Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HRK9_LEIIN

TriTrypDb:

LINF_020005600

Length:

397

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HRK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRK9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	210	214	PF00656	0.649
CLV_C14_Caspase3-7	215	219	PF00656	0.676
CLV_C14_Caspase3-7	230	234	PF00656	0.642
CLV_C14_Caspase3-7	330	334	PF00656	0.584
CLV_C14_Caspase3-7	344	348	PF00656	0.494
CLV_C14_Caspase3-7	383	387	PF00656	0.681
CLV_C14_Caspase3-7	67	71	PF00656	0.643
CLV_NRD_NRD_1	270	272	PF00675	0.418
CLV_NRD_NRD_1	286	288	PF00675	0.370
CLV_NRD_NRD_1	363	365	PF00675	0.675
CLV_PCSK_KEX2_1	24	26	PF00082	0.388
CLV_PCSK_KEX2_1	286	288	PF00082	0.484
CLV_PCSK_KEX2_1	293	295	PF00082	0.378
CLV_PCSK_KEX2_1	363	365	PF00082	0.636
CLV_PCSK_PC1ET2_1	24	26	PF00082	0.388
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.411
CLV_PCSK_SKI1_1	14	18	PF00082	0.385
CLV_PCSK_SKI1_1	205	209	PF00082	0.609
CLV_PCSK_SKI1_1	237	241	PF00082	0.552
CLV_PCSK_SKI1_1	24	28	PF00082	0.487
CLV_PCSK_SKI1_1	286	290	PF00082	0.413
CLV_PCSK_SKI1_1	297	301	PF00082	0.400
CLV_PCSK_SKI1_1	3	7	PF00082	0.558
CLV_PCSK_SKI1_1	309	313	PF00082	0.450
CLV_Separin_Metazoa	277	281	PF03568	0.566
DEG_Nend_Nbox_1	1	3	PF02207	0.691
DEG_SPOP_SBC_1	225	229	PF00917	0.696
DEG_SPOP_SBC_1	97	101	PF00917	0.738
DOC_MAPK_gen_1	293	300	PF00069	0.394
DOC_MAPK_RevD_3	257	272	PF00069	0.380
DOC_PP1_RVXF_1	295	301	PF00149	0.508
DOC_PP2B_LxvP_1	155	158	PF13499	0.461
DOC_USP7_MATH_1	178	182	PF00917	0.531
DOC_USP7_MATH_1	251	255	PF00917	0.527
DOC_USP7_MATH_1	261	265	PF00917	0.362
DOC_USP7_MATH_1	301	305	PF00917	0.560
DOC_USP7_MATH_1	95	99	PF00917	0.698
DOC_USP7_UBL2_3	3	7	PF12436	0.634
DOC_WW_Pin1_4	198	203	PF00397	0.535
DOC_WW_Pin1_4	217	222	PF00397	0.500
DOC_WW_Pin1_4	249	254	PF00397	0.525
DOC_WW_Pin1_4	365	370	PF00397	0.724
LIG_14-3-3_CanoR_1	127	136	PF00244	0.639
LIG_14-3-3_CanoR_1	363	369	PF00244	0.723
LIG_Actin_WH2_2	303	319	PF00022	0.523
LIG_BIR_III_2	218	222	PF00653	0.705
LIG_BIR_III_4	333	337	PF00653	0.595
LIG_Clathr_ClatBox_1	172	176	PF01394	0.411
LIG_FHA_1	13	19	PF00498	0.484
LIG_FHA_1	322	328	PF00498	0.523
LIG_FHA_1	44	50	PF00498	0.444
LIG_FHA_1	91	97	PF00498	0.684
LIG_FHA_2	108	114	PF00498	0.681
LIG_FHA_2	208	214	PF00498	0.628
LIG_FHA_2	226	232	PF00498	0.672
LIG_FHA_2	368	374	PF00498	0.721
LIG_FHA_2	65	71	PF00498	0.683
LIG_GBD_Chelix_1	147	155	PF00786	0.406
LIG_LIR_Apic_2	388	393	PF02991	0.786
LIG_LIR_Gen_1	113	122	PF02991	0.647
LIG_LIR_Gen_1	252	262	PF02991	0.431
LIG_LIR_Gen_1	275	283	PF02991	0.544
LIG_LIR_Nem_3	113	117	PF02991	0.659
LIG_LIR_Nem_3	135	139	PF02991	0.544
LIG_LIR_Nem_3	166	172	PF02991	0.369
LIG_LIR_Nem_3	220	226	PF02991	0.673
LIG_LIR_Nem_3	252	258	PF02991	0.446
LIG_NRBOX	203	209	PF00104	0.579
LIG_Pex14_1	136	140	PF04695	0.530
LIG_Pex14_2	164	168	PF04695	0.473
LIG_SH2_CRK	144	148	PF00017	0.468
LIG_SH2_CRK	169	173	PF00017	0.372
LIG_SH2_CRK	255	259	PF00017	0.442
LIG_SH2_CRK	270	274	PF00017	0.331
LIG_SH2_GRB2like	57	60	PF00017	0.545
LIG_SH2_STAP1	144	148	PF00017	0.468
LIG_SH2_STAP1	255	259	PF00017	0.395
LIG_SH2_STAT5	140	143	PF00017	0.417
LIG_SH2_STAT5	238	241	PF00017	0.452
LIG_SH2_STAT5	28	31	PF00017	0.398
LIG_SH2_STAT5	320	323	PF00017	0.550
LIG_SH2_STAT5	57	60	PF00017	0.468
LIG_SH3_3	218	224	PF00018	0.752
LIG_SUMO_SIM_anti_2	152	158	PF11976	0.501
LIG_SUMO_SIM_par_1	171	176	PF11976	0.497
LIG_SUMO_SIM_par_1	287	292	PF11976	0.411
LIG_SUMO_SIM_par_1	83	91	PF11976	0.439
LIG_TYR_ITIM	236	241	PF00017	0.462
LIG_TYR_ITIM	268	273	PF00017	0.457
LIG_UBA3_1	288	293	PF00899	0.540
LIG_UBA3_1	77	84	PF00899	0.708
MOD_CDK_SPxxK_3	198	205	PF00069	0.552
MOD_CK1_1	335	341	PF00069	0.738
MOD_CK1_1	367	373	PF00069	0.713
MOD_CK1_1	98	104	PF00069	0.682
MOD_CK2_1	147	153	PF00069	0.478
MOD_CK2_1	209	215	PF00069	0.652
MOD_CK2_1	367	373	PF00069	0.727
MOD_GlcNHglycan	101	104	PF01048	0.711
MOD_GlcNHglycan	131	134	PF01048	0.555
MOD_GlcNHglycan	180	183	PF01048	0.478
MOD_GlcNHglycan	333	337	PF01048	0.653
MOD_GlcNHglycan	340	343	PF01048	0.690
MOD_GlcNHglycan	90	93	PF01048	0.679
MOD_GSK3_1	178	185	PF00069	0.586
MOD_GSK3_1	203	210	PF00069	0.539
MOD_GSK3_1	213	220	PF00069	0.606
MOD_GSK3_1	34	41	PF00069	0.511
MOD_GSK3_1	363	370	PF00069	0.671
MOD_GSK3_1	95	102	PF00069	0.672
MOD_N-GLC_1	115	120	PF02516	0.564
MOD_NEK2_1	147	152	PF00069	0.400
MOD_NEK2_1	207	212	PF00069	0.607
MOD_NEK2_1	96	101	PF00069	0.701
MOD_NEK2_2	43	48	PF00069	0.477
MOD_PK_1	287	293	PF00069	0.417
MOD_PKA_1	363	369	PF00069	0.636
MOD_PKA_2	128	134	PF00069	0.643
MOD_PKA_2	363	369	PF00069	0.726
MOD_PKB_1	127	135	PF00069	0.528
MOD_Plk_1	115	121	PF00069	0.651
MOD_Plk_2-3	213	219	PF00069	0.501
MOD_Plk_2-3	34	40	PF00069	0.549
MOD_Plk_4	203	209	PF00069	0.554
MOD_Plk_4	261	267	PF00069	0.416
MOD_Plk_4	38	44	PF00069	0.603
MOD_Plk_4	385	391	PF00069	0.759
MOD_ProDKin_1	198	204	PF00069	0.529
MOD_ProDKin_1	217	223	PF00069	0.502
MOD_ProDKin_1	249	255	PF00069	0.509
MOD_ProDKin_1	365	371	PF00069	0.728
MOD_SUMO_rev_2	367	377	PF00179	0.722
TRG_ENDOCYTIC_2	144	147	PF00928	0.388
TRG_ENDOCYTIC_2	169	172	PF00928	0.364
TRG_ENDOCYTIC_2	238	241	PF00928	0.448
TRG_ENDOCYTIC_2	255	258	PF00928	0.318
TRG_ENDOCYTIC_2	270	273	PF00928	0.388
TRG_ENDOCYTIC_2	276	279	PF00928	0.418
TRG_ENDOCYTIC_2	57	60	PF00928	0.506
TRG_ER_diArg_1	126	129	PF00400	0.568
TRG_ER_diArg_1	285	287	PF00400	0.475
TRG_NES_CRM1_1	231	243	PF08389	0.548
TRG_NES_CRM1_1	50	62	PF08389	0.578
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.585
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	287	292	PF00026	0.350
TRG_Pf-PMV_PEXEL_1	314	318	PF00026	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAV1	Leptomonas seymouri	61%	95%
A0A0S4JHJ5	Bodo saltans	30%	100%
A0A1X0NJT7	Trypanosomatidae	34%	100%
A0A3S5H4X8	Leishmania donovani	100%	100%
A0A3S5IQM7	Trypanosoma rangeli	36%	98%
A4H3A3	Leishmania braziliensis	83%	100%
E9AC81	Leishmania major	94%	100%
E9AJH3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BAQ0	Trypanosoma cruzi	36%	100%