LeishMANIAdb
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Putative proteasome regulatory non-ATPase subunit 6

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative proteasome regulatory non-ATPase subunit 6
Gene product:
proteasome regulatory non-ATPase subunit 6 - putative
Species:
Leishmania infantum
UniProt:
A4HRN4_LEIIN
TriTrypDb:
LINF_020008700
Length:
529

Annotations

Annotations by Jardim et al.

Proteasome, proteasome regulatory non-ATPase subunit 6

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 2
Pissara et al. yes yes: 10
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 4
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 4
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0000502 proteasome complex 3 10
GO:0032991 protein-containing complex 1 11
GO:0140535 intracellular protein-containing complex 2 10
GO:1902494 catalytic complex 2 10
GO:1905368 peptidase complex 3 10
GO:1905369 endopeptidase complex 4 10
GO:0005737 cytoplasm 2 1
GO:0008541 proteasome regulatory particle, lid subcomplex 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HRN4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRN4

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 1
GO:0006511 ubiquitin-dependent protein catabolic process 7 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009056 catabolic process 2 1
GO:0009057 macromolecule catabolic process 4 1
GO:0009987 cellular process 1 1
GO:0019538 protein metabolic process 3 1
GO:0019941 modification-dependent protein catabolic process 6 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043632 modification-dependent macromolecule catabolic process 5 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044248 cellular catabolic process 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0044265 obsolete cellular macromolecule catabolic process 4 1
GO:0051603 proteolysis involved in protein catabolic process 5 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1901575 organic substance catabolic process 3 1
Molecular functions
Term Name Level Count
GO:0005198 structural molecule activity 1 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 225 229 PF00656 0.470
CLV_C14_Caspase3-7 288 292 PF00656 0.377
CLV_C14_Caspase3-7 43 47 PF00656 0.462
CLV_C14_Caspase3-7 503 507 PF00656 0.619
CLV_NRD_NRD_1 122 124 PF00675 0.270
CLV_NRD_NRD_1 126 128 PF00675 0.253
CLV_NRD_NRD_1 146 148 PF00675 0.194
CLV_NRD_NRD_1 163 165 PF00675 0.265
CLV_NRD_NRD_1 254 256 PF00675 0.350
CLV_NRD_NRD_1 339 341 PF00675 0.239
CLV_NRD_NRD_1 390 392 PF00675 0.309
CLV_NRD_NRD_1 493 495 PF00675 0.609
CLV_NRD_NRD_1 527 529 PF00675 0.564
CLV_NRD_NRD_1 94 96 PF00675 0.206
CLV_PCSK_KEX2_1 126 128 PF00082 0.208
CLV_PCSK_KEX2_1 163 165 PF00082 0.366
CLV_PCSK_KEX2_1 254 256 PF00082 0.470
CLV_PCSK_KEX2_1 339 341 PF00082 0.239
CLV_PCSK_KEX2_1 497 499 PF00082 0.691
CLV_PCSK_KEX2_1 522 524 PF00082 0.604
CLV_PCSK_KEX2_1 527 529 PF00082 0.577
CLV_PCSK_PC1ET2_1 497 499 PF00082 0.686
CLV_PCSK_PC1ET2_1 522 524 PF00082 0.598
CLV_PCSK_PC1ET2_1 527 529 PF00082 0.583
CLV_PCSK_PC7_1 523 529 PF00082 0.611
CLV_PCSK_SKI1_1 127 131 PF00082 0.220
CLV_PCSK_SKI1_1 168 172 PF00082 0.312
CLV_PCSK_SKI1_1 192 196 PF00082 0.321
CLV_PCSK_SKI1_1 280 284 PF00082 0.346
CLV_PCSK_SKI1_1 29 33 PF00082 0.206
CLV_PCSK_SKI1_1 352 356 PF00082 0.264
CLV_PCSK_SKI1_1 481 485 PF00082 0.628
CLV_PCSK_SKI1_1 79 83 PF00082 0.210
CLV_PCSK_SKI1_1 95 99 PF00082 0.206
CLV_Separin_Metazoa 336 340 PF03568 0.501
DEG_APCC_DBOX_1 132 140 PF00400 0.522
DEG_APCC_DBOX_1 167 175 PF00400 0.301
DEG_APCC_DBOX_1 253 261 PF00400 0.314
DEG_APCC_DBOX_1 28 36 PF00400 0.406
DEG_APCC_DBOX_1 351 359 PF00400 0.420
DOC_CYCLIN_RxL_1 25 34 PF00134 0.453
DOC_CYCLIN_RxL_1 349 359 PF00134 0.395
DOC_CYCLIN_RxL_1 89 99 PF00134 0.420
DOC_MAPK_gen_1 254 262 PF00069 0.343
DOC_MAPK_MEF2A_6 168 176 PF00069 0.278
DOC_USP7_MATH_1 151 155 PF00917 0.387
DOC_USP7_MATH_1 194 198 PF00917 0.426
DOC_USP7_MATH_1 253 257 PF00917 0.364
DOC_USP7_MATH_1 3 7 PF00917 0.486
DOC_USP7_MATH_1 319 323 PF00917 0.453
DOC_USP7_MATH_1 324 328 PF00917 0.419
DOC_USP7_MATH_1 367 371 PF00917 0.506
DOC_USP7_MATH_1 412 416 PF00917 0.681
DOC_USP7_UBL2_3 464 468 PF12436 0.425
DOC_USP7_UBL2_3 92 96 PF12436 0.462
DOC_WW_Pin1_4 266 271 PF00397 0.379
DOC_WW_Pin1_4 356 361 PF00397 0.501
LIG_14-3-3_CanoR_1 126 130 PF00244 0.501
LIG_14-3-3_CanoR_1 147 155 PF00244 0.415
LIG_14-3-3_CanoR_1 199 206 PF00244 0.466
LIG_14-3-3_CanoR_1 25 32 PF00244 0.479
LIG_14-3-3_CanoR_1 254 258 PF00244 0.366
LIG_Actin_WH2_2 342 358 PF00022 0.462
LIG_Actin_WH2_2 380 396 PF00022 0.462
LIG_APCC_ABBA_1 404 409 PF00400 0.485
LIG_BRCT_BRCA1_1 421 425 PF00533 0.536
LIG_Clathr_ClatBox_1 372 376 PF01394 0.406
LIG_Clathr_ClatBox_1 404 408 PF01394 0.462
LIG_eIF4E_1 56 62 PF01652 0.462
LIG_FHA_1 10 16 PF00498 0.474
LIG_FHA_1 167 173 PF00498 0.423
LIG_FHA_1 328 334 PF00498 0.501
LIG_FHA_1 89 95 PF00498 0.407
LIG_FHA_2 25 31 PF00498 0.491
LIG_FHA_2 286 292 PF00498 0.353
LIG_FHA_2 346 352 PF00498 0.453
LIG_FHA_2 447 453 PF00498 0.441
LIG_Integrin_RGD_1 22 24 PF01839 0.420
LIG_LIR_Apic_2 204 209 PF02991 0.344
LIG_LIR_Gen_1 231 240 PF02991 0.300
LIG_LIR_Gen_1 241 250 PF02991 0.337
LIG_LIR_Gen_1 256 265 PF02991 0.287
LIG_LIR_Gen_1 305 312 PF02991 0.420
LIG_LIR_Gen_1 344 354 PF02991 0.417
LIG_LIR_Gen_1 359 369 PF02991 0.384
LIG_LIR_Gen_1 452 462 PF02991 0.372
LIG_LIR_Nem_3 179 185 PF02991 0.275
LIG_LIR_Nem_3 231 236 PF02991 0.349
LIG_LIR_Nem_3 238 243 PF02991 0.336
LIG_LIR_Nem_3 256 262 PF02991 0.286
LIG_LIR_Nem_3 305 311 PF02991 0.420
LIG_LIR_Nem_3 344 349 PF02991 0.408
LIG_LIR_Nem_3 359 364 PF02991 0.414
LIG_LIR_Nem_3 452 457 PF02991 0.369
LIG_LIR_Nem_3 459 465 PF02991 0.382
LIG_NRBOX 154 160 PF00104 0.350
LIG_NRBOX 272 278 PF00104 0.362
LIG_NRBOX 57 63 PF00104 0.436
LIG_PCNA_yPIPBox_3 455 468 PF02747 0.531
LIG_Rb_pABgroove_1 456 464 PF01858 0.396
LIG_SH2_CRK 206 210 PF00017 0.346
LIG_SH2_CRK 233 237 PF00017 0.385
LIG_SH2_CRK 259 263 PF00017 0.288
LIG_SH2_CRK 346 350 PF00017 0.406
LIG_SH2_CRK 361 365 PF00017 0.406
LIG_SH2_CRK 454 458 PF00017 0.380
LIG_SH2_GRB2like 426 429 PF00017 0.621
LIG_SH2_NCK_1 361 365 PF00017 0.420
LIG_SH2_NCK_1 426 430 PF00017 0.618
LIG_SH2_PTP2 138 141 PF00017 0.414
LIG_SH2_SRC 138 141 PF00017 0.414
LIG_SH2_SRC 426 429 PF00017 0.621
LIG_SH2_SRC 444 447 PF00017 0.404
LIG_SH2_STAP1 233 237 PF00017 0.385
LIG_SH2_STAP1 426 430 PF00017 0.618
LIG_SH2_STAT3 300 303 PF00017 0.432
LIG_SH2_STAT5 138 141 PF00017 0.450
LIG_SH2_STAT5 175 178 PF00017 0.370
LIG_SH2_STAT5 206 209 PF00017 0.372
LIG_SH2_STAT5 235 238 PF00017 0.356
LIG_SH2_STAT5 368 371 PF00017 0.448
LIG_SH3_3 354 360 PF00018 0.501
LIG_SUMO_SIM_par_1 11 18 PF11976 0.478
LIG_SUMO_SIM_par_1 166 173 PF11976 0.431
LIG_SUMO_SIM_par_1 60 65 PF11976 0.437
LIG_TRAF2_1 485 488 PF00917 0.506
LIG_TYR_ITIM 136 141 PF00017 0.416
LIG_TYR_ITIM 257 262 PF00017 0.287
LIG_UBA3_1 307 314 PF00899 0.319
MOD_CDK_SPxxK_3 356 363 PF00069 0.374
MOD_CK1_1 197 203 PF00069 0.446
MOD_CK1_1 263 269 PF00069 0.373
MOD_CK1_1 278 284 PF00069 0.414
MOD_CK1_1 310 316 PF00069 0.386
MOD_CK1_1 327 333 PF00069 0.150
MOD_CK2_1 208 214 PF00069 0.449
MOD_CK2_1 24 30 PF00069 0.407
MOD_CK2_1 266 272 PF00069 0.376
MOD_CK2_1 278 284 PF00069 0.325
MOD_CK2_1 345 351 PF00069 0.284
MOD_CK2_1 446 452 PF00069 0.443
MOD_GlcNHglycan 155 158 PF01048 0.445
MOD_GlcNHglycan 196 199 PF01048 0.444
MOD_GlcNHglycan 218 221 PF01048 0.297
MOD_GlcNHglycan 320 324 PF01048 0.305
MOD_GlcNHglycan 516 519 PF01048 0.649
MOD_GSK3_1 194 201 PF00069 0.366
MOD_GSK3_1 260 267 PF00069 0.509
MOD_GSK3_1 272 279 PF00069 0.399
MOD_GSK3_1 31 38 PF00069 0.385
MOD_N-GLC_1 228 233 PF02516 0.360
MOD_N-GLC_1 327 332 PF02516 0.262
MOD_NEK2_1 176 181 PF00069 0.263
MOD_NEK2_1 260 265 PF00069 0.353
MOD_NEK2_1 276 281 PF00069 0.361
MOD_NEK2_1 307 312 PF00069 0.262
MOD_NEK2_1 31 36 PF00069 0.389
MOD_NEK2_1 345 350 PF00069 0.260
MOD_NEK2_2 115 120 PF00069 0.262
MOD_NEK2_2 253 258 PF00069 0.362
MOD_NEK2_2 500 505 PF00069 0.468
MOD_PIKK_1 208 214 PF00454 0.449
MOD_PIKK_1 382 388 PF00454 0.253
MOD_PKA_2 125 131 PF00069 0.374
MOD_PKA_2 146 152 PF00069 0.366
MOD_PKA_2 198 204 PF00069 0.454
MOD_PKA_2 24 30 PF00069 0.322
MOD_PKA_2 253 259 PF00069 0.360
MOD_Plk_1 166 172 PF00069 0.459
MOD_Plk_1 228 234 PF00069 0.363
MOD_Plk_4 201 207 PF00069 0.338
MOD_Plk_4 231 237 PF00069 0.382
MOD_Plk_4 272 278 PF00069 0.477
MOD_Plk_4 307 313 PF00069 0.262
MOD_Plk_4 31 37 PF00069 0.330
MOD_Plk_4 345 351 PF00069 0.265
MOD_Plk_4 439 445 PF00069 0.432
MOD_Plk_4 453 459 PF00069 0.361
MOD_ProDKin_1 266 272 PF00069 0.383
MOD_ProDKin_1 356 362 PF00069 0.374
MOD_SUMO_for_1 485 488 PF00179 0.650
MOD_SUMO_rev_2 173 181 PF00179 0.398
MOD_SUMO_rev_2 225 232 PF00179 0.332
MOD_SUMO_rev_2 278 288 PF00179 0.427
MOD_SUMO_rev_2 376 385 PF00179 0.304
TRG_DiLeu_BaEn_1 272 277 PF01217 0.358
TRG_DiLeu_BaEn_2 124 130 PF01217 0.260
TRG_ENDOCYTIC_2 138 141 PF00928 0.449
TRG_ENDOCYTIC_2 182 185 PF00928 0.283
TRG_ENDOCYTIC_2 233 236 PF00928 0.354
TRG_ENDOCYTIC_2 237 240 PF00928 0.343
TRG_ENDOCYTIC_2 259 262 PF00928 0.336
TRG_ENDOCYTIC_2 346 349 PF00928 0.264
TRG_ENDOCYTIC_2 361 364 PF00928 0.324
TRG_ENDOCYTIC_2 454 457 PF00928 0.383
TRG_ER_diArg_1 130 133 PF00400 0.263
TRG_ER_diArg_1 162 164 PF00400 0.343
TRG_ER_diArg_1 338 340 PF00400 0.290
TRG_NES_CRM1_1 30 46 PF08389 0.306
TRG_NES_CRM1_1 365 376 PF08389 0.260
TRG_NLS_MonoExtC_3 493 498 PF00514 0.615
TRG_Pf-PMV_PEXEL_1 163 167 PF00026 0.375
TRG_Pf-PMV_PEXEL_1 168 173 PF00026 0.347
TRG_Pf-PMV_PEXEL_1 29 33 PF00026 0.374
TRG_Pf-PMV_PEXEL_1 294 298 PF00026 0.311
TRG_Pf-PMV_PEXEL_1 394 398 PF00026 0.319
TRG_Pf-PMV_PEXEL_1 95 99 PF00026 0.260

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3L4 Leptomonas seymouri 79% 100%
A0A0S4JHD2 Bodo saltans 55% 100%
A0A1X0NKK6 Trypanosomatidae 60% 93%
A0A3R7KIY0 Trypanosoma rangeli 58% 100%
A0A3S5H4Z8 Leishmania donovani 100% 100%
A4H3D3 Leishmania braziliensis 93% 100%
A8X379 Caenorhabditis briggsae 30% 100%
C9ZJ16 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 100%
E9ACB2 Leishmania major 97% 100%
E9AJK0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
F1LMZ8 Rattus norvegicus 42% 100%
F1QGH9 Danio rerio 43% 100%
F6P3G4 Danio rerio 43% 100%
F6XBL2 Xenopus tropicalis 41% 100%
O00231 Homo sapiens 42% 100%
P34481 Caenorhabditis elegans 31% 100%
Q12377 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 34% 100%
Q20938 Caenorhabditis elegans 38% 100%
Q2KI42 Bos taurus 42% 100%
Q54UB5 Dictyostelium discoideum 38% 100%
Q7KLV9 Drosophila melanogaster 38% 100%
Q8BG32 Mus musculus 42% 100%
Q9LP45 Arabidopsis thaliana 46% 100%
Q9P7S2 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 38% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS