RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein - putative

Species:

Leishmania infantum

UniProt:

A4HRG6_LEIIN

TriTrypDb:

LINF_010009400

Length:

744

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HRG6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRG6

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0007165	signal transduction	2	1
GO:0007264	small GTPase mediated signal transduction	4	1
GO:0007265	Ras protein signal transduction	5	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0035556	intracellular signal transduction	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0008270	zinc ion binding	6	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7
GO:0003824	catalytic activity	1	2
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0061630	ubiquitin protein ligase activity	5	1
GO:0061659	ubiquitin-like protein ligase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	247	251	PF00656	0.804
CLV_C14_Caspase3-7	253	257	PF00656	0.754
CLV_C14_Caspase3-7	550	554	PF00656	0.773
CLV_C14_Caspase3-7	69	73	PF00656	0.583
CLV_NRD_NRD_1	150	152	PF00675	0.510
CLV_NRD_NRD_1	193	195	PF00675	0.710
CLV_NRD_NRD_1	308	310	PF00675	0.840
CLV_NRD_NRD_1	453	455	PF00675	0.335
CLV_NRD_NRD_1	599	601	PF00675	0.606
CLV_NRD_NRD_1	602	604	PF00675	0.648
CLV_NRD_NRD_1	616	618	PF00675	0.655
CLV_NRD_NRD_1	648	650	PF00675	0.564
CLV_NRD_NRD_1	652	654	PF00675	0.569
CLV_NRD_NRD_1	716	718	PF00675	0.613
CLV_NRD_NRD_1	85	87	PF00675	0.664
CLV_PCSK_FUR_1	451	455	PF00082	0.346
CLV_PCSK_FUR_1	600	604	PF00082	0.565
CLV_PCSK_FUR_1	649	653	PF00082	0.568
CLV_PCSK_KEX2_1	150	152	PF00082	0.583
CLV_PCSK_KEX2_1	193	195	PF00082	0.677
CLV_PCSK_KEX2_1	453	455	PF00082	0.335
CLV_PCSK_KEX2_1	598	600	PF00082	0.619
CLV_PCSK_KEX2_1	602	604	PF00082	0.642
CLV_PCSK_KEX2_1	616	618	PF00082	0.570
CLV_PCSK_KEX2_1	648	650	PF00082	0.564
CLV_PCSK_KEX2_1	651	653	PF00082	0.576
CLV_PCSK_PC7_1	594	600	PF00082	0.595
CLV_PCSK_PC7_1	648	654	PF00082	0.570
CLV_PCSK_SKI1_1	159	163	PF00082	0.486
CLV_PCSK_SKI1_1	483	487	PF00082	0.346
CLV_PCSK_SKI1_1	652	656	PF00082	0.567
DEG_Nend_UBRbox_2	1	3	PF02207	0.609
DEG_SCF_FBW7_1	332	339	PF00400	0.596
DEG_SPOP_SBC_1	522	526	PF00917	0.790
DEG_SPOP_SBC_1	96	100	PF00917	0.672
DOC_CKS1_1	292	297	PF01111	0.825
DOC_CKS1_1	352	357	PF01111	0.616
DOC_CYCLIN_yCln2_LP_2	170	176	PF00134	0.656
DOC_CYCLIN_yCln2_LP_2	21	24	PF00134	0.594
DOC_MAPK_DCC_7	350	360	PF00069	0.619
DOC_PP2B_LxvP_1	170	173	PF13499	0.680
DOC_PP2B_LxvP_1	21	24	PF13499	0.594
DOC_SPAK_OSR1_1	417	421	PF12202	0.548
DOC_USP7_MATH_1	103	107	PF00917	0.718
DOC_USP7_MATH_1	30	34	PF00917	0.612
DOC_USP7_MATH_1	302	306	PF00917	0.764
DOC_USP7_MATH_1	327	331	PF00917	0.707
DOC_USP7_MATH_1	336	340	PF00917	0.623
DOC_USP7_MATH_1	346	350	PF00917	0.551
DOC_USP7_MATH_1	407	411	PF00917	0.411
DOC_USP7_MATH_1	522	526	PF00917	0.806
DOC_USP7_MATH_1	621	625	PF00917	0.596
DOC_USP7_MATH_1	740	744	PF00917	0.650
DOC_USP7_MATH_1	80	84	PF00917	0.713
DOC_USP7_MATH_1	94	98	PF00917	0.586
DOC_WW_Pin1_4	281	286	PF00397	0.757
DOC_WW_Pin1_4	291	296	PF00397	0.615
DOC_WW_Pin1_4	298	303	PF00397	0.756
DOC_WW_Pin1_4	328	333	PF00397	0.701
DOC_WW_Pin1_4	344	349	PF00397	0.734
DOC_WW_Pin1_4	351	356	PF00397	0.671
DOC_WW_Pin1_4	504	509	PF00397	0.745
DOC_WW_Pin1_4	536	541	PF00397	0.740
DOC_WW_Pin1_4	87	92	PF00397	0.626
LIG_14-3-3_CanoR_1	318	325	PF00244	0.676
LIG_14-3-3_CanoR_1	417	421	PF00244	0.498
LIG_14-3-3_CanoR_1	478	486	PF00244	0.614
LIG_14-3-3_CanoR_1	547	552	PF00244	0.666
LIG_APCC_ABBA_1	484	489	PF00400	0.546
LIG_APCC_ABBAyCdc20_2	483	489	PF00400	0.546
LIG_BIR_III_2	179	183	PF00653	0.633
LIG_BRCT_BRCA1_1	372	376	PF00533	0.569
LIG_BRCT_BRCA1_1	481	485	PF00533	0.546
LIG_Clathr_ClatBox_1	54	58	PF01394	0.487
LIG_FHA_1	123	129	PF00498	0.543
LIG_FHA_1	14	20	PF00498	0.583
LIG_FHA_1	169	175	PF00498	0.551
LIG_FHA_1	376	382	PF00498	0.450
LIG_FHA_1	38	44	PF00498	0.540
LIG_FHA_1	4	10	PF00498	0.594
LIG_FHA_1	575	581	PF00498	0.545
LIG_FHA_1	660	666	PF00498	0.643
LIG_FHA_1	675	681	PF00498	0.414
LIG_FHA_1	710	716	PF00498	0.667
LIG_FHA_2	432	438	PF00498	0.546
LIG_FHA_2	522	528	PF00498	0.651
LIG_LIR_Gen_1	125	135	PF02991	0.570
LIG_LIR_Gen_1	227	237	PF02991	0.734
LIG_LIR_Gen_1	373	384	PF02991	0.394
LIG_LIR_Gen_1	401	411	PF02991	0.515
LIG_LIR_Gen_1	419	427	PF02991	0.376
LIG_LIR_Gen_1	434	443	PF02991	0.546
LIG_LIR_Nem_3	125	130	PF02991	0.624
LIG_LIR_Nem_3	227	232	PF02991	0.712
LIG_LIR_Nem_3	373	379	PF02991	0.527
LIG_LIR_Nem_3	401	406	PF02991	0.515
LIG_LIR_Nem_3	419	424	PF02991	0.381
LIG_LIR_Nem_3	434	438	PF02991	0.546
LIG_PCNA_PIPBox_1	690	699	PF02747	0.549
LIG_PDZ_Class_1	739	744	PF00595	0.545
LIG_SH2_CRK	143	147	PF00017	0.476
LIG_SH2_CRK	403	407	PF00017	0.411
LIG_SH2_CRK	421	425	PF00017	0.571
LIG_SH2_STAP1	435	439	PF00017	0.546
LIG_SH2_STAP1	576	580	PF00017	0.545
LIG_SH2_STAP1	591	595	PF00017	0.557
LIG_SH2_STAT3	279	282	PF00017	0.692
LIG_SH2_STAT3	575	578	PF00017	0.650
LIG_SH2_STAT5	135	138	PF00017	0.544
LIG_SH2_STAT5	143	146	PF00017	0.481
LIG_SH2_STAT5	176	179	PF00017	0.651
LIG_SH2_STAT5	385	388	PF00017	0.512
LIG_SH2_STAT5	576	579	PF00017	0.542
LIG_SH2_STAT5	658	661	PF00017	0.634
LIG_SH3_1	345	351	PF00018	0.790
LIG_SH3_3	289	295	PF00018	0.822
LIG_SH3_3	345	351	PF00018	0.795
LIG_SH3_3	353	359	PF00018	0.634
LIG_SUMO_SIM_anti_2	489	497	PF11976	0.571
LIG_SUMO_SIM_anti_2	662	667	PF11976	0.636
LIG_SUMO_SIM_par_1	181	186	PF11976	0.658
LIG_SUMO_SIM_par_1	223	230	PF11976	0.674
LIG_SUMO_SIM_par_1	52	58	PF11976	0.501
LIG_TRAF2_1	161	164	PF00917	0.546
LIG_TRAF2_1	525	528	PF00917	0.647
LIG_TRAF2_1	567	570	PF00917	0.587
LIG_TRAF2_1	727	730	PF00917	0.600
MOD_CDC14_SPxK_1	296	299	PF00782	0.726
MOD_CDC14_SPxK_1	347	350	PF00782	0.726
MOD_CDK_SPK_2	328	333	PF00069	0.700
MOD_CDK_SPxK_1	293	299	PF00069	0.725
MOD_CDK_SPxK_1	344	350	PF00069	0.735
MOD_CK1_1	107	113	PF00069	0.545
MOD_CK1_1	284	290	PF00069	0.750
MOD_CK1_1	321	327	PF00069	0.698
MOD_CK1_1	464	470	PF00069	0.411
MOD_CK1_1	507	513	PF00069	0.745
MOD_CK1_1	60	66	PF00069	0.573
MOD_CK1_1	620	626	PF00069	0.612
MOD_CK1_1	635	641	PF00069	0.697
MOD_CK1_1	92	98	PF00069	0.728
MOD_CK1_1	99	105	PF00069	0.769
MOD_CK2_1	115	121	PF00069	0.741
MOD_CK2_1	123	129	PF00069	0.571
MOD_CK2_1	224	230	PF00069	0.729
MOD_CK2_1	521	527	PF00069	0.790
MOD_CK2_1	564	570	PF00069	0.690
MOD_CMANNOS	35	38	PF00535	0.514
MOD_Cter_Amidation	614	617	PF01082	0.699
MOD_GlcNHglycan	101	104	PF01048	0.728
MOD_GlcNHglycan	106	109	PF01048	0.611
MOD_GlcNHglycan	24	27	PF01048	0.633
MOD_GlcNHglycan	243	246	PF01048	0.827
MOD_GlcNHglycan	252	255	PF01048	0.756
MOD_GlcNHglycan	289	292	PF01048	0.753
MOD_GlcNHglycan	305	308	PF01048	0.653
MOD_GlcNHglycan	320	323	PF01048	0.635
MOD_GlcNHglycan	338	341	PF01048	0.610
MOD_GlcNHglycan	372	375	PF01048	0.570
MOD_GlcNHglycan	386	389	PF01048	0.394
MOD_GlcNHglycan	407	410	PF01048	0.411
MOD_GlcNHglycan	463	466	PF01048	0.411
MOD_GlcNHglycan	512	515	PF01048	0.695
MOD_GlcNHglycan	518	521	PF01048	0.746
MOD_GlcNHglycan	58	62	PF01048	0.583
MOD_GlcNHglycan	619	622	PF01048	0.638
MOD_GlcNHglycan	623	626	PF01048	0.580
MOD_GlcNHglycan	634	637	PF01048	0.588
MOD_GlcNHglycan	698	701	PF01048	0.534
MOD_GlcNHglycan	78	81	PF01048	0.647
MOD_GlcNHglycan	91	94	PF01048	0.724
MOD_GSK3_1	103	110	PF00069	0.573
MOD_GSK3_1	280	287	PF00069	0.775
MOD_GSK3_1	298	305	PF00069	0.774
MOD_GSK3_1	314	321	PF00069	0.704
MOD_GSK3_1	328	335	PF00069	0.620
MOD_GSK3_1	37	44	PF00069	0.583
MOD_GSK3_1	384	391	PF00069	0.512
MOD_GSK3_1	394	401	PF00069	0.347
MOD_GSK3_1	45	52	PF00069	0.509
MOD_GSK3_1	466	473	PF00069	0.431
MOD_GSK3_1	512	519	PF00069	0.786
MOD_GSK3_1	53	60	PF00069	0.506
MOD_GSK3_1	534	541	PF00069	0.748
MOD_GSK3_1	547	554	PF00069	0.606
MOD_GSK3_1	617	624	PF00069	0.625
MOD_GSK3_1	692	699	PF00069	0.649
MOD_GSK3_1	76	83	PF00069	0.755
MOD_GSK3_1	92	99	PF00069	0.661
MOD_N-GLC_1	478	483	PF02516	0.411
MOD_N-GLC_1	564	569	PF02516	0.595
MOD_NEK2_1	115	120	PF00069	0.625
MOD_NEK2_1	168	173	PF00069	0.572
MOD_NEK2_1	3	8	PF00069	0.579
MOD_NEK2_1	37	42	PF00069	0.474
MOD_NEK2_1	384	389	PF00069	0.512
MOD_NEK2_1	398	403	PF00069	0.282
MOD_NEK2_1	47	52	PF00069	0.511
MOD_NEK2_1	534	539	PF00069	0.772
MOD_NEK2_1	676	681	PF00069	0.520
MOD_NEK2_1	692	697	PF00069	0.620
MOD_NEK2_1	76	81	PF00069	0.578
MOD_NEK2_2	231	236	PF00069	0.700
MOD_NEK2_2	394	399	PF00069	0.394
MOD_NEK2_2	416	421	PF00069	0.543
MOD_PIKK_1	574	580	PF00454	0.648
MOD_PIKK_1	60	66	PF00454	0.483
MOD_PK_1	53	59	PF00069	0.501
MOD_PKA_2	113	119	PF00069	0.723
MOD_PKA_2	264	270	PF00069	0.731
MOD_PKA_2	416	422	PF00069	0.493
MOD_PKB_1	216	224	PF00069	0.585
MOD_PKB_1	476	484	PF00069	0.512
MOD_PKB_1	545	553	PF00069	0.723
MOD_PKB_1	651	659	PF00069	0.668
MOD_PKB_1	707	715	PF00069	0.558
MOD_Plk_1	122	128	PF00069	0.598
MOD_Plk_1	57	63	PF00069	0.531
MOD_Plk_2-3	123	129	PF00069	0.661
MOD_Plk_2-3	203	209	PF00069	0.634
MOD_Plk_2-3	252	258	PF00069	0.827
MOD_Plk_4	123	129	PF00069	0.661
MOD_Plk_4	224	230	PF00069	0.655
MOD_Plk_4	231	237	PF00069	0.615
MOD_Plk_4	31	37	PF00069	0.560
MOD_Plk_4	551	557	PF00069	0.760
MOD_ProDKin_1	281	287	PF00069	0.758
MOD_ProDKin_1	291	297	PF00069	0.613
MOD_ProDKin_1	298	304	PF00069	0.755
MOD_ProDKin_1	328	334	PF00069	0.699
MOD_ProDKin_1	344	350	PF00069	0.734
MOD_ProDKin_1	351	357	PF00069	0.676
MOD_ProDKin_1	504	510	PF00069	0.744
MOD_ProDKin_1	536	542	PF00069	0.740
MOD_ProDKin_1	87	93	PF00069	0.626
MOD_SUMO_rev_2	79	88	PF00179	0.699
TRG_DiLeu_BaEn_1	489	494	PF01217	0.542
TRG_DiLeu_BaEn_1	732	737	PF01217	0.574
TRG_DiLeu_BaEn_4	163	169	PF01217	0.598
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.567
TRG_DiLeu_BaLyEn_6	367	372	PF01217	0.608
TRG_ENDOCYTIC_2	143	146	PF00928	0.481
TRG_ENDOCYTIC_2	403	406	PF00928	0.411
TRG_ENDOCYTIC_2	421	424	PF00928	0.570
TRG_ENDOCYTIC_2	435	438	PF00928	0.411
TRG_ENDOCYTIC_2	576	579	PF00928	0.643
TRG_ENDOCYTIC_2	673	676	PF00928	0.554
TRG_ER_diArg_1	112	115	PF00400	0.639
TRG_ER_diArg_1	213	216	PF00400	0.598
TRG_ER_diArg_1	451	454	PF00400	0.390
TRG_ER_diArg_1	545	548	PF00400	0.730
TRG_ER_diArg_1	598	600	PF00400	0.620
TRG_ER_diArg_1	648	651	PF00400	0.570
TRG_ER_diArg_1	652	654	PF00400	0.569
TRG_ER_diArg_1	708	711	PF00400	0.553
TRG_Pf-PMV_PEXEL_1	581	585	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	653	657	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2L0	Leptomonas seymouri	46%	87%
A0A3S5H4V1	Leishmania donovani	99%	100%
A4H369	Leishmania braziliensis	71%	98%
E9AC34	Leishmania major	90%	100%
E9AJD0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	97%