RING-type domain-containing protein

Quick info Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (many copies)/Ankyrin repeats (3 copies)/Zinc finger - C3HC4 type (RING finger) containing protein - putativ

Species:

Leishmania infantum

UniProt:

A4HRL7_LEIIN

TriTrypDb:

LINF_020006400

Length:

611

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0110165	cellular anatomical entity	1	1

Phosphorylation

Amastigote: 5

Expansion

Sequence features

A4HRL7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRL7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016740	transferase activity	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	402	406	PF00656	0.712
CLV_C14_Caspase3-7	519	523	PF00656	0.676
CLV_C14_Caspase3-7	84	88	PF00656	0.765
CLV_NRD_NRD_1	161	163	PF00675	0.455
CLV_NRD_NRD_1	19	21	PF00675	0.674
CLV_PCSK_KEX2_1	161	163	PF00082	0.458
CLV_PCSK_KEX2_1	248	250	PF00082	0.539
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.585
CLV_PCSK_SKI1_1	243	247	PF00082	0.587
CLV_PCSK_SKI1_1	474	478	PF00082	0.545
CLV_PCSK_SKI1_1	566	570	PF00082	0.389
CLV_PCSK_SKI1_1	59	63	PF00082	0.463
CLV_Separin_Metazoa	447	451	PF03568	0.503
DEG_Kelch_Keap1_1	438	443	PF01344	0.485
DEG_Nend_UBRbox_1	1	4	PF02207	0.486
DEG_SPOP_SBC_1	516	520	PF00917	0.529
DOC_CDC14_PxL_1	197	205	PF14671	0.420
DOC_CKS1_1	13	18	PF01111	0.675
DOC_CKS1_1	71	76	PF01111	0.403
DOC_CYCLIN_yCln2_LP_2	13	19	PF00134	0.691
DOC_MAPK_DCC_7	195	205	PF00069	0.501
DOC_MAPK_gen_1	144	151	PF00069	0.522
DOC_MAPK_gen_1	277	286	PF00069	0.554
DOC_PP2B_LxvP_1	203	206	PF13499	0.503
DOC_PP2B_LxvP_1	295	298	PF13499	0.653
DOC_PP4_FxxP_1	117	120	PF00568	0.683
DOC_PP4_FxxP_1	525	528	PF00568	0.706
DOC_PP4_FxxP_1	594	597	PF00568	0.444
DOC_USP7_MATH_1	123	127	PF00917	0.735
DOC_USP7_MATH_1	206	210	PF00917	0.504
DOC_USP7_MATH_1	216	220	PF00917	0.514
DOC_USP7_MATH_1	247	251	PF00917	0.624
DOC_USP7_MATH_1	4	8	PF00917	0.586
DOC_USP7_MATH_1	419	423	PF00917	0.771
DOC_USP7_MATH_1	458	462	PF00917	0.523
DOC_USP7_MATH_1	547	551	PF00917	0.708
DOC_USP7_MATH_1	85	89	PF00917	0.765
DOC_USP7_MATH_1	98	102	PF00917	0.647
DOC_WW_Pin1_4	12	17	PF00397	0.674
DOC_WW_Pin1_4	127	132	PF00397	0.757
DOC_WW_Pin1_4	307	312	PF00397	0.731
DOC_WW_Pin1_4	324	329	PF00397	0.417
DOC_WW_Pin1_4	359	364	PF00397	0.561
DOC_WW_Pin1_4	395	400	PF00397	0.490
DOC_WW_Pin1_4	488	493	PF00397	0.741
DOC_WW_Pin1_4	524	529	PF00397	0.670
DOC_WW_Pin1_4	70	75	PF00397	0.408
LIG_14-3-3_CanoR_1	124	131	PF00244	0.790
LIG_14-3-3_CanoR_1	301	311	PF00244	0.679
LIG_14-3-3_CanoR_1	450	456	PF00244	0.495
LIG_14-3-3_CanoR_1	549	557	PF00244	0.485
LIG_14-3-3_CanoR_1	584	593	PF00244	0.403
LIG_Actin_WH2_2	458	476	PF00022	0.522
LIG_APCC_ABBA_1	284	289	PF00400	0.557
LIG_BRCT_BRCA1_1	208	212	PF00533	0.516
LIG_BRCT_BRCA1_1	6	10	PF00533	0.674
LIG_EH1_1	55	63	PF00400	0.506
LIG_FHA_1	184	190	PF00498	0.565
LIG_FHA_1	340	346	PF00498	0.625
LIG_FHA_1	399	405	PF00498	0.624
LIG_FHA_1	439	445	PF00498	0.494
LIG_FHA_1	516	522	PF00498	0.604
LIG_FHA_1	71	77	PF00498	0.400
LIG_FHA_2	400	406	PF00498	0.617
LIG_LIR_Apic_2	164	168	PF02991	0.455
LIG_LIR_Apic_2	207	213	PF02991	0.547
LIG_LIR_Apic_2	522	528	PF02991	0.708
LIG_LIR_Apic_2	591	597	PF02991	0.444
LIG_LIR_Apic_2	69	74	PF02991	0.478
LIG_LIR_Gen_1	179	189	PF02991	0.494
LIG_LIR_Gen_1	443	451	PF02991	0.484
LIG_LIR_Gen_1	461	469	PF02991	0.506
LIG_LIR_Gen_1	7	17	PF02991	0.680
LIG_LIR_Nem_3	179	185	PF02991	0.488
LIG_LIR_Nem_3	443	448	PF02991	0.598
LIG_LIR_Nem_3	45	50	PF02991	0.477
LIG_LIR_Nem_3	461	466	PF02991	0.473
LIG_LIR_Nem_3	551	557	PF02991	0.466
LIG_LIR_Nem_3	69	75	PF02991	0.512
LIG_LIR_Nem_3	7	13	PF02991	0.706
LIG_PCNA_yPIPBox_3	338	351	PF02747	0.491
LIG_PDZ_Class_2	606	611	PF00595	0.561
LIG_SH2_CRK	182	186	PF00017	0.474
LIG_SH2_CRK	210	214	PF00017	0.559
LIG_SH2_CRK	384	388	PF00017	0.529
LIG_SH2_CRK	463	467	PF00017	0.507
LIG_SH2_CRK	72	76	PF00017	0.398
LIG_SH2_NCK_1	384	388	PF00017	0.570
LIG_SH2_PTP2	165	168	PF00017	0.446
LIG_SH2_PTP2	283	286	PF00017	0.521
LIG_SH2_SRC	165	168	PF00017	0.421
LIG_SH2_SRC	23	26	PF00017	0.616
LIG_SH2_SRC	273	276	PF00017	0.568
LIG_SH2_SRC	283	286	PF00017	0.492
LIG_SH2_STAP1	303	307	PF00017	0.736
LIG_SH2_STAP1	463	467	PF00017	0.495
LIG_SH2_STAT3	557	560	PF00017	0.444
LIG_SH2_STAT5	140	143	PF00017	0.659
LIG_SH2_STAT5	165	168	PF00017	0.421
LIG_SH2_STAT5	188	191	PF00017	0.472
LIG_SH2_STAT5	273	276	PF00017	0.573
LIG_SH2_STAT5	283	286	PF00017	0.478
LIG_SH2_STAT5	391	394	PF00017	0.396
LIG_SH2_STAT5	49	52	PF00017	0.491
LIG_SH2_STAT5	554	557	PF00017	0.450
LIG_SH2_STAT5	64	67	PF00017	0.326
LIG_SH2_STAT5	72	75	PF00017	0.397
LIG_SH3_1	210	216	PF00018	0.566
LIG_SH3_2	16	21	PF14604	0.672
LIG_SH3_2	561	566	PF14604	0.369
LIG_SH3_3	108	114	PF00018	0.648
LIG_SH3_3	13	19	PF00018	0.730
LIG_SH3_3	210	216	PF00018	0.566
LIG_SH3_3	558	564	PF00018	0.443
LIG_SH3_3	76	82	PF00018	0.582
LIG_SUMO_SIM_par_1	201	209	PF11976	0.534
LIG_SUMO_SIM_par_1	73	78	PF11976	0.412
LIG_TRAF2_1	494	497	PF00917	0.754
LIG_TYR_ITIM	281	286	PF00017	0.515
LIG_TYR_ITIM	70	75	PF00017	0.433
LIG_WRC_WIRS_1	477	482	PF05994	0.561
LIG_WW_3	386	390	PF00397	0.446
MOD_CDC14_SPxK_1	362	365	PF00782	0.604
MOD_CDK_SPxK_1	12	18	PF00069	0.676
MOD_CDK_SPxK_1	359	365	PF00069	0.572
MOD_CDK_SPxxK_3	488	495	PF00069	0.707
MOD_CK1_1	126	132	PF00069	0.765
MOD_CK1_1	223	229	PF00069	0.634
MOD_CK1_1	327	333	PF00069	0.756
MOD_CK1_1	398	404	PF00069	0.551
MOD_CK1_1	422	428	PF00069	0.679
MOD_CK1_1	452	458	PF00069	0.498
MOD_CK1_1	488	494	PF00069	0.625
MOD_CK1_1	500	506	PF00069	0.741
MOD_CK1_1	527	533	PF00069	0.695
MOD_CK1_1	537	543	PF00069	0.605
MOD_GlcNHglycan	100	103	PF01048	0.565
MOD_GlcNHglycan	169	172	PF01048	0.463
MOD_GlcNHglycan	223	226	PF01048	0.662
MOD_GlcNHglycan	249	252	PF01048	0.540
MOD_GlcNHglycan	319	322	PF01048	0.664
MOD_GlcNHglycan	329	332	PF01048	0.739
MOD_GlcNHglycan	408	411	PF01048	0.698
MOD_GlcNHglycan	421	424	PF01048	0.537
MOD_GlcNHglycan	458	461	PF01048	0.569
MOD_GlcNHglycan	487	490	PF01048	0.597
MOD_GlcNHglycan	500	503	PF01048	0.756
MOD_GlcNHglycan	536	539	PF01048	0.739
MOD_GlcNHglycan	542	546	PF01048	0.716
MOD_GlcNHglycan	551	554	PF01048	0.625
MOD_GlcNHglycan	6	9	PF01048	0.740
MOD_GlcNHglycan	83	86	PF01048	0.708
MOD_GlcNHglycan	93	96	PF01048	0.689
MOD_GSK3_1	123	130	PF00069	0.774
MOD_GSK3_1	216	223	PF00069	0.559
MOD_GSK3_1	303	310	PF00069	0.673
MOD_GSK3_1	317	324	PF00069	0.562
MOD_GSK3_1	395	402	PF00069	0.438
MOD_GSK3_1	4	11	PF00069	0.742
MOD_GSK3_1	418	425	PF00069	0.749
MOD_GSK3_1	452	459	PF00069	0.528
MOD_GSK3_1	476	483	PF00069	0.497
MOD_GSK3_1	537	544	PF00069	0.694
MOD_GSK3_1	62	69	PF00069	0.531
MOD_GSK3_1	81	88	PF00069	0.448
MOD_N-GLC_1	216	221	PF02516	0.495
MOD_N-GLC_1	456	461	PF02516	0.438
MOD_NEK2_1	157	162	PF00069	0.456
MOD_NEK2_1	221	226	PF00069	0.642
MOD_NEK2_1	480	485	PF00069	0.529
MOD_NEK2_1	529	534	PF00069	0.675
MOD_NEK2_2	458	463	PF00069	0.535
MOD_NEK2_2	66	71	PF00069	0.581
MOD_PIKK_1	123	129	PF00454	0.729
MOD_PIKK_1	216	222	PF00454	0.583
MOD_PIKK_1	339	345	PF00454	0.658
MOD_PIKK_1	449	455	PF00454	0.563
MOD_PIKK_1	527	533	PF00454	0.702
MOD_PKA_2	123	129	PF00069	0.714
MOD_PKA_2	438	444	PF00069	0.552
MOD_PKA_2	449	455	PF00069	0.506
MOD_PKA_2	548	554	PF00069	0.682
MOD_PKA_2	66	72	PF00069	0.548
MOD_Plk_1	216	222	PF00069	0.516
MOD_Plk_1	261	267	PF00069	0.514
MOD_Plk_4	399	405	PF00069	0.557
MOD_Plk_4	458	464	PF00069	0.437
MOD_Plk_4	480	486	PF00069	0.510
MOD_Plk_4	66	72	PF00069	0.582
MOD_ProDKin_1	12	18	PF00069	0.676
MOD_ProDKin_1	127	133	PF00069	0.755
MOD_ProDKin_1	307	313	PF00069	0.728
MOD_ProDKin_1	324	330	PF00069	0.418
MOD_ProDKin_1	359	365	PF00069	0.572
MOD_ProDKin_1	395	401	PF00069	0.499
MOD_ProDKin_1	488	494	PF00069	0.743
MOD_ProDKin_1	524	530	PF00069	0.674
MOD_ProDKin_1	70	76	PF00069	0.408
MOD_SUMO_rev_2	288	293	PF00179	0.631
TRG_DiLeu_BaLyEn_6	199	204	PF01217	0.515
TRG_ENDOCYTIC_2	182	185	PF00928	0.477
TRG_ENDOCYTIC_2	283	286	PF00928	0.497
TRG_ENDOCYTIC_2	463	466	PF00928	0.457
TRG_ENDOCYTIC_2	72	75	PF00928	0.397
TRG_ER_diArg_1	17	20	PF00400	0.695
TRG_NES_CRM1_1	183	198	PF08389	0.517
TRG_Pf-PMV_PEXEL_1	356	360	PF00026	0.356
TRG_Pf-PMV_PEXEL_1	566	570	PF00026	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB49	Leptomonas seymouri	59%	70%
A0A1X0NJS7	Trypanosomatidae	27%	72%
A0A3R7M1K8	Trypanosoma rangeli	28%	81%
A0A3S7WNL7	Leishmania donovani	100%	68%
A4H3A8	Leishmania braziliensis	71%	100%
C9ZJ09	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	90%
E9AC88	Leishmania major	91%	100%
E9AJI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%