LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
beta eliminating lyase -putative
Species:
Leishmania infantum
UniProt:
A4HRH1_LEIIN
TriTrypDb:
LINF_010009900
Length:
359

Annotations

Annotations by Jardim et al.

Amino acid metabolism, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. yes yes: 12
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 7
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HRH1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRH1

PDB structure(s): 1svv_A , 1svv_B

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 6
GO:0006520 amino acid metabolic process 3 6
GO:0006807 nitrogen compound metabolic process 2 6
GO:0008152 metabolic process 1 6
GO:0009987 cellular process 1 6
GO:0019752 carboxylic acid metabolic process 5 6
GO:0043436 oxoacid metabolic process 4 6
GO:0044237 cellular metabolic process 2 6
GO:0044238 primary metabolic process 2 6
GO:0044281 small molecule metabolic process 2 6
GO:0071704 organic substance metabolic process 2 6
GO:1901564 organonitrogen compound metabolic process 3 6
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 6
GO:0016829 lyase activity 2 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 323 327 PF00656 0.319
CLV_PCSK_KEX2_1 352 354 PF00082 0.441
CLV_PCSK_PC1ET2_1 352 354 PF00082 0.441
CLV_PCSK_SKI1_1 115 119 PF00082 0.431
CLV_PCSK_SKI1_1 243 247 PF00082 0.362
DEG_SCF_FBW7_1 1 7 PF00400 0.702
DEG_SPOP_SBC_1 4 8 PF00917 0.722
DOC_CKS1_1 1 6 PF01111 0.703
DOC_CYCLIN_RxL_1 26 37 PF00134 0.474
DOC_CYCLIN_yClb5_NLxxxL_5 260 269 PF00134 0.363
DOC_MAPK_MEF2A_6 174 182 PF00069 0.474
DOC_MAPK_MEF2A_6 249 257 PF00069 0.465
DOC_PIKK_1 305 312 PF02985 0.359
DOC_PP1_RVXF_1 288 294 PF00149 0.474
DOC_USP7_MATH_1 292 296 PF00917 0.377
DOC_WW_Pin1_4 190 195 PF00397 0.377
LIG_14-3-3_CanoR_1 186 195 PF00244 0.451
LIG_14-3-3_CanoR_1 205 212 PF00244 0.377
LIG_14-3-3_CanoR_1 332 338 PF00244 0.407
LIG_14-3-3_CanoR_1 5 15 PF00244 0.652
LIG_Actin_WH2_2 112 129 PF00022 0.349
LIG_APCC_ABBA_1 178 183 PF00400 0.377
LIG_APCC_ABBAyCdc20_2 262 268 PF00400 0.474
LIG_BIR_II_1 1 5 PF00653 0.704
LIG_BRCT_BRCA1_1 312 316 PF00533 0.405
LIG_FHA_1 104 110 PF00498 0.377
LIG_FHA_1 152 158 PF00498 0.377
LIG_FHA_1 76 82 PF00498 0.474
LIG_FHA_2 160 166 PF00498 0.335
LIG_FHA_2 197 203 PF00498 0.363
LIG_FHA_2 305 311 PF00498 0.365
LIG_LIR_Gen_1 177 187 PF02991 0.299
LIG_LIR_Gen_1 313 324 PF02991 0.419
LIG_LIR_Nem_3 177 182 PF02991 0.299
LIG_LIR_Nem_3 263 269 PF02991 0.474
LIG_LIR_Nem_3 313 319 PF02991 0.464
LIG_PDZ_Class_1 354 359 PF00595 0.523
LIG_SH2_CRK 16 20 PF00017 0.545
LIG_SH2_STAT3 161 164 PF00017 0.474
LIG_SH2_STAT5 150 153 PF00017 0.377
LIG_SH2_STAT5 161 164 PF00017 0.377
LIG_SH2_STAT5 179 182 PF00017 0.409
LIG_SH2_STAT5 211 214 PF00017 0.377
LIG_SH3_3 114 120 PF00018 0.424
LIG_SUMO_SIM_anti_2 223 230 PF11976 0.474
LIG_SUMO_SIM_par_1 223 230 PF11976 0.474
LIG_TRAF2_1 162 165 PF00917 0.474
LIG_TRAF2_1 338 341 PF00917 0.372
LIG_UBA3_1 209 216 PF00899 0.377
LIG_UBA3_1 308 314 PF00899 0.419
MOD_CK1_1 152 158 PF00069 0.377
MOD_CK1_1 189 195 PF00069 0.377
MOD_CK1_1 336 342 PF00069 0.426
MOD_CK1_1 73 79 PF00069 0.377
MOD_CK2_1 159 165 PF00069 0.377
MOD_CK2_1 304 310 PF00069 0.359
MOD_CK2_1 99 105 PF00069 0.377
MOD_GlcNHglycan 132 135 PF01048 0.474
MOD_GlcNHglycan 167 172 PF01048 0.424
MOD_GlcNHglycan 188 191 PF01048 0.377
MOD_GlcNHglycan 294 297 PF01048 0.479
MOD_GlcNHglycan 65 68 PF01048 0.343
MOD_GlcNHglycan 72 75 PF01048 0.334
MOD_GSK3_1 152 159 PF00069 0.327
MOD_GSK3_1 186 193 PF00069 0.377
MOD_GSK3_1 332 339 PF00069 0.405
MOD_GSK3_1 99 106 PF00069 0.377
MOD_N-GLC_1 137 142 PF02516 0.474
MOD_N-GLC_1 152 157 PF02516 0.377
MOD_N-GLC_1 37 42 PF02516 0.474
MOD_N-GLC_2 327 329 PF02516 0.339
MOD_NEK2_1 304 309 PF00069 0.528
MOD_NEK2_1 333 338 PF00069 0.405
MOD_NEK2_1 354 359 PF00069 0.524
MOD_PIKK_1 156 162 PF00454 0.377
MOD_PIKK_1 37 43 PF00454 0.474
MOD_PIKK_1 73 79 PF00454 0.377
MOD_PIKK_1 93 99 PF00454 0.150
MOD_PKA_2 204 210 PF00069 0.377
MOD_PKA_2 4 10 PF00069 0.692
MOD_Plk_1 167 173 PF00069 0.349
MOD_Plk_1 196 202 PF00069 0.377
MOD_Plk_1 20 26 PF00069 0.489
MOD_Plk_1 304 310 PF00069 0.534
MOD_Plk_1 325 331 PF00069 0.405
MOD_Plk_2-3 317 323 PF00069 0.548
MOD_Plk_4 14 20 PF00069 0.412
MOD_Plk_4 304 310 PF00069 0.534
MOD_ProDKin_1 190 196 PF00069 0.377
TRG_DiLeu_BaEn_1 223 228 PF01217 0.349
TRG_DiLeu_BaEn_2 342 348 PF01217 0.516
TRG_ENDOCYTIC_2 16 19 PF00928 0.451
TRG_ENDOCYTIC_2 179 182 PF00928 0.474
TRG_NES_CRM1_1 310 322 PF08389 0.413
TRG_Pf-PMV_PEXEL_1 237 242 PF00026 0.369
TRG_Pf-PMV_PEXEL_1 56 60 PF00026 0.474

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1P9M0 Leptomonas seymouri 66% 94%
A0A3S5H4V5 Leishmania donovani 99% 100%
E9AC39 Leishmania major 94% 100%
E9AJD5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
O50584 Pseudomonas sp. (strain NCIMB 10558) 31% 100%
O74267 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 28% 94%
P37303 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 27% 93%
Q9HTF1 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 30% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS