Transmembrane protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

EamA-like transporter family/Triose-phosphate Transporter family/UAA transporter family - putative

Species:

Leishmania infantum

UniProt:

A4HRN1_LEIIN

TriTrypDb:

LINF_020008400

Length:

972

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HRN1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRN1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	5
GO:0009987	cellular process	1	5
GO:0051179	localization	1	5
GO:0051234	establishment of localization	2	5
GO:0055085	transmembrane transport	2	5

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	307	311	PF00656	0.792
CLV_C14_Caspase3-7	323	327	PF00656	0.649
CLV_C14_Caspase3-7	331	335	PF00656	0.666
CLV_C14_Caspase3-7	543	547	PF00656	0.421
CLV_NRD_NRD_1	105	107	PF00675	0.520
CLV_NRD_NRD_1	230	232	PF00675	0.447
CLV_NRD_NRD_1	324	326	PF00675	0.497
CLV_NRD_NRD_1	357	359	PF00675	0.589
CLV_NRD_NRD_1	397	399	PF00675	0.616
CLV_NRD_NRD_1	509	511	PF00675	0.435
CLV_NRD_NRD_1	681	683	PF00675	0.647
CLV_NRD_NRD_1	836	838	PF00675	0.728
CLV_NRD_NRD_1	853	855	PF00675	0.547
CLV_NRD_NRD_1	927	929	PF00675	0.530
CLV_NRD_NRD_1	942	944	PF00675	0.458
CLV_NRD_NRD_1	968	970	PF00675	0.523
CLV_PCSK_FUR_1	966	970	PF00082	0.510
CLV_PCSK_KEX2_1	105	107	PF00082	0.520
CLV_PCSK_KEX2_1	230	232	PF00082	0.447
CLV_PCSK_KEX2_1	324	326	PF00082	0.497
CLV_PCSK_KEX2_1	357	359	PF00082	0.589
CLV_PCSK_KEX2_1	397	399	PF00082	0.617
CLV_PCSK_KEX2_1	467	469	PF00082	0.541
CLV_PCSK_KEX2_1	509	511	PF00082	0.435
CLV_PCSK_KEX2_1	681	683	PF00082	0.647
CLV_PCSK_KEX2_1	836	838	PF00082	0.728
CLV_PCSK_KEX2_1	853	855	PF00082	0.547
CLV_PCSK_KEX2_1	942	944	PF00082	0.636
CLV_PCSK_KEX2_1	966	968	PF00082	0.500
CLV_PCSK_PC1ET2_1	467	469	PF00082	0.513
CLV_PCSK_PC7_1	226	232	PF00082	0.448
CLV_PCSK_SKI1_1	230	234	PF00082	0.441
CLV_PCSK_SKI1_1	455	459	PF00082	0.546
CLV_PCSK_SKI1_1	509	513	PF00082	0.425
CLV_PCSK_SKI1_1	566	570	PF00082	0.686
CLV_PCSK_SKI1_1	789	793	PF00082	0.669
CLV_PCSK_SKI1_1	928	932	PF00082	0.530
CLV_PCSK_SKI1_1	942	946	PF00082	0.470
CLV_Separin_Metazoa	495	499	PF03568	0.678
DEG_APCC_DBOX_1	853	861	PF00400	0.487
DEG_APCC_DBOX_1	927	935	PF00400	0.530
DEG_Nend_UBRbox_2	1	3	PF02207	0.776
DEG_SPOP_SBC_1	29	33	PF00917	0.809
DEG_SPOP_SBC_1	738	742	PF00917	0.711
DOC_ANK_TNKS_1	178	185	PF00023	0.804
DOC_CYCLIN_RxL_1	506	516	PF00134	0.617
DOC_CYCLIN_RxL_1	786	796	PF00134	0.574
DOC_CYCLIN_yCln2_LP_2	477	483	PF00134	0.688
DOC_MAPK_gen_1	203	211	PF00069	0.688
DOC_MAPK_gen_1	273	283	PF00069	0.530
DOC_MAPK_gen_1	928	935	PF00069	0.530
DOC_MAPK_HePTP_8	238	250	PF00069	0.538
DOC_MAPK_MEF2A_6	241	250	PF00069	0.538
DOC_MAPK_MEF2A_6	928	937	PF00069	0.530
DOC_MAPK_RevD_3	841	854	PF00069	0.413
DOC_PP2B_LxvP_1	614	617	PF13499	0.591
DOC_PP4_FxxP_1	68	71	PF00568	0.527
DOC_USP7_MATH_1	218	222	PF00917	0.767
DOC_USP7_MATH_1	29	33	PF00917	0.698
DOC_USP7_MATH_1	447	451	PF00917	0.737
DOC_USP7_MATH_1	457	461	PF00917	0.671
DOC_USP7_MATH_1	542	546	PF00917	0.522
DOC_USP7_MATH_1	577	581	PF00917	0.553
DOC_USP7_MATH_1	621	625	PF00917	0.512
DOC_USP7_MATH_1	629	633	PF00917	0.395
DOC_USP7_MATH_1	635	639	PF00917	0.381
DOC_USP7_MATH_1	680	684	PF00917	0.834
DOC_USP7_MATH_1	738	742	PF00917	0.744
DOC_USP7_MATH_1	747	751	PF00917	0.694
DOC_USP7_MATH_1	896	900	PF00917	0.402
DOC_USP7_MATH_1	9	13	PF00917	0.766
DOC_WW_Pin1_4	128	133	PF00397	0.852
DOC_WW_Pin1_4	158	163	PF00397	0.744
DOC_WW_Pin1_4	214	219	PF00397	0.803
DOC_WW_Pin1_4	288	293	PF00397	0.647
DOC_WW_Pin1_4	363	368	PF00397	0.829
DOC_WW_Pin1_4	376	381	PF00397	0.660
DOC_WW_Pin1_4	460	465	PF00397	0.701
DOC_WW_Pin1_4	5	10	PF00397	0.764
DOC_WW_Pin1_4	617	622	PF00397	0.599
DOC_WW_Pin1_4	625	630	PF00397	0.522
DOC_WW_Pin1_4	720	725	PF00397	0.752
DOC_WW_Pin1_4	758	763	PF00397	0.602
LIG_14-3-3_CanoR_1	105	114	PF00244	0.794
LIG_14-3-3_CanoR_1	259	263	PF00244	0.437
LIG_14-3-3_CanoR_1	28	38	PF00244	0.717
LIG_14-3-3_CanoR_1	315	322	PF00244	0.750
LIG_14-3-3_CanoR_1	384	392	PF00244	0.805
LIG_14-3-3_CanoR_1	39	49	PF00244	0.602
LIG_14-3-3_CanoR_1	397	401	PF00244	0.760
LIG_14-3-3_CanoR_1	415	420	PF00244	0.715
LIG_14-3-3_CanoR_1	435	442	PF00244	0.700
LIG_14-3-3_CanoR_1	468	477	PF00244	0.726
LIG_14-3-3_CanoR_1	639	644	PF00244	0.500
LIG_14-3-3_CanoR_1	718	723	PF00244	0.705
LIG_14-3-3_CanoR_1	836	844	PF00244	0.427
LIG_14-3-3_CanoR_1	942	947	PF00244	0.397
LIG_Actin_WH2_2	484	500	PF00022	0.627
LIG_BIR_III_4	156	160	PF00653	0.664
LIG_BRCT_BRCA1_1	367	371	PF00533	0.710
LIG_BRCT_BRCA1_1	618	622	PF00533	0.598
LIG_BRCT_BRCA1_1	888	892	PF00533	0.316
LIG_CSL_BTD_1	419	422	PF09270	0.747
LIG_eIF4E_1	506	512	PF01652	0.566
LIG_FHA_1	187	193	PF00498	0.757
LIG_FHA_1	371	377	PF00498	0.788
LIG_FHA_1	41	47	PF00498	0.739
LIG_FHA_1	58	64	PF00498	0.249
LIG_FHA_1	640	646	PF00498	0.333
LIG_FHA_1	72	78	PF00498	0.371
LIG_FHA_1	85	91	PF00498	0.315
LIG_FHA_1	904	910	PF00498	0.394
LIG_FHA_1	930	936	PF00498	0.530
LIG_FHA_2	301	307	PF00498	0.774
LIG_FHA_2	436	442	PF00498	0.634
LIG_FHA_2	803	809	PF00498	0.547
LIG_FHA_2	816	822	PF00498	0.395
LIG_GBD_Chelix_1	246	254	PF00786	0.452
LIG_GBD_Chelix_1	504	512	PF00786	0.520
LIG_LIR_Apic_2	418	422	PF02991	0.718
LIG_LIR_Apic_2	65	71	PF02991	0.516
LIG_LIR_Gen_1	240	250	PF02991	0.591
LIG_LIR_Gen_1	313	322	PF02991	0.695
LIG_LIR_Gen_1	368	378	PF02991	0.782
LIG_LIR_Gen_1	492	502	PF02991	0.682
LIG_LIR_Gen_1	788	798	PF02991	0.376
LIG_LIR_Gen_1	889	900	PF02991	0.373
LIG_LIR_Nem_3	240	246	PF02991	0.569
LIG_LIR_Nem_3	260	266	PF02991	0.272
LIG_LIR_Nem_3	313	319	PF02991	0.697
LIG_LIR_Nem_3	368	374	PF02991	0.780
LIG_LIR_Nem_3	418	424	PF02991	0.716
LIG_LIR_Nem_3	492	497	PF02991	0.693
LIG_LIR_Nem_3	788	793	PF02991	0.371
LIG_LIR_Nem_3	889	895	PF02991	0.373
LIG_LIR_Nem_3	915	919	PF02991	0.606
LIG_LIR_Nem_3	936	940	PF02991	0.530
LIG_MLH1_MIPbox_1	888	892	PF16413	0.316
LIG_NRBOX	507	513	PF00104	0.721
LIG_NRBOX	889	895	PF00104	0.404
LIG_NRBOX	89	95	PF00104	0.530
LIG_NRBOX	930	936	PF00104	0.530
LIG_PAM2_1	233	245	PF00658	0.667
LIG_Pex14_1	420	424	PF04695	0.742
LIG_Pex14_2	530	534	PF04695	0.452
LIG_PROFILIN_1	875	881	PF00235	0.462
LIG_Rb_LxCxE_1	74	88	PF01857	0.435
LIG_RPA_C_Fungi	596	608	PF08784	0.674
LIG_SH2_CRK	100	104	PF00017	0.696
LIG_SH2_NCK_1	585	589	PF00017	0.541
LIG_SH2_PTP2	243	246	PF00017	0.530
LIG_SH2_STAP1	266	270	PF00017	0.355
LIG_SH2_STAP1	532	536	PF00017	0.522
LIG_SH2_STAP1	585	589	PF00017	0.629
LIG_SH2_STAT3	266	269	PF00017	0.530
LIG_SH2_STAT3	532	535	PF00017	0.534
LIG_SH2_STAT3	962	965	PF00017	0.588
LIG_SH2_STAT5	243	246	PF00017	0.530
LIG_SH2_STAT5	255	258	PF00017	0.331
LIG_SH2_STAT5	665	668	PF00017	0.573
LIG_SH3_3	129	135	PF00018	0.826
LIG_SH3_3	229	235	PF00018	0.716
LIG_SH3_3	316	322	PF00018	0.709
LIG_SH3_3	32	38	PF00018	0.679
LIG_SH3_3	375	381	PF00018	0.708
LIG_SH3_3	570	576	PF00018	0.585
LIG_SH3_3	623	629	PF00018	0.677
LIG_SH3_3	706	712	PF00018	0.755
LIG_SH3_3	721	727	PF00018	0.596
LIG_SH3_3	741	747	PF00018	0.663
LIG_SH3_3	753	759	PF00018	0.556
LIG_SH3_3	872	878	PF00018	0.762
LIG_Sin3_3	891	898	PF02671	0.316
LIG_SUMO_SIM_anti_2	74	80	PF11976	0.530
LIG_SUMO_SIM_par_1	372	379	PF11976	0.740
LIG_SUMO_SIM_par_1	74	80	PF11976	0.530
LIG_SUMO_SIM_par_1	790	796	PF11976	0.482
LIG_SUMO_SIM_par_1	893	899	PF11976	0.530
LIG_SUMO_SIM_par_1	931	936	PF11976	0.530
LIG_TRAF2_1	62	65	PF00917	0.620
LIG_TRAF2_1	761	764	PF00917	0.632
LIG_WRC_WIRS_1	527	532	PF05994	0.491
LIG_WRC_WIRS_1	772	777	PF05994	0.452
LIG_WRC_WIRS_1	794	799	PF05994	0.556
LIG_WRC_WIRS_1	934	939	PF05994	0.530
LIG_WW_3	36	40	PF00397	0.814
LIG_WW_3	678	682	PF00397	0.618
MOD_CDK_SPxxK_3	460	467	PF00069	0.623
MOD_CK1_1	118	124	PF00069	0.846
MOD_CK1_1	12	18	PF00069	0.723
MOD_CK1_1	207	213	PF00069	0.827
MOD_CK1_1	217	223	PF00069	0.640
MOD_CK1_1	224	230	PF00069	0.455
MOD_CK1_1	30	36	PF00069	0.626
MOD_CK1_1	363	369	PF00069	0.803
MOD_CK1_1	408	414	PF00069	0.599
