Dymeclin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Dymeclin

Gene product:

Dyggve-Melchior-Clausen syndrome protein - putative

Species:

Leishmania infantum

UniProt:

A4HRG1_LEIIN

TriTrypDb:

LINF_010008900

Length:

816

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HRG1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRG1

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0007030	Golgi organization	5	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	417	421	PF00656	0.366
CLV_C14_Caspase3-7	633	637	PF00656	0.484
CLV_NRD_NRD_1	5	7	PF00675	0.447
CLV_NRD_NRD_1	615	617	PF00675	0.342
CLV_NRD_NRD_1	684	686	PF00675	0.301
CLV_NRD_NRD_1	722	724	PF00675	0.325
CLV_NRD_NRD_1	80	82	PF00675	0.374
CLV_NRD_NRD_1	806	808	PF00675	0.375
CLV_PCSK_KEX2_1	615	617	PF00082	0.336
CLV_PCSK_KEX2_1	684	686	PF00082	0.301
CLV_PCSK_KEX2_1	722	724	PF00082	0.325
CLV_PCSK_KEX2_1	80	82	PF00082	0.374
CLV_PCSK_KEX2_1	806	808	PF00082	0.375
CLV_PCSK_PC7_1	611	617	PF00082	0.347
CLV_PCSK_SKI1_1	105	109	PF00082	0.350
CLV_PCSK_SKI1_1	148	152	PF00082	0.381
CLV_PCSK_SKI1_1	172	176	PF00082	0.337
CLV_PCSK_SKI1_1	313	317	PF00082	0.381
CLV_PCSK_SKI1_1	412	416	PF00082	0.525
CLV_PCSK_SKI1_1	433	437	PF00082	0.513
CLV_PCSK_SKI1_1	475	479	PF00082	0.369
CLV_PCSK_SKI1_1	600	604	PF00082	0.289
CLV_PCSK_SKI1_1	650	654	PF00082	0.338
CLV_PCSK_SKI1_1	69	73	PF00082	0.301
CLV_Separin_Metazoa	169	173	PF03568	0.553
CLV_Separin_Metazoa	77	81	PF03568	0.553
DEG_APCC_DBOX_1	599	607	PF00400	0.498
DEG_SPOP_SBC_1	268	272	PF00917	0.498
DEG_SPOP_SBC_1	562	566	PF00917	0.555
DOC_CYCLIN_RxL_1	167	179	PF00134	0.562
DOC_MAPK_FxFP_2	441	444	PF00069	0.301
DOC_MAPK_gen_1	806	813	PF00069	0.554
DOC_MAPK_MEF2A_6	439	448	PF00069	0.362
DOC_PP1_RVXF_1	431	437	PF00149	0.381
DOC_PP2B_LxvP_1	266	269	PF13499	0.581
DOC_PP4_FxxP_1	441	444	PF00568	0.287
DOC_PP4_FxxP_1	783	786	PF00568	0.476
DOC_USP7_MATH_1	158	162	PF00917	0.547
DOC_USP7_MATH_1	16	20	PF00917	0.563
DOC_USP7_MATH_1	25	29	PF00917	0.345
DOC_USP7_MATH_1	277	281	PF00917	0.477
DOC_USP7_MATH_1	483	487	PF00917	0.544
DOC_USP7_MATH_1	57	61	PF00917	0.591
DOC_USP7_MATH_1	578	582	PF00917	0.566
DOC_WW_Pin1_4	200	205	PF00397	0.562
DOC_WW_Pin1_4	226	231	PF00397	0.519
DOC_WW_Pin1_4	342	347	PF00397	0.563
DOC_WW_Pin1_4	467	472	PF00397	0.562
DOC_WW_Pin1_4	672	677	PF00397	0.537
DOC_WW_Pin1_4	90	95	PF00397	0.562
LIG_14-3-3_CanoR_1	148	154	PF00244	0.552
LIG_14-3-3_CanoR_1	172	178	PF00244	0.584
LIG_14-3-3_CanoR_1	313	322	PF00244	0.550
LIG_14-3-3_CanoR_1	357	366	PF00244	0.591
LIG_14-3-3_CanoR_1	439	444	PF00244	0.340
LIG_Actin_WH2_2	532	547	PF00022	0.492
LIG_Actin_WH2_2	584	602	PF00022	0.562
LIG_Actin_WH2_2	92	107	PF00022	0.537
LIG_APCC_ABBA_1	193	198	PF00400	0.483
LIG_BRCT_BRCA1_1	441	445	PF00533	0.287
LIG_BRCT_BRCA1_1	779	783	PF00533	0.476
LIG_BRCT_BRCA1_1	9	13	PF00533	0.562
LIG_FHA_1	12	18	PF00498	0.562
LIG_FHA_1	140	146	PF00498	0.560
LIG_FHA_1	190	196	PF00498	0.519
LIG_FHA_1	214	220	PF00498	0.428
LIG_FHA_1	314	320	PF00498	0.574
LIG_FHA_1	404	410	PF00498	0.370
LIG_FHA_1	450	456	PF00498	0.351
LIG_FHA_1	468	474	PF00498	0.562
LIG_FHA_1	539	545	PF00498	0.536
LIG_FHA_1	63	69	PF00498	0.494
LIG_FHA_1	647	653	PF00498	0.560
LIG_FHA_1	91	97	PF00498	0.493
LIG_FHA_2	164	170	PF00498	0.525
LIG_FHA_2	415	421	PF00498	0.300
LIG_FHA_2	563	569	PF00498	0.567
LIG_FHA_2	578	584	PF00498	0.574
LIG_GBD_Chelix_1	392	400	PF00786	0.525
LIG_LIR_Apic_2	780	786	PF02991	0.476
LIG_LIR_Gen_1	194	204	PF02991	0.487
LIG_LIR_Gen_1	240	248	PF02991	0.563
LIG_LIR_Gen_1	306	315	PF02991	0.562
LIG_LIR_Gen_1	348	356	PF02991	0.540
LIG_LIR_Gen_1	376	385	PF02991	0.354
LIG_LIR_Gen_1	442	453	PF02991	0.383
LIG_LIR_Gen_1	773	781	PF02991	0.502
LIG_LIR_Nem_3	194	199	PF02991	0.480
LIG_LIR_Nem_3	240	244	PF02991	0.518
LIG_LIR_Nem_3	306	311	PF02991	0.562
LIG_LIR_Nem_3	348	352	PF02991	0.540
LIG_LIR_Nem_3	361	366	PF02991	0.427
LIG_LIR_Nem_3	376	381	PF02991	0.290
LIG_LIR_Nem_3	442	448	PF02991	0.344
LIG_LIR_Nem_3	773	777	PF02991	0.492
LIG_LIR_Nem_3	780	784	PF02991	0.467
LIG_LYPXL_yS_3	443	446	PF13949	0.363
LIG_MLH1_MIPbox_1	9	13	PF16413	0.562
LIG_NRBOX	170	176	PF00104	0.562
LIG_NRBOX	209	215	PF00104	0.542
LIG_NRBOX	365	371	PF00104	0.411
LIG_NRBOX	395	401	PF00104	0.325
LIG_PCNA_yPIPBox_3	501	514	PF02747	0.287
LIG_Pex14_2	241	245	PF04695	0.566
LIG_Pex14_2	441	445	PF04695	0.287
LIG_Pex14_2	783	787	PF04695	0.476
LIG_SH2_CRK	645	649	PF00017	0.428
LIG_SH2_NCK_1	645	649	PF00017	0.525
LIG_SH2_PTP2	371	374	PF00017	0.385
LIG_SH2_STAP1	481	485	PF00017	0.562
LIG_SH2_STAP1	622	626	PF00017	0.478
LIG_SH2_STAT3	531	534	PF00017	0.501
LIG_SH2_STAT3	595	598	PF00017	0.581
LIG_SH2_STAT5	12	15	PF00017	0.487
LIG_SH2_STAT5	264	267	PF00017	0.562
LIG_SH2_STAT5	337	340	PF00017	0.495
LIG_SH2_STAT5	371	374	PF00017	0.344
LIG_SH2_STAT5	531	534	PF00017	0.520
LIG_SH2_STAT5	595	598	PF00017	0.571
LIG_SH2_STAT5	626	629	PF00017	0.581
LIG_SH3_3	152	158	PF00018	0.501
LIG_SH3_3	249	255	PF00018	0.562
LIG_SH3_3	291	297	PF00018	0.581
LIG_SH3_3	47	53	PF00018	0.551
LIG_SH3_3	510	516	PF00018	0.344
LIG_SH3_3	80	86	PF00018	0.581
LIG_SH3_3	809	815	PF00018	0.711
LIG_SUMO_SIM_anti_2	166	172	PF11976	0.495
LIG_SUMO_SIM_anti_2	208	214	PF11976	0.525
LIG_SUMO_SIM_anti_2	348	354	PF11976	0.587
LIG_SUMO_SIM_anti_2	365	370	PF11976	0.289
LIG_SUMO_SIM_anti_2	450	458	PF11976	0.345
LIG_SUMO_SIM_anti_2	678	684	PF11976	0.501
LIG_SUMO_SIM_anti_2	767	773	PF11976	0.562
LIG_SUMO_SIM_par_1	264	273	PF11976	0.553
LIG_SUMO_SIM_par_1	398	403	PF11976	0.347
LIG_SUMO_SIM_par_1	450	458	PF11976	0.364
LIG_SUMO_SIM_par_1	491	496	PF11976	0.415
LIG_TRAF2_1	675	678	PF00917	0.539
LIG_TRAF2_1	773	776	PF00917	0.562
LIG_TYR_ITIM	369	374	PF00017	0.344
LIG_TYR_ITIM	620	625	PF00017	0.487
LIG_UBA3_1	103	112	PF00899	0.586
LIG_UBA3_1	318	327	PF00899	0.487
LIG_UBA3_1	399	405	PF00899	0.298
LIG_UBA3_1	652	661	PF00899	0.553
MOD_CK1_1	270	276	PF00069	0.575
MOD_CK1_1	345	351	PF00069	0.545
MOD_CK1_1	696	702	PF00069	0.505
MOD_CK1_1	744	750	PF00069	0.561
MOD_CK2_1	163	169	PF00069	0.561
MOD_CK2_1	303	309	PF00069	0.495
MOD_CK2_1	359	365	PF00069	0.423
MOD_CK2_1	562	568	PF00069	0.542
MOD_CK2_1	577	583	PF00069	0.564
MOD_CK2_1	672	678	PF00069	0.541
MOD_CK2_1	770	776	PF00069	0.538
MOD_GlcNHglycan	114	117	PF01048	0.350
MOD_GlcNHglycan	160	163	PF01048	0.348
MOD_GlcNHglycan	179	182	PF01048	0.164
MOD_GlcNHglycan	252	255	PF01048	0.228
MOD_GlcNHglycan	258	261	PF01048	0.216
MOD_GlcNHglycan	275	278	PF01048	0.357
MOD_GlcNHglycan	279	282	PF01048	0.353
MOD_GlcNHglycan	285	288	PF01048	0.346
MOD_GlcNHglycan	353	356	PF01048	0.358
MOD_GlcNHglycan	482	486	PF01048	0.326
MOD_GlcNHglycan	550	553	PF01048	0.310
MOD_GlcNHglycan	580	583	PF01048	0.334
MOD_GlcNHglycan	701	704	PF01048	0.367
MOD_GlcNHglycan	708	712	PF01048	0.389
MOD_GlcNHglycan	746	749	PF01048	0.344
MOD_GlcNHglycan	793	796	PF01048	0.451
MOD_GSK3_1	108	115	PF00069	0.532
MOD_GSK3_1	149	156	PF00069	0.499
MOD_GSK3_1	173	180	PF00069	0.519
MOD_GSK3_1	246	253	PF00069	0.548
MOD_GSK3_1	269	276	PF00069	0.551
MOD_GSK3_1	338	345	PF00069	0.546
MOD_GSK3_1	403	410	PF00069	0.301
MOD_GSK3_1	548	555	PF00069	0.500
MOD_GSK3_1	573	580	PF00069	0.578
MOD_GSK3_1	693	700	PF00069	0.539
MOD_GSK3_1	7	14	PF00069	0.542
MOD_GSK3_1	737	744	PF00069	0.568
MOD_N-GLC_1	403	408	PF02516	0.559
MOD_N-GLC_2	303	305	PF02516	0.325
MOD_N-GLC_2	726	728	PF02516	0.228
MOD_NEK2_1	108	113	PF00069	0.527
MOD_NEK2_1	149	154	PF00069	0.512
MOD_NEK2_1	173	178	PF00069	0.463
MOD_NEK2_1	199	204	PF00069	0.519
MOD_NEK2_1	213	218	PF00069	0.459
MOD_NEK2_1	248	253	PF00069	0.525
MOD_NEK2_1	301	306	PF00069	0.562
MOD_NEK2_1	380	385	PF00069	0.289
MOD_NEK2_1	391	396	PF00069	0.263
MOD_NEK2_1	400	405	PF00069	0.145
MOD_NEK2_1	413	418	PF00069	0.273
MOD_NEK2_1	448	453	PF00069	0.330
MOD_NEK2_1	539	544	PF00069	0.497
MOD_PIKK_1	455	461	PF00454	0.339
MOD_PIKK_1	693	699	PF00454	0.574
MOD_PKA_2	108	114	PF00069	0.538
MOD_PKA_2	407	413	PF00069	0.372
MOD_PKA_2	548	554	PF00069	0.513
MOD_PKA_2	805	811	PF00069	0.667
MOD_Plk_1	189	195	PF00069	0.551
MOD_Plk_1	364	370	PF00069	0.390
MOD_Plk_1	735	741	PF00069	0.525
MOD_Plk_1	751	757	PF00069	0.381
MOD_Plk_2-3	764	770	PF00069	0.562
MOD_Plk_4	213	219	PF00069	0.542
MOD_Plk_4	237	243	PF00069	0.558
MOD_Plk_4	345	351	PF00069	0.551
MOD_Plk_4	364	370	PF00069	0.304
MOD_Plk_4	380	386	PF00069	0.249
MOD_Plk_4	449	455	PF00069	0.355
MOD_Plk_4	741	747	PF00069	0.581
MOD_Plk_4	788	794	PF00069	0.560
MOD_ProDKin_1	200	206	PF00069	0.562
MOD_ProDKin_1	226	232	PF00069	0.519
MOD_ProDKin_1	342	348	PF00069	0.563
MOD_ProDKin_1	467	473	PF00069	0.562
MOD_ProDKin_1	672	678	PF00069	0.537
MOD_ProDKin_1	90	96	PF00069	0.562
TRG_DiLeu_BaEn_1	169	174	PF01217	0.470
TRG_DiLeu_BaEn_1	365	370	PF01217	0.423
TRG_DiLeu_BaEn_1	387	392	PF01217	0.368
TRG_DiLeu_BaLyEn_6	201	206	PF01217	0.571
TRG_DiLeu_BaLyEn_6	462	467	PF01217	0.581
TRG_DiLeu_LyEn_5	169	174	PF01217	0.553
TRG_ENDOCYTIC_2	371	374	PF00928	0.328
TRG_ENDOCYTIC_2	378	381	PF00928	0.276
TRG_ENDOCYTIC_2	443	446	PF00928	0.363
TRG_ENDOCYTIC_2	622	625	PF00928	0.478
TRG_ENDOCYTIC_2	774	777	PF00928	0.508
TRG_ENDOCYTIC_2	781	784	PF00928	0.468
TRG_ER_diArg_1	683	685	PF00400	0.501
TRG_ER_diArg_1	79	81	PF00400	0.527
TRG_ER_FFAT_2	8	18	PF00635	0.581
TRG_NES_CRM1_1	365	376	PF08389	0.428
TRG_NES_CRM1_1	590	604	PF08389	0.581
TRG_Pf-PMV_PEXEL_1	433	437	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	501	505	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	600	604	PF00026	0.320

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6M9	Leptomonas seymouri	55%	97%
A0A0S4JPV7	Bodo saltans	26%	100%
A0A1X0P2R5	Trypanosomatidae	32%	100%
A0A3S5H4V0	Leishmania donovani	100%	100%
A0A422NY99	Trypanosoma rangeli	33%	100%
A4H364	Leishmania braziliensis	74%	98%
C9ZXI6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AC29	Leishmania major	91%	100%
E9AJC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5AX12	Trypanosoma cruzi	33%	100%