Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HRJ0_LEIIN

TriTrypDb:

LINF_010011800

Length:

302

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HRJ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRJ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	5	9	PF00656	0.459
CLV_PCSK_SKI1_1	16	20	PF00082	0.552
DEG_SCF_FBW7_1	165	172	PF00400	0.691
DOC_CKS1_1	142	147	PF01111	0.672
DOC_CKS1_1	166	171	PF01111	0.693
DOC_CYCLIN_yClb3_PxF_3	165	171	PF00134	0.623
DOC_MAPK_gen_1	126	136	PF00069	0.636
DOC_PP1_RVXF_1	14	20	PF00149	0.534
DOC_PP4_FxxP_1	19	22	PF00568	0.511
DOC_USP7_MATH_1	125	129	PF00917	0.607
DOC_USP7_MATH_1	198	202	PF00917	0.607
DOC_USP7_MATH_1	40	44	PF00917	0.734
DOC_USP7_MATH_1	79	83	PF00917	0.625
DOC_WW_Pin1_4	141	146	PF00397	0.707
DOC_WW_Pin1_4	161	166	PF00397	0.623
DOC_WW_Pin1_4	169	174	PF00397	0.685
DOC_WW_Pin1_4	211	216	PF00397	0.696
DOC_WW_Pin1_4	223	228	PF00397	0.746
DOC_WW_Pin1_4	235	240	PF00397	0.690
DOC_WW_Pin1_4	275	280	PF00397	0.661
DOC_WW_Pin1_4	63	68	PF00397	0.629
LIG_14-3-3_CanoR_1	129	134	PF00244	0.730
LIG_14-3-3_CanoR_1	16	22	PF00244	0.544
LIG_14-3-3_CanoR_1	293	302	PF00244	0.599
LIG_14-3-3_CanoR_1	50	55	PF00244	0.571
LIG_14-3-3_CanoR_1	85	93	PF00244	0.632
LIG_14-3-3_CanoR_1	95	104	PF00244	0.480
LIG_BRCT_BRCA1_1	295	299	PF00533	0.591
LIG_FHA_2	188	194	PF00498	0.566
LIG_FHA_2	22	28	PF00498	0.640
LIG_LIR_Gen_1	183	194	PF02991	0.585
LIG_LIR_Gen_1	296	302	PF02991	0.580
LIG_LIR_Gen_1	45	54	PF02991	0.597
LIG_LIR_Gen_1	8	18	PF02991	0.438
LIG_LIR_LC3C_4	12	15	PF02991	0.429
LIG_LIR_Nem_3	183	189	PF02991	0.598
LIG_LIR_Nem_3	219	225	PF02991	0.587
LIG_LIR_Nem_3	296	302	PF02991	0.580
LIG_LIR_Nem_3	45	51	PF02991	0.597
LIG_LIR_Nem_3	8	13	PF02991	0.434
LIG_PDZ_Class_3	297	302	PF00595	0.646
LIG_SH2_CRK	206	210	PF00017	0.642
LIG_SH3_3	163	169	PF00018	0.687
LIG_SUMO_SIM_par_1	131	138	PF11976	0.649
LIG_TRAF2_1	190	193	PF00917	0.579
MOD_CDK_SPK_2	141	146	PF00069	0.677
MOD_CDK_SPxK_1	235	241	PF00069	0.665
MOD_CK1_1	128	134	PF00069	0.605
MOD_CK1_1	135	141	PF00069	0.616
MOD_CK1_1	159	165	PF00069	0.751
MOD_CK1_1	234	240	PF00069	0.739
MOD_CK1_1	248	254	PF00069	0.654
MOD_CK1_1	291	297	PF00069	0.622
MOD_CK1_1	42	48	PF00069	0.592
MOD_CK1_1	94	100	PF00069	0.587
MOD_CK2_1	187	193	PF00069	0.646
MOD_CK2_1	28	34	PF00069	0.644
MOD_CK2_1	292	298	PF00069	0.699
MOD_GlcNHglycan	146	149	PF01048	0.697
MOD_GlcNHglycan	158	161	PF01048	0.753
MOD_GlcNHglycan	200	203	PF01048	0.606
MOD_GlcNHglycan	218	221	PF01048	0.620
MOD_GlcNHglycan	42	45	PF01048	0.583
MOD_GlcNHglycan	81	84	PF01048	0.619
MOD_GlcNHglycan	97	100	PF01048	0.623
MOD_GSK3_1	125	132	PF00069	0.636
MOD_GSK3_1	140	147	PF00069	0.609
MOD_GSK3_1	161	168	PF00069	0.705
MOD_GSK3_1	17	24	PF00069	0.620
MOD_GSK3_1	174	181	PF00069	0.610
MOD_GSK3_1	231	238	PF00069	0.715
MOD_GSK3_1	245	252	PF00069	0.713
MOD_GSK3_1	277	284	PF00069	0.626
MOD_GSK3_1	288	295	PF00069	0.622
MOD_GSK3_1	42	49	PF00069	0.576
MOD_GSK3_1	79	86	PF00069	0.807
MOD_GSK3_1	87	94	PF00069	0.531
MOD_N-GLC_1	140	145	PF02516	0.679
MOD_N-GLC_1	234	239	PF02516	0.619
MOD_N-GLC_1	281	286	PF02516	0.651
MOD_N-GLC_1	40	45	PF02516	0.645
MOD_NEK2_1	156	161	PF00069	0.617
MOD_NEK2_1	179	184	PF00069	0.786
MOD_NEK2_1	246	251	PF00069	0.760
MOD_NEK2_1	267	272	PF00069	0.691
MOD_NEK2_1	68	73	PF00069	0.597
MOD_PIKK_1	159	165	PF00454	0.692
MOD_PIKK_1	277	283	PF00454	0.665
MOD_PIKK_1	288	294	PF00454	0.625
MOD_PIKK_1	42	48	PF00454	0.567
MOD_PK_1	129	135	PF00069	0.635
MOD_PKA_2	125	131	PF00069	0.682
MOD_PKA_2	288	294	PF00069	0.623
MOD_PKA_2	84	90	PF00069	0.665
MOD_PKA_2	94	100	PF00069	0.507
MOD_Plk_4	129	135	PF00069	0.607
MOD_Plk_4	182	188	PF00069	0.610
MOD_ProDKin_1	141	147	PF00069	0.704
MOD_ProDKin_1	161	167	PF00069	0.626
MOD_ProDKin_1	169	175	PF00069	0.683
MOD_ProDKin_1	211	217	PF00069	0.697
MOD_ProDKin_1	223	229	PF00069	0.748
MOD_ProDKin_1	235	241	PF00069	0.690
MOD_ProDKin_1	275	281	PF00069	0.663
MOD_ProDKin_1	63	69	PF00069	0.629
TRG_DiLeu_BaLyEn_6	151	156	PF01217	0.528
TRG_ENDOCYTIC_2	206	209	PF00928	0.641

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I318	Leptomonas seymouri	43%	93%
A0A3S5H4W5	Leishmania donovani	99%	100%
A4H385	Leishmania braziliensis	70%	92%
E9AC58	Leishmania major	91%	100%
E9AJF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	95%