Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HRK2_LEIIN

TriTrypDb:

LINF_010013000

Length:

530

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HRK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRK2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.664
CLV_C14_Caspase3-7	64	68	PF00656	0.644
CLV_C14_Caspase3-7	91	95	PF00656	0.659
CLV_NRD_NRD_1	130	132	PF00675	0.691
CLV_NRD_NRD_1	210	212	PF00675	0.696
CLV_NRD_NRD_1	346	348	PF00675	0.748
CLV_NRD_NRD_1	386	388	PF00675	0.716
CLV_NRD_NRD_1	477	479	PF00675	0.682
CLV_NRD_NRD_1	69	71	PF00675	0.822
CLV_PCSK_KEX2_1	130	132	PF00082	0.691
CLV_PCSK_KEX2_1	210	212	PF00082	0.696
CLV_PCSK_KEX2_1	345	347	PF00082	0.744
CLV_PCSK_KEX2_1	386	388	PF00082	0.716
CLV_PCSK_KEX2_1	477	479	PF00082	0.682
CLV_PCSK_KEX2_1	484	486	PF00082	0.522
CLV_PCSK_KEX2_1	69	71	PF00082	0.817
CLV_PCSK_PC1ET2_1	484	486	PF00082	0.597
CLV_PCSK_SKI1_1	131	135	PF00082	0.630
CLV_PCSK_SKI1_1	158	162	PF00082	0.554
CLV_PCSK_SKI1_1	512	516	PF00082	0.590
DEG_Nend_Nbox_1	1	3	PF02207	0.667
DEG_SCF_FBW7_1	201	206	PF00400	0.620
DEG_SPOP_SBC_1	423	427	PF00917	0.712
DEG_SPOP_SBC_1	53	57	PF00917	0.578
DOC_MAPK_gen_1	277	286	PF00069	0.607
DOC_MAPK_gen_1	386	393	PF00069	0.669
DOC_MAPK_gen_1	484	491	PF00069	0.588
DOC_PP1_RVXF_1	488	494	PF00149	0.574
DOC_PP4_MxPP_1	235	238	PF00568	0.597
DOC_USP7_MATH_1	113	117	PF00917	0.736
DOC_USP7_MATH_1	144	148	PF00917	0.665
DOC_USP7_MATH_1	167	171	PF00917	0.541
DOC_USP7_MATH_1	201	205	PF00917	0.789
DOC_USP7_MATH_1	254	258	PF00917	0.707
DOC_USP7_MATH_1	288	292	PF00917	0.641
DOC_USP7_MATH_1	321	325	PF00917	0.644
DOC_USP7_MATH_1	370	374	PF00917	0.713
DOC_USP7_MATH_1	423	427	PF00917	0.712
DOC_USP7_MATH_1	440	444	PF00917	0.644
DOC_USP7_MATH_1	454	458	PF00917	0.516
DOC_USP7_MATH_1	494	498	PF00917	0.600
DOC_USP7_MATH_1	53	57	PF00917	0.715
DOC_USP7_MATH_1	84	88	PF00917	0.694
DOC_WW_Pin1_4	107	112	PF00397	0.697
DOC_WW_Pin1_4	136	141	PF00397	0.737
DOC_WW_Pin1_4	199	204	PF00397	0.747
DOC_WW_Pin1_4	238	243	PF00397	0.724
DOC_WW_Pin1_4	301	306	PF00397	0.717
DOC_WW_Pin1_4	406	411	PF00397	0.712
LIG_14-3-3_CanoR_1	107	111	PF00244	0.726
LIG_14-3-3_CanoR_1	130	140	PF00244	0.690
LIG_14-3-3_CanoR_1	287	293	PF00244	0.734
LIG_14-3-3_CanoR_1	345	354	PF00244	0.671
LIG_14-3-3_CanoR_1	424	434	PF00244	0.715
LIG_14-3-3_CanoR_1	455	462	PF00244	0.676
LIG_14-3-3_CanoR_1	512	517	PF00244	0.621
LIG_14-3-3_CanoR_1	80	84	PF00244	0.682
LIG_BIR_III_4	364	368	PF00653	0.652
LIG_BIR_III_4	394	398	PF00653	0.663
LIG_FHA_1	1	7	PF00498	0.635
LIG_FHA_1	411	417	PF00498	0.669
LIG_FHA_1	430	436	PF00498	0.567
LIG_FHA_1	509	515	PF00498	0.589
LIG_FHA_2	215	221	PF00498	0.664
LIG_FHA_2	74	80	PF00498	0.604
LIG_LIR_Apic_2	163	169	PF02991	0.562
LIG_LIR_Apic_2	467	471	PF02991	0.610
LIG_LIR_Gen_1	175	183	PF02991	0.533
LIG_LIR_Nem_3	170	174	PF02991	0.520
LIG_LIR_Nem_3	175	181	PF02991	0.491
LIG_LIR_Nem_3	398	404	PF02991	0.698
LIG_LIR_Nem_3	446	450	PF02991	0.666
LIG_SH2_CRK	451	455	PF00017	0.638
LIG_SH2_GRB2like	227	230	PF00017	0.636
LIG_SH2_GRB2like	447	450	PF00017	0.668
LIG_SH2_PTP2	273	276	PF00017	0.573
LIG_SH2_SRC	468	471	PF00017	0.603
LIG_SH2_STAT5	273	276	PF00017	0.660
LIG_SH2_STAT5	468	471	PF00017	0.558
LIG_SH3_1	299	305	PF00018	0.698
LIG_SH3_2	239	244	PF14604	0.614
LIG_SH3_3	231	237	PF00018	0.649
LIG_SH3_3	299	305	PF00018	0.722
LIG_SH3_3	44	50	PF00018	0.692
LIG_TRAF2_1	217	220	PF00917	0.663
MOD_CDC14_SPxK_1	241	244	PF00782	0.615
MOD_CDK_SPxK_1	238	244	PF00069	0.613
MOD_CK1_1	116	122	PF00069	0.744
MOD_CK1_1	136	142	PF00069	0.733
MOD_CK1_1	147	153	PF00069	0.529
MOD_CK1_1	18	24	PF00069	0.836
MOD_CK1_1	26	32	PF00069	0.720
MOD_CK1_1	426	432	PF00069	0.714
MOD_CK1_1	443	449	PF00069	0.655
MOD_CK1_1	458	464	PF00069	0.554
MOD_CK1_1	497	503	PF00069	0.618
MOD_CK1_1	56	62	PF00069	0.705
MOD_CK1_1	8	14	PF00069	0.678
MOD_CK2_1	214	220	PF00069	0.668
MOD_GlcNHglycan	103	106	PF01048	0.863
MOD_GlcNHglycan	142	145	PF01048	0.724
MOD_GlcNHglycan	203	206	PF01048	0.789
MOD_GlcNHglycan	25	28	PF01048	0.694
MOD_GlcNHglycan	256	260	PF01048	0.641
MOD_GlcNHglycan	290	293	PF01048	0.737
MOD_GlcNHglycan	309	312	PF01048	0.805
MOD_GlcNHglycan	348	351	PF01048	0.839
MOD_GlcNHglycan	372	375	PF01048	0.657
MOD_GlcNHglycan	43	46	PF01048	0.755
MOD_GlcNHglycan	60	63	PF01048	0.794
MOD_GSK3_1	132	139	PF00069	0.738
MOD_GSK3_1	140	147	PF00069	0.658
MOD_GSK3_1	15	22	PF00069	0.815
MOD_GSK3_1	199	206	PF00069	0.679
MOD_GSK3_1	37	44	PF00069	0.846
MOD_GSK3_1	406	413	PF00069	0.800
MOD_GSK3_1	422	429	PF00069	0.588
MOD_GSK3_1	439	446	PF00069	0.647
MOD_GSK3_1	454	461	PF00069	0.564
MOD_GSK3_1	508	515	PF00069	0.633
MOD_GSK3_1	52	59	PF00069	0.596
MOD_GSK3_1	79	86	PF00069	0.737
MOD_GSK3_1	88	95	PF00069	0.645
MOD_NEK2_1	2	7	PF00069	0.722
MOD_NEK2_1	73	78	PF00069	0.680
MOD_NEK2_2	309	314	PF00069	0.636
MOD_OFUCOSY	453	459	PF10250	0.674
MOD_PIKK_1	321	327	PF00454	0.680
MOD_PIKK_1	497	503	PF00454	0.706
MOD_PKA_1	345	351	PF00069	0.745
MOD_PKA_2	106	112	PF00069	0.639
MOD_PKA_2	144	150	PF00069	0.559
MOD_PKA_2	196	202	PF00069	0.669
MOD_PKA_2	286	292	PF00069	0.734
MOD_PKA_2	345	351	PF00069	0.770
MOD_PKA_2	423	429	PF00069	0.712
MOD_PKA_2	454	460	PF00069	0.602
MOD_PKA_2	79	85	PF00069	0.727
MOD_PKA_2	92	98	PF00069	0.609
MOD_PKB_1	39	47	PF00069	0.627
MOD_PKB_1	510	518	PF00069	0.601
MOD_Plk_1	214	220	PF00069	0.668
MOD_Plk_4	167	173	PF00069	0.466
MOD_Plk_4	376	382	PF00069	0.599
MOD_Plk_4	412	418	PF00069	0.670
MOD_Plk_4	430	436	PF00069	0.525
MOD_Plk_4	464	470	PF00069	0.631
MOD_Plk_4	494	500	PF00069	0.583
MOD_Plk_4	61	67	PF00069	0.648
MOD_ProDKin_1	107	113	PF00069	0.695
MOD_ProDKin_1	136	142	PF00069	0.738
MOD_ProDKin_1	199	205	PF00069	0.746
MOD_ProDKin_1	238	244	PF00069	0.726
MOD_ProDKin_1	301	307	PF00069	0.718
MOD_ProDKin_1	406	412	PF00069	0.710
TRG_DiLeu_BaEn_1	256	261	PF01217	0.633
TRG_DiLeu_BaEn_1	487	492	PF01217	0.574
TRG_DiLeu_LyEn_5	487	492	PF01217	0.574
TRG_ENDOCYTIC_2	273	276	PF00928	0.685
TRG_ER_diArg_1	210	212	PF00400	0.741
TRG_ER_diArg_1	345	347	PF00400	0.805
TRG_ER_diArg_1	476	478	PF00400	0.643
TRG_ER_diArg_1	509	512	PF00400	0.583
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.676

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A451EJD3	Leishmania donovani	99%	100%
A4H394	Leishmania braziliensis	61%	100%
E9AC70	Leishmania major	89%	100%
E9AJG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	96%