Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HRL0_LEIIN

TriTrypDb:

LINF_020005700

Length:

993

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HRL0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRL0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	345	349	PF00656	0.693
CLV_C14_Caspase3-7	939	943	PF00656	0.640
CLV_NRD_NRD_1	145	147	PF00675	0.545
CLV_NRD_NRD_1	228	230	PF00675	0.465
CLV_NRD_NRD_1	450	452	PF00675	0.485
CLV_NRD_NRD_1	891	893	PF00675	0.524
CLV_PCSK_FUR_1	143	147	PF00082	0.531
CLV_PCSK_FUR_1	889	893	PF00082	0.553
CLV_PCSK_KEX2_1	143	145	PF00082	0.520
CLV_PCSK_KEX2_1	228	230	PF00082	0.459
CLV_PCSK_KEX2_1	450	452	PF00082	0.485
CLV_PCSK_KEX2_1	740	742	PF00082	0.723
CLV_PCSK_KEX2_1	891	893	PF00082	0.550
CLV_PCSK_KEX2_1	974	976	PF00082	0.646
CLV_PCSK_PC1ET2_1	740	742	PF00082	0.517
CLV_PCSK_PC1ET2_1	974	976	PF00082	0.646
CLV_PCSK_PC7_1	140	146	PF00082	0.555
CLV_PCSK_SKI1_1	130	134	PF00082	0.506
CLV_PCSK_SKI1_1	228	232	PF00082	0.398
CLV_PCSK_SKI1_1	421	425	PF00082	0.454
CLV_PCSK_SKI1_1	482	486	PF00082	0.573
CLV_PCSK_SKI1_1	587	591	PF00082	0.440
CLV_PCSK_SKI1_1	592	596	PF00082	0.448
CLV_PCSK_SKI1_1	611	615	PF00082	0.355
CLV_PCSK_SKI1_1	740	744	PF00082	0.624
CLV_PCSK_SKI1_1	824	828	PF00082	0.570
CLV_PCSK_SKI1_1	894	898	PF00082	0.554
CLV_Separin_Metazoa	112	116	PF03568	0.661
DEG_APCC_DBOX_1	420	428	PF00400	0.449
DEG_APCC_DBOX_1	823	831	PF00400	0.696
DEG_Kelch_actinfilin_1	645	649	PF01344	0.442
DEG_Kelch_Keap1_1	954	959	PF01344	0.731
DEG_SCF_FBW7_1	950	956	PF00400	0.723
DEG_SCF_FBW7_2	829	835	PF00400	0.720
DOC_CKS1_1	510	515	PF01111	0.592
DOC_CKS1_1	614	619	PF01111	0.538
DOC_CKS1_1	829	834	PF01111	0.718
DOC_CKS1_1	950	955	PF01111	0.723
DOC_CYCLIN_RxL_1	584	595	PF00134	0.343
DOC_CYCLIN_yCln2_LP_2	614	620	PF00134	0.527
DOC_CYCLIN_yCln2_LP_2	87	93	PF00134	0.577
DOC_MAPK_MEF2A_6	248	255	PF00069	0.477
DOC_PP2B_LxvP_1	114	117	PF13499	0.674
DOC_PP2B_LxvP_1	750	753	PF13499	0.703
DOC_PP4_MxPP_1	1	4	PF00568	0.598
DOC_USP7_MATH_1	11	15	PF00917	0.601
DOC_USP7_MATH_1	340	344	PF00917	0.590
DOC_USP7_MATH_1	359	363	PF00917	0.663
DOC_USP7_MATH_1	43	47	PF00917	0.709
DOC_USP7_MATH_1	678	682	PF00917	0.597
DOC_USP7_MATH_1	703	707	PF00917	0.800
DOC_USP7_MATH_1	806	810	PF00917	0.754
DOC_USP7_MATH_1	845	849	PF00917	0.675
DOC_USP7_MATH_1	914	918	PF00917	0.555
DOC_USP7_MATH_1	953	957	PF00917	0.833
DOC_USP7_MATH_1	973	977	PF00917	0.435
DOC_WW_Pin1_4	167	172	PF00397	0.658
DOC_WW_Pin1_4	221	226	PF00397	0.532
DOC_WW_Pin1_4	352	357	PF00397	0.734
DOC_WW_Pin1_4	39	44	PF00397	0.760
DOC_WW_Pin1_4	509	514	PF00397	0.586
DOC_WW_Pin1_4	613	618	PF00397	0.576
DOC_WW_Pin1_4	758	763	PF00397	0.572
DOC_WW_Pin1_4	813	818	PF00397	0.783
DOC_WW_Pin1_4	828	833	PF00397	0.544
DOC_WW_Pin1_4	843	848	PF00397	0.661
DOC_WW_Pin1_4	949	954	PF00397	0.754
DOC_WW_Pin1_4	962	967	PF00397	0.681
LIG_14-3-3_CanoR_1	360	366	PF00244	0.621
LIG_14-3-3_CanoR_1	450	454	PF00244	0.495
LIG_14-3-3_CanoR_1	472	480	PF00244	0.506
LIG_14-3-3_CanoR_1	482	487	PF00244	0.410
LIG_14-3-3_CanoR_1	521	526	PF00244	0.497
LIG_14-3-3_CanoR_1	592	597	PF00244	0.550
LIG_14-3-3_CanoR_1	636	641	PF00244	0.676
LIG_14-3-3_CanoR_1	781	788	PF00244	0.596
LIG_14-3-3_CanoR_1	89	97	PF00244	0.623
LIG_14-3-3_CanoR_1	920	924	PF00244	0.527
LIG_14-3-3_CanoR_1	961	966	PF00244	0.711
LIG_14-3-3_CanoR_1	984	990	PF00244	0.583
LIG_Actin_WH2_2	390	405	PF00022	0.573
LIG_BIR_II_1	1	5	PF00653	0.640
LIG_BIR_III_1	1	5	PF00653	0.599
LIG_BIR_III_3	1	5	PF00653	0.599
LIG_BRCT_BRCA1_1	312	316	PF00533	0.557
LIG_BRCT_BRCA1_1	318	322	PF00533	0.563
LIG_BRCT_BRCA1_1	556	560	PF00533	0.606
LIG_BRCT_BRCA1_1	670	674	PF00533	0.708
LIG_BRCT_BRCA1_1	931	935	PF00533	0.667
LIG_eIF4E_1	584	590	PF01652	0.349
LIG_FHA_1	158	164	PF00498	0.688
LIG_FHA_1	178	184	PF00498	0.522
LIG_FHA_1	34	40	PF00498	0.577
LIG_FHA_1	455	461	PF00498	0.537
LIG_FHA_1	512	518	PF00498	0.400
LIG_FHA_1	547	553	PF00498	0.661
LIG_FHA_1	586	592	PF00498	0.443
LIG_FHA_1	759	765	PF00498	0.769
LIG_FHA_1	853	859	PF00498	0.639
LIG_FHA_1	891	897	PF00498	0.522
LIG_FHA_1	978	984	PF00498	0.626
LIG_FHA_2	180	186	PF00498	0.606
LIG_FHA_2	289	295	PF00498	0.444
LIG_FHA_2	438	444	PF00498	0.455
LIG_FHA_2	45	51	PF00498	0.692
LIG_FHA_2	781	787	PF00498	0.766
LIG_GBD_Chelix_1	396	404	PF00786	0.459
LIG_LIR_Apic_2	717	722	PF02991	0.719
LIG_LIR_Gen_1	392	402	PF02991	0.425
LIG_LIR_Gen_1	438	448	PF02991	0.590
LIG_LIR_Gen_1	485	493	PF02991	0.491
LIG_LIR_Gen_1	557	568	PF02991	0.494
LIG_LIR_Gen_1	588	598	PF02991	0.547
LIG_LIR_Gen_1	768	777	PF02991	0.609
LIG_LIR_Gen_1	80	87	PF02991	0.425
LIG_LIR_Nem_3	392	397	PF02991	0.440
LIG_LIR_Nem_3	438	444	PF02991	0.601
LIG_LIR_Nem_3	485	490	PF02991	0.478
LIG_LIR_Nem_3	557	563	PF02991	0.482
LIG_LIR_Nem_3	588	593	PF02991	0.395
LIG_LIR_Nem_3	671	677	PF02991	0.695
LIG_LIR_Nem_3	724	730	PF02991	0.619
LIG_LIR_Nem_3	768	772	PF02991	0.606
LIG_LIR_Nem_3	80	84	PF02991	0.415
LIG_MLH1_MIPbox_1	312	316	PF16413	0.455
LIG_NRBOX	592	598	PF00104	0.550
LIG_Pex14_1	197	201	PF04695	0.383
LIG_Pex14_1	365	369	PF04695	0.557
LIG_RPA_C_Fungi	299	311	PF08784	0.483
LIG_SH2_CRK	326	330	PF00017	0.399
LIG_SH2_GRB2like	147	150	PF00017	0.605
LIG_SH2_GRB2like	584	587	PF00017	0.502
LIG_SH2_SRC	328	331	PF00017	0.499
LIG_SH2_STAP1	201	205	PF00017	0.473
LIG_SH2_STAP1	285	289	PF00017	0.592
LIG_SH2_STAP1	293	297	PF00017	0.429
LIG_SH2_STAP1	326	330	PF00017	0.475
LIG_SH2_STAT3	201	204	PF00017	0.462
LIG_SH2_STAT3	898	901	PF00017	0.611
LIG_SH2_STAT5	147	150	PF00017	0.605
LIG_SH2_STAT5	315	318	PF00017	0.618
LIG_SH2_STAT5	328	331	PF00017	0.560
LIG_SH2_STAT5	401	404	PF00017	0.451
LIG_SH2_STAT5	441	444	PF00017	0.588
LIG_SH2_STAT5	719	722	PF00017	0.702
LIG_SH3_3	350	356	PF00018	0.731
LIG_SH3_3	672	678	PF00018	0.689
LIG_SH3_3	826	832	PF00018	0.641
LIG_SH3_3	861	867	PF00018	0.654
LIG_SH3_3	980	986	PF00018	0.588
LIG_SUMO_SIM_par_1	456	462	PF11976	0.537
LIG_TRAF2_1	159	162	PF00917	0.660
LIG_TRAF2_1	182	185	PF00917	0.596
LIG_TRAF2_1	499	502	PF00917	0.508
LIG_TRAF2_1	685	688	PF00917	0.582
LIG_TRAF2_1	783	786	PF00917	0.764
LIG_TYR_ITIM	324	329	PF00017	0.574
LIG_UBA3_1	565	569	PF00899	0.621
LIG_WRC_WIRS_1	366	371	PF05994	0.549
LIG_WRC_WIRS_1	78	83	PF05994	0.420
LIG_WRPW_2	88	91	PF00400	0.572
MOD_CDK_SPxxK_3	221	228	PF00069	0.530
MOD_CDK_SPxxK_3	758	765	PF00069	0.564
MOD_CK1_1	164	170	PF00069	0.635
MOD_CK1_1	216	222	PF00069	0.643
MOD_CK1_1	260	266	PF00069	0.604
MOD_CK1_1	355	361	PF00069	0.685
MOD_CK1_1	364	370	PF00069	0.394
MOD_CK1_1	46	52	PF00069	0.688
MOD_CK1_1	511	517	PF00069	0.567
MOD_CK1_1	554	560	PF00069	0.504
MOD_CK1_1	639	645	PF00069	0.563
MOD_CK1_1	807	813	PF00069	0.786
MOD_CK1_1	954	960	PF00069	0.733
MOD_CK2_1	106	112	PF00069	0.700
MOD_CK2_1	125	131	PF00069	0.438
MOD_CK2_1	156	162	PF00069	0.651
MOD_CK2_1	179	185	PF00069	0.514
MOD_CK2_1	204	210	PF00069	0.635
MOD_CK2_1	221	227	PF00069	0.480
MOD_CK2_1	288	294	PF00069	0.491
MOD_CK2_1	626	632	PF00069	0.529
MOD_CK2_1	780	786	PF00069	0.764
MOD_CK2_1	854	860	PF00069	0.638
MOD_CK2_1	953	959	PF00069	0.718
MOD_CK2_1	973	979	PF00069	0.725
MOD_GlcNHglycan	101	104	PF01048	0.703
MOD_GlcNHglycan	106	111	PF01048	0.757
MOD_GlcNHglycan	259	262	PF01048	0.599
MOD_GlcNHglycan	265	268	PF01048	0.687
MOD_GlcNHglycan	294	297	PF01048	0.566
MOD_GlcNHglycan	298	301	PF01048	0.535
MOD_GlcNHglycan	318	321	PF01048	0.556
MOD_GlcNHglycan	342	345	PF01048	0.700
MOD_GlcNHglycan	357	360	PF01048	0.639
MOD_GlcNHglycan	474	477	PF01048	0.372
MOD_GlcNHglycan	553	556	PF01048	0.621
MOD_GlcNHglycan	628	631	PF01048	0.504
MOD_GlcNHglycan	641	644	PF01048	0.616
MOD_GlcNHglycan	806	809	PF01048	0.775
MOD_GlcNHglycan	810	813	PF01048	0.711
MOD_GlcNHglycan	843	846	PF01048	0.662
MOD_GlcNHglycan	9	12	PF01048	0.689
MOD_GlcNHglycan	91	94	PF01048	0.575
MOD_GlcNHglycan	931	934	PF01048	0.621
MOD_GlcNHglycan	953	956	PF01048	0.831
MOD_GlcNHglycan	969	972	PF01048	0.553
MOD_GlcNHglycan	975	978	PF01048	0.612
MOD_GSK3_1	121	128	PF00069	0.513
MOD_GSK3_1	157	164	PF00069	0.668
MOD_GSK3_1	173	180	PF00069	0.640
MOD_GSK3_1	199	206	PF00069	0.601
MOD_GSK3_1	209	216	PF00069	0.598
MOD_GSK3_1	259	266	PF00069	0.581
MOD_GSK3_1	284	291	PF00069	0.465
MOD_GSK3_1	29	36	PF00069	0.608
MOD_GSK3_1	292	299	PF00069	0.450
MOD_GSK3_1	311	318	PF00069	0.684
MOD_GSK3_1	355	362	PF00069	0.626
MOD_GSK3_1	39	46	PF00069	0.694
MOD_GSK3_1	413	420	PF00069	0.538
MOD_GSK3_1	449	456	PF00069	0.550
MOD_GSK3_1	521	528	PF00069	0.613
MOD_GSK3_1	55	62	PF00069	0.483
MOD_GSK3_1	551	558	PF00069	0.542
MOD_GSK3_1	635	642	PF00069	0.584
MOD_GSK3_1	664	671	PF00069	0.717
MOD_GSK3_1	7	14	PF00069	0.639
MOD_GSK3_1	804	811	PF00069	0.756
MOD_GSK3_1	841	848	PF00069	0.670
MOD_GSK3_1	852	859	PF00069	0.612
MOD_GSK3_1	949	956	PF00069	0.758
MOD_GSK3_1	95	102	PF00069	0.575
MOD_GSK3_1	973	980	PF00069	0.744
MOD_N-GLC_1	585	590	PF02516	0.488
MOD_N-GLC_1	961	966	PF02516	0.751
MOD_N-GLC_2	714	716	PF02516	0.554
MOD_NEK2_1	199	204	PF00069	0.581
MOD_NEK2_1	292	297	PF00069	0.557
MOD_NEK2_1	309	314	PF00069	0.472
MOD_NEK2_1	324	329	PF00069	0.574
MOD_NEK2_1	453	458	PF00069	0.507
MOD_NEK2_1	551	556	PF00069	0.559
MOD_NEK2_1	60	65	PF00069	0.593
MOD_NEK2_1	841	846	PF00069	0.747
MOD_NEK2_1	858	863	PF00069	0.428
MOD_NEK2_1	919	924	PF00069	0.593
MOD_NEK2_1	927	932	PF00069	0.517
MOD_NEK2_2	555	560	PF00069	0.508
MOD_NEK2_2	585	590	PF00069	0.450