MOD_CK1_1	460	466	PF00069	0.750
MOD_CK1_1	472	478	PF00069	0.625
MOD_CK1_1	541	547	PF00069	0.505
MOD_CK1_1	602	608	PF00069	0.736
MOD_CK1_1	625	631	PF00069	0.674
MOD_CK1_1	638	644	PF00069	0.496
MOD_CK1_1	730	736	PF00069	0.716
MOD_CK1_1	835	841	PF00069	0.613
MOD_CK1_1	899	905	PF00069	0.475
MOD_CK2_1	187	193	PF00069	0.603
MOD_CK2_1	296	302	PF00069	0.836
MOD_CK2_1	435	441	PF00069	0.535
MOD_CK2_1	489	495	PF00069	0.591
MOD_CK2_1	747	753	PF00069	0.828
MOD_CK2_1	758	764	PF00069	0.471
MOD_CK2_1	77	83	PF00069	0.460
MOD_CK2_1	802	808	PF00069	0.679
MOD_CK2_1	815	821	PF00069	0.480
MOD_Cter_Amidation	940	943	PF01082	0.452
MOD_GlcNHglycan	117	120	PF01048	0.812
MOD_GlcNHglycan	206	209	PF01048	0.817
MOD_GlcNHglycan	220	223	PF01048	0.574
MOD_GlcNHglycan	316	319	PF01048	0.769
MOD_GlcNHglycan	411	414	PF01048	0.610
MOD_GlcNHglycan	459	462	PF01048	0.678
MOD_GlcNHglycan	471	474	PF01048	0.599
MOD_GlcNHglycan	491	494	PF01048	0.582
MOD_GlcNHglycan	540	543	PF01048	0.535
MOD_GlcNHglycan	558	561	PF01048	0.596
MOD_GlcNHglycan	577	580	PF01048	0.480
MOD_GlcNHglycan	60	63	PF01048	0.452
MOD_GlcNHglycan	749	752	PF01048	0.639
MOD_GlcNHglycan	781	784	PF01048	0.452
MOD_GlcNHglycan	872	875	PF01048	0.790
MOD_GlcNHglycan	9	12	PF01048	0.713
MOD_GSK3_1	124	131	PF00069	0.834
MOD_GSK3_1	214	221	PF00069	0.804
MOD_GSK3_1	233	240	PF00069	0.373
MOD_GSK3_1	250	257	PF00069	0.315
MOD_GSK3_1	258	265	PF00069	0.498
MOD_GSK3_1	296	303	PF00069	0.726
MOD_GSK3_1	310	317	PF00069	0.610
MOD_GSK3_1	361	368	PF00069	0.800
MOD_GSK3_1	382	389	PF00069	0.736
MOD_GSK3_1	401	408	PF00069	0.531
MOD_GSK3_1	411	418	PF00069	0.530
MOD_GSK3_1	431	438	PF00069	0.732
MOD_GSK3_1	5	12	PF00069	0.710
MOD_GSK3_1	538	545	PF00069	0.493
MOD_GSK3_1	575	582	PF00069	0.650
MOD_GSK3_1	617	624	PF00069	0.736
MOD_GSK3_1	625	632	PF00069	0.637
MOD_GSK3_1	635	642	PF00069	0.417
MOD_GSK3_1	738	745	PF00069	0.721
MOD_GSK3_1	77	84	PF00069	0.530
MOD_GSK3_1	781	788	PF00069	0.324
MOD_GSK3_1	793	800	PF00069	0.423
MOD_GSK3_1	880	887	PF00069	0.648
MOD_GSK3_1	899	906	PF00069	0.364
MOD_GSK3_1	929	936	PF00069	0.530
MOD_LATS_1	350	356	PF00433	0.739
MOD_N-GLC_1	257	262	PF02516	0.628
MOD_N-GLC_1	300	305	PF02516	0.727
MOD_N-GLC_1	483	488	PF02516	0.592
MOD_NEK2_1	250	255	PF00069	0.530
MOD_NEK2_1	262	267	PF00069	0.448
MOD_NEK2_1	272	277	PF00069	0.394
MOD_NEK2_1	386	391	PF00069	0.723
MOD_NEK2_1	597	602	PF00069	0.690
MOD_NEK2_1	63	68	PF00069	0.506
MOD_NEK2_1	673	678	PF00069	0.734
MOD_NEK2_1	728	733	PF00069	0.580
MOD_NEK2_1	77	82	PF00069	0.378
MOD_NEK2_1	781	786	PF00069	0.410
MOD_NEK2_1	793	798	PF00069	0.559
MOD_NEK2_1	832	837	PF00069	0.624
MOD_NEK2_1	85	90	PF00069	0.398
MOD_NEK2_1	886	891	PF00069	0.460
MOD_NEK2_2	225	230	PF00069	0.520
MOD_PIKK_1	18	24	PF00454	0.629
MOD_PIKK_1	352	358	PF00454	0.740
MOD_PIKK_1	40	46	PF00454	0.691
MOD_PIKK_1	730	736	PF00454	0.707
MOD_PKA_1	942	948	PF00069	0.530
MOD_PKA_2	225	231	PF00069	0.617
MOD_PKA_2	258	264	PF00069	0.529
MOD_PKA_2	27	33	PF00069	0.638
MOD_PKA_2	314	320	PF00069	0.766
MOD_PKA_2	396	402	PF00069	0.728
MOD_PKA_2	436	442	PF00069	0.535
MOD_PKA_2	512	518	PF00069	0.621
MOD_PKA_2	597	603	PF00069	0.713
MOD_PKA_2	638	644	PF00069	0.660
MOD_PKA_2	680	686	PF00069	0.829
MOD_PKA_2	742	748	PF00069	0.654
MOD_PKA_2	835	841	PF00069	0.652
MOD_PKA_2	942	948	PF00069	0.530
MOD_Plk_1	257	263	PF00069	0.628
MOD_Plk_1	369	375	PF00069	0.742
MOD_Plk_1	635	641	PF00069	0.553
MOD_Plk_1	845	851	PF00069	0.598
MOD_Plk_2-3	300	306	PF00069	0.831
MOD_Plk_4	15	21	PF00069	0.719
MOD_Plk_4	187	193	PF00069	0.778
MOD_Plk_4	250	256	PF00069	0.499
MOD_Plk_4	258	264	PF00069	0.525
MOD_Plk_4	370	376	PF00069	0.781
MOD_Plk_4	63	69	PF00069	0.412
MOD_Plk_4	639	645	PF00069	0.424
MOD_Plk_4	771	777	PF00069	0.530
MOD_Plk_4	781	787	PF00069	0.365
MOD_Plk_4	85	91	PF00069	0.530
MOD_Plk_4	886	892	PF00069	0.433
MOD_Plk_4	899	905	PF00069	0.316
MOD_Plk_4	929	935	PF00069	0.530
MOD_ProDKin_1	128	134	PF00069	0.831
MOD_ProDKin_1	158	164	PF00069	0.685
MOD_ProDKin_1	214	220	PF00069	0.764
MOD_ProDKin_1	288	294	PF00069	0.552
MOD_ProDKin_1	363	369	PF00069	0.801
MOD_ProDKin_1	376	382	PF00069	0.567
MOD_ProDKin_1	460	466	PF00069	0.622
MOD_ProDKin_1	5	11	PF00069	0.709
MOD_ProDKin_1	617	623	PF00069	0.761
MOD_ProDKin_1	625	631	PF00069	0.646
MOD_ProDKin_1	720	726	PF00069	0.688
MOD_ProDKin_1	758	764	PF00069	0.476
MOD_SUMO_rev_2	334	344	PF00179	0.652
TRG_DiLeu_BaEn_1	846	851	PF01217	0.662
TRG_DiLeu_BaLyEn_6	507	512	PF01217	0.605
TRG_DiLeu_BaLyEn_6	827	832	PF01217	0.474
TRG_ENDOCYTIC_2	100	103	PF00928	0.647
TRG_ENDOCYTIC_2	243	246	PF00928	0.464
TRG_ER_diArg_1	104	106	PF00400	0.638
TRG_ER_diArg_1	177	180	PF00400	0.826
TRG_ER_diArg_1	229	231	PF00400	0.560
TRG_ER_diArg_1	508	510	PF00400	0.526
TRG_ER_diArg_1	680	682	PF00400	0.689
TRG_ER_diArg_1	853	855	PF00400	0.621
TRG_ER_diArg_1	942	944	PF00400	0.530
TRG_ER_diArg_1	966	969	PF00400	0.628
TRG_Pf-PMV_PEXEL_1	349	353	PF00026	0.750
TRG_Pf-PMV_PEXEL_1	509	514	PF00026	0.644
TRG_Pf-PMV_PEXEL_1	699	703	PF00026	0.755
TRG_Pf-PMV_PEXEL_1	911	915	PF00026	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A451EJH0	Leishmania donovani	99%	100%
A4H3D0	Leishmania braziliensis	59%	98%
E9ACA9	Leishmania major	85%	100%
E9AJJ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	96%