LeishMANIAdb
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Putative mitochondrial processing peptide beta subunit

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative mitochondrial processing peptide beta subunit
Gene product:
metallo-peptidase - Clan ME - Family M16
Species:
Leishmania infantum
UniProt:
A4HRI8_LEIIN
TriTrypDb:
LINF_010011600
Length:
494

Annotations

Annotations by Jardim et al.

Electron Transport Chain (see tricarboxylic acid section for Complex II), mitochondrial processing peptide beta subunit

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 1
GO:0017087 mitochondrial processing peptidase complex 3 1
GO:0032991 protein-containing complex 1 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0098798 mitochondrial protein-containing complex 2 1
GO:0110165 cellular anatomical entity 1 1
GO:1902494 catalytic complex 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HRI8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRI8

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0019538 protein metabolic process 3 11
GO:0043170 macromolecule metabolic process 3 11
GO:0044238 primary metabolic process 2 11
GO:0071704 organic substance metabolic process 2 11
GO:1901564 organonitrogen compound metabolic process 3 11
GO:0006810 transport 3 1
GO:0006839 mitochondrial transport 4 1
GO:0006886 intracellular protein transport 4 1
GO:0008104 protein localization 4 1
GO:0009987 cellular process 1 1
GO:0015031 protein transport 4 1
GO:0030150 protein import into mitochondrial matrix 4 1
GO:0033036 macromolecule localization 2 1
GO:0033365 protein localization to organelle 5 1
GO:0044743 protein transmembrane import into intracellular organelle 4 1
GO:0045184 establishment of protein localization 3 1
GO:0046907 intracellular transport 3 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0055085 transmembrane transport 2 1
GO:0065002 intracellular protein transmembrane transport 4 1
GO:0070585 protein localization to mitochondrion 6 1
GO:0070727 cellular macromolecule localization 3 1
GO:0071702 organic substance transport 4 1
GO:0071705 nitrogen compound transport 4 1
GO:0071806 protein transmembrane transport 3 1
GO:0072594 establishment of protein localization to organelle 4 1
GO:0072655 establishment of protein localization to mitochondrion 5 1
GO:1990542 mitochondrial transmembrane transport 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0004175 endopeptidase activity 4 11
GO:0004222 metalloendopeptidase activity 5 11
GO:0005488 binding 1 11
GO:0008233 peptidase activity 3 11
GO:0008237 metallopeptidase activity 4 11
GO:0016787 hydrolase activity 2 11
GO:0043167 ion binding 2 11
GO:0043169 cation binding 3 11
GO:0046872 metal ion binding 4 11
GO:0140096 catalytic activity, acting on a protein 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 284 288 PF00656 0.240
CLV_C14_Caspase3-7 429 433 PF00656 0.333
CLV_NRD_NRD_1 145 147 PF00675 0.350
CLV_NRD_NRD_1 3 5 PF00675 0.524
CLV_NRD_NRD_1 313 315 PF00675 0.388
CLV_NRD_NRD_1 420 422 PF00675 0.263
CLV_PCSK_FUR_1 143 147 PF00082 0.350
CLV_PCSK_KEX2_1 145 147 PF00082 0.350
CLV_PCSK_KEX2_1 3 5 PF00082 0.524
CLV_PCSK_KEX2_1 313 315 PF00082 0.388
CLV_PCSK_KEX2_1 420 422 PF00082 0.263
CLV_PCSK_PC7_1 141 147 PF00082 0.276
CLV_PCSK_SKI1_1 122 126 PF00082 0.299
CLV_PCSK_SKI1_1 250 254 PF00082 0.262
CLV_PCSK_SKI1_1 350 354 PF00082 0.438
CLV_PCSK_SKI1_1 45 49 PF00082 0.213
DEG_APCC_DBOX_1 249 257 PF00400 0.226
DEG_APCC_DBOX_1 420 428 PF00400 0.366
DEG_SCF_FBW7_2 331 338 PF00400 0.276
DOC_CKS1_1 332 337 PF01111 0.258
DOC_PP4_FxxP_1 332 335 PF00568 0.257
DOC_USP7_MATH_1 110 114 PF00917 0.205
DOC_USP7_MATH_1 182 186 PF00917 0.240
DOC_USP7_MATH_1 452 456 PF00917 0.308
DOC_USP7_UBL2_3 122 126 PF12436 0.299
DOC_USP7_UBL2_3 200 204 PF12436 0.345
DOC_USP7_UBL2_3 390 394 PF12436 0.286
DOC_WW_Pin1_4 226 231 PF00397 0.299
DOC_WW_Pin1_4 30 35 PF00397 0.332
DOC_WW_Pin1_4 331 336 PF00397 0.254
DOC_WW_Pin1_4 432 437 PF00397 0.301
DOC_WW_Pin1_4 464 469 PF00397 0.286
LIG_14-3-3_CanoR_1 91 101 PF00244 0.248
LIG_Actin_WH2_2 424 442 PF00022 0.402
LIG_BRCT_BRCA1_1 481 485 PF00533 0.340
LIG_CtBP_PxDLS_1 436 440 PF00389 0.412
LIG_CtBP_PxDLS_1 468 472 PF00389 0.440
LIG_eIF4E_1 336 342 PF01652 0.245
LIG_eIF4E_1 466 472 PF01652 0.409
LIG_FHA_1 123 129 PF00498 0.368
LIG_FHA_1 182 188 PF00498 0.350
LIG_FHA_1 3 9 PF00498 0.641
LIG_FHA_1 31 37 PF00498 0.319
LIG_FHA_1 337 343 PF00498 0.270
LIG_FHA_1 351 357 PF00498 0.455
LIG_FHA_1 361 367 PF00498 0.315
LIG_FHA_1 46 52 PF00498 0.230
LIG_FHA_1 56 62 PF00498 0.209
LIG_FHA_2 110 116 PF00498 0.215
LIG_FHA_2 17 23 PF00498 0.408
LIG_FHA_2 332 338 PF00498 0.286
LIG_FHA_2 377 383 PF00498 0.345
LIG_GBD_Chelix_1 198 206 PF00786 0.265
LIG_LIR_Gen_1 208 218 PF02991 0.229
LIG_LIR_Gen_1 426 436 PF02991 0.325
LIG_LIR_Gen_1 444 454 PF02991 0.380
LIG_LIR_Gen_1 53 63 PF02991 0.266
LIG_LIR_Gen_1 67 77 PF02991 0.165
LIG_LIR_Nem_3 208 213 PF02991 0.229
LIG_LIR_Nem_3 238 244 PF02991 0.220
LIG_LIR_Nem_3 303 309 PF02991 0.278
LIG_LIR_Nem_3 426 431 PF02991 0.293
LIG_LIR_Nem_3 444 449 PF02991 0.434
LIG_LIR_Nem_3 53 59 PF02991 0.273
LIG_LIR_Nem_3 67 72 PF02991 0.185
LIG_PCNA_yPIPBox_3 358 369 PF02747 0.292
LIG_PCNA_yPIPBox_3 68 81 PF02747 0.205
LIG_Rb_pABgroove_1 368 376 PF01858 0.373
LIG_SH2_CRK 215 219 PF00017 0.205
LIG_SH2_CRK 344 348 PF00017 0.232
LIG_SH2_CRK 37 41 PF00017 0.288
LIG_SH2_CRK 466 470 PF00017 0.489
LIG_SH2_PTP2 210 213 PF00017 0.370
LIG_SH2_STAP1 336 340 PF00017 0.397
LIG_SH2_STAP1 374 378 PF00017 0.390
LIG_SH2_STAT3 289 292 PF00017 0.220
LIG_SH2_STAT5 111 114 PF00017 0.205
LIG_SH2_STAT5 120 123 PF00017 0.205
LIG_SH2_STAT5 210 213 PF00017 0.225
LIG_SH2_STAT5 215 218 PF00017 0.212
LIG_SH2_STAT5 240 243 PF00017 0.376
LIG_SH2_STAT5 333 336 PF00017 0.254
LIG_SH2_STAT5 368 371 PF00017 0.245
LIG_SH2_STAT5 446 449 PF00017 0.303
LIG_SH2_STAT5 50 53 PF00017 0.240
LIG_SH3_1 313 319 PF00018 0.397
LIG_SH3_3 273 279 PF00018 0.240
LIG_SH3_3 313 319 PF00018 0.338
LIG_SH3_3 446 452 PF00018 0.424
LIG_SH3_3 472 478 PF00018 0.449
LIG_SUMO_SIM_anti_2 467 473 PF11976 0.502
LIG_SUMO_SIM_par_1 129 137 PF11976 0.265
LIG_SUMO_SIM_par_1 467 473 PF11976 0.506
LIG_TRAF2_1 335 338 PF00917 0.297
LIG_TRAF2_1 423 426 PF00917 0.381
LIG_TYR_ITIM 342 347 PF00017 0.231
LIG_TYR_ITIM 35 40 PF00017 0.272
MOD_CK1_1 242 248 PF00069 0.262
MOD_CK1_1 30 36 PF00069 0.342
MOD_CK1_1 467 473 PF00069 0.511
MOD_CK2_1 202 208 PF00069 0.276
MOD_CK2_1 331 337 PF00069 0.273
MOD_CK2_1 381 387 PF00069 0.357
MOD_CK2_1 64 70 PF00069 0.225
MOD_CK2_1 92 98 PF00069 0.365
MOD_Cter_Amidation 418 421 PF01082 0.283
MOD_GlcNHglycan 184 187 PF01048 0.240
MOD_GlcNHglycan 224 227 PF01048 0.220
MOD_GlcNHglycan 241 244 PF01048 0.353
MOD_GlcNHglycan 353 356 PF01048 0.453
MOD_GlcNHglycan 406 409 PF01048 0.340
MOD_GlcNHglycan 481 484 PF01048 0.496
MOD_GlcNHglycan 74 77 PF01048 0.313
MOD_GSK3_1 110 117 PF00069 0.242
MOD_GSK3_1 222 229 PF00069 0.277
MOD_GSK3_1 239 246 PF00069 0.276
MOD_GSK3_1 281 288 PF00069 0.240
MOD_GSK3_1 400 407 PF00069 0.387
MOD_GSK3_1 86 93 PF00069 0.205
MOD_N-GLC_1 16 21 PF02516 0.372
MOD_N-GLC_1 202 207 PF02516 0.332
MOD_NEK2_1 2 7 PF00069 0.512
MOD_NEK2_1 222 227 PF00069 0.233
MOD_NEK2_1 244 249 PF00069 0.289
MOD_NEK2_1 351 356 PF00069 0.520
MOD_NEK2_1 376 381 PF00069 0.314
MOD_NEK2_1 393 398 PF00069 0.355
MOD_NEK2_1 400 405 PF00069 0.366
MOD_PIKK_1 308 314 PF00454 0.398
MOD_PKA_2 152 158 PF00069 0.221
MOD_PKA_2 2 8 PF00069 0.484
MOD_PKA_2 400 406 PF00069 0.357
MOD_PKA_2 90 96 PF00069 0.299
MOD_Plk_1 114 120 PF00069 0.248
MOD_Plk_1 16 22 PF00069 0.389
MOD_Plk_1 202 208 PF00069 0.276
MOD_Plk_1 336 342 PF00069 0.246
MOD_Plk_1 381 387 PF00069 0.464
MOD_Plk_4 152 158 PF00069 0.205
MOD_Plk_4 187 193 PF00069 0.275
MOD_Plk_4 202 208 PF00069 0.326
MOD_Plk_4 259 265 PF00069 0.245
MOD_Plk_4 360 366 PF00069 0.341
MOD_Plk_4 369 375 PF00069 0.297
MOD_Plk_4 381 387 PF00069 0.305
MOD_Plk_4 393 399 PF00069 0.330
MOD_Plk_4 467 473 PF00069 0.461
MOD_ProDKin_1 226 232 PF00069 0.299
MOD_ProDKin_1 30 36 PF00069 0.328
MOD_ProDKin_1 331 337 PF00069 0.258
MOD_ProDKin_1 432 438 PF00069 0.300
MOD_ProDKin_1 464 470 PF00069 0.288
MOD_SUMO_for_1 389 392 PF00179 0.304
MOD_SUMO_rev_2 387 396 PF00179 0.306
TRG_DiLeu_BaEn_1 162 167 PF01217 0.229
TRG_DiLeu_BaEn_1 337 342 PF01217 0.262
TRG_DiLeu_BaEn_4 337 343 PF01217 0.279
TRG_DiLeu_BaLyEn_6 248 253 PF01217 0.345
TRG_ENDOCYTIC_2 210 213 PF00928 0.370
TRG_ENDOCYTIC_2 306 309 PF00928 0.272
TRG_ENDOCYTIC_2 344 347 PF00928 0.238
TRG_ENDOCYTIC_2 37 40 PF00928 0.276
TRG_ENDOCYTIC_2 446 449 PF00928 0.427
TRG_ENDOCYTIC_2 466 469 PF00928 0.220
TRG_ER_diArg_1 141 144 PF00400 0.366
TRG_ER_diArg_1 2 4 PF00400 0.527
TRG_ER_diArg_1 420 422 PF00400 0.263
TRG_NES_CRM1_1 414 426 PF08389 0.290

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P575 Leptomonas seymouri 83% 100%
A0A0N1PEB5 Leptomonas seymouri 30% 100%
A0A0S4IUJ1 Bodo saltans 53% 96%
A0A0S4KFV6 Bodo saltans 31% 98%
A0A1X0NHX2 Trypanosomatidae 29% 96%
A0A1X0P2L6 Trypanosomatidae 70% 96%
A0A3S7X938 Leishmania donovani 30% 100%
A0A422N9N5 Trypanosoma rangeli 28% 100%
A0A422NGW3 Trypanosoma rangeli 69% 100%
A0A451EJB9 Leishmania donovani 100% 100%
A4HMG0 Leishmania braziliensis 30% 100%
A4IB31 Leishmania infantum 30% 100%
C9ZNM7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
C9ZXM0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 70% 100%
E9AC56 Leishmania major 98% 100%
E9AEW1 Leishmania major 30% 100%
E9AJF2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
E9B617 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
O04308 Arabidopsis thaliana 25% 99%
O05945 Rickettsia prowazekii (strain Madrid E) 21% 100%
O32965 Mycobacterium leprae (strain TN) 25% 100%
O75439 Homo sapiens 35% 100%
O86835 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) 22% 100%
O94745 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 24% 98%
P07256 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 22% 100%
P0A5S9 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 24% 100%
P10507 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 32% 100%
P11913 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 33% 100%
P11914 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 100%
P20069 Rattus norvegicus 27% 94%
P22695 Homo sapiens 21% 100%
P23004 Bos taurus 22% 100%
P29677 Solanum tuberosum 25% 98%
P31800 Bos taurus 33% 100%
P31930 Homo sapiens 33% 100%
P32551 Rattus norvegicus 20% 100%
P43264 Euglena gracilis 40% 100%
P97997 Blastocladiella emersonii 24% 100%
P98080 Caenorhabditis elegans 28% 100%
P9WHT4 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 24% 100%
P9WHT5 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 24% 100%
Q00302 Blastocladiella emersonii 34% 100%
Q03346 Rattus norvegicus 36% 100%
Q04805 Bacillus subtilis (strain 168) 25% 100%
Q0P5M8 Bos taurus 28% 94%
Q10713 Homo sapiens 28% 94%
Q1RJ61 Rickettsia bellii (strain RML369-C) 22% 100%
Q23295 Caenorhabditis elegans 34% 100%
Q3SZ71 Bos taurus 37% 100%
Q42290 Arabidopsis thaliana 35% 93%
Q4UML9 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) 22% 100%
Q4W6B5 Dictyostelium discoideum 32% 100%
Q54F93 Dictyostelium discoideum 23% 100%
Q5R513 Pongo abelii 28% 94%
Q5REK3 Pongo abelii 34% 100%
Q68FY0 Rattus norvegicus 32% 100%
Q92IX7 Rickettsia conorii (strain ATCC VR-613 / Malish 7) 22% 100%
Q9CXT8 Mus musculus 35% 100%
Q9CZ13 Mus musculus 32% 100%
Q9DC61 Mus musculus 28% 94%
Q9P7X1 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 35% 100%
Q9Y8B5 Lentinula edodes 36% 100%
Q9ZU25 Arabidopsis thaliana 25% 98%
V5BGV2 Trypanosoma cruzi 29% 100%
V5BH27 Trypanosoma cruzi 70% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS