LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
NIMA/Nek Serine/threonine-protein kinase family - putative
Species:
Leishmania infantum
UniProt:
A4HRM6_LEIIN
TriTrypDb:
LINF_020007900
Length:
530

Annotations

Annotations by Jardim et al.

Protein kinase, Mitogen-activated kinase kinase kinase Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 25
NetGPI no yes: 0, no: 25
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HRM6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRM6

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 26
GO:0006793 phosphorus metabolic process 3 26
GO:0006796 phosphate-containing compound metabolic process 4 26
GO:0006807 nitrogen compound metabolic process 2 26
GO:0008152 metabolic process 1 26
GO:0009987 cellular process 1 26
GO:0016310 phosphorylation 5 26
GO:0019538 protein metabolic process 3 26
GO:0036211 protein modification process 4 26
GO:0043170 macromolecule metabolic process 3 26
GO:0043412 macromolecule modification 4 26
GO:0044237 cellular metabolic process 2 26
GO:0044238 primary metabolic process 2 26
GO:0071704 organic substance metabolic process 2 26
GO:1901564 organonitrogen compound metabolic process 3 26
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 26
GO:0003824 catalytic activity 1 26
GO:0004672 protein kinase activity 3 26
GO:0005488 binding 1 26
GO:0005524 ATP binding 5 26
GO:0016301 kinase activity 4 26
GO:0016740 transferase activity 2 26
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 26
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 26
GO:0017076 purine nucleotide binding 4 26
GO:0030554 adenyl nucleotide binding 5 26
GO:0032553 ribonucleotide binding 3 26
GO:0032555 purine ribonucleotide binding 4 26
GO:0032559 adenyl ribonucleotide binding 5 26
GO:0035639 purine ribonucleoside triphosphate binding 4 26
GO:0036094 small molecule binding 2 26
GO:0043167 ion binding 2 26
GO:0043168 anion binding 3 26
GO:0097159 organic cyclic compound binding 2 26
GO:0097367 carbohydrate derivative binding 2 26
GO:0140096 catalytic activity, acting on a protein 2 26
GO:1901265 nucleoside phosphate binding 3 26
GO:1901363 heterocyclic compound binding 2 26
GO:0004674 protein serine/threonine kinase activity 4 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 168 172 PF00656 0.326
CLV_C14_Caspase3-7 58 62 PF00656 0.499
CLV_NRD_NRD_1 256 258 PF00675 0.300
CLV_NRD_NRD_1 448 450 PF00675 0.251
CLV_PCSK_KEX2_1 256 258 PF00082 0.300
CLV_PCSK_KEX2_1 448 450 PF00082 0.241
CLV_PCSK_PC7_1 444 450 PF00082 0.247
CLV_PCSK_SKI1_1 211 215 PF00082 0.240
CLV_PCSK_SKI1_1 317 321 PF00082 0.318
CLV_PCSK_SKI1_1 427 431 PF00082 0.407
CLV_PCSK_SKI1_1 448 452 PF00082 0.263
DEG_APCC_DBOX_1 443 451 PF00400 0.243
DEG_APCC_DBOX_1 456 464 PF00400 0.394
DEG_Nend_UBRbox_2 1 3 PF02207 0.495
DEG_SIAH_1 73 81 PF03145 0.482
