Mis18 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HRL1_LEIIN

TriTrypDb:

LINF_020005800

Length:

314

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HRL1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRL1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	145	147	PF00675	0.529
CLV_NRD_NRD_1	240	242	PF00675	0.657
CLV_NRD_NRD_1	42	44	PF00675	0.667
CLV_PCSK_KEX2_1	145	147	PF00082	0.529
CLV_PCSK_KEX2_1	242	244	PF00082	0.681
CLV_PCSK_KEX2_1	42	44	PF00082	0.666
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.609
DEG_SCF_FBW7_1	212	218	PF00400	0.541
DOC_CKS1_1	176	181	PF01111	0.551
DOC_CKS1_1	212	217	PF01111	0.601
DOC_CYCLIN_RxL_1	145	155	PF00134	0.391
DOC_CYCLIN_RxL_1	27	39	PF00134	0.557
DOC_MAPK_gen_1	145	152	PF00069	0.450
DOC_MAPK_gen_1	241	249	PF00069	0.630
DOC_MAPK_MEF2A_6	266	275	PF00069	0.583
DOC_PP1_RVXF_1	146	153	PF00149	0.442
DOC_PP1_RVXF_1	160	166	PF00149	0.546
DOC_PP2B_LxvP_1	122	125	PF13499	0.487
DOC_PP4_FxxP_1	173	176	PF00568	0.399
DOC_PP4_MxPP_1	1	4	PF00568	0.572
DOC_USP7_MATH_1	102	106	PF00917	0.667
DOC_USP7_MATH_1	158	162	PF00917	0.502
DOC_USP7_MATH_1	17	21	PF00917	0.669
DOC_USP7_MATH_1	274	278	PF00917	0.478
DOC_USP7_MATH_1	46	50	PF00917	0.632
DOC_WW_Pin1_4	133	138	PF00397	0.514
DOC_WW_Pin1_4	175	180	PF00397	0.539
DOC_WW_Pin1_4	196	201	PF00397	0.683
DOC_WW_Pin1_4	211	216	PF00397	0.632
DOC_WW_Pin1_4	278	283	PF00397	0.499
DOC_WW_Pin1_4	308	313	PF00397	0.591
DOC_WW_Pin1_4	71	76	PF00397	0.688
DOC_WW_Pin1_4	98	103	PF00397	0.736
LIG_14-3-3_CanoR_1	183	188	PF00244	0.579
LIG_14-3-3_CanoR_1	203	212	PF00244	0.465
LIG_14-3-3_CanoR_1	295	304	PF00244	0.446
LIG_14-3-3_CanoR_1	43	53	PF00244	0.710
LIG_14-3-3_CanoR_1	57	67	PF00244	0.685
LIG_14-3-3_CanoR_1	77	81	PF00244	0.775
LIG_BIR_III_2	113	117	PF00653	0.561
LIG_BRCT_BRCA1_1	153	157	PF00533	0.432
LIG_EVH1_2	116	120	PF00568	0.615
LIG_FHA_1	158	164	PF00498	0.542
LIG_FHA_1	216	222	PF00498	0.662
LIG_FHA_1	244	250	PF00498	0.616
LIG_FHA_1	292	298	PF00498	0.496
LIG_FHA_1	7	13	PF00498	0.625
LIG_FHA_1	76	82	PF00498	0.665
LIG_FHA_2	128	134	PF00498	0.594
LIG_FHA_2	197	203	PF00498	0.626
LIG_FHA_2	252	258	PF00498	0.546
LIG_LIR_Apic_2	172	176	PF02991	0.429
LIG_LIR_Gen_1	123	133	PF02991	0.633
LIG_LIR_Nem_3	123	129	PF02991	0.490
LIG_LIR_Nem_3	168	173	PF02991	0.394
LIG_SH2_STAT5	142	145	PF00017	0.410
LIG_SH2_STAT5	296	299	PF00017	0.372
LIG_SH3_1	32	38	PF00018	0.597
LIG_SH3_3	173	179	PF00018	0.540
LIG_SH3_3	32	38	PF00018	0.710
LIG_SUMO_SIM_anti_2	268	274	PF11976	0.513
LIG_SUMO_SIM_par_1	245	252	PF11976	0.607
LIG_SUMO_SIM_par_1	271	277	PF11976	0.457
LIG_TRAF2_1	130	133	PF00917	0.512
LIG_TRAF2_1	248	251	PF00917	0.599
LIG_TRFH_1	120	124	PF08558	0.610
LIG_WW_1	2	5	PF00397	0.569
MOD_CDC14_SPxK_1	101	104	PF00782	0.735
MOD_CDC14_SPxK_1	74	77	PF00782	0.688
MOD_CDK_SPK_2	196	201	PF00069	0.680
MOD_CDK_SPK_2	308	313	PF00069	0.495
MOD_CDK_SPxK_1	211	217	PF00069	0.602
MOD_CDK_SPxK_1	71	77	PF00069	0.691
MOD_CDK_SPxK_1	98	104	PF00069	0.716
MOD_CDK_SPxxK_3	196	203	PF00069	0.609
MOD_CK1_1	206	212	PF00069	0.794
MOD_CK1_1	49	55	PF00069	0.717
MOD_CK1_1	83	89	PF00069	0.698
MOD_CK2_1	127	133	PF00069	0.591
MOD_CK2_1	245	251	PF00069	0.658
MOD_CK2_1	308	314	PF00069	0.611
MOD_GlcNHglycan	14	17	PF01048	0.690
MOD_GlcNHglycan	167	170	PF01048	0.463
MOD_GlcNHglycan	179	182	PF01048	0.449
MOD_GlcNHglycan	19	22	PF01048	0.644
MOD_GlcNHglycan	208	211	PF01048	0.731
MOD_GlcNHglycan	276	279	PF01048	0.497
MOD_GlcNHglycan	288	291	PF01048	0.614
MOD_GlcNHglycan	61	64	PF01048	0.766
MOD_GlcNHglycan	86	89	PF01048	0.785
MOD_GSK3_1	165	172	PF00069	0.475
MOD_GSK3_1	206	213	PF00069	0.761
MOD_GSK3_1	245	252	PF00069	0.687
MOD_GSK3_1	274	281	PF00069	0.478
MOD_GSK3_1	291	298	PF00069	0.586
MOD_GSK3_1	45	52	PF00069	0.728
MOD_GSK3_1	71	78	PF00069	0.687
MOD_GSK3_1	80	87	PF00069	0.576
MOD_GSK3_1	98	105	PF00069	0.725
MOD_NEK2_1	12	17	PF00069	0.721
MOD_NEK2_1	157	162	PF00069	0.523
MOD_NEK2_1	182	187	PF00069	0.520
MOD_NEK2_1	188	193	PF00069	0.585
MOD_NEK2_1	22	27	PF00069	0.662
MOD_NEK2_1	249	254	PF00069	0.727
MOD_NEK2_1	45	50	PF00069	0.721
MOD_NEK2_1	53	58	PF00069	0.629
MOD_NEK2_1	66	71	PF00069	0.498
MOD_NEK2_2	6	11	PF00069	0.587
MOD_PIKK_1	284	290	PF00454	0.563
MOD_PKA_2	127	133	PF00069	0.538
MOD_PKA_2	182	188	PF00069	0.606
MOD_PKA_2	194	200	PF00069	0.603
MOD_PKA_2	23	29	PF00069	0.761
MOD_PKA_2	255	261	PF00069	0.617
MOD_PKA_2	49	55	PF00069	0.721
MOD_PKA_2	76	82	PF00069	0.780
MOD_PKB_1	201	209	PF00069	0.619
MOD_PKB_1	241	249	PF00069	0.731
MOD_Plk_1	158	164	PF00069	0.513
MOD_Plk_2-3	251	257	PF00069	0.665
MOD_Plk_4	169	175	PF00069	0.518
MOD_Plk_4	183	189	PF00069	0.514
MOD_Plk_4	76	82	PF00069	0.727
MOD_ProDKin_1	133	139	PF00069	0.512
MOD_ProDKin_1	175	181	PF00069	0.533
MOD_ProDKin_1	196	202	PF00069	0.683
MOD_ProDKin_1	211	217	PF00069	0.632
MOD_ProDKin_1	278	284	PF00069	0.495
MOD_ProDKin_1	308	314	PF00069	0.609
MOD_ProDKin_1	71	77	PF00069	0.691
MOD_ProDKin_1	98	104	PF00069	0.739
TRG_ENDOCYTIC_2	5	8	PF00928	0.669
TRG_ER_diArg_1	145	148	PF00400	0.471
TRG_ER_diArg_1	240	243	PF00400	0.656
TRG_ER_diArg_1	42	44	PF00400	0.665
TRG_Pf-PMV_PEXEL_1	231	236	PF00026	0.580
TRG_Pf-PMV_PEXEL_1	32	37	PF00026	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NLG5	Trypanosomatidae	36%	100%
A0A3R7LQ19	Trypanosoma rangeli	31%	100%
A0A3S5H4Y0	Leishmania donovani	99%	100%
A4H3B3	Leishmania braziliensis	63%	100%
C9ZIZ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AC83	Leishmania major	88%	100%
E9AJH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%