Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HRI6_LEIIN

TriTrypDb:

LINF_010011400

Length:

902

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HRI6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRI6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.563
CLV_C14_Caspase3-7	287	291	PF00656	0.573
CLV_C14_Caspase3-7	382	386	PF00656	0.676
CLV_C14_Caspase3-7	387	391	PF00656	0.675
CLV_C14_Caspase3-7	400	404	PF00656	0.559
CLV_C14_Caspase3-7	660	664	PF00656	0.686
CLV_NRD_NRD_1	120	122	PF00675	0.559
CLV_NRD_NRD_1	221	223	PF00675	0.571
CLV_NRD_NRD_1	277	279	PF00675	0.514
CLV_NRD_NRD_1	295	297	PF00675	0.564
CLV_NRD_NRD_1	308	310	PF00675	0.605
CLV_NRD_NRD_1	379	381	PF00675	0.673
CLV_NRD_NRD_1	538	540	PF00675	0.706
CLV_NRD_NRD_1	607	609	PF00675	0.643
CLV_NRD_NRD_1	697	699	PF00675	0.683
CLV_NRD_NRD_1	796	798	PF00675	0.615
CLV_NRD_NRD_1	800	802	PF00675	0.583
CLV_PCSK_FUR_1	377	381	PF00082	0.650
CLV_PCSK_FUR_1	538	542	PF00082	0.666
CLV_PCSK_KEX2_1	120	122	PF00082	0.559
CLV_PCSK_KEX2_1	221	223	PF00082	0.571
CLV_PCSK_KEX2_1	277	279	PF00082	0.514
CLV_PCSK_KEX2_1	295	297	PF00082	0.564
CLV_PCSK_KEX2_1	308	310	PF00082	0.605
CLV_PCSK_KEX2_1	379	381	PF00082	0.673
CLV_PCSK_KEX2_1	538	540	PF00082	0.800
CLV_PCSK_KEX2_1	607	609	PF00082	0.643
CLV_PCSK_KEX2_1	696	698	PF00082	0.666
CLV_PCSK_KEX2_1	796	798	PF00082	0.615
CLV_PCSK_KEX2_1	800	802	PF00082	0.583
CLV_PCSK_PC1ET2_1	540	542	PF00082	0.764
CLV_PCSK_PC7_1	304	310	PF00082	0.610
CLV_PCSK_PC7_1	796	802	PF00082	0.526
CLV_PCSK_SKI1_1	172	176	PF00082	0.520
CLV_PCSK_SKI1_1	213	217	PF00082	0.572
CLV_PCSK_SKI1_1	687	691	PF00082	0.494
CLV_Separin_Metazoa	360	364	PF03568	0.643
DEG_Nend_UBRbox_2	1	3	PF02207	0.550
DEG_SCF_FBW7_1	67	73	PF00400	0.573
DEG_SPOP_SBC_1	18	22	PF00917	0.553
DEG_SPOP_SBC_1	28	32	PF00917	0.520
DEG_SPOP_SBC_1	405	409	PF00917	0.593
DOC_ANK_TNKS_1	285	292	PF00023	0.572
DOC_CKS1_1	484	489	PF01111	0.617
DOC_CKS1_1	633	638	PF01111	0.619
DOC_CKS1_1	67	72	PF01111	0.573
DOC_MAPK_DCC_7	731	741	PF00069	0.638
DOC_PP1_RVXF_1	315	321	PF00149	0.614
DOC_PP2B_LxvP_1	129	132	PF13499	0.610
DOC_PP2B_LxvP_1	50	53	PF13499	0.540
DOC_PP2B_LxvP_1	785	788	PF13499	0.610
DOC_PP4_FxxP_1	51	54	PF00568	0.542
DOC_USP7_MATH_1	18	22	PF00917	0.525
DOC_USP7_MATH_1	215	219	PF00917	0.605
DOC_USP7_MATH_1	26	30	PF00917	0.531
DOC_USP7_MATH_1	313	317	PF00917	0.639
DOC_USP7_MATH_1	37	41	PF00917	0.518
DOC_USP7_MATH_1	405	409	PF00917	0.651
DOC_USP7_MATH_1	415	419	PF00917	0.518
DOC_USP7_MATH_1	443	447	PF00917	0.638
DOC_USP7_MATH_1	5	9	PF00917	0.534
DOC_USP7_MATH_1	501	505	PF00917	0.653
DOC_USP7_MATH_1	516	520	PF00917	0.672
DOC_USP7_MATH_1	546	550	PF00917	0.701
DOC_USP7_MATH_1	61	65	PF00917	0.581
DOC_USP7_MATH_1	621	625	PF00917	0.663
DOC_USP7_MATH_1	643	647	PF00917	0.668
DOC_USP7_MATH_1	70	74	PF00917	0.585
DOC_USP7_MATH_1	774	778	PF00917	0.665
DOC_USP7_MATH_1	781	785	PF00917	0.617
DOC_USP7_MATH_1	792	796	PF00917	0.534
DOC_USP7_MATH_1	889	893	PF00917	0.592
DOC_WW_Pin1_4	233	238	PF00397	0.656
DOC_WW_Pin1_4	295	300	PF00397	0.639
DOC_WW_Pin1_4	318	323	PF00397	0.658
DOC_WW_Pin1_4	483	488	PF00397	0.644
DOC_WW_Pin1_4	548	553	PF00397	0.675
DOC_WW_Pin1_4	57	62	PF00397	0.596
DOC_WW_Pin1_4	632	637	PF00397	0.636
DOC_WW_Pin1_4	66	71	PF00397	0.562
DOC_WW_Pin1_4	663	668	PF00397	0.811
DOC_WW_Pin1_4	734	739	PF00397	0.809
DOC_WW_Pin1_4	78	83	PF00397	0.572
DOC_WW_Pin1_4	850	855	PF00397	0.581
DOC_WW_Pin1_4	897	902	PF00397	0.629
LIG_14-3-3_CanoR_1	115	122	PF00244	0.576
LIG_14-3-3_CanoR_1	124	132	PF00244	0.595
LIG_14-3-3_CanoR_1	172	180	PF00244	0.502
LIG_14-3-3_CanoR_1	379	388	PF00244	0.651
LIG_14-3-3_CanoR_1	417	421	PF00244	0.700
LIG_14-3-3_CanoR_1	429	437	PF00244	0.659
LIG_14-3-3_CanoR_1	459	465	PF00244	0.615
LIG_14-3-3_CanoR_1	46	51	PF00244	0.592
LIG_14-3-3_CanoR_1	627	633	PF00244	0.644
LIG_14-3-3_CanoR_1	66	70	PF00244	0.530
LIG_14-3-3_CanoR_1	703	712	PF00244	0.539
LIG_14-3-3_CanoR_1	731	736	PF00244	0.649
LIG_14-3-3_CanoR_1	796	804	PF00244	0.587
LIG_BIR_III_4	345	349	PF00653	0.572
LIG_BRCT_BRCA1_1	462	466	PF00533	0.674
LIG_BRCT_BRCA1_1	479	483	PF00533	0.533
LIG_BRCT_BRCA1_1	884	888	PF00533	0.567
LIG_CSL_BTD_1	319	322	PF09270	0.661
LIG_FHA_1	117	123	PF00498	0.582
LIG_FHA_1	124	130	PF00498	0.603
LIG_FHA_1	175	181	PF00498	0.558
LIG_FHA_1	188	194	PF00498	0.463
LIG_FHA_1	262	268	PF00498	0.624
LIG_FHA_1	30	36	PF00498	0.537
LIG_FHA_1	300	306	PF00498	0.610
LIG_FHA_1	339	345	PF00498	0.678
LIG_FHA_1	407	413	PF00498	0.635
LIG_FHA_1	429	435	PF00498	0.726
LIG_FHA_2	137	143	PF00498	0.564
LIG_FHA_2	173	179	PF00498	0.500
LIG_FHA_2	380	386	PF00498	0.627
LIG_FHA_2	658	664	PF00498	0.684
LIG_FHA_2	690	696	PF00498	0.456
LIG_FHA_2	757	763	PF00498	0.624
LIG_FHA_2	81	87	PF00498	0.574
LIG_LIR_Apic_2	48	54	PF02991	0.539
LIG_LIR_Gen_1	396	405	PF02991	0.650
LIG_LIR_Gen_1	452	462	PF02991	0.629
LIG_LIR_Gen_1	463	472	PF02991	0.615
LIG_LIR_Nem_3	111	116	PF02991	0.533
LIG_LIR_Nem_3	39	44	PF02991	0.529
LIG_LIR_Nem_3	396	402	PF02991	0.649
LIG_LIR_Nem_3	452	458	PF02991	0.649
LIG_LIR_Nem_3	463	469	PF02991	0.599
LIG_LIR_Nem_3	648	654	PF02991	0.695
LIG_MYND_1	78	82	PF01753	0.606
LIG_MYND_1	783	787	PF01753	0.607
LIG_PCNA_yPIPBox_3	244	254	PF02747	0.546
LIG_PCNA_yPIPBox_3	696	709	PF02747	0.456
LIG_PDZ_Class_1	897	902	PF00595	0.545
LIG_SH2_NCK_1	399	403	PF00017	0.651
LIG_SH2_SRC	343	346	PF00017	0.630
LIG_SH2_STAT5	343	346	PF00017	0.687
LIG_SH3_3	181	187	PF00018	0.484
LIG_SH3_3	399	405	PF00018	0.663
LIG_SH3_3	408	414	PF00018	0.627
LIG_SH3_3	481	487	PF00018	0.642
LIG_SH3_3	540	546	PF00018	0.585
LIG_SH3_3	72	78	PF00018	0.617
LIG_SH3_3	780	786	PF00018	0.607
LIG_SH3_3	883	889	PF00018	0.585
LIG_SUMO_SIM_par_1	737	745	PF11976	0.596
LIG_TRAF2_1	692	695	PF00917	0.560
MOD_CDC14_SPxK_1	853	856	PF00782	0.584
MOD_CDK_SPK_2	233	238	PF00069	0.580
MOD_CDK_SPK_2	548	553	PF00069	0.619
MOD_CDK_SPxK_1	850	856	PF00069	0.582
MOD_CDK_SPxxK_3	297	304	PF00069	0.604
MOD_CDK_SPxxK_3	632	639	PF00069	0.593
MOD_CDK_SPxxK_3	78	85	PF00069	0.569
MOD_CK1_1	109	115	PF00069	0.585
MOD_CK1_1	123	129	PF00069	0.542
MOD_CK1_1	173	179	PF00069	0.572
MOD_CK1_1	200	206	PF00069	0.595
MOD_CK1_1	29	35	PF00069	0.539
MOD_CK1_1	300	306	PF00069	0.692
MOD_CK1_1	386	392	PF00069	0.687
MOD_CK1_1	416	422	PF00069	0.730
MOD_CK1_1	428	434	PF00069	0.596
MOD_CK1_1	438	444	PF00069	0.596
MOD_CK1_1	454	460	PF00069	0.528
MOD_CK1_1	519	525	PF00069	0.644
MOD_CK1_1	548	554	PF00069	0.769
MOD_CK1_1	57	63	PF00069	0.595
MOD_CK1_1	573	579	PF00069	0.621
MOD_CK1_1	628	634	PF00069	0.646
MOD_CK1_1	645	651	PF00069	0.569
MOD_CK1_1	659	665	PF00069	0.579
MOD_CK1_1	68	74	PF00069	0.553
MOD_CK1_1	7	13	PF00069	0.542
MOD_CK1_1	729	735	PF00069	0.694
MOD_CK1_1	795	801	PF00069	0.663
MOD_CK1_1	841	847	PF00069	0.625
MOD_CK1_1	855	861	PF00069	0.585
MOD_CK1_1	882	888	PF00069	0.565
MOD_CK2_1	172	178	PF00069	0.513
MOD_CK2_1	37	43	PF00069	0.531
MOD_CK2_1	488	494	PF00069	0.678
MOD_CK2_1	587	593	PF00069	0.699
MOD_CK2_1	619	625	PF00069	0.688
MOD_CK2_1	689	695	PF00069	0.455
MOD_CK2_1	756	762	PF00069	0.626
MOD_CK2_1	774	780	PF00069	0.539
MOD_Cter_Amidation	293	296	PF01082	0.625
MOD_Cter_Amidation	377	380	PF01082	0.670
MOD_GlcNHglycan	100	103	PF01048	0.617
MOD_GlcNHglycan	108	111	PF01048	0.541
MOD_GlcNHglycan	144	147	PF01048	0.658
MOD_GlcNHglycan	163	166	PF01048	0.579
MOD_GlcNHglycan	227	230	PF01048	0.702
MOD_GlcNHglycan	313	316	PF01048	0.718
MOD_GlcNHglycan	437	440	PF01048	0.693
MOD_GlcNHglycan	521	524	PF01048	0.665
MOD_GlcNHglycan	566	569	PF01048	0.657
MOD_GlcNHglycan	578	582	PF01048	0.578
MOD_GlcNHglycan	610	613	PF01048	0.712
MOD_GlcNHglycan	647	650	PF01048	0.720
MOD_GlcNHglycan	705	708	PF01048	0.530
MOD_GlcNHglycan	72	75	PF01048	0.574
MOD_GlcNHglycan	720	723	PF01048	0.590
MOD_GlcNHglycan	767	770	PF01048	0.663
MOD_GlcNHglycan	776	779	PF01048	0.608
MOD_GlcNHglycan	817	820	PF01048	0.643
MOD_GlcNHglycan	843	846	PF01048	0.604
MOD_GSK3_1	116	123	PF00069	0.578
MOD_GSK3_1	13	20	PF00069	0.531
MOD_GSK3_1	142	149	PF00069	0.613
MOD_GSK3_1	151	158	PF00069	0.587
MOD_GSK3_1	170	177	PF00069	0.601
MOD_GSK3_1	209	216	PF00069	0.571
MOD_GSK3_1	295	302	PF00069	0.783
MOD_GSK3_1	334	341	PF00069	0.690
MOD_GSK3_1	379	386	PF00069	0.709
MOD_GSK3_1	425	432	PF00069	0.798
MOD_GSK3_1	441	448	PF00069	0.555
MOD_GSK3_1	454	461	PF00069	0.562
MOD_GSK3_1	479	486	PF00069	0.773
MOD_GSK3_1	488	495	PF00069	0.671
MOD_GSK3_1	5	12	PF00069	0.538
MOD_GSK3_1	519	526	PF00069	0.648
MOD_GSK3_1	57	64	PF00069	0.583
MOD_GSK3_1	573	580	PF00069	0.648
MOD_GSK3_1	583	590	PF00069	0.575
MOD_GSK3_1	621	628	PF00069	0.727
MOD_GSK3_1	638	645	PF00069	0.527
MOD_GSK3_1	65	72	PF00069	0.557
MOD_GSK3_1	657	664	PF00069	0.592
MOD_GSK3_1	667	674	PF00069	0.712
MOD_GSK3_1	726	733	PF00069	0.719
MOD_GSK3_1	761	768	PF00069	0.666
MOD_GSK3_1	791	798	PF00069	0.626
MOD_GSK3_1	852	859	PF00069	0.609
MOD_GSK3_1	877	884	PF00069	0.635
MOD_GSK3_1	889	896	PF00069	0.528
MOD_LATS_1	170	176	PF00433	0.532
MOD_N-GLC_1	170	175	PF02516	0.587
MOD_N-GLC_1	441	446	PF02516	0.693
MOD_N-GLC_1	553	558	PF02516	0.664
MOD_N-GLC_1	98	103	PF02516	0.550
MOD_NEK2_1	108	113	PF00069	0.551
MOD_NEK2_1	116	121	PF00069	0.531
MOD_NEK2_1	453	458	PF00069	0.624
MOD_NEK2_1	478	483	PF00069	0.597
MOD_NEK2_1	577	582	PF00069	0.626
MOD_NEK2_1	730	735	PF00069	0.671
MOD_NEK2_1	815	820	PF00069	0.657
MOD_NEK2_1	862	867	PF00069	0.628
MOD_NEK2_2	189	194	PF00069	0.519
MOD_PIKK_1	441	447	PF00454	0.751
MOD_PIKK_1	756	762	PF00454	0.598
MOD_PIKK_1	795	801	PF00454	0.585
MOD_PIKK_1	808	814	PF00454	0.535
MOD_PIKK_1	856	862	PF00454	0.634
MOD_PIKK_1	863	869	PF00454	0.623
MOD_PK_1	429	435	PF00069	0.681
MOD_PKA_1	120	126	PF00069	0.557
MOD_PKA_1	379	385	PF00069	0.653
MOD_PKA_2	106	112	PF00069	0.539
MOD_PKA_2	114	120	PF00069	0.551
MOD_PKA_2	123	129	PF00069	0.579
MOD_PKA_2	285	291	PF00069	0.642
MOD_PKA_2	362	368	PF00069	0.648
MOD_PKA_2	378	384	PF00069	0.561
MOD_PKA_2	416	422	PF00069	0.705
MOD_PKA_2	428	434	PF00069	0.722
MOD_PKA_2	45	51	PF00069	0.591
MOD_PKA_2	458	464	PF00069	0.617
MOD_PKA_2	638	644	PF00069	0.649
MOD_PKA_2	65	71	PF00069	0.531
MOD_PKA_2	730	736	PF00069	0.666
MOD_PKA_2	765	771	PF00069	0.610
MOD_PKA_2	781	787	PF00069	0.569
MOD_PKA_2	795	801	PF00069	0.534
MOD_PKA_2	841	847	PF00069	0.602
MOD_PKB_1	377	385	PF00069	0.656
MOD_Plk_1	170	176	PF00069	0.588
MOD_Plk_1	384	390	PF00069	0.698
MOD_Plk_1	451	457	PF00069	0.657
MOD_Plk_1	625	631	PF00069	0.636
MOD_Plk_4	197	203	PF00069	0.506
MOD_Plk_4	338	344	PF00069	0.691
MOD_Plk_4	429	435	PF00069	0.670
MOD_Plk_4	46	52	PF00069	0.536
MOD_Plk_4	465	471	PF00069	0.567
MOD_Plk_4	628	634	PF00069	0.649
MOD_Plk_4	882	888	PF00069	0.599
MOD_ProDKin_1	233	239	PF00069	0.646
MOD_ProDKin_1	295	301	PF00069	0.640
MOD_ProDKin_1	318	324	PF00069	0.654
MOD_ProDKin_1	483	489	PF00069	0.645
MOD_ProDKin_1	548	554	PF00069	0.674
MOD_ProDKin_1	57	63	PF00069	0.595
MOD_ProDKin_1	632	638	PF00069	0.634
MOD_ProDKin_1	66	72	PF00069	0.564
MOD_ProDKin_1	663	669	PF00069	0.808
MOD_ProDKin_1	734	740	PF00069	0.809
MOD_ProDKin_1	78	84	PF00069	0.573
MOD_ProDKin_1	850	856	PF00069	0.582
MOD_SUMO_rev_2	11	21	PF00179	0.548
TRG_DiLeu_BaEn_4	694	700	PF01217	0.569
TRG_ENDOCYTIC_2	399	402	PF00928	0.652
TRG_ENDOCYTIC_2	41	44	PF00928	0.529
TRG_ER_diArg_1	120	122	PF00400	0.559
TRG_ER_diArg_1	276	278	PF00400	0.522
TRG_ER_diArg_1	377	380	PF00400	0.635
TRG_ER_diArg_1	538	541	PF00400	0.717
TRG_ER_diArg_1	606	608	PF00400	0.643
TRG_ER_diArg_1	696	698	PF00400	0.635
TRG_ER_diArg_1	800	802	PF00400	0.575
TRG_NLS_MonoExtN_4	538	543	PF00514	0.634
TRG_Pf-PMV_PEXEL_1	697	702	PF00026	0.634
TRG_Pf-PMV_PEXEL_1	800	805	PF00026	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H4W2	Leishmania donovani	99%	100%
A4H332	Leishmania braziliensis	47%	100%
E9AC54	Leishmania major	75%	97%
E9AJF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	93%