UDENN domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pre-mRNA processing factor 3 (PRP3)/Protein of unknown function (DUF1115) - putative

Species:

Leishmania infantum

UniProt:

A4HRH9_LEIIN

TriTrypDb:

LINF_010010700

Length:

622

Annotations

Annotations by Jardim et al.

RNA Processing, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0030532	small nuclear ribonucleoprotein complex	3	10
GO:0032991	protein-containing complex	1	10
GO:0046540	U4/U6 x U5 tri-snRNP complex	6	10
GO:0097525	spliceosomal snRNP complex	4	10
GO:0097526	spliceosomal tri-snRNP complex	5	10
GO:0120114	Sm-like protein family complex	2	10
GO:0140513	nuclear protein-containing complex	2	10
GO:1990904	ribonucleoprotein complex	2	10

Expansion

Sequence features

A4HRH9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRH9

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	10
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	10
GO:0000398	mRNA splicing, via spliceosome	8	10
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006396	RNA processing	6	10
GO:0006397	mRNA processing	7	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0008380	RNA splicing	7	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0016071	mRNA metabolic process	6	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	562	566	PF00656	0.501
CLV_NRD_NRD_1	126	128	PF00675	0.584
CLV_NRD_NRD_1	193	195	PF00675	0.243
CLV_NRD_NRD_1	21	23	PF00675	0.721
CLV_NRD_NRD_1	334	336	PF00675	0.248
CLV_NRD_NRD_1	421	423	PF00675	0.249
CLV_NRD_NRD_1	443	445	PF00675	0.486
CLV_NRD_NRD_1	589	591	PF00675	0.271
CLV_NRD_NRD_1	86	88	PF00675	0.703
CLV_PCSK_KEX2_1	125	127	PF00082	0.562
CLV_PCSK_KEX2_1	193	195	PF00082	0.227
CLV_PCSK_KEX2_1	334	336	PF00082	0.260
CLV_PCSK_KEX2_1	421	423	PF00082	0.249
CLV_PCSK_KEX2_1	437	439	PF00082	0.429
CLV_PCSK_KEX2_1	443	445	PF00082	0.426
CLV_PCSK_KEX2_1	548	550	PF00082	0.281
CLV_PCSK_KEX2_1	556	558	PF00082	0.359
CLV_PCSK_KEX2_1	589	591	PF00082	0.271
CLV_PCSK_KEX2_1	86	88	PF00082	0.703
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.429
CLV_PCSK_PC1ET2_1	548	550	PF00082	0.281
CLV_PCSK_PC1ET2_1	556	558	PF00082	0.359
CLV_PCSK_PC7_1	82	88	PF00082	0.658
CLV_PCSK_SKI1_1	128	132	PF00082	0.710
CLV_PCSK_SKI1_1	241	245	PF00082	0.332
CLV_PCSK_SKI1_1	341	345	PF00082	0.313
CLV_PCSK_SKI1_1	444	448	PF00082	0.455
CLV_PCSK_SKI1_1	606	610	PF00082	0.425
DEG_SPOP_SBC_1	17	21	PF00917	0.584
DOC_CKS1_1	147	152	PF01111	0.643
DOC_CYCLIN_yClb5_NLxxxL_5	384	393	PF00134	0.451
DOC_MAPK_gen_1	125	131	PF00069	0.596
DOC_MAPK_gen_1	520	529	PF00069	0.532
DOC_PP1_RVXF_1	125	132	PF00149	0.577
DOC_PP2B_LxvP_1	591	594	PF13499	0.567
DOC_PP4_MxPP_1	1	4	PF00568	0.687
DOC_USP7_MATH_1	11	15	PF00917	0.615
DOC_USP7_MATH_1	115	119	PF00917	0.666
DOC_USP7_MATH_1	17	21	PF00917	0.591
DOC_USP7_MATH_1	267	271	PF00917	0.418
DOC_USP7_MATH_1	350	354	PF00917	0.531
DOC_USP7_MATH_1	370	374	PF00917	0.518
DOC_USP7_MATH_1	42	46	PF00917	0.770
DOC_USP7_MATH_1	48	52	PF00917	0.744
DOC_USP7_MATH_1	58	62	PF00917	0.625
DOC_USP7_MATH_1	592	596	PF00917	0.565
DOC_USP7_MATH_1	6	10	PF00917	0.648
DOC_USP7_UBL2_3	344	348	PF12436	0.426
DOC_WW_Pin1_4	146	151	PF00397	0.733
DOC_WW_Pin1_4	276	281	PF00397	0.471
DOC_WW_Pin1_4	593	598	PF00397	0.554
LIG_14-3-3_CanoR_1	18	24	PF00244	0.597
LIG_14-3-3_CanoR_1	256	262	PF00244	0.552
LIG_14-3-3_CanoR_1	383	391	PF00244	0.532
LIG_14-3-3_CanoR_1	443	452	PF00244	0.443
LIG_14-3-3_CanoR_1	523	528	PF00244	0.449
LIG_Actin_WH2_2	424	439	PF00022	0.608
LIG_APCC_Cbox_2	425	431	PF00515	0.507
LIG_BRCT_BRCA1_1	533	537	PF00533	0.507
LIG_Clathr_ClatBox_2	252	257	PF01394	0.449
LIG_deltaCOP1_diTrp_1	252	257	PF00928	0.449
LIG_deltaCOP1_diTrp_1	505	514	PF00928	0.449
LIG_FHA_1	107	113	PF00498	0.595
LIG_FHA_1	234	240	PF00498	0.492
LIG_FHA_1	280	286	PF00498	0.471
LIG_FHA_1	384	390	PF00498	0.532
LIG_FHA_1	404	410	PF00498	0.532
LIG_FHA_1	517	523	PF00498	0.452
LIG_FHA_2	578	584	PF00498	0.471
LIG_LIR_Gen_1	35	43	PF02991	0.509
LIG_LIR_Gen_1	571	581	PF02991	0.449
LIG_LIR_Gen_1	595	604	PF02991	0.538
LIG_LIR_Nem_3	311	315	PF02991	0.500
LIG_LIR_Nem_3	35	41	PF02991	0.523
LIG_LIR_Nem_3	595	601	PF02991	0.430
LIG_Pex14_1	605	609	PF04695	0.513
LIG_PROFILIN_1	2	8	PF00235	0.613
LIG_SH2_CRK	88	92	PF00017	0.673
LIG_SH2_STAP1	108	112	PF00017	0.598
LIG_SH2_STAP1	306	310	PF00017	0.449
LIG_SH2_STAT3	197	200	PF00017	0.532
LIG_SH2_STAT5	108	111	PF00017	0.622
LIG_SH2_STAT5	197	200	PF00017	0.532
LIG_SH2_STAT5	306	309	PF00017	0.536
LIG_SH2_STAT5	484	487	PF00017	0.552
LIG_SH3_3	144	150	PF00018	0.752
LIG_SH3_3	155	161	PF00018	0.614
LIG_SH3_3	2	8	PF00018	0.620
LIG_SH3_3	274	280	PF00018	0.587
LIG_SH3_3	293	299	PF00018	0.392
LIG_SH3_3	395	401	PF00018	0.455
LIG_SH3_3	591	597	PF00018	0.561
LIG_SH3_4	23	30	PF00018	0.614
LIG_SUMO_SIM_anti_2	489	495	PF11976	0.449
LIG_SUMO_SIM_anti_2	61	68	PF11976	0.506
LIG_SUMO_SIM_par_1	27	33	PF11976	0.556
LIG_TRAF2_1	141	144	PF00917	0.593
LIG_TRAF2_1	580	583	PF00917	0.451
LIG_WRC_WIRS_1	201	206	PF05994	0.470
LIG_WW_2	5	8	PF00397	0.627
MOD_CK1_1	279	285	PF00069	0.459
MOD_CK1_1	374	380	PF00069	0.464
MOD_CK1_1	53	59	PF00069	0.660
MOD_CK1_1	596	602	PF00069	0.474
MOD_CK1_1	9	15	PF00069	0.657
MOD_CK2_1	138	144	PF00069	0.585
MOD_CK2_1	159	165	PF00069	0.574
MOD_CK2_1	577	583	PF00069	0.451
MOD_CMANNOS	254	257	PF00535	0.249
MOD_Cter_Amidation	554	557	PF01082	0.271
MOD_Cter_Amidation	84	87	PF01082	0.690
MOD_GlcNHglycan	13	16	PF01048	0.613
MOD_GlcNHglycan	140	143	PF01048	0.664
MOD_GlcNHglycan	185	188	PF01048	0.380
MOD_GlcNHglycan	217	220	PF01048	0.341
MOD_GlcNHglycan	265	268	PF01048	0.395
MOD_GlcNHglycan	269	272	PF01048	0.373
MOD_GlcNHglycan	37	41	PF01048	0.523
MOD_GlcNHglycan	373	376	PF01048	0.376
MOD_GlcNHglycan	44	47	PF01048	0.584
MOD_GlcNHglycan	461	464	PF01048	0.289
MOD_GlcNHglycan	52	55	PF01048	0.589
MOD_GlcNHglycan	9	12	PF01048	0.644
MOD_GSK3_1	148	155	PF00069	0.790
MOD_GSK3_1	160	167	PF00069	0.638
MOD_GSK3_1	263	270	PF00069	0.470
MOD_GSK3_1	32	39	PF00069	0.616
MOD_GSK3_1	358	365	PF00069	0.509
MOD_GSK3_1	366	373	PF00069	0.486
MOD_GSK3_1	42	49	PF00069	0.691
MOD_GSK3_1	592	599	PF00069	0.558
MOD_GSK3_1	6	13	PF00069	0.653
MOD_LATS_1	381	387	PF00433	0.532
MOD_LATS_1	547	553	PF00433	0.471
MOD_NEK2_1	164	169	PF00069	0.644
MOD_NEK2_1	281	286	PF00069	0.531
MOD_NEK2_1	358	363	PF00069	0.568
MOD_NEK2_1	371	376	PF00069	0.447
MOD_NEK2_1	393	398	PF00069	0.497
MOD_NEK2_2	533	538	PF00069	0.435
MOD_PIKK_1	164	170	PF00454	0.569
MOD_PIKK_1	304	310	PF00454	0.467
MOD_PIKK_1	65	71	PF00454	0.650
MOD_PK_1	523	529	PF00069	0.507
MOD_PKA_2	106	112	PF00069	0.742
MOD_PKA_2	17	23	PF00069	0.577
MOD_PKA_2	255	261	PF00069	0.552
MOD_PKA_2	382	388	PF00069	0.449
MOD_Plk_1	32	38	PF00069	0.518
MOD_Plk_2-3	32	38	PF00069	0.547
MOD_Plk_4	235	241	PF00069	0.467
MOD_Plk_4	394	400	PF00069	0.449
MOD_Plk_4	58	64	PF00069	0.623
MOD_ProDKin_1	146	152	PF00069	0.734
MOD_ProDKin_1	276	282	PF00069	0.471
MOD_ProDKin_1	593	599	PF00069	0.560
TRG_DiLeu_BaEn_3	582	588	PF01217	0.532
TRG_DiLeu_BaLyEn_6	375	380	PF01217	0.507
TRG_DiLeu_BaLyEn_6	447	452	PF01217	0.474
TRG_ENDOCYTIC_2	312	315	PF00928	0.532
TRG_ENDOCYTIC_2	455	458	PF00928	0.452
TRG_ENDOCYTIC_2	88	91	PF00928	0.680
TRG_ER_diArg_1	125	127	PF00400	0.622
TRG_ER_diArg_1	588	590	PF00400	0.471
TRG_ER_diArg_1	86	88	PF00400	0.741
TRG_NLS_MonoExtN_4	546	552	PF00514	0.463
TRG_Pf-PMV_PEXEL_1	378	382	PF00026	0.307
TRG_Pf-PMV_PEXEL_1	415	420	PF00026	0.267

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXQ4	Leptomonas seymouri	56%	100%
A0A1X0P2M3	Trypanosomatidae	44%	100%
A0A3R7KZ00	Trypanosoma rangeli	42%	100%
A0A3S5H4W0	Leishmania donovani	99%	100%
A4H379	Leishmania braziliensis	75%	94%
E9AC47	Leishmania major	92%	100%
E9AJE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BLJ6	Trypanosoma cruzi	38%	100%