Protein-tyrosine-phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HRG3_LEIIN

TriTrypDb:

LINF_010009100

Length:

637

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HRG3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRG3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0031123	RNA 3'-end processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071076	RNA 3' uridylation	8	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0050265	RNA uridylyltransferase activity	4	1
GO:0070569	uridylyltransferase activity	5	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	177	181	PF00656	0.522
CLV_NRD_NRD_1	132	134	PF00675	0.567
CLV_NRD_NRD_1	229	231	PF00675	0.650
CLV_NRD_NRD_1	265	267	PF00675	0.407
CLV_NRD_NRD_1	342	344	PF00675	0.619
CLV_NRD_NRD_1	356	358	PF00675	0.565
CLV_NRD_NRD_1	420	422	PF00675	0.576
CLV_NRD_NRD_1	425	427	PF00675	0.474
CLV_NRD_NRD_1	444	446	PF00675	0.258
CLV_NRD_NRD_1	472	474	PF00675	0.602
CLV_NRD_NRD_1	502	504	PF00675	0.429
CLV_NRD_NRD_1	598	600	PF00675	0.577
CLV_NRD_NRD_1	8	10	PF00675	0.484
CLV_PCSK_FUR_1	442	446	PF00082	0.429
CLV_PCSK_KEX2_1	132	134	PF00082	0.567
CLV_PCSK_KEX2_1	229	231	PF00082	0.650
CLV_PCSK_KEX2_1	265	267	PF00082	0.407
CLV_PCSK_KEX2_1	342	344	PF00082	0.646
CLV_PCSK_KEX2_1	356	358	PF00082	0.592
CLV_PCSK_KEX2_1	419	421	PF00082	0.557
CLV_PCSK_KEX2_1	425	427	PF00082	0.484
CLV_PCSK_KEX2_1	444	446	PF00082	0.361
CLV_PCSK_KEX2_1	502	504	PF00082	0.429
CLV_PCSK_KEX2_1	597	599	PF00082	0.589
CLV_PCSK_KEX2_1	8	10	PF00082	0.484
CLV_PCSK_PC7_1	225	231	PF00082	0.523
CLV_PCSK_PC7_1	421	427	PF00082	0.527
CLV_PCSK_SKI1_1	364	368	PF00082	0.693
CLV_PCSK_SKI1_1	426	430	PF00082	0.579
CLV_PCSK_SKI1_1	444	448	PF00082	0.313
CLV_PCSK_SKI1_1	508	512	PF00082	0.345
CLV_PCSK_SKI1_1	522	526	PF00082	0.357
DEG_APCC_DBOX_1	443	451	PF00400	0.418
DEG_APCC_DBOX_1	502	510	PF00400	0.365
DEG_Nend_UBRbox_3	1	3	PF02207	0.494
DEG_SPOP_SBC_1	157	161	PF00917	0.601
DEG_SPOP_SBC_1	163	167	PF00917	0.597
DOC_CYCLIN_RxL_1	517	530	PF00134	0.432
DOC_CYCLIN_yCln2_LP_2	146	152	PF00134	0.606
DOC_CYCLIN_yCln2_LP_2	185	188	PF00134	0.573
DOC_CYCLIN_yCln2_LP_2	250	256	PF00134	0.377
DOC_MAPK_gen_1	132	138	PF00069	0.562
DOC_PP1_RVXF_1	202	209	PF00149	0.600
DOC_PP2B_LxvP_1	146	149	PF13499	0.628
DOC_PP2B_LxvP_1	185	188	PF13499	0.573
DOC_PP2B_LxvP_1	217	220	PF13499	0.443
DOC_PP2B_LxvP_1	250	253	PF13499	0.459
DOC_PP2B_LxvP_1	369	372	PF13499	0.625
DOC_PP2B_LxvP_1	44	47	PF13499	0.482
DOC_PP4_FxxP_1	208	211	PF00568	0.486
DOC_USP7_MATH_1	153	157	PF00917	0.632
DOC_USP7_MATH_1	162	166	PF00917	0.678
DOC_USP7_MATH_1	28	32	PF00917	0.514
DOC_USP7_MATH_1	318	322	PF00917	0.744
DOC_USP7_MATH_1	341	345	PF00917	0.699
DOC_USP7_MATH_1	375	379	PF00917	0.636
DOC_USP7_MATH_1	382	386	PF00917	0.641
DOC_USP7_MATH_1	428	432	PF00917	0.596
DOC_USP7_MATH_1	437	441	PF00917	0.502
DOC_USP7_MATH_1	446	450	PF00917	0.297
DOC_USP7_MATH_1	465	469	PF00917	0.443
DOC_USP7_MATH_1	92	96	PF00917	0.556
DOC_WW_Pin1_4	136	141	PF00397	0.600
DOC_WW_Pin1_4	42	47	PF00397	0.481
DOC_WW_Pin1_4	433	438	PF00397	0.428
LIG_14-3-3_CanoR_1	132	137	PF00244	0.590
LIG_14-3-3_CanoR_1	426	435	PF00244	0.520
LIG_14-3-3_CanoR_1	493	498	PF00244	0.484
LIG_BIR_III_4	317	321	PF00653	0.617
LIG_eIF4E_1	218	224	PF01652	0.453
LIG_FHA_1	133	139	PF00498	0.534
LIG_FHA_1	169	175	PF00498	0.570
LIG_FHA_1	283	289	PF00498	0.482
LIG_FHA_1	531	537	PF00498	0.402
LIG_FHA_1	569	575	PF00498	0.587
LIG_FHA_2	525	531	PF00498	0.382
LIG_FHA_2	63	69	PF00498	0.497
LIG_LIR_Apic_2	183	187	PF02991	0.524
LIG_LIR_Nem_3	139	145	PF02991	0.548
LIG_NRBOX	246	252	PF00104	0.370
LIG_PCNA_yPIPBox_3	225	235	PF02747	0.397
LIG_SH2_CRK	218	222	PF00017	0.512
LIG_SH2_NCK_1	111	115	PF00017	0.531
LIG_SH2_SRC	218	221	PF00017	0.549
LIG_SH2_SRC	482	485	PF00017	0.445
LIG_SH2_STAP1	237	241	PF00017	0.388
LIG_SH2_STAT5	276	279	PF00017	0.334
LIG_SH2_STAT5	455	458	PF00017	0.361
LIG_SH2_STAT5	477	480	PF00017	0.436
LIG_SH2_STAT5	631	634	PF00017	0.485
LIG_SH3_1	481	487	PF00018	0.492
LIG_SH3_3	176	182	PF00018	0.572
LIG_SH3_3	24	30	PF00018	0.536
LIG_SH3_3	330	336	PF00018	0.649
LIG_SH3_3	369	375	PF00018	0.629
LIG_SH3_3	40	46	PF00018	0.455
LIG_SH3_3	459	465	PF00018	0.448
LIG_SH3_3	481	487	PF00018	0.492
LIG_TRAF2_1	387	390	PF00917	0.634
LIG_UBA3_1	626	634	PF00899	0.352
LIG_WW_3	490	494	PF00397	0.493
MOD_CK1_1	156	162	PF00069	0.542
MOD_CK1_1	321	327	PF00069	0.759
MOD_CK1_1	373	379	PF00069	0.621
MOD_CK1_1	427	433	PF00069	0.442
MOD_CK1_1	45	51	PF00069	0.488
MOD_CK1_1	58	64	PF00069	0.476
MOD_CK1_1	94	100	PF00069	0.589
MOD_CK2_1	187	193	PF00069	0.619
MOD_CK2_1	384	390	PF00069	0.615
MOD_CK2_1	465	471	PF00069	0.457
MOD_CK2_1	524	530	PF00069	0.405
MOD_Cter_Amidation	130	133	PF01082	0.551
MOD_GlcNHglycan	160	163	PF01048	0.650
MOD_GlcNHglycan	189	192	PF01048	0.607
MOD_GlcNHglycan	316	321	PF01048	0.625
MOD_GlcNHglycan	323	326	PF01048	0.655
MOD_GlcNHglycan	375	378	PF01048	0.686
MOD_GlcNHglycan	394	397	PF01048	0.668
MOD_GlcNHglycan	426	429	PF01048	0.432
MOD_GlcNHglycan	430	433	PF01048	0.393
MOD_GlcNHglycan	457	460	PF01048	0.464
MOD_GlcNHglycan	561	564	PF01048	0.567
MOD_GlcNHglycan	571	574	PF01048	0.592
MOD_GSK3_1	132	139	PF00069	0.645
MOD_GSK3_1	153	160	PF00069	0.622
MOD_GSK3_1	164	171	PF00069	0.604
MOD_GSK3_1	187	194	PF00069	0.631
MOD_GSK3_1	278	285	PF00069	0.409
MOD_GSK3_1	321	328	PF00069	0.729
MOD_GSK3_1	424	431	PF00069	0.509
MOD_GSK3_1	433	440	PF00069	0.402
MOD_GSK3_1	51	58	PF00069	0.503
MOD_GSK3_1	530	537	PF00069	0.403
MOD_LATS_1	130	136	PF00433	0.516
MOD_LATS_1	591	597	PF00433	0.600
MOD_N-GLC_1	18	23	PF02516	0.546
MOD_N-GLC_1	568	573	PF02516	0.603
MOD_NEK2_1	192	197	PF00069	0.545
MOD_NEK2_1	414	419	PF00069	0.577
MOD_NEK2_1	476	481	PF00069	0.386
MOD_NEK2_1	524	529	PF00069	0.366
MOD_OFUCOSY	279	286	PF10250	0.373
MOD_OFUCOSY	42	49	PF10250	0.485
MOD_PIKK_1	192	198	PF00454	0.558
MOD_PIKK_1	463	469	PF00454	0.507
MOD_PIKK_1	485	491	PF00454	0.411
MOD_PKA_1	132	138	PF00069	0.501
MOD_PKA_2	132	138	PF00069	0.607
MOD_PKA_2	15	21	PF00069	0.544
MOD_PKA_2	341	347	PF00069	0.664
MOD_PKA_2	349	355	PF00069	0.534
MOD_PKA_2	424	430	PF00069	0.468
MOD_Plk_1	23	29	PF00069	0.543
MOD_Plk_2-3	233	239	PF00069	0.393
MOD_Plk_4	180	186	PF00069	0.585
MOD_Plk_4	242	248	PF00069	0.450
MOD_Plk_4	446	452	PF00069	0.486
MOD_ProDKin_1	136	142	PF00069	0.592
MOD_ProDKin_1	42	48	PF00069	0.482
MOD_ProDKin_1	433	439	PF00069	0.423
MOD_SUMO_rev_2	68	73	PF00179	0.472
TRG_DiLeu_BaLyEn_6	210	215	PF01217	0.473
TRG_ER_diArg_1	120	123	PF00400	0.644
TRG_ER_diArg_1	229	231	PF00400	0.595
TRG_ER_diArg_1	356	359	PF00400	0.608
TRG_ER_diArg_1	410	413	PF00400	0.597
TRG_ER_diArg_1	418	421	PF00400	0.520
TRG_ER_diArg_1	441	444	PF00400	0.441
TRG_ER_diArg_1	501	503	PF00400	0.438
TRG_ER_diArg_1	597	599	PF00400	0.592
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	628	633	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL81	Leptomonas seymouri	36%	100%
A0A451EJ97	Leishmania donovani	99%	100%
A4H366	Leishmania braziliensis	69%	100%
E9AC31	Leishmania major	88%	98%
E9AJC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	97%