01753	0.744
LIG_Pex14_1	227	231	PF04695	0.312
LIG_PTB_Apo_2	146	153	PF02174	0.454
LIG_RPA_C_Fungi	267	279	PF08784	0.513
LIG_SH2_CRK	52	56	PF00017	0.725
LIG_SH2_NCK_1	52	56	PF00017	0.725
LIG_SH2_STAP1	164	168	PF00017	0.369
LIG_SH2_STAP1	210	214	PF00017	0.518
LIG_SH2_STAP1	251	255	PF00017	0.328
LIG_SH2_STAT3	231	234	PF00017	0.312
LIG_SH2_STAT3	367	370	PF00017	0.606
LIG_SH2_STAT5	164	167	PF00017	0.401
LIG_SH2_STAT5	196	199	PF00017	0.385
LIG_SH2_STAT5	238	241	PF00017	0.454
LIG_SH3_2	462	467	PF14604	0.748
LIG_SH3_3	18	24	PF00018	0.519
LIG_SH3_3	459	465	PF00018	0.730
LIG_SUMO_SIM_anti_2	181	186	PF11976	0.419
LIG_SUMO_SIM_par_1	181	186	PF11976	0.447
LIG_SUMO_SIM_par_1	218	226	PF11976	0.473
LIG_TRAF2_1	279	282	PF00917	0.542
LIG_WRC_WIRS_1	483	488	PF05994	0.589
LIG_WW_3	464	468	PF00397	0.759
MOD_CDK_SPK_2	103	108	PF00069	0.620
MOD_CK1_1	116	122	PF00069	0.664
MOD_CK1_1	133	139	PF00069	0.445
MOD_CK1_1	190	196	PF00069	0.356
MOD_CK1_1	222	228	PF00069	0.462
MOD_CK1_1	291	297	PF00069	0.623
MOD_CK1_1	298	304	PF00069	0.636
MOD_CK1_1	310	316	PF00069	0.642
MOD_CK1_1	34	40	PF00069	0.706
MOD_CK1_1	421	427	PF00069	0.736
MOD_CK1_1	470	476	PF00069	0.665
MOD_CK2_1	175	181	PF00069	0.564
MOD_CK2_1	308	314	PF00069	0.793
MOD_CK2_1	355	361	PF00069	0.687
MOD_CK2_1	409	415	PF00069	0.562
MOD_CK2_1	482	488	PF00069	0.496
MOD_GlcNHglycan	132	135	PF01048	0.665
MOD_GlcNHglycan	178	181	PF01048	0.532
MOD_GlcNHglycan	185	188	PF01048	0.403
MOD_GlcNHglycan	192	195	PF01048	0.270
MOD_GlcNHglycan	340	343	PF01048	0.642
MOD_GlcNHglycan	404	407	PF01048	0.695
MOD_GlcNHglycan	418	421	PF01048	0.623
MOD_GlcNHglycan	470	473	PF01048	0.800
MOD_GlcNHglycan	501	504	PF01048	0.684
MOD_GlcNHglycan	505	508	PF01048	0.615
MOD_GlcNHglycan	65	68	PF01048	0.722
MOD_GlcNHglycan	93	96	PF01048	0.734
MOD_GSK3_1	102	109	PF00069	0.643
MOD_GSK3_1	113	120	PF00069	0.697
MOD_GSK3_1	171	178	PF00069	0.566
MOD_GSK3_1	183	190	PF00069	0.507
MOD_GSK3_1	219	226	PF00069	0.472
MOD_GSK3_1	285	292	PF00069	0.527
MOD_GSK3_1	294	301	PF00069	0.615
MOD_GSK3_1	306	313	PF00069	0.691
MOD_GSK3_1	31	38	PF00069	0.751
MOD_GSK3_1	377	384	PF00069	0.691
MOD_GSK3_1	398	405	PF00069	0.616
MOD_GSK3_1	414	421	PF00069	0.777
MOD_GSK3_1	453	460	PF00069	0.792
MOD_GSK3_1	499	506	PF00069	0.632
MOD_GSK3_1	51	58	PF00069	0.712
MOD_GSK3_1	61	68	PF00069	0.711
MOD_GSK3_1	74	81	PF00069	0.701
MOD_GSK3_1	91	98	PF00069	0.716
MOD_N-GLC_1	148	153	PF02516	0.464
MOD_N-GLC_1	190	195	PF02516	0.354
MOD_N-GLC_1	260	265	PF02516	0.516
MOD_N-GLC_1	398	403	PF02516	0.612
MOD_N-GLC_1	40	45	PF02516	0.737
MOD_N-GLC_1	79	84	PF02516	0.729
MOD_NEK2_1	171	176	PF00069	0.538
MOD_NEK2_1	183	188	PF00069	0.453
MOD_NEK2_1	223	228	PF00069	0.526
MOD_NEK2_1	268	273	PF00069	0.471
MOD_NEK2_1	285	290	PF00069	0.583
MOD_NEK2_1	299	304	PF00069	0.665
MOD_NEK2_1	453	458	PF00069	0.684
MOD_NEK2_1	63	68	PF00069	0.680
MOD_NEK2_1	78	83	PF00069	0.569
MOD_NEK2_1	85	90	PF00069	0.710
MOD_NEK2_2	409	414	PF00069	0.558
MOD_PIKK_1	121	127	PF00454	0.727
MOD_PIKK_1	31	37	PF00454	0.743
MOD_PIKK_1	321	327	PF00454	0.734
MOD_PK_1	414	420	PF00069	0.675
MOD_PKA_1	467	473	PF00069	0.813
MOD_PKA_2	223	229	PF00069	0.423
MOD_PKA_2	285	291	PF00069	0.485
MOD_PKA_2	338	344	PF00069	0.628
MOD_PKA_2	377	383	PF00069	0.670
MOD_PKA_2	392	398	PF00069	0.749
MOD_PKA_2	421	427	PF00069	0.656
MOD_PKA_2	467	473	PF00069	0.751
MOD_PKA_2	85	91	PF00069	0.797
MOD_Plk_1	113	119	PF00069	0.672
MOD_Plk_1	148	154	PF00069	0.459
MOD_Plk_1	217	223	PF00069	0.498
MOD_Plk_1	260	266	PF00069	0.520
MOD_Plk_1	355	361	PF00069	0.549
MOD_Plk_1	398	404	PF00069	0.706
MOD_Plk_1	414	420	PF00069	0.755
MOD_Plk_4	223	229	PF00069	0.423
MOD_Plk_4	260	266	PF00069	0.467
MOD_ProDKin_1	103	109	PF00069	0.620
MOD_ProDKin_1	381	387	PF00069	0.744
MOD_ProDKin_1	448	454	PF00069	0.758
MOD_ProDKin_1	470	476	PF00069	0.666
MOD_ProDKin_1	51	57	PF00069	0.708
MOD_ProDKin_1	86	92	PF00069	0.673
MOD_SUMO_for_1	351	354	PF00179	0.527
MOD_SUMO_rev_2	141	147	PF00179	0.464
TRG_DiLeu_BaLyEn_6	508	513	PF01217	0.520
TRG_ENDOCYTIC_2	238	241	PF00928	0.438
TRG_ER_diArg_1	274	277	PF00400	0.522
TRG_ER_diArg_1	285	287	PF00400	0.621
TRG_ER_diArg_1	375	378	PF00400	0.575
TRG_ER_diArg_1	466	469	PF00400	0.704
TRG_ER_diArg_1	516	519	PF00400	0.499
TRG_NLS_MonoCore_2	516	521	PF00514	0.556
TRG_NLS_MonoExtN_4	517	522	PF00514	0.500
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0B2	Leptomonas seymouri	49%	93%
A0A1X0NJW2	Trypanosomatidae	34%	100%
A0A3S5H509	Leishmania donovani	100%	100%
A0A422NAY7	Trypanosoma rangeli	30%	100%
A4H3F0	Leishmania braziliensis	73%	100%
E9ACD3	Leishmania major	93%	98%
E9AJM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5B5N7	Trypanosoma cruzi	33%	100%