LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HRL2_LEIIN
TriTrypDb:
LINF_020005900
Length:
354

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 10
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HRL2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRL2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 151 155 PF00656 0.538
CLV_NRD_NRD_1 118 120 PF00675 0.411
CLV_NRD_NRD_1 301 303 PF00675 0.412
CLV_NRD_NRD_1 69 71 PF00675 0.583
CLV_NRD_NRD_1 74 76 PF00675 0.522
CLV_NRD_NRD_1 8 10 PF00675 0.570
CLV_PCSK_KEX2_1 117 119 PF00082 0.421
CLV_PCSK_KEX2_1 351 353 PF00082 0.604
CLV_PCSK_KEX2_1 69 71 PF00082 0.578
CLV_PCSK_KEX2_1 73 75 PF00082 0.537
CLV_PCSK_PC1ET2_1 117 119 PF00082 0.548
CLV_PCSK_PC1ET2_1 351 353 PF00082 0.606
CLV_PCSK_PC7_1 69 75 PF00082 0.640
CLV_PCSK_SKI1_1 111 115 PF00082 0.559
CLV_PCSK_SKI1_1 15 19 PF00082 0.409
DEG_SPOP_SBC_1 321 325 PF00917 0.522
DOC_CKS1_1 333 338 PF01111 0.635
DOC_MAPK_gen_1 73 84 PF00069 0.529
DOC_MAPK_MEF2A_6 78 86 PF00069 0.459
DOC_PP2B_LxvP_1 168 171 PF13499 0.509
DOC_USP7_MATH_1 162 166 PF00917 0.457
DOC_USP7_MATH_1 228 232 PF00917 0.443
DOC_USP7_MATH_1 321 325 PF00917 0.641
DOC_USP7_MATH_1 342 346 PF00917 0.633
DOC_USP7_MATH_1 46 50 PF00917 0.581
DOC_USP7_UBL2_3 29 33 PF12436 0.512
DOC_USP7_UBL2_3 59 63 PF12436 0.593
DOC_WW_Pin1_4 145 150 PF00397 0.549
DOC_WW_Pin1_4 226 231 PF00397 0.548
DOC_WW_Pin1_4 332 337 PF00397 0.699
LIG_14-3-3_CanoR_1 223 230 PF00244 0.503
LIG_14-3-3_CanoR_1 73 82 PF00244 0.491
LIG_BRCT_BRCA1_1 21 25 PF00533 0.492
LIG_FHA_1 264 270 PF00498 0.442
LIG_FHA_1 279 285 PF00498 0.355
LIG_FHA_1 99 105 PF00498 0.578
LIG_FHA_2 146 152 PF00498 0.526
LIG_FHA_2 204 210 PF00498 0.478
LIG_FHA_2 231 237 PF00498 0.537
LIG_FHA_2 62 68 PF00498 0.611
LIG_Integrin_isoDGR_2 37 39 PF01839 0.575
LIG_LIR_Gen_1 131 142 PF02991 0.330
LIG_LIR_Gen_1 208 218 PF02991 0.390
LIG_LIR_Gen_1 22 30 PF02991 0.489
LIG_LIR_Gen_1 81 90 PF02991 0.428
LIG_LIR_Nem_3 131 137 PF02991 0.307
LIG_LIR_Nem_3 208 213 PF02991 0.409
LIG_LIR_Nem_3 22 28 PF02991 0.402
LIG_LIR_Nem_3 295 300 PF02991 0.430
LIG_LIR_Nem_3 5 11 PF02991 0.508
LIG_LIR_Nem_3 81 86 PF02991 0.439
LIG_NRP_CendR_1 351 354 PF00754 0.713
LIG_Pex14_2 293 297 PF04695 0.431
LIG_SH2_NCK_1 161 165 PF00017 0.358
LIG_SH2_SRC 129 132 PF00017 0.429
LIG_SH2_STAT5 129 132 PF00017 0.404
LIG_SH2_STAT5 156 159 PF00017 0.369
LIG_SH2_STAT5 203 206 PF00017 0.568
LIG_SH2_STAT5 224 227 PF00017 0.372
