SERPIN domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HRH8_LEIIN

TriTrypDb:

LINF_010010600

Length:

287

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HRH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRH8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	4
GO:0005488	binding	1	4
GO:0008270	zinc ion binding	6	4
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4
GO:0046914	transition metal ion binding	5	4
GO:0097159	organic cyclic compound binding	2	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	232	236	PF00656	0.712
CLV_C14_Caspase3-7	36	40	PF00656	0.508
CLV_NRD_NRD_1	267	269	PF00675	0.480
CLV_NRD_NRD_1	52	54	PF00675	0.421
CLV_PCSK_FUR_1	265	269	PF00082	0.478
CLV_PCSK_KEX2_1	207	209	PF00082	0.785
CLV_PCSK_KEX2_1	222	224	PF00082	0.490
CLV_PCSK_KEX2_1	228	230	PF00082	0.615
CLV_PCSK_KEX2_1	265	267	PF00082	0.511
CLV_PCSK_KEX2_1	5	7	PF00082	0.613
CLV_PCSK_KEX2_1	52	54	PF00082	0.443
CLV_PCSK_PC1ET2_1	207	209	PF00082	0.785
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.490
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.615
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.570
CLV_PCSK_SKI1_1	53	57	PF00082	0.413
DEG_SPOP_SBC_1	138	142	PF00917	0.529
DEG_SPOP_SBC_1	215	219	PF00917	0.597
DEG_SPOP_SBC_1	239	243	PF00917	0.682
DOC_CDC14_PxL_1	169	177	PF14671	0.477
DOC_MAPK_gen_1	178	186	PF00069	0.481
DOC_MAPK_gen_1	52	59	PF00069	0.558
DOC_MAPK_MEF2A_6	178	186	PF00069	0.518
DOC_MAPK_MEF2A_6	52	59	PF00069	0.494
DOC_MAPK_NFAT4_5	52	60	PF00069	0.500
DOC_PP2B_LxvP_1	133	136	PF13499	0.638
DOC_PP4_FxxP_1	134	137	PF00568	0.610
DOC_SPAK_OSR1_1	63	67	PF12202	0.422
DOC_USP7_MATH_1	13	17	PF00917	0.686
DOC_USP7_MATH_1	138	142	PF00917	0.640
DOC_USP7_MATH_1	215	219	PF00917	0.655
DOC_USP7_MATH_1	239	243	PF00917	0.610
DOC_USP7_MATH_1	244	248	PF00917	0.586
DOC_USP7_MATH_1	25	29	PF00917	0.486
DOC_USP7_MATH_1	256	260	PF00917	0.723
DOC_USP7_MATH_1	33	37	PF00917	0.397
DOC_USP7_MATH_1	38	42	PF00917	0.323
DOC_USP7_MATH_1	96	100	PF00917	0.675
DOC_WW_Pin1_4	23	28	PF00397	0.508
DOC_WW_Pin1_4	240	245	PF00397	0.705
LIG_14-3-3_CanoR_1	208	215	PF00244	0.595
LIG_14-3-3_CanoR_1	216	224	PF00244	0.531
LIG_14-3-3_CanoR_1	52	56	PF00244	0.420
LIG_BIR_II_1	1	5	PF00653	0.642
LIG_BRCT_BRCA1_1	165	169	PF00533	0.573
LIG_FHA_1	235	241	PF00498	0.711
LIG_FHA_2	127	133	PF00498	0.511
LIG_FHA_2	228	234	PF00498	0.685
LIG_LIR_Apic_2	132	137	PF02991	0.595
LIG_LIR_Gen_1	122	133	PF02991	0.677
LIG_LIR_Gen_1	166	176	PF02991	0.536
LIG_LIR_Gen_1	39	47	PF02991	0.364
LIG_LIR_Nem_3	166	172	PF02991	0.534
LIG_LIR_Nem_3	26	32	PF02991	0.437
LIG_LIR_Nem_3	39	45	PF02991	0.269
LIG_LIR_Nem_3	54	59	PF02991	0.416
LIG_SH2_STAT5	174	177	PF00017	0.605
LIG_SH3_3	218	224	PF00018	0.773
LIG_SH3_3	273	279	PF00018	0.540
LIG_SH3_3	7	13	PF00018	0.727
LIG_SH3_3	86	92	PF00018	0.477
LIG_TRAF2_1	149	152	PF00917	0.746
LIG_TRAF2_1	98	101	PF00917	0.661
MOD_CK1_1	142	148	PF00069	0.701
MOD_Cter_Amidation	226	229	PF01082	0.642
MOD_GlcNHglycan	101	105	PF01048	0.687
MOD_GlcNHglycan	144	147	PF01048	0.674
MOD_GlcNHglycan	15	18	PF01048	0.681
MOD_GlcNHglycan	156	159	PF01048	0.679
MOD_GlcNHglycan	186	189	PF01048	0.496
MOD_GlcNHglycan	196	199	PF01048	0.591
MOD_GlcNHglycan	258	261	PF01048	0.688
MOD_GlcNHglycan	70	73	PF01048	0.541
MOD_GSK3_1	138	145	PF00069	0.683
MOD_GSK3_1	163	170	PF00069	0.564
MOD_GSK3_1	223	230	PF00069	0.771
MOD_GSK3_1	234	241	PF00069	0.612
MOD_GSK3_1	47	54	PF00069	0.484
MOD_GSK3_1	96	103	PF00069	0.744
MOD_LATS_1	205	211	PF00433	0.619
MOD_NEK2_1	1	6	PF00069	0.754
MOD_NEK2_1	167	172	PF00069	0.564
MOD_NEK2_1	194	199	PF00069	0.550
MOD_NEK2_1	47	52	PF00069	0.529
MOD_PIKK_1	139	145	PF00454	0.674
MOD_PIKK_1	244	250	PF00454	0.621
MOD_PIKK_1	96	102	PF00454	0.660
MOD_PKA_1	207	213	PF00069	0.741
MOD_PKA_1	222	228	PF00069	0.512
MOD_PKA_2	207	213	PF00069	0.710
MOD_PKA_2	215	221	PF00069	0.644
MOD_PKA_2	222	228	PF00069	0.535
MOD_PKA_2	51	57	PF00069	0.428
MOD_Plk_1	167	173	PF00069	0.474
MOD_Plk_1	38	44	PF00069	0.365
MOD_Plk_2-3	126	132	PF00069	0.514
MOD_Plk_4	25	31	PF00069	0.437
MOD_Plk_4	38	44	PF00069	0.259
MOD_Plk_4	77	83	PF00069	0.368
MOD_ProDKin_1	23	29	PF00069	0.495
MOD_ProDKin_1	240	246	PF00069	0.705
TRG_ER_diArg_1	265	268	PF00400	0.512
TRG_ER_diArg_1	51	53	PF00400	0.378
TRG_ER_diArg_1	61	64	PF00400	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P578	Leptomonas seymouri	45%	74%
A0A3R7NL08	Trypanosoma rangeli	32%	90%
A0A3S5H4V9	Leishmania donovani	100%	78%
E9AC46	Leishmania major	89%	99%
E9AJE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%