Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HRJ1_LEIIN

TriTrypDb:

LINF_010011900

Length:

801

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HRJ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRJ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.762
CLV_C14_Caspase3-7	182	186	PF00656	0.635
CLV_C14_Caspase3-7	324	328	PF00656	0.703
CLV_C14_Caspase3-7	641	645	PF00656	0.644
CLV_NRD_NRD_1	213	215	PF00675	0.687
CLV_NRD_NRD_1	248	250	PF00675	0.667
CLV_NRD_NRD_1	260	262	PF00675	0.601
CLV_NRD_NRD_1	306	308	PF00675	0.573
CLV_NRD_NRD_1	34	36	PF00675	0.611
CLV_NRD_NRD_1	608	610	PF00675	0.729
CLV_NRD_NRD_1	62	64	PF00675	0.650
CLV_NRD_NRD_1	726	728	PF00675	0.662
CLV_NRD_NRD_1	86	88	PF00675	0.720
CLV_NRD_NRD_1	99	101	PF00675	0.561
CLV_PCSK_FUR_1	211	215	PF00082	0.692
CLV_PCSK_FUR_1	97	101	PF00082	0.672
CLV_PCSK_KEX2_1	213	215	PF00082	0.687
CLV_PCSK_KEX2_1	247	249	PF00082	0.659
CLV_PCSK_KEX2_1	260	262	PF00082	0.593
CLV_PCSK_KEX2_1	306	308	PF00082	0.573
CLV_PCSK_KEX2_1	34	36	PF00082	0.618
CLV_PCSK_KEX2_1	608	610	PF00082	0.729
CLV_PCSK_KEX2_1	711	713	PF00082	0.651
CLV_PCSK_KEX2_1	726	728	PF00082	0.559
CLV_PCSK_KEX2_1	86	88	PF00082	0.720
CLV_PCSK_KEX2_1	99	101	PF00082	0.561
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.609
CLV_PCSK_PC1ET2_1	711	713	PF00082	0.651
CLV_PCSK_PC7_1	243	249	PF00082	0.565
CLV_PCSK_SKI1_1	28	32	PF00082	0.532
CLV_PCSK_SKI1_1	673	677	PF00082	0.690
CLV_PCSK_SKI1_1	774	778	PF00082	0.549
DEG_SCF_FBW7_1	539	546	PF00400	0.688
DEG_SPOP_SBC_1	368	372	PF00917	0.658
DEG_SPOP_SBC_1	386	390	PF00917	0.507
DEG_SPOP_SBC_1	538	542	PF00917	0.695
DEG_SPOP_SBC_1	575	579	PF00917	0.660
DEG_SPOP_SBC_1	755	759	PF00917	0.679
DOC_CKS1_1	300	305	PF01111	0.831
DOC_CYCLIN_RxL_1	771	780	PF00134	0.555
DOC_CYCLIN_yCln2_LP_2	187	193	PF00134	0.668
DOC_MAPK_gen_1	630	639	PF00069	0.598
DOC_MAPK_gen_1	710	718	PF00069	0.678
DOC_PP2B_LxvP_1	187	190	PF13499	0.664
DOC_USP7_MATH_1	179	183	PF00917	0.640
DOC_USP7_MATH_1	217	221	PF00917	0.681
DOC_USP7_MATH_1	234	238	PF00917	0.572
DOC_USP7_MATH_1	274	278	PF00917	0.686
DOC_USP7_MATH_1	368	372	PF00917	0.691
DOC_USP7_MATH_1	373	377	PF00917	0.623
DOC_USP7_MATH_1	386	390	PF00917	0.510
DOC_USP7_MATH_1	445	449	PF00917	0.605
DOC_USP7_MATH_1	50	54	PF00917	0.703
DOC_USP7_MATH_1	515	519	PF00917	0.711
DOC_USP7_MATH_1	570	574	PF00917	0.552
DOC_USP7_MATH_1	721	725	PF00917	0.655
DOC_USP7_MATH_1	754	758	PF00917	0.682
DOC_WW_Pin1_4	1	6	PF00397	0.658
DOC_WW_Pin1_4	122	127	PF00397	0.685
DOC_WW_Pin1_4	131	136	PF00397	0.605
DOC_WW_Pin1_4	148	153	PF00397	0.542
DOC_WW_Pin1_4	299	304	PF00397	0.774
DOC_WW_Pin1_4	336	341	PF00397	0.763
DOC_WW_Pin1_4	357	362	PF00397	0.653
DOC_WW_Pin1_4	382	387	PF00397	0.689
DOC_WW_Pin1_4	417	422	PF00397	0.657
DOC_WW_Pin1_4	52	57	PF00397	0.661
DOC_WW_Pin1_4	539	544	PF00397	0.691
DOC_WW_Pin1_4	599	604	PF00397	0.654
DOC_WW_Pin1_4	658	663	PF00397	0.734
DOC_WW_Pin1_4	98	103	PF00397	0.649
LIG_14-3-3_CanoR_1	129	137	PF00244	0.721
LIG_14-3-3_CanoR_1	155	160	PF00244	0.692
LIG_14-3-3_CanoR_1	248	258	PF00244	0.619
LIG_14-3-3_CanoR_1	394	398	PF00244	0.625
LIG_14-3-3_CanoR_1	413	421	PF00244	0.616
LIG_14-3-3_CanoR_1	450	456	PF00244	0.674
LIG_14-3-3_CanoR_1	596	604	PF00244	0.650
LIG_14-3-3_CanoR_1	630	639	PF00244	0.711
LIG_14-3-3_CanoR_1	667	675	PF00244	0.706
LIG_14-3-3_CanoR_1	712	718	PF00244	0.715
LIG_14-3-3_CanoR_1	731	737	PF00244	0.527
LIG_APCC_ABBA_1	781	786	PF00400	0.586
LIG_BIR_II_1	1	5	PF00653	0.601
LIG_BIR_III_2	185	189	PF00653	0.655
LIG_BIR_III_2	474	478	PF00653	0.616
LIG_BIR_III_2	737	741	PF00653	0.649
LIG_BRCT_BRCA1_1	271	275	PF00533	0.650
LIG_BRCT_BRCA1_1	38	42	PF00533	0.542
LIG_CaM_NSCaTE_8	439	446	PF13499	0.653
LIG_deltaCOP1_diTrp_1	33	42	PF00928	0.446
LIG_FHA_1	163	169	PF00498	0.539
LIG_FHA_1	182	188	PF00498	0.597
LIG_FHA_1	286	292	PF00498	0.645
LIG_FHA_1	299	305	PF00498	0.690
LIG_FHA_1	314	320	PF00498	0.583
LIG_FHA_1	333	339	PF00498	0.609
LIG_FHA_1	460	466	PF00498	0.687
LIG_FHA_1	575	581	PF00498	0.685
LIG_FHA_1	768	774	PF00498	0.618
LIG_FHA_2	194	200	PF00498	0.713
LIG_FHA_2	228	234	PF00498	0.534
LIG_FHA_2	313	319	PF00498	0.713
LIG_FHA_2	64	70	PF00498	0.669
LIG_FHA_2	766	772	PF00498	0.563
LIG_Integrin_RGD_1	76	78	PF01839	0.606
LIG_LIR_Gen_1	4	12	PF02991	0.621
LIG_LIR_Gen_1	480	489	PF02991	0.568
LIG_LIR_Gen_1	500	507	PF02991	0.375
LIG_LIR_Nem_3	158	163	PF02991	0.704
LIG_LIR_Nem_3	4	9	PF02991	0.652
LIG_LIR_Nem_3	480	484	PF02991	0.601
LIG_LIR_Nem_3	486	492	PF02991	0.588
LIG_LIR_Nem_3	500	505	PF02991	0.393
LIG_PTAP_UEV_1	101	106	PF05743	0.694
LIG_Rb_LxCxE_1	106	125	PF01857	0.614
LIG_SH2_CRK	481	485	PF00017	0.563
LIG_SH2_SRC	784	787	PF00017	0.601
LIG_SH2_STAP1	183	187	PF00017	0.639
LIG_SH2_STAT5	183	186	PF00017	0.615
LIG_SH2_STAT5	502	505	PF00017	0.586
LIG_SH3_1	99	105	PF00018	0.666
LIG_SH3_2	255	260	PF14604	0.732
LIG_SH3_2	662	667	PF14604	0.726
LIG_SH3_3	146	152	PF00018	0.668
LIG_SH3_3	252	258	PF00018	0.724
LIG_SH3_3	294	300	PF00018	0.813
LIG_SH3_3	462	468	PF00018	0.636
LIG_SH3_3	659	665	PF00018	0.729
LIG_SH3_3	683	689	PF00018	0.597
LIG_SH3_3	99	105	PF00018	0.666
LIG_SH3_CIN85_PxpxPR_1	150	155	PF14604	0.637
LIG_SUMO_SIM_anti_2	422	428	PF11976	0.559
LIG_SUMO_SIM_par_1	116	122	PF11976	0.650
LIG_SUMO_SIM_par_1	635	642	PF11976	0.637
LIG_TYR_ITIM	479	484	PF00017	0.566
MOD_CDC14_SPxK_1	664	667	PF00782	0.726
MOD_CDK_SPK_2	150	155	PF00069	0.637
MOD_CDK_SPxK_1	661	667	PF00069	0.727
MOD_CDK_SPxxK_3	122	129	PF00069	0.657
MOD_CDK_SPxxK_3	148	155	PF00069	0.640
MOD_CDK_SPxxK_3	299	306	PF00069	0.592
MOD_CK1_1	119	125	PF00069	0.633
MOD_CK1_1	138	144	PF00069	0.569
MOD_CK1_1	181	187	PF00069	0.724
MOD_CK1_1	220	226	PF00069	0.679
MOD_CK1_1	263	269	PF00069	0.825
MOD_CK1_1	277	283	PF00069	0.603
MOD_CK1_1	4	10	PF00069	0.667
MOD_CK1_1	414	420	PF00069	0.727
MOD_CK1_1	448	454	PF00069	0.709
MOD_CK1_1	459	465	PF00069	0.587
MOD_CK1_1	519	525	PF00069	0.763
MOD_CK1_1	533	539	PF00069	0.699
MOD_CK1_1	562	568	PF00069	0.676
MOD_CK1_1	573	579	PF00069	0.639
MOD_CK1_1	599	605	PF00069	0.704
MOD_CK1_1	635	641	PF00069	0.700
MOD_CK1_1	649	655	PF00069	0.574
MOD_CK1_1	660	666	PF00069	0.631
MOD_CK1_1	729	735	PF00069	0.684
MOD_CK1_1	758	764	PF00069	0.650
MOD_CK2_1	107	113	PF00069	0.649
MOD_CK2_1	193	199	PF00069	0.709
MOD_CK2_1	227	233	PF00069	0.578
MOD_CK2_1	234	240	PF00069	0.522
MOD_CK2_1	525	531	PF00069	0.646
MOD_CK2_1	622	628	PF00069	0.673
MOD_CK2_1	63	69	PF00069	0.672
MOD_Cter_Amidation	211	214	PF01082	0.606
MOD_GlcNHglycan	1	4	PF01048	0.654
MOD_GlcNHglycan	102	105	PF01048	0.693
MOD_GlcNHglycan	131	134	PF01048	0.680
MOD_GlcNHglycan	140	143	PF01048	0.614
MOD_GlcNHglycan	191	194	PF01048	0.690
MOD_GlcNHglycan	208	211	PF01048	0.670
MOD_GlcNHglycan	219	222	PF01048	0.559
MOD_GlcNHglycan	251	254	PF01048	0.709
MOD_GlcNHglycan	371	374	PF01048	0.611
MOD_GlcNHglycan	38	41	PF01048	0.594
MOD_GlcNHglycan	382	385	PF01048	0.571
MOD_GlcNHglycan	389	392	PF01048	0.525
MOD_GlcNHglycan	443	446	PF01048	0.658
MOD_GlcNHglycan	447	450	PF01048	0.701
MOD_GlcNHglycan	459	462	PF01048	0.568
MOD_GlcNHglycan	518	521	PF01048	0.799
MOD_GlcNHglycan	52	55	PF01048	0.612
MOD_GlcNHglycan	535	538	PF01048	0.567
MOD_GlcNHglycan	561	564	PF01048	0.667
MOD_GlcNHglycan	6	9	PF01048	0.636
MOD_GlcNHglycan	632	635	PF01048	0.617
MOD_GlcNHglycan	649	652	PF01048	0.634
MOD_GlcNHglycan	728	731	PF01048	0.688
MOD_GlcNHglycan	752	755	PF01048	0.723
MOD_GlcNHglycan	758	761	PF01048	0.638
MOD_GlcNHglycan	78	83	PF01048	0.598
MOD_GSK3_1	118	125	PF00069	0.785
MOD_GSK3_1	131	138	PF00069	0.610
MOD_GSK3_1	189	196	PF00069	0.721
MOD_GSK3_1	198	205	PF00069	0.685
MOD_GSK3_1	262	269	PF00069	0.756
MOD_GSK3_1	270	277	PF00069	0.670
MOD_GSK3_1	298	305	PF00069	0.781
MOD_GSK3_1	332	339	PF00069	0.707
MOD_GSK3_1	363	370	PF00069	0.794
MOD_GSK3_1	382	389	PF00069	0.520
MOD_GSK3_1	411	418	PF00069	0.671
MOD_GSK3_1	441	448	PF00069	0.720
MOD_GSK3_1	450	457	PF00069	0.626
MOD_GSK3_1	515	522	PF00069	0.795
MOD_GSK3_1	533	540	PF00069	0.624
MOD_GSK3_1	569	576	PF00069	0.734
MOD_GSK3_1	599	606	PF00069	0.582
MOD_GSK3_1	622	629	PF00069	0.708
MOD_GSK3_1	635	642	PF00069	0.623
MOD_GSK3_1	64	71	PF00069	0.706
MOD_GSK3_1	657	664	PF00069	0.678
MOD_GSK3_1	673	680	PF00069	0.548
MOD_GSK3_1	706	713	PF00069	0.654
MOD_GSK3_1	726	733	PF00069	0.593
MOD_GSK3_1	746	753	PF00069	0.587
MOD_GSK3_1	754	761	PF00069	0.651
MOD_GSK3_1	763	770	PF00069	0.491
MOD_N-GLC_1	197	202	PF02516	0.687
MOD_N-GLC_1	266	271	PF02516	0.737
MOD_N-GLC_1	325	330	PF02516	0.659
MOD_N-GLC_1	428	433	PF02516	0.518
MOD_NEK2_1	118	123	PF00069	0.583
MOD_NEK2_1	227	232	PF00069	0.548
MOD_NEK2_1	275	280	PF00069	0.691
MOD_NEK2_1	291	296	PF00069	0.665
MOD_NEK2_1	312	317	PF00069	0.782
MOD_NEK2_1	380	385	PF00069	0.766
MOD_NEK2_1	393	398	PF00069	0.620
MOD_NEK2_1	443	448	PF00069	0.720
MOD_NEK2_1	456	461	PF00069	0.581
MOD_NEK2_1	488	493	PF00069	0.646
MOD_NEK2_1	666	671	PF00069	0.717
MOD_NEK2_1	777	782	PF00069	0.610
MOD_NEK2_2	603	608	PF00069	0.583
MOD_PIKK_1	22	28	PF00454	0.524
MOD_PIKK_1	373	379	PF00454	0.708
MOD_PIKK_1	564	570	PF00454	0.707
MOD_PIKK_1	622	628	PF00454	0.723
MOD_PIKK_1	721	727	PF00454	0.658
MOD_PK_1	116	122	PF00069	0.637
MOD_PK_1	779	785	PF00069	0.552
MOD_PKA_1	248	254	PF00069	0.666
MOD_PKA_1	260	266	PF00069	0.626
MOD_PKA_1	608	614	PF00069	0.709
MOD_PKA_1	63	69	PF00069	0.646
MOD_PKA_1	710	716	PF00069	0.652
MOD_PKA_1	726	732	PF00069	0.554
MOD_PKA_2	128	134	PF00069	0.608
MOD_PKA_2	248	254	PF00069	0.717
MOD_PKA_2	260	266	PF00069	0.733
MOD_PKA_2	291	297	PF00069	0.625
MOD_PKA_2	393	399	PF00069	0.704
MOD_PKA_2	414	420	PF00069	0.608
MOD_PKA_2	533	539	PF00069	0.811
MOD_PKA_2	607	613	PF00069	0.705
MOD_PKA_2	666	672	PF00069	0.654
MOD_PKA_2	711	717	PF00069	0.689
MOD_PKA_2	726	732	PF00069	0.572
MOD_PKB_1	413	421	PF00069	0.653
MOD_PKB_1	630	638	PF00069	0.600
MOD_Plk_1	197	203	PF00069	0.686
MOD_Plk_1	227	233	PF00069	0.546
MOD_Plk_1	266	272	PF00069	0.665
MOD_Plk_1	325	331	PF00069	0.662
MOD_Plk_4	422	428	PF00069	0.647
MOD_Plk_4	451	457	PF00069	0.670
MOD_Plk_4	632	638	PF00069	0.659
MOD_Plk_4	779	785	PF00069	0.609
MOD_ProDKin_1	1	7	PF00069	0.659
MOD_ProDKin_1	122	128	PF00069	0.685
MOD_ProDKin_1	131	137	PF00069	0.606
MOD_ProDKin_1	148	154	PF00069	0.541
MOD_ProDKin_1	299	305	PF00069	0.771
MOD_ProDKin_1	336	342	PF00069	0.763
MOD_ProDKin_1	357	363	PF00069	0.654
MOD_ProDKin_1	382	388	PF00069	0.690
MOD_ProDKin_1	417	423	PF00069	0.657
MOD_ProDKin_1	52	58	PF00069	0.663
MOD_ProDKin_1	539	545	PF00069	0.690
MOD_ProDKin_1	599	605	PF00069	0.651
MOD_ProDKin_1	658	664	PF00069	0.733
MOD_ProDKin_1	98	104	PF00069	0.648
MOD_SUMO_rev_2	110	118	PF00179	0.630
TRG_DiLeu_BaEn_1	113	118	PF01217	0.629
TRG_DiLeu_BaLyEn_6	54	59	PF01217	0.718
TRG_ENDOCYTIC_2	160	163	PF00928	0.688
TRG_ENDOCYTIC_2	481	484	PF00928	0.568
TRG_ENDOCYTIC_2	502	505	PF00928	0.591
TRG_ER_diArg_1	211	214	PF00400	0.693
TRG_ER_diArg_1	259	261	PF00400	0.673
TRG_ER_diArg_1	34	36	PF00400	0.568
TRG_ER_diArg_1	532	535	PF00400	0.695
TRG_ER_diArg_1	607	609	PF00400	0.732
TRG_NES_CRM1_1	771	786	PF08389	0.542
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A451EJC2	Leishmania donovani	99%	100%
A4H386	Leishmania braziliensis	52%	100%
E9AC59	Leishmania major	85%	98%
E9AJF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	98%