LIG_SH2_STAT5 237 240 PF00017 0.512
LIG_SH2_STAT5 292 295 PF00017 0.414
LIG_SH3_3 55 61 PF00018 0.649
LIG_UBA3_1 17 23 PF00899 0.390
LIG_UBA3_1 24 33 PF00899 0.450
MOD_CK1_1 19 25 PF00069 0.494
MOD_CK1_1 324 330 PF00069 0.694
MOD_CK1_1 94 100 PF00069 0.616
MOD_CK2_1 145 151 PF00069 0.487
MOD_CK2_1 203 209 PF00069 0.451
MOD_Cter_Amidation 347 350 PF01082 0.685
MOD_GlcNHglycan 108 111 PF01048 0.552
MOD_GlcNHglycan 131 134 PF01048 0.429
MOD_GlcNHglycan 186 189 PF01048 0.534
MOD_GlcNHglycan 226 229 PF01048 0.483
MOD_GlcNHglycan 230 233 PF01048 0.502
MOD_GlcNHglycan 304 308 PF01048 0.517
MOD_GlcNHglycan 337 340 PF01048 0.604
MOD_GSK3_1 141 148 PF00069 0.551
MOD_GSK3_1 180 187 PF00069 0.523
MOD_GSK3_1 201 208 PF00069 0.515
MOD_GSK3_1 224 231 PF00069 0.501
MOD_GSK3_1 278 285 PF00069 0.399
MOD_GSK3_1 320 327 PF00069 0.643
MOD_GSK3_1 331 338 PF00069 0.572
MOD_GSK3_1 61 68 PF00069 0.622
MOD_GSK3_1 69 76 PF00069 0.542
MOD_GSK3_1 94 101 PF00069 0.523
MOD_N-GLC_1 342 347 PF02516 0.658
MOD_NEK2_1 180 185 PF00069 0.519
MOD_NEK2_1 305 310 PF00069 0.489
MOD_PIKK_1 272 278 PF00454 0.523
MOD_PIKK_1 73 79 PF00454 0.663
MOD_PK_1 78 84 PF00069 0.565
MOD_PKA_1 69 75 PF00069 0.571
MOD_PKA_2 106 112 PF00069 0.496
MOD_PKA_2 272 278 PF00069 0.425
MOD_PKA_2 69 75 PF00069 0.579
MOD_Plk_1 201 207 PF00069 0.551
MOD_Plk_4 78 84 PF00069 0.442
MOD_ProDKin_1 145 151 PF00069 0.550
MOD_ProDKin_1 226 232 PF00069 0.549
MOD_ProDKin_1 332 338 PF00069 0.699
TRG_DiLeu_BaEn_1 13 18 PF01217 0.456
TRG_DiLeu_BaEn_4 13 19 PF01217 0.477
TRG_ER_diArg_1 270 273 PF00400 0.410
TRG_ER_diArg_1 352 354 PF00400 0.647
TRG_ER_diArg_1 73 75 PF00400 0.678
TRG_ER_diLys_1 349 354 PF00400 0.663
TRG_NLS_MonoCore_2 348 353 PF00514 0.707
TRG_NLS_MonoExtC_3 348 353 PF00514 0.633
TRG_NLS_MonoExtC_3 61 67 PF00514 0.630
TRG_NLS_MonoExtN_4 349 354 PF00514 0.655
TRG_NLS_MonoExtN_4 59 66 PF00514 0.646
TRG_Pf-PMV_PEXEL_1 111 116 PF00026 0.476
TRG_Pf-PMV_PEXEL_1 9 13 PF00026 0.444

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HWM5 Leptomonas seymouri 60% 100%
A0A0S4JHT8 Bodo saltans 28% 99%
A0A1X0NKG5 Trypanosomatidae 37% 90%
A0A3S5H4Y1 Leishmania donovani 99% 100%
A0A422N6Z1 Trypanosoma rangeli 39% 91%
A4H3B2 Leishmania braziliensis 77% 100%
C9ZJ00 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 91%
E9AC84 Leishmania major 89% 99%
E9AJH6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
V5B685 Trypanosoma cruzi 38% 91%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS