Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HRI1_LEIIN

TriTrypDb:

LINF_010010900

Length:

964

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HRI1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRI1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	413	417	PF00656	0.393
CLV_C14_Caspase3-7	45	49	PF00656	0.640
CLV_C14_Caspase3-7	868	872	PF00656	0.744
CLV_C14_Caspase3-7	890	894	PF00656	0.704
CLV_NRD_NRD_1	399	401	PF00675	0.385
CLV_NRD_NRD_1	432	434	PF00675	0.477
CLV_NRD_NRD_1	464	466	PF00675	0.538
CLV_NRD_NRD_1	56	58	PF00675	0.690
CLV_NRD_NRD_1	563	565	PF00675	0.578
CLV_NRD_NRD_1	862	864	PF00675	0.768
CLV_PCSK_FUR_1	560	564	PF00082	0.441
CLV_PCSK_KEX2_1	432	434	PF00082	0.519
CLV_PCSK_KEX2_1	55	57	PF00082	0.635
CLV_PCSK_KEX2_1	559	561	PF00082	0.451
CLV_PCSK_KEX2_1	562	564	PF00082	0.534
CLV_PCSK_KEX2_1	862	864	PF00082	0.768
CLV_PCSK_PC1ET2_1	559	561	PF00082	0.488
CLV_PCSK_SKI1_1	221	225	PF00082	0.469
CLV_PCSK_SKI1_1	285	289	PF00082	0.536
CLV_PCSK_SKI1_1	400	404	PF00082	0.344
CLV_PCSK_SKI1_1	435	439	PF00082	0.442
CLV_PCSK_SKI1_1	546	550	PF00082	0.406
CLV_PCSK_SKI1_1	60	64	PF00082	0.514
CLV_PCSK_SKI1_1	68	72	PF00082	0.425
CLV_PCSK_SKI1_1	735	739	PF00082	0.493
CLV_PCSK_SKI1_1	914	918	PF00082	0.493
DEG_APCC_DBOX_1	806	814	PF00400	0.416
DEG_MDM2_SWIB_1	800	808	PF02201	0.380
DEG_SCF_FBW7_1	348	355	PF00400	0.502
DEG_SCF_FBW7_1	422	428	PF00400	0.569
DEG_SPOP_SBC_1	145	149	PF00917	0.541
DEG_SPOP_SBC_1	328	332	PF00917	0.788
DOC_CKS1_1	349	354	PF01111	0.501
DOC_CKS1_1	422	427	PF01111	0.572
DOC_CKS1_1	737	742	PF01111	0.459
DOC_CYCLIN_RxL_1	279	292	PF00134	0.483
DOC_MAPK_DCC_7	807	815	PF00069	0.417
DOC_MAPK_gen_1	432	438	PF00069	0.456
DOC_MAPK_gen_1	63	71	PF00069	0.465
DOC_MAPK_gen_1	954	962	PF00069	0.451
DOC_MAPK_MEF2A_6	124	132	PF00069	0.509
DOC_MAPK_MEF2A_6	475	484	PF00069	0.407
DOC_MAPK_MEF2A_6	629	638	PF00069	0.401
DOC_MAPK_MEF2A_6	735	744	PF00069	0.425
DOC_MAPK_MEF2A_6	807	815	PF00069	0.417
DOC_MAPK_MEF2A_6	956	964	PF00069	0.494
DOC_PP1_RVXF_1	433	439	PF00149	0.519
DOC_PP1_RVXF_1	952	958	PF00149	0.348
DOC_PP2B_LxvP_1	179	182	PF13499	0.400
DOC_PP2B_PxIxI_1	127	133	PF00149	0.431
DOC_PP2B_PxIxI_1	739	745	PF00149	0.346
DOC_SPAK_OSR1_1	475	479	PF12202	0.457
DOC_SPAK_OSR1_1	66	70	PF12202	0.516
DOC_USP7_MATH_1	101	105	PF00917	0.587
DOC_USP7_MATH_1	141	145	PF00917	0.497
DOC_USP7_MATH_1	19	23	PF00917	0.748
DOC_USP7_MATH_1	255	259	PF00917	0.541
DOC_USP7_MATH_1	277	281	PF00917	0.603
DOC_USP7_MATH_1	313	317	PF00917	0.798
DOC_USP7_MATH_1	327	331	PF00917	0.763
DOC_USP7_MATH_1	389	393	PF00917	0.400
DOC_USP7_MATH_1	4	8	PF00917	0.697
DOC_USP7_MATH_1	512	516	PF00917	0.573
DOC_USP7_MATH_1	519	523	PF00917	0.696
DOC_USP7_MATH_1	582	586	PF00917	0.534
DOC_USP7_MATH_1	630	634	PF00917	0.402
DOC_USP7_MATH_1	825	829	PF00917	0.643
DOC_USP7_MATH_1	85	89	PF00917	0.672
DOC_USP7_MATH_1	875	879	PF00917	0.689
DOC_USP7_MATH_1	940	944	PF00917	0.388
DOC_WW_Pin1_4	15	20	PF00397	0.713
DOC_WW_Pin1_4	187	192	PF00397	0.449
DOC_WW_Pin1_4	240	245	PF00397	0.576
DOC_WW_Pin1_4	251	256	PF00397	0.564
DOC_WW_Pin1_4	278	283	PF00397	0.478
DOC_WW_Pin1_4	297	302	PF00397	0.477
DOC_WW_Pin1_4	31	36	PF00397	0.774
DOC_WW_Pin1_4	348	353	PF00397	0.576
DOC_WW_Pin1_4	421	426	PF00397	0.603
DOC_WW_Pin1_4	529	534	PF00397	0.458
DOC_WW_Pin1_4	730	735	PF00397	0.482
DOC_WW_Pin1_4	736	741	PF00397	0.473
LIG_14-3-3_CanoR_1	221	230	PF00244	0.473
LIG_14-3-3_CanoR_1	400	409	PF00244	0.336
LIG_14-3-3_CanoR_1	475	479	PF00244	0.436
LIG_14-3-3_CanoR_1	562	567	PF00244	0.505
LIG_14-3-3_CanoR_1	644	650	PF00244	0.496
LIG_14-3-3_CanoR_1	658	668	PF00244	0.643
LIG_14-3-3_CanoR_1	779	787	PF00244	0.627
LIG_14-3-3_CanoR_1	849	853	PF00244	0.346
LIG_AP2alpha_2	421	423	PF02296	0.569
LIG_APCC_ABBA_1	680	685	PF00400	0.555
LIG_BIR_II_1	1	5	PF00653	0.614
LIG_BRCT_BRCA1_1	372	376	PF00533	0.336
LIG_BRCT_BRCA1_1	902	906	PF00533	0.637
LIG_Clathr_ClatBox_1	673	677	PF01394	0.402
LIG_CtBP_PxDLS_1	94	98	PF00389	0.554
LIG_eIF4E_1	836	842	PF01652	0.469
LIG_EVH1_1	349	353	PF00568	0.585
LIG_EVH1_2	651	655	PF00568	0.468
LIG_FHA_1	229	235	PF00498	0.631
LIG_FHA_1	255	261	PF00498	0.549
LIG_FHA_1	385	391	PF00498	0.412
LIG_FHA_1	397	403	PF00498	0.440
LIG_FHA_1	547	553	PF00498	0.479
LIG_FHA_1	645	651	PF00498	0.504
LIG_FHA_1	669	675	PF00498	0.424
LIG_FHA_1	737	743	PF00498	0.447
LIG_FHA_1	757	763	PF00498	0.275
LIG_FHA_1	781	787	PF00498	0.717
LIG_FHA_1	906	912	PF00498	0.624
LIG_FHA_2	204	210	PF00498	0.507
LIG_FHA_2	32	38	PF00498	0.771
LIG_FHA_2	333	339	PF00498	0.594
LIG_FHA_2	43	49	PF00498	0.489
LIG_FHA_2	652	658	PF00498	0.612
LIG_GBD_Chelix_1	260	268	PF00786	0.439
LIG_Integrin_RGD_1	218	220	PF01839	0.520
LIG_LIR_Apic_2	647	652	PF02991	0.495
LIG_LIR_Gen_1	167	176	PF02991	0.499
LIG_LIR_Gen_1	254	264	PF02991	0.394
LIG_LIR_Gen_1	367	377	PF02991	0.329
LIG_LIR_Gen_1	573	583	PF02991	0.458
LIG_LIR_Gen_1	640	650	PF02991	0.364
LIG_LIR_Gen_1	716	726	PF02991	0.396
LIG_LIR_Gen_1	753	763	PF02991	0.507
LIG_LIR_Gen_1	913	921	PF02991	0.518
LIG_LIR_Nem_3	148	154	PF02991	0.542
LIG_LIR_Nem_3	167	171	PF02991	0.538
LIG_LIR_Nem_3	254	259	PF02991	0.411
LIG_LIR_Nem_3	367	372	PF02991	0.343
LIG_LIR_Nem_3	420	426	PF02991	0.668
LIG_LIR_Nem_3	573	578	PF02991	0.463
LIG_LIR_Nem_3	585	591	PF02991	0.312
LIG_LIR_Nem_3	640	645	PF02991	0.437
LIG_LIR_Nem_3	716	721	PF02991	0.412
LIG_LIR_Nem_3	753	758	PF02991	0.451
LIG_LIR_Nem_3	850	855	PF02991	0.360
LIG_LIR_Nem_3	903	909	PF02991	0.617
LIG_LIR_Nem_3	913	918	PF02991	0.496
LIG_LYPXL_SIV_4	717	725	PF13949	0.373
LIG_LYPXL_yS_3	151	154	PF13949	0.590
LIG_MLH1_MIPbox_1	372	376	PF16413	0.336
LIG_NRBOX	283	289	PF00104	0.486
LIG_NRBOX	492	498	PF00104	0.329
LIG_NRBOX	757	763	PF00104	0.425
LIG_PAM2_1	637	649	PF00658	0.292
LIG_PCNA_PIPBox_1	498	507	PF02747	0.348
LIG_PDZ_Class_2	959	964	PF00595	0.477
LIG_Pex14_1	853	857	PF04695	0.449
LIG_Pex14_2	800	804	PF04695	0.409
LIG_PTAP_UEV_1	300	305	PF05743	0.646
LIG_PTB_Apo_2	620	627	PF02174	0.424
LIG_REV1ctd_RIR_1	449	459	PF16727	0.521
LIG_SH2_CRK	256	260	PF00017	0.388
LIG_SH2_CRK	386	390	PF00017	0.424
LIG_SH2_CRK	589	593	PF00017	0.454
LIG_SH2_CRK	718	722	PF00017	0.495
LIG_SH2_NCK_1	589	593	PF00017	0.454
LIG_SH2_NCK_1	718	722	PF00017	0.495
LIG_SH2_PTP2	915	918	PF00017	0.540
LIG_SH2_SRC	649	652	PF00017	0.532
LIG_SH2_STAP1	256	260	PF00017	0.450
LIG_SH2_STAP1	642	646	PF00017	0.443
LIG_SH2_STAT5	146	149	PF00017	0.590
LIG_SH2_STAT5	193	196	PF00017	0.605
LIG_SH2_STAT5	256	259	PF00017	0.566
LIG_SH2_STAT5	375	378	PF00017	0.438
LIG_SH2_STAT5	386	389	PF00017	0.475
LIG_SH2_STAT5	649	652	PF00017	0.521
LIG_SH2_STAT5	736	739	PF00017	0.394
LIG_SH2_STAT5	836	839	PF00017	0.483
LIG_SH2_STAT5	915	918	PF00017	0.540
LIG_SH3_2	427	432	PF14604	0.634
LIG_SH3_3	122	128	PF00018	0.504
LIG_SH3_3	185	191	PF00018	0.405
LIG_SH3_3	25	31	PF00018	0.821
LIG_SH3_3	298	304	PF00018	0.642
LIG_SH3_3	32	38	PF00018	0.592
LIG_SH3_3	344	350	PF00018	0.553
LIG_SH3_3	416	422	PF00018	0.622
LIG_SH3_3	424	430	PF00018	0.680
LIG_SH3_3	527	533	PF00018	0.415
LIG_SH3_3	633	639	PF00018	0.400
LIG_SH3_3	699	705	PF00018	0.472
LIG_SH3_3	810	816	PF00018	0.423
LIG_SH3_3	915	921	PF00018	0.448
LIG_SH3_3	923	929	PF00018	0.404
LIG_SUMO_SIM_anti_2	698	703	PF11976	0.405
LIG_SUMO_SIM_par_1	671	678	PF11976	0.341
LIG_SUMO_SIM_par_1	907	913	PF11976	0.505
LIG_TRAF2_1	335	338	PF00917	0.602
LIG_TRAF2_1	444	447	PF00917	0.461
LIG_TRFH_1	736	740	PF08558	0.429
LIG_TRFH_1	925	929	PF08558	0.364
LIG_TYR_ITSM	147	154	PF00017	0.632
LIG_TYR_ITSM	714	721	PF00017	0.495
LIG_WRC_WIRS_1	165	170	PF05994	0.632
LIG_WRC_WIRS_1	638	643	PF05994	0.346
LIG_WRC_WIRS_1	86	91	PF05994	0.582
LIG_WW_2	347	350	PF00397	0.612
LIG_WW_3	429	433	PF00397	0.472
MOD_CDK_SPK_2	730	735	PF00069	0.382
MOD_CDK_SPxxK_3	278	285	PF00069	0.472
MOD_CK1_1	13	19	PF00069	0.772
MOD_CK1_1	144	150	PF00069	0.589
MOD_CK1_1	172	178	PF00069	0.438
MOD_CK1_1	2	8	PF00069	0.720
MOD_CK1_1	254	260	PF00069	0.526
MOD_CK1_1	299	305	PF00069	0.755
MOD_CK1_1	330	336	PF00069	0.769
MOD_CK1_1	365	371	PF00069	0.409
MOD_CK1_1	396	402	PF00069	0.490
MOD_CK1_1	454	460	PF00069	0.522
MOD_CK1_1	517	523	PF00069	0.497
MOD_CK1_1	532	538	PF00069	0.368
MOD_CK1_1	565	571	PF00069	0.547
MOD_CK1_1	766	772	PF00069	0.641
MOD_CK1_1	778	784	PF00069	0.617
MOD_CK1_1	803	809	PF00069	0.464
MOD_CK1_1	87	93	PF00069	0.681
MOD_CK1_1	878	884	PF00069	0.629
MOD_CK2_1	102	108	PF00069	0.565
MOD_CK2_1	174	180	PF00069	0.503
MOD_CK2_1	31	37	PF00069	0.680
MOD_CK2_1	332	338	PF00069	0.637
MOD_CK2_1	657	663	PF00069	0.463
MOD_CK2_1	778	784	PF00069	0.795
MOD_CK2_1	878	884	PF00069	0.727
MOD_GlcNHglycan	143	146	PF01048	0.491
MOD_GlcNHglycan	2	5	PF01048	0.692
MOD_GlcNHglycan	21	24	PF01048	0.802
MOD_GlcNHglycan	301	304	PF01048	0.658
MOD_GlcNHglycan	313	316	PF01048	0.690
MOD_GlcNHglycan	322	325	PF01048	0.528
MOD_GlcNHglycan	364	367	PF01048	0.463
MOD_GlcNHglycan	393	396	PF01048	0.502
MOD_GlcNHglycan	507	510	PF01048	0.482
MOD_GlcNHglycan	512	515	PF01048	0.502
MOD_GlcNHglycan	519	522	PF01048	0.536
MOD_GlcNHglycan	553	556	PF01048	0.407
MOD_GlcNHglycan	6	9	PF01048	0.709
MOD_GlcNHglycan	677	680	PF01048	0.442
MOD_GlcNHglycan	745	748	PF01048	0.437
MOD_GlcNHglycan	829	832	PF01048	0.661
MOD_GlcNHglycan	857	860	PF01048	0.594
MOD_GlcNHglycan	871	874	PF01048	0.687
MOD_GlcNHglycan	877	880	PF01048	0.694
MOD_GlcNHglycan	95	100	PF01048	0.568
MOD_GSK3_1	10	17	PF00069	0.777
MOD_GSK3_1	141	148	PF00069	0.479
MOD_GSK3_1	153	160	PF00069	0.490
MOD_GSK3_1	183	190	PF00069	0.519
MOD_GSK3_1	19	26	PF00069	0.686
MOD_GSK3_1	203	210	PF00069	0.495
MOD_GSK3_1	251	258	PF00069	0.520
MOD_GSK3_1	289	296	PF00069	0.515
MOD_GSK3_1	327	334	PF00069	0.674
MOD_GSK3_1	348	355	PF00069	0.650
MOD_GSK3_1	389	396	PF00069	0.357
MOD_GSK3_1	421	428	PF00069	0.609
MOD_GSK3_1	510	517	PF00069	0.483
MOD_GSK3_1	668	675	PF00069	0.447
MOD_GSK3_1	709	716	PF00069	0.508
MOD_GSK3_1	75	82	PF00069	0.697
MOD_GSK3_1	762	769	PF00069	0.535
MOD_GSK3_1	775	782	PF00069	0.706
MOD_GSK3_1	940	947	PF00069	0.475
MOD_N-GLC_1	505	510	PF02516	0.395
MOD_N-GLC_1	763	768	PF02516	0.540
MOD_N-GLC_1	775	780	PF02516	0.675
MOD_N-GLC_2	121	123	PF02516	0.488
MOD_NEK2_1	12	17	PF00069	0.609
MOD_NEK2_1	153	158	PF00069	0.584
MOD_NEK2_1	384	389	PF00069	0.458
MOD_NEK2_1	393	398	PF00069	0.427
MOD_NEK2_1	451	456	PF00069	0.547
MOD_NEK2_1	492	497	PF00069	0.307
MOD_NEK2_1	505	510	PF00069	0.472
MOD_NEK2_1	551	556	PF00069	0.395
MOD_NEK2_1	645	650	PF00069	0.501
MOD_NEK2_1	727	732	PF00069	0.375
MOD_NEK2_1	800	805	PF00069	0.370
MOD_NEK2_1	841	846	PF00069	0.324
MOD_NEK2_1	897	902	PF00069	0.722
MOD_NEK2_1	944	949	PF00069	0.336
MOD_NEK2_2	940	945	PF00069	0.367
MOD_OFUCOSY	531	536	PF10250	0.465
MOD_PIKK_1	266	272	PF00454	0.473
MOD_PIKK_1	756	762	PF00454	0.410
MOD_PK_1	956	962	PF00069	0.389
MOD_PKA_1	400	406	PF00069	0.343
MOD_PKA_1	546	552	PF00069	0.441
MOD_PKA_1	562	568	PF00069	0.375
MOD_PKA_2	214	220	PF00069	0.395
MOD_PKA_2	431	437	PF00069	0.434
MOD_PKA_2	474	480	PF00069	0.496
MOD_PKA_2	510	516	PF00069	0.628
MOD_PKA_2	562	568	PF00069	0.524
MOD_PKA_2	657	663	PF00069	0.700
MOD_PKA_2	778	784	PF00069	0.538
MOD_PKA_2	848	854	PF00069	0.359
MOD_PKB_1	560	568	PF00069	0.418
MOD_Plk_1	134	140	PF00069	0.490
MOD_Plk_1	748	754	PF00069	0.372
MOD_Plk_1	775	781	PF00069	0.673
MOD_Plk_4	134	140	PF00069	0.404
MOD_Plk_4	164	170	PF00069	0.558
MOD_Plk_4	183	189	PF00069	0.320
MOD_Plk_4	207	213	PF00069	0.481
MOD_Plk_4	255	261	PF00069	0.464
MOD_Plk_4	359	365	PF00069	0.358
MOD_Plk_4	591	597	PF00069	0.305
MOD_Plk_4	637	643	PF00069	0.506
MOD_Plk_4	645	651	PF00069	0.478
MOD_Plk_4	669	675	PF00069	0.407
MOD_Plk_4	848	854	PF00069	0.339
MOD_Plk_4	891	897	PF00069	0.584
MOD_Plk_4	940	946	PF00069	0.441
MOD_ProDKin_1	15	21	PF00069	0.713
MOD_ProDKin_1	187	193	PF00069	0.461
MOD_ProDKin_1	240	246	PF00069	0.579
MOD_ProDKin_1	251	257	PF00069	0.553
MOD_ProDKin_1	278	284	PF00069	0.470
MOD_ProDKin_1	297	303	PF00069	0.481
MOD_ProDKin_1	31	37	PF00069	0.776
MOD_ProDKin_1	348	354	PF00069	0.579
MOD_ProDKin_1	421	427	PF00069	0.606
MOD_ProDKin_1	529	535	PF00069	0.458
MOD_ProDKin_1	730	736	PF00069	0.485
MOD_SUMO_rev_2	539	549	PF00179	0.427
TRG_DiLeu_BaEn_1	207	212	PF01217	0.476
TRG_DiLeu_BaEn_1	414	419	PF01217	0.486
TRG_DiLeu_BaEn_1	479	484	PF01217	0.355
TRG_DiLeu_BaEn_1	684	689	PF01217	0.421
TRG_ENDOCYTIC_2	151	154	PF00928	0.549
TRG_ENDOCYTIC_2	165	168	PF00928	0.441
TRG_ENDOCYTIC_2	256	259	PF00928	0.391
TRG_ENDOCYTIC_2	588	591	PF00928	0.499
TRG_ENDOCYTIC_2	642	645	PF00928	0.333
TRG_ENDOCYTIC_2	718	721	PF00928	0.494
TRG_ENDOCYTIC_2	836	839	PF00928	0.483
TRG_ENDOCYTIC_2	915	918	PF00928	0.505
TRG_ER_diArg_1	431	433	PF00400	0.435
TRG_ER_diArg_1	54	57	PF00400	0.616
TRG_ER_diArg_1	560	563	PF00400	0.529
TRG_ER_diArg_1	791	794	PF00400	0.409
TRG_NLS_Bipartite_1	546	563	PF00514	0.343
TRG_NLS_MonoExtC_3	558	563	PF00514	0.364
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	285	290	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5V6	Leptomonas seymouri	58%	91%
A0A1X0P2P9	Trypanosomatidae	29%	100%
A0A3S5IR38	Trypanosoma rangeli	30%	100%
A0A451EJB3	Leishmania donovani	99%	100%
A4H381	Leishmania braziliensis	70%	100%
C9ZXL0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AC49	Leishmania major	89%	100%
E9AJE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5AX28	Trypanosoma cruzi	30%	100%