Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HRL3_LEIIN

TriTrypDb:

LINF_020006000

Length:

918

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HRL3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRL3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	243	247	PF00656	0.667
CLV_C14_Caspase3-7	365	369	PF00656	0.752
CLV_C14_Caspase3-7	435	439	PF00656	0.497
CLV_C14_Caspase3-7	446	450	PF00656	0.502
CLV_NRD_NRD_1	249	251	PF00675	0.824
CLV_NRD_NRD_1	912	914	PF00675	0.648
CLV_PCSK_KEX2_1	248	250	PF00082	0.828
CLV_PCSK_KEX2_1	642	644	PF00082	0.567
CLV_PCSK_KEX2_1	912	914	PF00082	0.642
CLV_PCSK_PC1ET2_1	642	644	PF00082	0.567
CLV_PCSK_SKI1_1	783	787	PF00082	0.653
CLV_PCSK_SKI1_1	854	858	PF00082	0.650
DEG_SCF_TRCP1_1	74	80	PF00400	0.675
DEG_SPOP_SBC_1	211	215	PF00917	0.743
DEG_SPOP_SBC_1	36	40	PF00917	0.821
DEG_SPOP_SBC_1	678	682	PF00917	0.569
DOC_CKS1_1	216	221	PF01111	0.653
DOC_CKS1_1	371	376	PF01111	0.755
DOC_CKS1_1	858	863	PF01111	0.647
DOC_CYCLIN_RxL_1	849	860	PF00134	0.652
DOC_CYCLIN_yCln2_LP_2	753	759	PF00134	0.722
DOC_MAPK_gen_1	482	490	PF00069	0.446
DOC_MAPK_gen_1	849	858	PF00069	0.653
DOC_MAPK_MEF2A_6	663	672	PF00069	0.555
DOC_PP2B_LxvP_1	743	746	PF13499	0.738
DOC_PP2B_LxvP_1	79	82	PF13499	0.815
DOC_USP7_MATH_1	116	120	PF00917	0.733
DOC_USP7_MATH_1	143	147	PF00917	0.692
DOC_USP7_MATH_1	211	215	PF00917	0.799
DOC_USP7_MATH_1	253	257	PF00917	0.820
DOC_USP7_MATH_1	295	299	PF00917	0.790
DOC_USP7_MATH_1	309	313	PF00917	0.595
DOC_USP7_MATH_1	333	337	PF00917	0.748
DOC_USP7_MATH_1	362	366	PF00917	0.730
DOC_USP7_MATH_1	419	423	PF00917	0.634
DOC_USP7_MATH_1	424	428	PF00917	0.490
DOC_USP7_MATH_1	465	469	PF00917	0.633
DOC_USP7_MATH_1	678	682	PF00917	0.569
DOC_USP7_MATH_1	72	76	PF00917	0.825
DOC_USP7_MATH_1	766	770	PF00917	0.672
DOC_USP7_MATH_1	94	98	PF00917	0.646
DOC_USP7_MATH_2	148	154	PF00917	0.667
DOC_WW_Pin1_4	139	144	PF00397	0.717
DOC_WW_Pin1_4	215	220	PF00397	0.654
DOC_WW_Pin1_4	254	259	PF00397	0.817
DOC_WW_Pin1_4	370	375	PF00397	0.750
DOC_WW_Pin1_4	44	49	PF00397	0.732
DOC_WW_Pin1_4	589	594	PF00397	0.585
DOC_WW_Pin1_4	62	67	PF00397	0.829
DOC_WW_Pin1_4	857	862	PF00397	0.649
LIG_14-3-3_CanoR_1	171	179	PF00244	0.656
LIG_14-3-3_CanoR_1	210	219	PF00244	0.736
LIG_14-3-3_CanoR_1	250	258	PF00244	0.677
LIG_14-3-3_CanoR_1	482	490	PF00244	0.454
LIG_14-3-3_CanoR_1	520	530	PF00244	0.594
LIG_14-3-3_CanoR_1	567	571	PF00244	0.641
LIG_14-3-3_CanoR_1	57	66	PF00244	0.832
LIG_14-3-3_CanoR_1	78	82	PF00244	0.682
LIG_BIR_III_4	617	621	PF00653	0.581
LIG_BIR_III_4	694	698	PF00653	0.626
LIG_BRCT_BRCA1_1	295	299	PF00533	0.670
LIG_BRCT_BRCA1_1	649	653	PF00533	0.585
LIG_EH1_1	651	659	PF00400	0.414
LIG_EVH1_1	743	747	PF00568	0.631
LIG_FHA_1	31	37	PF00498	0.716
LIG_FHA_1	432	438	PF00498	0.632
LIG_FHA_1	550	556	PF00498	0.553
LIG_FHA_1	575	581	PF00498	0.476
LIG_FHA_1	626	632	PF00498	0.558
LIG_FHA_1	678	684	PF00498	0.573
LIG_FHA_2	241	247	PF00498	0.664
LIG_FHA_2	734	740	PF00498	0.723
LIG_IBAR_NPY_1	54	56	PF08397	0.820
LIG_LIR_LC3C_4	534	537	PF02991	0.473
LIG_LIR_Nem_3	569	575	PF02991	0.604
LIG_LYPXL_S_1	800	804	PF13949	0.748
LIG_LYPXL_yS_3	572	575	PF13949	0.576
LIG_LYPXL_yS_3	801	804	PF13949	0.749
LIG_MYND_1	379	383	PF01753	0.670
LIG_MYND_1	405	409	PF01753	0.686
LIG_MYND_1	593	597	PF01753	0.418
LIG_PROFILIN_1	744	750	PF00235	0.623
LIG_REV1ctd_RIR_1	832	842	PF16727	0.643
LIG_SH2_CRK	138	142	PF00017	0.675
LIG_SH2_CRK	497	501	PF00017	0.578
LIG_SH2_CRK	56	60	PF00017	0.687
LIG_SH2_CRK	611	615	PF00017	0.478
LIG_SH2_NCK_1	222	226	PF00017	0.783
LIG_SH2_SRC	394	397	PF00017	0.688
LIG_SH2_SRC	531	534	PF00017	0.472
LIG_SH2_STAP1	473	477	PF00017	0.470
LIG_SH2_STAT3	123	126	PF00017	0.825
LIG_SH2_STAT3	396	399	PF00017	0.721
LIG_SH2_STAT5	138	141	PF00017	0.676
LIG_SH2_STAT5	518	521	PF00017	0.488
LIG_SH2_STAT5	531	534	PF00017	0.358
LIG_SH3_1	742	748	PF00018	0.637
LIG_SH3_3	213	219	PF00018	0.657
LIG_SH3_3	336	342	PF00018	0.786
LIG_SH3_3	368	374	PF00018	0.819
LIG_SH3_3	459	465	PF00018	0.650
LIG_SH3_3	580	586	PF00018	0.569
LIG_SH3_3	662	668	PF00018	0.694
LIG_SH3_3	683	689	PF00018	0.572
LIG_SH3_3	722	728	PF00018	0.700
LIG_SH3_3	741	747	PF00018	0.502
LIG_SH3_3	855	861	PF00018	0.647
LIG_SH3_3	862	868	PF00018	0.593
LIG_SH3_3	869	875	PF00018	0.531
LIG_SUMO_SIM_anti_2	180	185	PF11976	0.749
LIG_SUMO_SIM_anti_2	191	198	PF11976	0.665
LIG_SUMO_SIM_anti_2	860	867	PF11976	0.666
LIG_SUMO_SIM_par_1	284	290	PF11976	0.634
LIG_SUMO_SIM_par_1	30	40	PF11976	0.662
LIG_SUMO_SIM_par_1	670	675	PF11976	0.562
LIG_SUMO_SIM_par_1	854	860	PF11976	0.649
LIG_SxIP_EBH_1	651	663	PF03271	0.440
LIG_TRAF2_1	736	739	PF00917	0.780
LIG_TYR_ITIM	495	500	PF00017	0.589
LIG_TYR_ITIM	570	575	PF00017	0.595
LIG_WW_2	668	671	PF00397	0.686
MOD_CDK_SPK_2	139	144	PF00069	0.812
MOD_CDK_SPK_2	66	71	PF00069	0.827
MOD_CK1_1	109	115	PF00069	0.652
MOD_CK1_1	119	125	PF00069	0.653
MOD_CK1_1	130	136	PF00069	0.564
MOD_CK1_1	142	148	PF00069	0.616
MOD_CK1_1	153	159	PF00069	0.729
MOD_CK1_1	163	169	PF00069	0.628
MOD_CK1_1	214	220	PF00069	0.798
MOD_CK1_1	221	227	PF00069	0.675
MOD_CK1_1	251	257	PF00069	0.821
MOD_CK1_1	300	306	PF00069	0.656
MOD_CK1_1	312	318	PF00069	0.578
MOD_CK1_1	344	350	PF00069	0.839
MOD_CK1_1	39	45	PF00069	0.824
MOD_CK1_1	468	474	PF00069	0.595
MOD_CK1_1	538	544	PF00069	0.619
MOD_CK1_1	549	555	PF00069	0.500
MOD_CK1_1	60	66	PF00069	0.683
MOD_CK1_1	677	683	PF00069	0.568
MOD_CK1_1	705	711	PF00069	0.635
MOD_CK2_1	114	120	PF00069	0.803
MOD_CK2_1	295	301	PF00069	0.646
MOD_CK2_1	344	350	PF00069	0.839
MOD_CK2_1	496	502	PF00069	0.592
MOD_CK2_1	733	739	PF00069	0.722
MOD_GlcNHglycan	113	116	PF01048	0.658
MOD_GlcNHglycan	132	135	PF01048	0.638
MOD_GlcNHglycan	156	159	PF01048	0.821
MOD_GlcNHglycan	165	168	PF01048	0.751
MOD_GlcNHglycan	173	176	PF01048	0.498
MOD_GlcNHglycan	190	193	PF01048	0.635
MOD_GlcNHglycan	250	253	PF01048	0.797
MOD_GlcNHglycan	266	269	PF01048	0.563
MOD_GlcNHglycan	295	298	PF01048	0.641
MOD_GlcNHglycan	315	318	PF01048	0.659
MOD_GlcNHglycan	360	363	PF01048	0.740
MOD_GlcNHglycan	39	42	PF01048	0.723
MOD_GlcNHglycan	421	424	PF01048	0.725
MOD_GlcNHglycan	445	448	PF01048	0.531
MOD_GlcNHglycan	524	527	PF01048	0.508
MOD_GlcNHglycan	552	555	PF01048	0.690
MOD_GlcNHglycan	614	617	PF01048	0.654
MOD_GlcNHglycan	675	679	PF01048	0.674
MOD_GlcNHglycan	704	707	PF01048	0.662
MOD_GlcNHglycan	73	77	PF01048	0.807
MOD_GlcNHglycan	753	756	PF01048	0.746
MOD_GlcNHglycan	788	791	PF01048	0.642
MOD_GlcNHglycan	88	91	PF01048	0.537
MOD_GlcNHglycan	885	888	PF01048	0.637
MOD_GlcNHglycan	92	95	PF01048	0.618
MOD_GSK3_1	126	133	PF00069	0.811
MOD_GSK3_1	139	146	PF00069	0.599
MOD_GSK3_1	150	157	PF00069	0.713
MOD_GSK3_1	159	166	PF00069	0.557
MOD_GSK3_1	184	191	PF00069	0.658
MOD_GSK3_1	206	213	PF00069	0.679
MOD_GSK3_1	214	221	PF00069	0.643
MOD_GSK3_1	240	247	PF00069	0.664
MOD_GSK3_1	293	300	PF00069	0.708
MOD_GSK3_1	309	316	PF00069	0.644
MOD_GSK3_1	325	332	PF00069	0.570
MOD_GSK3_1	333	340	PF00069	0.678
MOD_GSK3_1	341	348	PF00069	0.545
MOD_GSK3_1	35	42	PF00069	0.744
MOD_GSK3_1	358	365	PF00069	0.581
MOD_GSK3_1	366	373	PF00069	0.706
MOD_GSK3_1	424	431	PF00069	0.569
MOD_GSK3_1	468	475	PF00069	0.599
MOD_GSK3_1	531	538	PF00069	0.497
MOD_GSK3_1	546	553	PF00069	0.417
MOD_GSK3_1	57	64	PF00069	0.694
MOD_GSK3_1	670	677	PF00069	0.562
MOD_GSK3_1	77	84	PF00069	0.707
MOD_GSK3_1	86	93	PF00069	0.756
MOD_LATS_1	480	486	PF00433	0.462
MOD_N-GLC_1	171	176	PF02516	0.648
MOD_N-GLC_1	589	594	PF02516	0.482
MOD_N-GLC_1	766	771	PF02516	0.673
MOD_N-GLC_1	774	779	PF02516	0.648
MOD_N-GLC_1	786	791	PF02516	0.574
MOD_N-GLC_1	90	95	PF02516	0.653
MOD_NEK2_1	152	157	PF00069	0.826
MOD_NEK2_1	229	234	PF00069	0.765
MOD_NEK2_1	23	28	PF00069	0.642
MOD_NEK2_1	286	291	PF00069	0.680
MOD_NEK2_1	299	304	PF00069	0.593
MOD_NEK2_1	313	318	PF00069	0.564
MOD_NEK2_1	428	433	PF00069	0.629
MOD_NEK2_1	535	540	PF00069	0.640
MOD_NEK2_1	647	652	PF00069	0.574
MOD_NEK2_1	653	658	PF00069	0.458
MOD_NEK2_1	679	684	PF00069	0.576
MOD_NEK2_1	85	90	PF00069	0.659
MOD_OFUCOSY	645	651	PF10250	0.564
MOD_PIKK_1	143	149	PF00454	0.652
MOD_PIKK_1	428	434	PF00454	0.630
MOD_PIKK_1	465	471	PF00454	0.622
MOD_PIKK_1	538	544	PF00454	0.619
MOD_PIKK_1	623	629	PF00454	0.630
MOD_PIKK_1	774	780	PF00454	0.798
MOD_PIKK_1	873	879	PF00454	0.649
MOD_PIKK_1	94	100	PF00454	0.660
MOD_PK_1	341	347	PF00069	0.684
MOD_PKA_1	248	254	PF00069	0.825
MOD_PKA_2	109	115	PF00069	0.651
MOD_PKA_2	153	159	PF00069	0.789
MOD_PKA_2	170	176	PF00069	0.637
MOD_PKA_2	248	254	PF00069	0.825
MOD_PKA_2	337	343	PF00069	0.830
MOD_PKA_2	521	527	PF00069	0.611
MOD_PKA_2	566	572	PF00069	0.505
MOD_PKA_2	77	83	PF00069	0.724
MOD_PKB_1	208	216	PF00069	0.656
MOD_PKB_1	441	449	PF00069	0.572
MOD_PKB_1	520	528	PF00069	0.470
MOD_Plk_1	119	125	PF00069	0.667
MOD_Plk_1	30	36	PF00069	0.652
MOD_Plk_1	300	306	PF00069	0.656
MOD_Plk_1	546	552	PF00069	0.504
MOD_Plk_1	674	680	PF00069	0.502
MOD_Plk_1	738	744	PF00069	0.668
MOD_Plk_2-3	30	36	PF00069	0.652
MOD_Plk_4	136	142	PF00069	0.819
MOD_Plk_4	341	347	PF00069	0.684
MOD_Plk_4	468	474	PF00069	0.391
MOD_Plk_4	531	537	PF00069	0.597
MOD_Plk_4	653	659	PF00069	0.556
MOD_Plk_4	81	87	PF00069	0.649
MOD_ProDKin_1	139	145	PF00069	0.715
MOD_ProDKin_1	215	221	PF00069	0.653
MOD_ProDKin_1	254	260	PF00069	0.817
MOD_ProDKin_1	370	376	PF00069	0.752
MOD_ProDKin_1	44	50	PF00069	0.733
MOD_ProDKin_1	589	595	PF00069	0.582
MOD_ProDKin_1	62	68	PF00069	0.829
MOD_ProDKin_1	857	863	PF00069	0.649
MOD_SUMO_for_1	483	486	PF00179	0.522
MOD_SUMO_rev_2	30	39	PF00179	0.588
TRG_DiLeu_BaLyEn_6	282	287	PF01217	0.635
TRG_DiLeu_BaLyEn_6	852	857	PF01217	0.654
TRG_DiLeu_BaLyEn_6	876	881	PF01217	0.620
TRG_ENDOCYTIC_2	138	141	PF00928	0.676
TRG_ENDOCYTIC_2	497	500	PF00928	0.521
TRG_ENDOCYTIC_2	56	59	PF00928	0.688
TRG_ENDOCYTIC_2	572	575	PF00928	0.576
TRG_ENDOCYTIC_2	611	614	PF00928	0.478
TRG_ENDOCYTIC_2	801	804	PF00928	0.708
TRG_ER_diArg_1	248	250	PF00400	0.751
TRG_ER_diArg_1	507	510	PF00400	0.483
TRG_ER_diArg_1	519	522	PF00400	0.373
TRG_ER_diArg_1	631	634	PF00400	0.626
TRG_ER_diArg_1	911	913	PF00400	0.654

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H4Y2	Leishmania donovani	99%	94%
E8NHD4	Leishmania braziliensis	57%	100%
E9AI19	Leishmania braziliensis	57%	100%