DOC_ANK_TNKS_1 491 498 PF00023 0.299
DOC_CDC14_PxL_1 359 367 PF14671 0.280
DOC_CYCLIN_RxL_1 387 398 PF00134 0.221
DOC_MAPK_gen_1 317 326 PF00069 0.326
DOC_USP7_MATH_1 121 125 PF00917 0.784
DOC_USP7_MATH_1 304 308 PF00917 0.337
DOC_USP7_MATH_1 46 50 PF00917 0.618
DOC_USP7_MATH_1 484 488 PF00917 0.688
DOC_USP7_MATH_1 522 526 PF00917 0.375
DOC_USP7_MATH_1 54 58 PF00917 0.660
DOC_WW_Pin1_4 266 271 PF00397 0.255
DOC_WW_Pin1_4 354 359 PF00397 0.310
DOC_WW_Pin1_4 409 414 PF00397 0.327
DOC_WW_Pin1_4 88 93 PF00397 0.675
LIG_14-3-3_CanoR_1 492 499 PF00244 0.540
LIG_14-3-3_CterR_2 526 530 PF00244 0.494
LIG_Actin_WH2_2 196 213 PF00022 0.209
LIG_Actin_WH2_2 432 450 PF00022 0.239
LIG_BRCT_BRCA1_1 425 429 PF00533 0.270
LIG_Clathr_ClatBox_1 436 440 PF01394 0.349
LIG_deltaCOP1_diTrp_1 376 384 PF00928 0.371
LIG_deltaCOP1_diTrp_1 6 10 PF00928 0.612
LIG_eIF4E_1 360 366 PF01652 0.371
LIG_FHA_1 105 111 PF00498 0.527
LIG_FHA_1 178 184 PF00498 0.283
LIG_FHA_1 330 336 PF00498 0.321
LIG_FHA_2 25 31 PF00498 0.739
LIG_FHA_2 340 346 PF00498 0.319
LIG_FHA_2 348 354 PF00498 0.203
LIG_FHA_2 56 62 PF00498 0.492
LIG_FHA_2 7 13 PF00498 0.667
LIG_HOMEOBOX 5 8 PF00046 0.511
LIG_LIR_Apic_2 357 363 PF02991 0.323
LIG_LIR_Gen_1 2 10 PF02991 0.631
LIG_LIR_Gen_1 237 245 PF02991 0.240
LIG_LIR_Gen_1 296 305 PF02991 0.298
LIG_LIR_Nem_3 146 150 PF02991 0.444
LIG_LIR_Nem_3 296 301 PF02991 0.462
LIG_LIR_Nem_3 310 315 PF02991 0.266
LIG_LIR_Nem_3 426 432 PF02991 0.270
LIG_LIR_Nem_3 496 502 PF02991 0.438
LIG_LIR_Nem_3 6 10 PF02991 0.612
LIG_LYPXL_S_1 520 524 PF13949 0.291
LIG_LYPXL_yS_3 521 524 PF13949 0.300
LIG_Rb_pABgroove_1 221 229 PF01858 0.319
LIG_SH2_CRK 312 316 PF00017 0.319
LIG_SH2_CRK 385 389 PF00017 0.239
LIG_SH2_CRK 499 503 PF00017 0.280
LIG_SH2_SRC 222 225 PF00017 0.262
LIG_SH2_SRC 462 465 PF00017 0.262
LIG_SH2_STAP1 425 429 PF00017 0.350
LIG_SH2_STAT3 128 131 PF00017 0.499
LIG_SH2_STAT3 425 428 PF00017 0.319
LIG_SH2_STAT5 222 225 PF00017 0.298
LIG_SH2_STAT5 243 246 PF00017 0.326
LIG_SH2_STAT5 455 458 PF00017 0.343
LIG_SH2_STAT5 462 465 PF00017 0.339
LIG_SH3_2 473 478 PF14604 0.358
LIG_SH3_3 229 235 PF00018 0.476
LIG_SH3_3 264 270 PF00018 0.214
LIG_SH3_3 470 476 PF00018 0.335
LIG_SUMO_SIM_par_1 272 279 PF11976 0.178
LIG_SUMO_SIM_par_1 434 440 PF11976 0.347
LIG_TRAF2_1 196 199 PF00917 0.217
LIG_TYR_ITIM 383 388 PF00017 0.286
LIG_WW_1 231 234 PF00397 0.203
MOD_CK1_1 143 149 PF00069 0.509
MOD_CK1_1 260 266 PF00069 0.340
MOD_CK1_1 269 275 PF00069 0.336
MOD_CK1_1 307 313 PF00069 0.319
MOD_CK1_1 423 429 PF00069 0.414
MOD_CK1_1 435 441 PF00069 0.234
MOD_CK1_1 466 472 PF00069 0.459
MOD_CK1_1 49 55 PF00069 0.644
MOD_CK1_1 88 94 PF00069 0.535
MOD_CK2_1 347 353 PF00069 0.340
MOD_CK2_1 395 401 PF00069 0.396
MOD_Cter_Amidation 254 257 PF01082 0.203
MOD_GlcNHglycan 12 17 PF01048 0.749
MOD_GlcNHglycan 123 126 PF01048 0.680
MOD_GlcNHglycan 132 135 PF01048 0.479
MOD_GlcNHglycan 142 145 PF01048 0.464
MOD_GlcNHglycan 173 176 PF01048 0.235
MOD_GlcNHglycan 20 23 PF01048 0.646
MOD_GlcNHglycan 259 262 PF01048 0.413
MOD_GlcNHglycan 397 400 PF01048 0.351
MOD_GlcNHglycan 480 483 PF01048 0.542
MOD_GlcNHglycan 493 496 PF01048 0.367
MOD_GlcNHglycan 82 85 PF01048 0.656
MOD_GSK3_1 226 233 PF00069 0.471
MOD_GSK3_1 255 262 PF00069 0.297
MOD_GSK3_1 265 272 PF00069 0.387
MOD_GSK3_1 275 282 PF00069 0.373
MOD_GSK3_1 431 438 PF00069 0.292
MOD_GSK3_1 522 529 PF00069 0.444
MOD_GSK3_1 55 62 PF00069 0.501
MOD_GSK3_1 80 87 PF00069 0.612
MOD_NEK2_1 226 231 PF00069 0.345
MOD_NEK2_1 275 280 PF00069 0.303
MOD_NEK2_1 338 343 PF00069 0.229
MOD_NEK2_1 432 437 PF00069 0.219
MOD_NEK2_2 162 167 PF00069 0.242
MOD_NEK2_2 293 298 PF00069 0.424
MOD_NEK2_2 304 309 PF00069 0.324
MOD_NEK2_2 94 99 PF00069 0.521
MOD_PIKK_1 339 345 PF00454 0.217
MOD_PIKK_1 510 516 PF00454 0.439
MOD_PKA_2 255 261 PF00069 0.337
MOD_PKA_2 423 429 PF00069 0.453
MOD_PKA_2 443 449 PF00069 0.304
MOD_PKA_2 456 462 PF00069 0.386
MOD_PKA_2 491 497 PF00069 0.342
MOD_PKA_2 80 86 PF00069 0.488
MOD_Plk_2-3 6 12 PF00069 0.490
MOD_Plk_4 162 168 PF00069 0.292
MOD_Plk_4 189 195 PF00069 0.350
MOD_Plk_4 234 240 PF00069 0.434
MOD_Plk_4 293 299 PF00069 0.272
MOD_Plk_4 432 438 PF00069 0.219
MOD_Plk_4 463 469 PF00069 0.359
MOD_ProDKin_1 266 272 PF00069 0.255
MOD_ProDKin_1 354 360 PF00069 0.310
MOD_ProDKin_1 409 415 PF00069 0.327
MOD_ProDKin_1 88 94 PF00069 0.680
TRG_DiLeu_BaEn_1 401 406 PF01217 0.217
TRG_ENDOCYTIC_2 312 315 PF00928 0.273
TRG_ENDOCYTIC_2 385 388 PF00928 0.308
TRG_ENDOCYTIC_2 499 502 PF00928 0.283
TRG_ENDOCYTIC_2 521 524 PF00928 0.300
TRG_ER_diArg_1 152 155 PF00400 0.275
TRG_ER_diArg_1 447 449 PF00400 0.250
TRG_NES_CRM1_1 329 343 PF08389 0.217

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2D3 Leptomonas seymouri 52% 100%
A0A0N1I9A0 Leptomonas seymouri 26% 82%
A0A0S4J757 Bodo saltans 26% 98%
A0A0S4J842 Bodo saltans 27% 99%
A0A0S4JIJ6 Bodo saltans 26% 94%
A0A0S4JMY6 Bodo saltans 24% 69%
A0A1X0NIX2 Trypanosomatidae 26% 100%
A0A1X0NKA1 Trypanosomatidae 39% 100%
A0A1X0NTN5 Trypanosomatidae 24% 70%
A0A2I0BVG8 Plasmodium falciparum (isolate NF54) 25% 100%
A0A3Q8IAQ1 Leishmania donovani 33% 100%
A0A3Q8IFK8 Leishmania donovani 28% 100%
A0A3Q8IFW0 Leishmania donovani 31% 100%
A0A3Q8IIG1 Leishmania donovani 29% 100%
A0A3Q8IIY5 Leishmania donovani 24% 100%
A0A3Q8IPJ5 Leishmania donovani 26% 100%
A0A3R7NGF4 Trypanosoma rangeli 27% 94%
A0A3S5H4Z4 Leishmania donovani 100% 100%
A0A3S5H789 Leishmania donovani 27% 100%
A0A3S7WWE7 Leishmania donovani 29% 100%
A0A3S7X6T8 Leishmania donovani 28% 100%
A0A422N701 Trypanosoma rangeli 41% 100%
A0A422NT89 Trypanosoma rangeli 23% 81%
A4H3C7 Leishmania braziliensis 77% 100%
A4HAS1 Leishmania braziliensis 24% 100%
A4HBL4 Leishmania braziliensis 28% 100%
A4HCE6 Leishmania braziliensis 30% 100%
A4HFA1 Leishmania braziliensis 26% 100%
A4HH03 Leishmania braziliensis 30% 100%
A4HHP8 Leishmania braziliensis 28% 100%
A4HJT5 Leishmania braziliensis 28% 100%
A4HJW2 Leishmania braziliensis 31% 100%
A4HLR0 Leishmania braziliensis 28% 100%
A4HYX6 Leishmania infantum 27% 100%
A4HZA2 Leishmania infantum 29% 100%
A4HZW8 Leishmania infantum 33% 100%
A4I2H8 Leishmania infantum 26% 100%
A4I435 Leishmania infantum 28% 100%
A4I7A1 Leishmania infantum 28% 100%
A4I7C4 Leishmania infantum 31% 100%
A4I960 Leishmania infantum 28% 100%
B2DD29 Rattus norvegicus 27% 68%
C9ZIZ0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
C9ZK32 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 85%
C9ZQL9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 83%
E9ACA4 Leishmania major 94% 100%
E9AE77 Leishmania major 24% 100%
E9AEB1 Leishmania major 28% 100%
E9AJJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
E9AUY2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9AVS7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9AYN8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9B0C2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9B296 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9B2B7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9B436 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
F4JBP3 Arabidopsis thaliana 28% 75%
P22209 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 25% 100%
P31748 AKT8 murine leukemia virus 25% 100%
P31749 Homo sapiens 25% 100%
P31750 Mus musculus 25% 100%
P34101 Dictyostelium discoideum 24% 89%
P47196 Rattus norvegicus 25% 100%
P49101 Zea mays 26% 100%
P51956 Homo sapiens 26% 100%
P62343 Plasmodium falciparum (isolate K1 / Thailand) 25% 100%
P62344 Plasmodium falciparum (isolate 3D7) 25% 100%
Q01314 Bos taurus 25% 100%
Q07832 Mus musculus 27% 88%
Q0VD22 Bos taurus 25% 100%
Q15349 Homo sapiens 25% 72%
Q16975 Aplysia californica 25% 71%
Q38870 Arabidopsis thaliana 25% 82%
Q4Q3Y9 Leishmania major 27% 100%
Q4Q5T9 Leishmania major 31% 100%
Q4Q5W2 Leishmania major 29% 100%
Q4Q7W2 Leishmania major 29% 100%
Q4Q8T4 Leishmania major 26% 100%
Q4QBQ2 Leishmania major 34% 100%
Q4QCK0 Leishmania major 28% 100%
Q4QEJ2 Leishmania major 26% 96%
Q5RJI5 Mus musculus 27% 68%
Q5UQ78 Acanthamoeba polyphaga mimivirus 24% 100%
Q5VQQ5 Oryza sativa subsp. japonica 28% 100%
Q6CWQ4 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 26% 100%
Q6Z2M9 Oryza sativa subsp. japonica 27% 100%
Q7XIM0 Oryza sativa subsp. japonica 29% 93%
Q852N6 Oryza sativa subsp. japonica 28% 92%
Q8TDC3 Homo sapiens 26% 68%
Q9H4B4 Homo sapiens 27% 82%
Q9NJU9 Plasmodium falciparum (isolate 3D7) 22% 94%
Q9Y6E0 Homo sapiens 26% 100%
V5BHW8 Trypanosoma cruzi 25% 84%
V5DC27 Trypanosoma cruzi 29% 90%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS