LeishMANIAdb
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NEDD8-activating enzyme E1 catalytic subunit

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
NEDD8-activating enzyme E1 catalytic subunit
Gene product:
ubiquitin activating enzyme - putative
Species:
Leishmania infantum
UniProt:
A4HRJ4_LEIIN
TriTrypDb:
LINF_010012200
Length:
539

Annotations

Annotations by Jardim et al.

Protein modification, ubiquitin activating enzyme

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HRJ4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRJ4

Function

Biological processes
Term Name Level Count
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0019538 protein metabolic process 3 11
GO:0032446 protein modification by small protein conjugation 6 11
GO:0036211 protein modification process 4 11
GO:0043170 macromolecule metabolic process 3 11
GO:0043412 macromolecule modification 4 11
GO:0044238 primary metabolic process 2 11
GO:0045116 protein neddylation 7 11
GO:0070647 protein modification by small protein conjugation or removal 5 11
GO:0071704 organic substance metabolic process 2 11
GO:1901564 organonitrogen compound metabolic process 3 11
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0008641 ubiquitin-like modifier activating enzyme activity 2 11
GO:0016874 ligase activity 2 11
GO:0016877 ligase activity, forming carbon-sulfur bonds 3 11
GO:0017076 purine nucleotide binding 4 11
GO:0019781 NEDD8 activating enzyme activity 3 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:0140096 catalytic activity, acting on a protein 2 11
GO:0140657 ATP-dependent activity 1 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11
GO:0016740 transferase activity 2 1
GO:0016746 acyltransferase activity 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 287 291 PF00656 0.278
CLV_C14_Caspase3-7 301 305 PF00656 0.347
CLV_MEL_PAP_1 192 198 PF00089 0.272
CLV_NRD_NRD_1 145 147 PF00675 0.303
CLV_NRD_NRD_1 149 151 PF00675 0.303
CLV_NRD_NRD_1 282 284 PF00675 0.430
CLV_NRD_NRD_1 458 460 PF00675 0.459
CLV_PCSK_FUR_1 277 281 PF00082 0.354
CLV_PCSK_KEX2_1 145 147 PF00082 0.303
CLV_PCSK_KEX2_1 157 159 PF00082 0.303
CLV_PCSK_KEX2_1 279 281 PF00082 0.421
CLV_PCSK_KEX2_1 282 284 PF00082 0.427
CLV_PCSK_KEX2_1 458 460 PF00082 0.459
CLV_PCSK_PC1ET2_1 157 159 PF00082 0.233
CLV_PCSK_PC7_1 277 283 PF00082 0.447
CLV_PCSK_SKI1_1 373 377 PF00082 0.303
CLV_PCSK_SKI1_1 513 517 PF00082 0.405
CLV_PCSK_SKI1_1 8 12 PF00082 0.506
CLV_PCSK_SKI1_1 84 88 PF00082 0.303
DEG_APCC_DBOX_1 439 447 PF00400 0.466
DEG_SPOP_SBC_1 96 100 PF00917 0.369
DOC_CKS1_1 161 166 PF01111 0.401
DOC_CYCLIN_yClb1_LxF_4 6 11 PF00134 0.590
DOC_MAPK_DCC_7 350 358 PF00069 0.303
DOC_MAPK_DCC_7 38 48 PF00069 0.463
DOC_MAPK_gen_1 458 466 PF00069 0.464
DOC_MAPK_MEF2A_6 130 139 PF00069 0.287
DOC_MAPK_MEF2A_6 350 358 PF00069 0.303
DOC_MAPK_MEF2A_6 458 466 PF00069 0.495
DOC_MAPK_NFAT4_5 458 466 PF00069 0.388
DOC_PP1_RVXF_1 6 12 PF00149 0.585
DOC_PP2B_LxvP_1 446 449 PF13499 0.441
DOC_PP4_FxxP_1 42 45 PF00568 0.453
DOC_USP7_MATH_1 110 114 PF00917 0.449
DOC_USP7_MATH_1 138 142 PF00917 0.322
DOC_USP7_MATH_1 171 175 PF00917 0.432
DOC_USP7_MATH_1 526 530 PF00917 0.424
DOC_WW_Pin1_4 160 165 PF00397 0.430
DOC_WW_Pin1_4 2 7 PF00397 0.613
DOC_WW_Pin1_4 20 25 PF00397 0.390
DOC_WW_Pin1_4 226 231 PF00397 0.322
LIG_14-3-3_CanoR_1 173 177 PF00244 0.429
LIG_14-3-3_CanoR_1 245 249 PF00244 0.272
LIG_14-3-3_CanoR_1 513 518 PF00244 0.494
LIG_14-3-3_CanoR_1 527 534 PF00244 0.472
LIG_14-3-3_CanoR_1 8 18 PF00244 0.496
LIG_APCC_ABBA_1 236 241 PF00400 0.350
LIG_BIR_II_1 1 5 PF00653 0.571
LIG_BRCT_BRCA1_1 24 28 PF00533 0.447
LIG_Clathr_ClatBox_1 136 140 PF01394 0.414
LIG_deltaCOP1_diTrp_1 39 42 PF00928 0.414
LIG_FHA_1 113 119 PF00498 0.386
LIG_FHA_1 227 233 PF00498 0.301
LIG_FHA_1 245 251 PF00498 0.374
LIG_FHA_1 343 349 PF00498 0.361
LIG_FHA_2 208 214 PF00498 0.279
LIG_FHA_2 396 402 PF00498 0.447
LIG_FHA_2 68 74 PF00498 0.303
LIG_FHA_2 87 93 PF00498 0.303
LIG_LIR_Apic_2 39 45 PF02991 0.453
LIG_LIR_Gen_1 131 139 PF02991 0.426
LIG_LIR_Gen_1 39 48 PF02991 0.306
LIG_LIR_Gen_1 64 74 PF02991 0.303
LIG_LIR_Nem_3 126 132 PF02991 0.303
LIG_LIR_Nem_3 39 43 PF02991 0.300
LIG_LIR_Nem_3 64 69 PF02991 0.303
LIG_NRBOX 442 448 PF00104 0.444
LIG_NRBOX 56 62 PF00104 0.414
LIG_PCNA_yPIPBox_3 525 535 PF02747 0.349
LIG_Pex14_2 128 132 PF04695 0.303
LIG_Pex14_2 504 508 PF04695 0.481
LIG_PTB_Apo_2 381 388 PF02174 0.375
LIG_SH2_GRB2like 397 400 PF00017 0.317
LIG_SH2_NCK_1 397 401 PF00017 0.350
LIG_SH2_PTP2 266 269 PF00017 0.447
LIG_SH2_STAT5 199 202 PF00017 0.444
LIG_SH2_STAT5 237 240 PF00017 0.414
LIG_SH2_STAT5 266 269 PF00017 0.322
LIG_SH2_STAT5 362 365 PF00017 0.414
LIG_SH2_STAT5 397 400 PF00017 0.337
LIG_SH3_1 307 313 PF00018 0.272
LIG_SH3_3 156 162 PF00018 0.421
LIG_SH3_3 254 260 PF00018 0.299
LIG_SH3_3 307 313 PF00018 0.350
LIG_SH3_3 417 423 PF00018 0.420
LIG_SH3_3 470 476 PF00018 0.521
LIG_SUMO_SIM_par_1 135 141 PF11976 0.322
LIG_SUMO_SIM_par_1 425 430 PF11976 0.310
LIG_SUMO_SIM_par_1 59 64 PF11976 0.313
LIG_SUMO_SIM_par_1 75 80 PF11976 0.218
LIG_TYR_ITIM 264 269 PF00017 0.447
LIG_WRC_WIRS_1 129 134 PF05994 0.369
MOD_CDK_SPxK_1 2 8 PF00069 0.605
MOD_CK1_1 2 8 PF00069 0.640
MOD_CK1_1 432 438 PF00069 0.483
MOD_CK1_1 491 497 PF00069 0.450
MOD_CK2_1 207 213 PF00069 0.279
MOD_CK2_1 395 401 PF00069 0.447
MOD_GlcNHglycan 165 168 PF01048 0.408
MOD_GlcNHglycan 24 27 PF01048 0.433
MOD_GlcNHglycan 410 413 PF01048 0.586
MOD_GlcNHglycan 430 434 PF01048 0.186
MOD_GlcNHglycan 467 470 PF01048 0.519
MOD_GlcNHglycan 528 531 PF01048 0.480
MOD_GlcNHglycan 63 66 PF01048 0.303
MOD_N-GLC_1 226 231 PF02516 0.414
MOD_NEK2_1 61 66 PF00069 0.303
MOD_NEK2_1 86 91 PF00069 0.414
MOD_NEK2_1 9 14 PF00069 0.612
MOD_PIKK_1 281 287 PF00454 0.421
MOD_PIKK_1 503 509 PF00454 0.368
MOD_PIKK_1 9 15 PF00454 0.611
MOD_PK_1 488 494 PF00069 0.402
MOD_PKA_1 281 287 PF00069 0.447
MOD_PKA_2 172 178 PF00069 0.429
MOD_PKA_2 244 250 PF00069 0.303
MOD_PKA_2 281 287 PF00069 0.449
MOD_PKA_2 526 532 PF00069 0.494
MOD_PKB_1 279 287 PF00069 0.331
MOD_Plk_1 38 44 PF00069 0.331
MOD_Plk_1 429 435 PF00069 0.510
MOD_Plk_4 491 497 PF00069 0.473
MOD_Plk_4 67 73 PF00069 0.414
MOD_ProDKin_1 160 166 PF00069 0.430
MOD_ProDKin_1 2 8 PF00069 0.610
MOD_ProDKin_1 20 26 PF00069 0.388
MOD_ProDKin_1 226 232 PF00069 0.322
MOD_SUMO_for_1 487 490 PF00179 0.517
MOD_SUMO_rev_2 198 207 PF00179 0.428
TRG_DiLeu_BaEn_1 202 207 PF01217 0.447
TRG_DiLeu_BaEn_1 56 61 PF01217 0.379
TRG_ENDOCYTIC_2 129 132 PF00928 0.294
TRG_ENDOCYTIC_2 266 269 PF00928 0.303
TRG_ENDOCYTIC_2 397 400 PF00928 0.424
TRG_ER_diArg_1 145 147 PF00400 0.303
TRG_ER_diArg_1 277 280 PF00400 0.403
TRG_ER_diArg_1 281 283 PF00400 0.411
TRG_ER_diArg_1 457 459 PF00400 0.420
TRG_Pf-PMV_PEXEL_1 417 422 PF00026 0.444

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IIU8 Leptomonas seymouri 62% 100%
A0A1X0P2L8 Trypanosomatidae 39% 100%
A0A3S7WNL1 Leishmania donovani 99% 100%
A0A422NGT4 Trypanosoma rangeli 45% 100%
A4H389 Leishmania braziliensis 82% 100%
C9ZXM5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 100%
E9AC62 Leishmania major 95% 100%
E9AJF8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 97%
O65041 Arabidopsis thaliana 33% 100%
Q09765 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 34% 100%
Q54QG9 Dictyostelium discoideum 34% 100%
Q5R4A0 Pongo abelii 36% 100%
Q7ZVX6 Danio rerio 35% 100%
Q8C878 Mus musculus 35% 100%
Q8TBC4 Homo sapiens 35% 100%
Q99MI7 Rattus norvegicus 35% 100%
Q9V6U8 Drosophila melanogaster 33% 100%
V5BH30 Trypanosoma cruzi 47% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS