LeishMANIAdb
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Voltage-dependent anion-selective channel

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Voltage-dependent anion-selective channel
Gene product:
voltage-dependent anion-selective channel - putative
Species:
Leishmania infantum
UniProt:
A4HRP2_LEIIN
TriTrypDb:
LINF_020009800
Length:
291

Annotations

Annotations by Jardim et al.

Pyruvate metabolism, Mitochondrial outer membrane porin, putative (VDAC) Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 4
Forrest at al. (procyclic) yes yes: 4
Silverman et al. no yes: 0
Pissara et al. no yes: 9
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 12
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 16
NetGPI no yes: 0, no: 16
Cellular components
Term Name Level Count
GO:0005741 mitochondrial outer membrane 5 17
GO:0016020 membrane 2 17
GO:0019867 outer membrane 3 17
GO:0031090 organelle membrane 3 17
GO:0031966 mitochondrial membrane 4 17
GO:0031968 organelle outer membrane 4 17
GO:0098588 bounding membrane of organelle 4 17
GO:0110165 cellular anatomical entity 1 17
GO:0005739 mitochondrion 5 1
GO:0016281 eukaryotic translation initiation factor 4F complex 2 1
GO:0020022 acidocalcisome 5 1
GO:0032991 protein-containing complex 1 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0046930 pore complex 3 1
GO:0098796 membrane protein complex 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HRP2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRP2

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 2
GO:0006811 monoatomic ion transport 4 1
GO:0006839 mitochondrial transport 4 2
GO:0009987 cellular process 1 2
GO:0046907 intracellular transport 3 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0051641 cellular localization 2 2
GO:0051649 establishment of localization in cell 3 2
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 17
GO:0005216 monoatomic ion channel activity 4 17
GO:0005244 voltage-gated monoatomic ion channel activity 4 17
GO:0005253 monoatomic anion channel activity 5 17
GO:0008308 voltage-gated monoatomic anion channel activity 5 17
GO:0008509 monoatomic anion transmembrane transporter activity 4 17
GO:0015075 monoatomic ion transmembrane transporter activity 3 17
GO:0015103 inorganic anion transmembrane transporter activity 4 17
GO:0015267 channel activity 4 17
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 17
GO:0022803 passive transmembrane transporter activity 3 17
GO:0022832 voltage-gated channel activity 6 17
GO:0022836 gated channel activity 5 17
GO:0022857 transmembrane transporter activity 2 17
GO:0015288 porin activity 6 1
GO:0022829 wide pore channel activity 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 131 133 PF00082 0.405
CLV_PCSK_PC1ET2_1 131 133 PF00082 0.405
CLV_PCSK_SKI1_1 256 260 PF00082 0.558
CLV_PCSK_SKI1_1 29 33 PF00082 0.366
CLV_PCSK_SKI1_1 41 45 PF00082 0.362
CLV_PCSK_SKI1_1 91 95 PF00082 0.578
CLV_Separin_Metazoa 88 92 PF03568 0.431
DOC_CKS1_1 15 20 PF01111 0.527
DOC_MAPK_gen_1 225 234 PF00069 0.541
DOC_PP4_FxxP_1 56 59 PF00568 0.416
DOC_USP7_MATH_1 59 63 PF00917 0.487
DOC_USP7_MATH_1 7 11 PF00917 0.648
DOC_USP7_UBL2_3 22 26 PF12436 0.400
DOC_WW_Pin1_4 137 142 PF00397 0.539
DOC_WW_Pin1_4 14 19 PF00397 0.550
DOC_WW_Pin1_4 83 88 PF00397 0.482
LIG_14-3-3_CanoR_1 192 197 PF00244 0.442
LIG_14-3-3_CanoR_1 212 216 PF00244 0.228
LIG_Actin_WH2_2 67 84 PF00022 0.492
LIG_BRCT_BRCA1_1 204 208 PF00533 0.542
LIG_eIF4E_1 15 21 PF01652 0.520
LIG_FHA_1 15 21 PF00498 0.451
LIG_FHA_1 161 167 PF00498 0.435
LIG_FHA_1 188 194 PF00498 0.427
LIG_FHA_1 239 245 PF00498 0.483
LIG_FHA_1 26 32 PF00498 0.478
LIG_FHA_1 271 277 PF00498 0.427
LIG_FHA_1 52 58 PF00498 0.531
LIG_FHA_1 84 90 PF00498 0.495
LIG_FHA_2 140 146 PF00498 0.406
LIG_Integrin_RGD_1 227 229 PF01839 0.543
LIG_LIR_Apic_2 45 51 PF02991 0.380
LIG_LIR_Apic_2 53 59 PF02991 0.402
LIG_LIR_Gen_1 23 32 PF02991 0.369
LIG_LIR_Nem_3 19 24 PF02991 0.416
LIG_Pex14_1 260 264 PF04695 0.392
LIG_RPA_C_Fungi 207 219 PF08784 0.368
LIG_SH2_CRK 15 19 PF00017 0.537
LIG_SH2_CRK 24 28 PF00017 0.501
LIG_SH2_CRK 48 52 PF00017 0.519
LIG_SH2_NCK_1 15 19 PF00017 0.537
LIG_SH2_SRC 119 122 PF00017 0.482
LIG_SH2_SRC 164 167 PF00017 0.550
LIG_SH2_STAT3 99 102 PF00017 0.415
LIG_SH2_STAT5 264 267 PF00017 0.393
LIG_SH2_STAT5 73 76 PF00017 0.380
LIG_SH2_STAT5 99 102 PF00017 0.549
LIG_SH3_3 240 246 PF00018 0.546
LIG_UBA3_1 89 94 PF00899 0.463
MOD_CK1_1 122 128 PF00069 0.473
MOD_CK1_1 16 22 PF00069 0.351
MOD_CK2_1 131 137 PF00069 0.484
MOD_CK2_1 139 145 PF00069 0.499
MOD_CK2_1 274 280 PF00069 0.406
MOD_GlcNHglycan 198 201 PF01048 0.490
MOD_GlcNHglycan 5 8 PF01048 0.572
MOD_GlcNHglycan 67 70 PF01048 0.446
MOD_GlcNHglycan 9 12 PF01048 0.514
MOD_GSK3_1 127 134 PF00069 0.500
MOD_GSK3_1 192 199 PF00069 0.419
MOD_GSK3_1 270 277 PF00069 0.419
MOD_GSK3_1 3 10 PF00069 0.686
MOD_GSK3_1 93 100 PF00069 0.516
MOD_N-GLC_1 270 275 PF02516 0.372
MOD_N-GLC_2 169 171 PF02516 0.519
MOD_N-GLC_2 211 213 PF02516 0.432
MOD_NEK2_1 238 243 PF00069 0.514
MOD_NEK2_1 81 86 PF00069 0.512
MOD_NEK2_2 246 251 PF00069 0.527
MOD_NEK2_2 51 56 PF00069 0.488
MOD_PK_1 131 137 PF00069 0.523
MOD_PKA_1 131 137 PF00069 0.390
MOD_PKA_2 131 137 PF00069 0.530
MOD_PKA_2 211 217 PF00069 0.356
MOD_Plk_4 16 22 PF00069 0.392
MOD_Plk_4 202 208 PF00069 0.540
MOD_Plk_4 51 57 PF00069 0.478
MOD_ProDKin_1 137 143 PF00069 0.538
MOD_ProDKin_1 14 20 PF00069 0.540
MOD_ProDKin_1 83 89 PF00069 0.491
MOD_SUMO_rev_2 255 261 PF00179 0.341
MOD_SUMO_rev_2 62 68 PF00179 0.451
MOD_SUMO_rev_2 88 96 PF00179 0.549
TRG_ENDOCYTIC_2 24 27 PF00928 0.373

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HUD3 Leptomonas seymouri 68% 98%
A0A0N1IIR1 Leptomonas seymouri 32% 100%
A0A0S4JQ02 Bodo saltans 35% 100%
A0A1X0NJX9 Trypanosomatidae 44% 100%
A0A3R7M1M0 Trypanosoma rangeli 43% 100%
A0A3S5H502 Leishmania donovani 30% 100%
A0A3S5H503 Leishmania donovani 100% 100%
A0A422NPQ5 Trypanosoma rangeli 44% 100%
A4H3D7 Leishmania braziliensis 78% 100%
A4HRP1 Leishmania infantum 30% 99%
C9ZJ24 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
E9ACB9 Leishmania major 28% 99%
E9ACC0 Leishmania major 97% 100%
E9AJK7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 99%
E9AJK8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS