LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
protein kinase - putative
Species:
Leishmania infantum
UniProt:
A4HRQ2_LEIIN
TriTrypDb:
LINF_020011000 *
Length:
981

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Annotations by Jardim et al.

Protein kinase, kinase Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7
GO:0005737 cytoplasm 2 1
GO:0005929 cilium 4 1
GO:0042995 cell projection 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0120025 plasma membrane bounded cell projection 3 1

Expansion

Sequence features

A4HRQ2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRQ2

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 7
GO:0006793 phosphorus metabolic process 3 7
GO:0006796 phosphate-containing compound metabolic process 4 7
GO:0006807 nitrogen compound metabolic process 2 7
GO:0008152 metabolic process 1 7
GO:0009987 cellular process 1 7
GO:0016310 phosphorylation 5 7
GO:0019538 protein metabolic process 3 7
GO:0036211 protein modification process 4 7
GO:0043170 macromolecule metabolic process 3 7
GO:0043412 macromolecule modification 4 7
GO:0044237 cellular metabolic process 2 7
GO:0044238 primary metabolic process 2 7
GO:0071704 organic substance metabolic process 2 7
GO:1901564 organonitrogen compound metabolic process 3 7
GO:0007165 signal transduction 2 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 7
GO:0003824 catalytic activity 1 7
GO:0004672 protein kinase activity 3 7
GO:0005488 binding 1 7
GO:0005524 ATP binding 5 7
GO:0016301 kinase activity 4 7
GO:0016740 transferase activity 2 7
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 7
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 7
GO:0017076 purine nucleotide binding 4 7
GO:0030554 adenyl nucleotide binding 5 7
GO:0032553 ribonucleotide binding 3 7
GO:0032555 purine ribonucleotide binding 4 7
GO:0032559 adenyl ribonucleotide binding 5 7
GO:0035639 purine ribonucleoside triphosphate binding 4 7
GO:0036094 small molecule binding 2 7
GO:0043167 ion binding 2 7
GO:0043168 anion binding 3 7
GO:0097159 organic cyclic compound binding 2 7
GO:0097367 carbohydrate derivative binding 2 7
GO:0140096 catalytic activity, acting on a protein 2 7
GO:1901265 nucleoside phosphate binding 3 7
GO:1901363 heterocyclic compound binding 2 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 190 194 PF00656 0.682
CLV_C14_Caspase3-7 236 240 PF00656 0.657
CLV_C14_Caspase3-7 316 320 PF00656 0.771
CLV_C14_Caspase3-7 402 406 PF00656 0.776
CLV_NRD_NRD_1 11 13 PF00675 0.400
CLV_NRD_NRD_1 518 520 PF00675 0.363
CLV_NRD_NRD_1 598 600 PF00675 0.387
CLV_NRD_NRD_1 913 915 PF00675 0.427
CLV_PCSK_FUR_1 911 915 PF00082 0.446
CLV_PCSK_KEX2_1 11 13 PF00082 0.400
CLV_PCSK_KEX2_1 219 221 PF00082 0.506
CLV_PCSK_KEX2_1 518 520 PF00082 0.375
CLV_PCSK_KEX2_1 598 600 PF00082 0.387
CLV_PCSK_KEX2_1 623 625 PF00082 0.360
CLV_PCSK_KEX2_1 911 913 PF00082 0.423
CLV_PCSK_PC1ET2_1 219 221 PF00082 0.506
CLV_PCSK_PC1ET2_1 623 625 PF00082 0.360
CLV_PCSK_PC7_1 619 625 PF00082 0.317
CLV_PCSK_SKI1_1 274 278 PF00082 0.464
CLV_PCSK_SKI1_1 347 351 PF00082 0.565
CLV_PCSK_SKI1_1 384 388 PF00082 0.555
CLV_PCSK_SKI1_1 519 523 PF00082 0.335
CLV_PCSK_SKI1_1 743 747 PF00082 0.299
CLV_PCSK_SKI1_1 764 768 PF00082 0.299
CLV_PCSK_SKI1_1 868 872 PF00082 0.299
CLV_Separin_Metazoa 202 206 PF03568 0.665
DEG_APCC_DBOX_1 962 970 PF00400 0.727
DEG_Nend_Nbox_1 1 3 PF02207 0.567
DEG_SCF_FBW7_2 35 41 PF00400 0.614
DEG_SPOP_SBC_1 388 392 PF00917 0.780
DEG_SPOP_SBC_1 544 548 PF00917 0.628
DOC_CKS1_1 35 40 PF01111 0.621
DOC_CKS1_1 385 390 PF01111 0.754
DOC_MAPK_gen_1 764 773 PF00069 0.499
DOC_MAPK_MEF2A_6 159 167 PF00069 0.299
DOC_MAPK_MEF2A_6 467 474 PF00069 0.578
DOC_MAPK_MEF2A_6 710 719 PF00069 0.499
DOC_MAPK_NFAT4_5 467 475 PF00069 0.581
DOC_PP1_RVXF_1 48 54 PF00149 0.674
DOC_PP1_RVXF_1 517 524 PF00149 0.550
DOC_PP2B_LxvP_1 541 544 PF13499 0.554
DOC_PP2B_LxvP_1 840 843 PF13499 0.499
DOC_PP2B_PxIxI_1 805 811 PF00149 0.551
DOC_PP4_FxxP_1 589 592 PF00568 0.631
DOC_PP4_FxxP_1 889 892 PF00568 0.499
DOC_SPAK_OSR1_1 489 493 PF12202 0.546
DOC_USP7_MATH_1 386 390 PF00917 0.813
DOC_USP7_MATH_1 501 505 PF00917 0.582
DOC_USP7_MATH_1 544 548 PF00917 0.572
DOC_USP7_MATH_1 648 652 PF00917 0.709
DOC_USP7_MATH_1 679 683 PF00917 0.662
DOC_WW_Pin1_4 13 18 PF00397 0.664
DOC_WW_Pin1_4 34 39 PF00397 0.658
DOC_WW_Pin1_4 384 389 PF00397 0.807
DOC_WW_Pin1_4 566 571 PF00397 0.734
DOC_WW_Pin1_4 660 665 PF00397 0.759
LIG_14-3-3_CanoR_1 11 18 PF00244 0.691
LIG_14-3-3_CanoR_1 116 123 PF00244 0.627
LIG_14-3-3_CanoR_1 22 32 PF00244 0.659
LIG_14-3-3_CanoR_1 274 283 PF00244 0.691
LIG_14-3-3_CanoR_1 50 56 PF00244 0.681
LIG_14-3-3_CanoR_1 74 79 PF00244 0.590
LIG_14-3-3_CanoR_1 882 890 PF00244 0.502
LIG_Actin_WH2_2 100 118 PF00022 0.620
LIG_Actin_WH2_2 367 383 PF00022 0.723
LIG_Actin_WH2_2 457 475 PF00022 0.566
LIG_Actin_WH2_2 780 797 PF00022 0.499
LIG_APCC_ABBA_1 715 720 PF00400 0.499
LIG_BRCT_BRCA1_1 100 104 PF00533 0.607
LIG_BRCT_BRCA1_1 195 199 PF00533 0.761
LIG_BRCT_BRCA1_1 486 490 PF00533 0.594
LIG_BRCT_BRCA1_1 533 537 PF00533 0.616
LIG_BRCT_BRCA1_1 585 589 PF00533 0.727
LIG_BRCT_BRCA1_1 92 96 PF00533 0.604
LIG_CSL_BTD_1 35 38 PF09270 0.626
LIG_eIF4E_1 62 68 PF01652 0.621
LIG_FHA_1 110 116 PF00498 0.670
LIG_FHA_1 135 141 PF00498 0.501
LIG_FHA_1 143 149 PF00498 0.434
LIG_FHA_1 158 164 PF00498 0.338
LIG_FHA_1 279 285 PF00498 0.695
LIG_FHA_1 444 450 PF00498 0.550
LIG_FHA_1 675 681 PF00498 0.680
LIG_FHA_2 14 20 PF00498 0.698
LIG_FHA_2 188 194 PF00498 0.675
LIG_FHA_2 234 240 PF00498 0.703
LIG_FHA_2 247 253 PF00498 0.714
LIG_FHA_2 314 320 PF00498 0.722
LIG_FHA_2 882 888 PF00498 0.487
LIG_LIR_Apic_2 586 592 PF02991 0.658
LIG_LIR_Apic_2 59 65 PF02991 0.663
LIG_LIR_Apic_2 69 73 PF02991 0.567
LIG_LIR_Apic_2 800 806 PF02991 0.499
LIG_LIR_Apic_2 887 892 PF02991 0.490
LIG_LIR_Gen_1 319 330 PF02991 0.768
LIG_LIR_Gen_1 466 477 PF02991 0.576
LIG_LIR_Gen_1 512 521 PF02991 0.569
LIG_LIR_Gen_1 52 61 PF02991 0.645
LIG_LIR_Gen_1 800 809 PF02991 0.499
LIG_LIR_Gen_1 93 104 PF02991 0.583
LIG_LIR_Nem_3 101 107 PF02991 0.594
LIG_LIR_Nem_3 319 325 PF02991 0.765
LIG_LIR_Nem_3 466 472 PF02991 0.571
LIG_LIR_Nem_3 487 493 PF02991 0.575
LIG_LIR_Nem_3 512 516 PF02991 0.564
LIG_LIR_Nem_3 52 56 PF02991 0.642
LIG_LIR_Nem_3 716 721 PF02991 0.499
LIG_LIR_Nem_3 887 893 PF02991 0.487
LIG_LIR_Nem_3 93 99 PF02991 0.577
LIG_MAD2 424 432 PF02301 0.746
LIG_MAD2 760 768 PF02301 0.491
LIG_MLH1_MIPbox_1 195 199 PF16413 0.748
LIG_NRBOX 139 145 PF00104 0.383
LIG_NRBOX 549 555 PF00104 0.582
LIG_PCNA_yPIPBox_3 442 452 PF02747 0.622
LIG_Pex14_1 465 469 PF04695 0.589
LIG_Pex14_2 153 157 PF04695 0.425
LIG_Pex14_2 605 609 PF04695 0.582
LIG_REV1ctd_RIR_1 520 530 PF16727 0.513
LIG_SH2_CRK 322 326 PF00017 0.748
LIG_SH2_CRK 890 894 PF00017 0.499
LIG_SH2_GRB2like 62 65 PF00017 0.627
LIG_SH2_NCK_1 191 195 PF00017 0.627
LIG_SH2_SRC 191 194 PF00017 0.683
LIG_SH2_SRC 62 65 PF00017 0.679
LIG_SH2_STAP1 191 195 PF00017 0.620
LIG_SH2_STAP1 92 96 PF00017 0.639
LIG_SH2_STAT5 179 182 PF00017 0.308
LIG_SH2_STAT5 198 201 PF00017 0.750
LIG_SH2_STAT5 248 251 PF00017 0.763
LIG_SH2_STAT5 594 597 PF00017 0.585
LIG_SH2_STAT5 62 65 PF00017 0.627
LIG_SH2_STAT5 626 629 PF00017 0.620
LIG_SH2_STAT5 707 710 PF00017 0.502
LIG_SH2_STAT5 755 758 PF00017 0.499
LIG_SH3_3 564 570 PF00018 0.744
LIG_SH3_3 582 588 PF00018 0.671
LIG_SH3_3 734 740 PF00018 0.499
LIG_SH3_3 807 813 PF00018 0.499
LIG_SH3_3 830 836 PF00018 0.499
LIG_SUMO_SIM_anti_2 145 150 PF11976 0.345
LIG_SUMO_SIM_anti_2 172 177 PF11976 0.345
LIG_SUMO_SIM_anti_2 690 696 PF11976 0.499
LIG_SUMO_SIM_par_1 139 145 PF11976 0.377
LIG_SUMO_SIM_par_1 64 69 PF11976 0.584
LIG_SUMO_SIM_par_1 829 834 PF11976 0.499
LIG_TRAF2_1 17 20 PF00917 0.738
LIG_TRAF2_1 573 576 PF00917 0.768
LIG_TRAF2_1 668 671 PF00917 0.680
LIG_TYR_ITIM 888 893 PF00017 0.335
LIG_WW_1 288 291 PF00397 0.738
MOD_CDK_SPK_2 660 665 PF00069 0.662
MOD_CDK_SPxK_1 34 40 PF00069 0.488
MOD_CK1_1 23 29 PF00069 0.597
MOD_CK1_1 31 37 PF00069 0.500
MOD_CK1_1 324 330 PF00069 0.626
MOD_CK1_1 351 357 PF00069 0.589
MOD_CK1_1 389 395 PF00069 0.728
MOD_CK1_1 406 412 PF00069 0.552
MOD_CK1_1 546 552 PF00069 0.401
MOD_CK1_1 660 666 PF00069 0.637
MOD_CK1_1 726 732 PF00069 0.335
MOD_CK1_1 751 757 PF00069 0.408
MOD_CK1_1 968 974 PF00069 0.625
MOD_CK2_1 13 19 PF00069 0.625
MOD_CK2_1 22 28 PF00069 0.592
MOD_CK2_1 460 466 PF00069 0.453
MOD_CK2_1 51 57 PF00069 0.521
MOD_CK2_1 881 887 PF00069 0.319
MOD_Cter_Amidation 421 424 PF01082 0.602
MOD_Cter_Amidation 596 599 PF01082 0.462
MOD_GlcNHglycan 128 131 PF01048 0.552
MOD_GlcNHglycan 225 228 PF01048 0.706
MOD_GlcNHglycan 298 301 PF01048 0.648
MOD_GlcNHglycan 391 394 PF01048 0.726
MOD_GlcNHglycan 405 408 PF01048 0.595
MOD_GlcNHglycan 502 506 PF01048 0.493
MOD_GlcNHglycan 526 529 PF01048 0.466
MOD_GlcNHglycan 537 540 PF01048 0.417
MOD_GlcNHglycan 640 643 PF01048 0.661
MOD_GlcNHglycan 650 653 PF01048 0.543
MOD_GlcNHglycan 659 662 PF01048 0.734
MOD_GlcNHglycan 732 735 PF01048 0.335
MOD_GlcNHglycan 750 753 PF01048 0.335
MOD_GlcNHglycan 92 95 PF01048 0.485
MOD_GlcNHglycan 970 973 PF01048 0.613
MOD_GSK3_1 105 112 PF00069 0.489
MOD_GSK3_1 115 122 PF00069 0.506
MOD_GSK3_1 165 172 PF00069 0.396
MOD_GSK3_1 22 29 PF00069 0.646
MOD_GSK3_1 274 281 PF00069 0.605
MOD_GSK3_1 380 387 PF00069 0.712
MOD_GSK3_1 388 395 PF00069 0.812
MOD_GSK3_1 396 403 PF00069 0.609
MOD_GSK3_1 455 462 PF00069 0.409
MOD_GSK3_1 531 538 PF00069 0.492
MOD_GSK3_1 675 682 PF00069 0.612
MOD_GSK3_1 726 733 PF00069 0.335
MOD_GSK3_1 778 785 PF00069 0.335
MOD_GSK3_1 971 978 PF00069 0.628
MOD_N-GLC_1 20 25 PF02516 0.647
MOD_N-GLC_1 443 448 PF02516 0.414
MOD_N-GLC_2 243 245 PF02516 0.657
MOD_NEK2_1 115 120 PF00069 0.535
MOD_NEK2_1 144 149 PF00069 0.501
MOD_NEK2_1 157 162 PF00069 0.412
MOD_NEK2_1 348 353 PF00069 0.607
MOD_NEK2_1 472 477 PF00069 0.484
MOD_NEK2_1 522 527 PF00069 0.378
MOD_NEK2_1 545 550 PF00069 0.503
MOD_NEK2_1 613 618 PF00069 0.450
MOD_NEK2_1 66 71 PF00069 0.460
MOD_NEK2_1 730 735 PF00069 0.335
MOD_NEK2_1 975 980 PF00069 0.682
MOD_NEK2_2 119 124 PF00069 0.534
MOD_OFUCOSY 113 119 PF10250 0.612
MOD_PIKK_1 11 17 PF00454 0.582
MOD_PIKK_1 157 163 PF00454 0.493
MOD_PIKK_1 455 461 PF00454 0.501
MOD_PIKK_1 583 589 PF00454 0.700
MOD_PIKK_1 679 685 PF00454 0.491
MOD_PK_1 897 903 PF00069 0.529
MOD_PKA_1 11 17 PF00069 0.556
MOD_PKA_2 10 16 PF00069 0.574
MOD_PKA_2 115 121 PF00069 0.527
MOD_PKA_2 291 297 PF00069 0.729
MOD_PKA_2 351 357 PF00069 0.662
MOD_PKA_2 380 386 PF00069 0.787
MOD_PKA_2 399 405 PF00069 0.585
MOD_PKA_2 472 478 PF00069 0.507
MOD_PKA_2 484 490 PF00069 0.458
MOD_PKA_2 49 55 PF00069 0.592
MOD_PKA_2 797 803 PF00069 0.408
MOD_PKA_2 881 887 PF00069 0.339
MOD_PKA_2 896 902 PF00069 0.477
MOD_Plk_1 134 140 PF00069 0.345
MOD_Plk_1 26 32 PF00069 0.667
MOD_Plk_1 264 270 PF00069 0.543
MOD_Plk_1 313 319 PF00069 0.634
MOD_Plk_1 443 449 PF00069 0.403
MOD_Plk_1 897 903 PF00069 0.529
MOD_Plk_2-3 313 319 PF00069 0.634
MOD_Plk_2-3 829 835 PF00069 0.335
MOD_Plk_4 144 150 PF00069 0.508
MOD_Plk_4 166 172 PF00069 0.300
MOD_Plk_4 31 37 PF00069 0.527
MOD_Plk_4 460 466 PF00069 0.453
MOD_Plk_4 509 515 PF00069 0.418
MOD_Plk_4 751 757 PF00069 0.408
MOD_ProDKin_1 13 19 PF00069 0.574
MOD_ProDKin_1 34 40 PF00069 0.550
MOD_ProDKin_1 384 390 PF00069 0.766
MOD_ProDKin_1 566 572 PF00069 0.668
MOD_ProDKin_1 660 666 PF00069 0.700
TRG_DiLeu_BaEn_1 345 350 PF01217 0.678
TRG_DiLeu_BaEn_1 741 746 PF01217 0.335
TRG_DiLeu_BaLyEn_6 344 349 PF01217 0.675
TRG_DiLeu_BaLyEn_6 537 542 PF01217 0.474
TRG_DiLeu_BaLyEn_6 567 572 PF01217 0.666
TRG_DiLeu_BaLyEn_6 62 67 PF01217 0.478
TRG_DiLeu_BaLyEn_6 792 797 PF01217 0.324
TRG_ENDOCYTIC_2 290 293 PF00928 0.669
TRG_ENDOCYTIC_2 322 325 PF00928 0.709
TRG_ENDOCYTIC_2 849 852 PF00928 0.335
TRG_ENDOCYTIC_2 890 893 PF00928 0.335
TRG_ER_diArg_1 228 231 PF00400 0.618
TRG_ER_diArg_1 518 520 PF00400 0.425
TRG_ER_diArg_1 598 600 PF00400 0.458
TRG_ER_diArg_1 73 76 PF00400 0.435
TRG_ER_diArg_1 911 914 PF00400 0.577
TRG_NES_CRM1_1 506 517 PF08389 0.405
TRG_Pf-PMV_PEXEL_1 274 278 PF00026 0.566
TRG_Pf-PMV_PEXEL_1 685 689 PF00026 0.335
TRG_Pf-PMV_PEXEL_1 76 81 PF00026 0.463
TRG_Pf-PMV_PEXEL_1 764 769 PF00026 0.335

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2E5 Leptomonas seymouri 57% 75%
A0A451EJJ2 Leishmania donovani 100% 69%
A4H3E7 Leishmania braziliensis 78% 100%
E9ACD1 Leishmania major 93% 100%
E9AJL9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS