This cluster contains a high variety of cytochrome b5 homologs. Although all membrane-anchored, some use the N-terminal [type-III] while others the C-terminal TM helix [type-IV]. The heme domain is assumed to be cytoplasmic.. Localization: ER (by homology) / Mitochondrial outer membrane (by homology)
Mitochondrial protein, cytochrome b-domain
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 8 |
| NetGPI | no | yes: 0, no: 8 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 9 |
| GO:0110165 | cellular anatomical entity | 1 | 9 |
| GO:0043226 | organelle | 2 | 1 |
| GO:0043227 | membrane-bounded organelle | 3 | 1 |
| GO:0043229 | intracellular organelle | 3 | 1 |
| GO:0043231 | intracellular membrane-bounded organelle | 4 | 1 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pescher et al. (upgregulation) | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
|
Lahav et al. - mRNA
- Protein
|
Related structures:
AlphaFold database: A4HRK7
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005488 | binding | 1 | 9 |
| GO:0020037 | heme binding | 4 | 9 |
| GO:0043167 | ion binding | 2 | 9 |
| GO:0043169 | cation binding | 3 | 9 |
| GO:0046872 | metal ion binding | 4 | 9 |
| GO:0046906 | tetrapyrrole binding | 3 | 9 |
| GO:0097159 | organic cyclic compound binding | 2 | 9 |
| GO:1901363 | heterocyclic compound binding | 2 | 9 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_NRD_NRD_1 | 162 | 164 | PF00675 | 0.387 |
| CLV_NRD_NRD_1 | 168 | 170 | PF00675 | 0.501 |
| CLV_NRD_NRD_1 | 67 | 69 | PF00675 | 0.221 |
| CLV_NRD_NRD_1 | 83 | 85 | PF00675 | 0.363 |
| CLV_PCSK_KEX2_1 | 67 | 69 | PF00082 | 0.195 |
| CLV_PCSK_KEX2_1 | 82 | 84 | PF00082 | 0.370 |
| CLV_PCSK_PC7_1 | 63 | 69 | PF00082 | 0.199 |
| CLV_PCSK_SKI1_1 | 122 | 126 | PF00082 | 0.255 |
| CLV_PCSK_SKI1_1 | 169 | 173 | PF00082 | 0.496 |
| CLV_PCSK_SKI1_1 | 41 | 45 | PF00082 | 0.264 |
| CLV_PCSK_SKI1_1 | 84 | 88 | PF00082 | 0.269 |
| DOC_MAPK_gen_1 | 67 | 74 | PF00069 | 0.457 |
| DOC_MAPK_gen_1 | 82 | 88 | PF00069 | 0.511 |
| DOC_MAPK_MEF2A_6 | 201 | 210 | PF00069 | 0.357 |
| DOC_MAPK_NFAT4_5 | 201 | 209 | PF00069 | 0.369 |
| DOC_USP7_MATH_1 | 93 | 97 | PF00917 | 0.514 |
| DOC_WW_Pin1_4 | 109 | 114 | PF00397 | 0.502 |
| LIG_14-3-3_CanoR_1 | 163 | 167 | PF00244 | 0.665 |
| LIG_14-3-3_CanoR_1 | 83 | 89 | PF00244 | 0.586 |
| LIG_APCC_ABBA_1 | 111 | 116 | PF00400 | 0.502 |
| LIG_FHA_1 | 110 | 116 | PF00498 | 0.479 |
| LIG_FHA_1 | 178 | 184 | PF00498 | 0.702 |
| LIG_LIR_Gen_1 | 112 | 119 | PF02991 | 0.467 |
| LIG_LIR_Gen_1 | 144 | 155 | PF02991 | 0.497 |
| LIG_LIR_Gen_1 | 17 | 28 | PF02991 | 0.515 |
| LIG_LIR_Nem_3 | 112 | 117 | PF02991 | 0.478 |
| LIG_LIR_Nem_3 | 17 | 23 | PF02991 | 0.441 |
| LIG_LIR_Nem_3 | 53 | 59 | PF02991 | 0.455 |
| LIG_PTB_Apo_2 | 103 | 110 | PF02174 | 0.455 |
| LIG_PTB_Apo_2 | 22 | 29 | PF02174 | 0.514 |
| LIG_PTB_Phospho_1 | 103 | 109 | PF10480 | 0.455 |
| LIG_PTB_Phospho_1 | 22 | 28 | PF10480 | 0.514 |
| LIG_SH2_PTP2 | 85 | 88 | PF00017 | 0.518 |
| LIG_SH2_SRC | 34 | 37 | PF00017 | 0.477 |
| LIG_SH2_STAT5 | 153 | 156 | PF00017 | 0.465 |
| LIG_SH2_STAT5 | 5 | 8 | PF00017 | 0.455 |
| LIG_SH2_STAT5 | 85 | 88 | PF00017 | 0.577 |
| MOD_CK1_1 | 15 | 21 | PF00069 | 0.469 |
| MOD_GlcNHglycan | 127 | 130 | PF01048 | 0.253 |
| MOD_GlcNHglycan | 17 | 20 | PF01048 | 0.284 |
| MOD_GlcNHglycan | 95 | 98 | PF01048 | 0.312 |
| MOD_GSK3_1 | 131 | 138 | PF00069 | 0.514 |
| MOD_GSK3_1 | 158 | 165 | PF00069 | 0.619 |
| MOD_N-GLC_1 | 188 | 193 | PF02516 | 0.391 |
| MOD_N-GLC_1 | 59 | 64 | PF02516 | 0.279 |
| MOD_NEK2_1 | 125 | 130 | PF00069 | 0.462 |
| MOD_PIKK_1 | 131 | 137 | PF00454 | 0.514 |
| MOD_PIKK_1 | 177 | 183 | PF00454 | 0.635 |
| MOD_PKA_1 | 169 | 175 | PF00069 | 0.693 |
| MOD_PKA_2 | 162 | 168 | PF00069 | 0.616 |
| MOD_PKB_1 | 82 | 90 | PF00069 | 0.575 |
| MOD_Plk_1 | 188 | 194 | PF00069 | 0.589 |
| MOD_Plk_4 | 162 | 168 | PF00069 | 0.616 |
| MOD_Plk_4 | 188 | 194 | PF00069 | 0.609 |
| MOD_ProDKin_1 | 109 | 115 | PF00069 | 0.502 |
| MOD_SUMO_for_1 | 185 | 188 | PF00179 | 0.624 |
| MOD_SUMO_rev_2 | 157 | 166 | PF00179 | 0.593 |
| TRG_DiLeu_BaEn_1 | 162 | 167 | PF01217 | 0.580 |
| TRG_DiLeu_BaEn_1 | 17 | 22 | PF01217 | 0.483 |
| TRG_DiLeu_BaEn_1 | 188 | 193 | PF01217 | 0.591 |
| TRG_DiLeu_BaEn_1 | 198 | 203 | PF01217 | 0.493 |
| TRG_DiLeu_LyEn_5 | 198 | 203 | PF01217 | 0.399 |
| TRG_ENDOCYTIC_2 | 147 | 150 | PF00928 | 0.514 |
| TRG_ENDOCYTIC_2 | 85 | 88 | PF00928 | 0.577 |
| TRG_ER_diArg_1 | 66 | 68 | PF00400 | 0.395 |
| TRG_ER_diArg_1 | 82 | 84 | PF00400 | 0.564 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N0P4I5 | Leptomonas seymouri | 71% | 100% |
| A0A1X0NJR3 | Trypanosomatidae | 50% | 98% |
| A0A3S5H4X7 | Leishmania donovani | 99% | 100% |
| A0A422N6Z2 | Trypanosoma rangeli | 51% | 96% |
| A4H3A1 | Leishmania braziliensis | 75% | 100% |
| E9AC79 | Leishmania major | 89% | 100% |
| E9AJH1 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 83% | 98% |