MOD_NEK2_2	914	919	PF00069	0.539
MOD_PIKK_1	177	183	PF00454	0.525
MOD_PIKK_1	435	441	PF00454	0.542
MOD_PIKK_1	664	670	PF00454	0.733
MOD_PIKK_1	781	787	PF00454	0.766
MOD_PKA_2	359	365	PF00069	0.639
MOD_PKA_2	449	455	PF00069	0.492
MOD_PKA_2	635	641	PF00069	0.587
MOD_PKA_2	780	786	PF00069	0.558
MOD_PKA_2	890	896	PF00069	0.629
MOD_PKA_2	919	925	PF00069	0.522
MOD_Plk_1	214	220	PF00069	0.471
MOD_Plk_1	417	423	PF00069	0.508
MOD_Plk_1	585	591	PF00069	0.447
MOD_Plk_2-3	273	279	PF00069	0.571
MOD_Plk_2-3	288	294	PF00069	0.342
MOD_Plk_4	204	210	PF00069	0.635
MOD_Plk_4	288	294	PF00069	0.485
MOD_Plk_4	311	317	PF00069	0.683
MOD_Plk_4	324	330	PF00069	0.426
MOD_Plk_4	361	367	PF00069	0.507
MOD_Plk_4	437	443	PF00069	0.503
MOD_Plk_4	482	488	PF00069	0.578
MOD_Plk_4	521	527	PF00069	0.538
MOD_Plk_4	555	561	PF00069	0.544
MOD_Plk_4	592	598	PF00069	0.482
MOD_Plk_4	61	67	PF00069	0.560
MOD_Plk_4	678	684	PF00069	0.628
MOD_Plk_4	714	720	PF00069	0.734
MOD_Plk_4	745	751	PF00069	0.678
MOD_Plk_4	77	83	PF00069	0.353
MOD_Plk_4	914	920	PF00069	0.537
MOD_Plk_4	977	983	PF00069	0.644
MOD_Plk_4	985	991	PF00069	0.582
MOD_ProDKin_1	167	173	PF00069	0.662
MOD_ProDKin_1	221	227	PF00069	0.526
MOD_ProDKin_1	352	358	PF00069	0.732
MOD_ProDKin_1	39	45	PF00069	0.759
MOD_ProDKin_1	509	515	PF00069	0.587
MOD_ProDKin_1	613	619	PF00069	0.568
MOD_ProDKin_1	758	764	PF00069	0.566
MOD_ProDKin_1	813	819	PF00069	0.780
MOD_ProDKin_1	828	834	PF00069	0.542
MOD_ProDKin_1	843	849	PF00069	0.664
MOD_ProDKin_1	949	955	PF00069	0.756
MOD_ProDKin_1	962	968	PF00069	0.679
MOD_SUMO_rev_2	564	571	PF00179	0.625
MOD_SUMO_rev_2	733	742	PF00179	0.523
MOD_SUMO_rev_2	932	941	PF00179	0.680
TRG_DiLeu_BaEn_3	737	743	PF01217	0.722
TRG_DiLeu_BaLyEn_6	589	594	PF01217	0.476
TRG_ENDOCYTIC_2	326	329	PF00928	0.456
TRG_ENDOCYTIC_2	401	404	PF00928	0.409
TRG_ENDOCYTIC_2	441	444	PF00928	0.588
TRG_ER_diArg_1	143	146	PF00400	0.524
TRG_ER_diArg_1	228	230	PF00400	0.459
TRG_ER_diArg_1	889	892	PF00400	0.559
TRG_NES_CRM1_1	520	535	PF08389	0.552
TRG_Pf-PMV_PEXEL_1	925	929	PF00026	0.606

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4K8	Leptomonas seymouri	38%	83%
A0A3S5H4X9	Leishmania donovani	99%	100%
A4H3A4	Leishmania braziliensis	71%	100%
E9AC82	Leishmania major	91%	100%
E9AJH4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%