Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HRF8_LEIIN

TriTrypDb:

LINF_010008600

Length:

748

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HRF8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRF8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	388	390	PF00675	0.415
CLV_NRD_NRD_1	395	397	PF00675	0.523
CLV_NRD_NRD_1	406	408	PF00675	0.491
CLV_NRD_NRD_1	45	47	PF00675	0.452
CLV_NRD_NRD_1	583	585	PF00675	0.448
CLV_NRD_NRD_1	743	745	PF00675	0.691
CLV_NRD_NRD_1	97	99	PF00675	0.488
CLV_PCSK_KEX2_1	390	392	PF00082	0.472
CLV_PCSK_KEX2_1	395	397	PF00082	0.541
CLV_PCSK_KEX2_1	406	408	PF00082	0.491
CLV_PCSK_KEX2_1	45	47	PF00082	0.392
CLV_PCSK_KEX2_1	583	585	PF00082	0.448
CLV_PCSK_KEX2_1	743	745	PF00082	0.691
CLV_PCSK_KEX2_1	97	99	PF00082	0.425
CLV_PCSK_PC1ET2_1	390	392	PF00082	0.472
CLV_PCSK_PC7_1	391	397	PF00082	0.617
CLV_PCSK_SKI1_1	330	334	PF00082	0.399
CLV_PCSK_SKI1_1	395	399	PF00082	0.572
CLV_PCSK_SKI1_1	442	446	PF00082	0.727
CLV_PCSK_SKI1_1	624	628	PF00082	0.538
DEG_APCC_DBOX_1	520	528	PF00400	0.532
DEG_SPOP_SBC_1	218	222	PF00917	0.577
DEG_SPOP_SBC_1	308	312	PF00917	0.411
DEG_SPOP_SBC_1	419	423	PF00917	0.833
DEG_SPOP_SBC_1	427	431	PF00917	0.771
DEG_SPOP_SBC_1	664	668	PF00917	0.477
DOC_CYCLIN_RxL_1	436	448	PF00134	0.559
DOC_CYCLIN_yClb5_NLxxxL_5	28	37	PF00134	0.511
DOC_CYCLIN_yCln2_LP_2	322	328	PF00134	0.470
DOC_CYCLIN_yCln2_LP_2	48	54	PF00134	0.338
DOC_MAPK_DCC_7	45	54	PF00069	0.465
DOC_MAPK_gen_1	333	342	PF00069	0.361
DOC_MAPK_gen_1	566	575	PF00069	0.467
DOC_MAPK_gen_1	97	104	PF00069	0.408
DOC_MAPK_HePTP_8	94	106	PF00069	0.400
DOC_MAPK_MEF2A_6	131	139	PF00069	0.382
DOC_MAPK_MEF2A_6	336	344	PF00069	0.356
DOC_MAPK_MEF2A_6	97	106	PF00069	0.485
DOC_MAPK_NFAT4_5	339	347	PF00069	0.344
DOC_PP1_RVXF_1	101	107	PF00149	0.456
DOC_PP1_RVXF_1	272	279	PF00149	0.349
DOC_PP2B_LxvP_1	322	325	PF13499	0.468
DOC_USP7_MATH_1	218	222	PF00917	0.589
DOC_USP7_MATH_1	250	254	PF00917	0.433
DOC_USP7_MATH_1	308	312	PF00917	0.501
DOC_USP7_MATH_1	418	422	PF00917	0.686
DOC_USP7_MATH_1	428	432	PF00917	0.773
DOC_USP7_MATH_1	549	553	PF00917	0.497
DOC_USP7_MATH_1	664	668	PF00917	0.629
DOC_USP7_MATH_1	689	693	PF00917	0.571
DOC_USP7_MATH_1	702	706	PF00917	0.604
DOC_USP7_UBL2_3	627	631	PF12436	0.541
DOC_WW_Pin1_4	296	301	PF00397	0.351
DOC_WW_Pin1_4	421	426	PF00397	0.754
DOC_WW_Pin1_4	7	12	PF00397	0.471
LIG_14-3-3_CanoR_1	154	164	PF00244	0.307
LIG_14-3-3_CanoR_1	208	212	PF00244	0.364
LIG_14-3-3_CanoR_1	292	297	PF00244	0.449
LIG_14-3-3_CanoR_1	371	375	PF00244	0.525
LIG_14-3-3_CanoR_1	378	386	PF00244	0.505
LIG_14-3-3_CanoR_1	389	394	PF00244	0.394
LIG_14-3-3_CanoR_1	395	400	PF00244	0.563
LIG_14-3-3_CanoR_1	436	445	PF00244	0.718
LIG_14-3-3_CanoR_1	45	49	PF00244	0.383
LIG_14-3-3_CanoR_1	452	460	PF00244	0.799
LIG_14-3-3_CanoR_1	529	534	PF00244	0.537
LIG_14-3-3_CanoR_1	583	589	PF00244	0.449
LIG_14-3-3_CanoR_1	598	607	PF00244	0.437
LIG_14-3-3_CanoR_1	624	630	PF00244	0.515
LIG_14-3-3_CanoR_1	642	648	PF00244	0.330
LIG_Actin_WH2_2	125	143	PF00022	0.505
LIG_Actin_WH2_2	229	246	PF00022	0.427
LIG_Actin_WH2_2	362	380	PF00022	0.576
LIG_Actin_WH2_2	575	592	PF00022	0.535
LIG_APCC_ABBA_1	143	148	PF00400	0.381
LIG_BIR_II_1	1	5	PF00653	0.432
LIG_BRCT_BRCA1_1	187	191	PF00533	0.441
LIG_eIF4E_1	297	303	PF01652	0.438
LIG_FHA_1	10	16	PF00498	0.366
LIG_FHA_1	231	237	PF00498	0.669
LIG_FHA_1	252	258	PF00498	0.403
LIG_FHA_1	377	383	PF00498	0.482
LIG_FHA_1	592	598	PF00498	0.582
LIG_FHA_2	371	377	PF00498	0.520
LIG_FHA_2	446	452	PF00498	0.693
LIG_FHA_2	600	606	PF00498	0.383
LIG_FHA_2	80	86	PF00498	0.415
LIG_GBD_Chelix_1	29	37	PF00786	0.338
LIG_IBAR_NPY_1	239	241	PF08397	0.368
LIG_LIR_Apic_2	294	300	PF02991	0.326
LIG_LIR_Gen_1	277	285	PF02991	0.409
LIG_LIR_Gen_1	323	334	PF02991	0.355
LIG_LIR_Gen_1	85	95	PF02991	0.434
LIG_LIR_LC3C_4	692	697	PF02991	0.436
LIG_LIR_Nem_3	109	114	PF02991	0.303
LIG_LIR_Nem_3	199	205	PF02991	0.307
LIG_LIR_Nem_3	277	281	PF02991	0.419
LIG_LIR_Nem_3	295	301	PF02991	0.284
LIG_LIR_Nem_3	323	329	PF02991	0.337
LIG_LIR_Nem_3	85	90	PF02991	0.432
LIG_MLH1_MIPbox_1	188	192	PF16413	0.413
LIG_MYND_1	735	739	PF01753	0.544
LIG_NRBOX	159	165	PF00104	0.434
LIG_NRBOX	3	9	PF00104	0.487
LIG_NRBOX	609	615	PF00104	0.397
LIG_REV1ctd_RIR_1	109	117	PF16727	0.335
LIG_RPA_C_Fungi	93	105	PF08784	0.401
LIG_SH2_GRB2like	501	504	PF00017	0.562
LIG_SH2_NCK_1	508	512	PF00017	0.649
LIG_SH2_PTP2	345	348	PF00017	0.489
LIG_SH2_SRC	326	329	PF00017	0.319
LIG_SH2_SRC	345	348	PF00017	0.495
LIG_SH2_SRC	501	504	PF00017	0.538
LIG_SH2_STAP1	571	575	PF00017	0.545
LIG_SH2_STAT3	682	685	PF00017	0.543
LIG_SH2_STAT5	241	244	PF00017	0.469
LIG_SH2_STAT5	297	300	PF00017	0.309
LIG_SH2_STAT5	321	324	PF00017	0.436
LIG_SH2_STAT5	345	348	PF00017	0.489
LIG_SH2_STAT5	42	45	PF00017	0.445
LIG_SH2_STAT5	501	504	PF00017	0.538
LIG_SH2_STAT5	682	685	PF00017	0.449
LIG_SH3_3	17	23	PF00018	0.505
LIG_SH3_3	302	308	PF00018	0.426
LIG_SH3_3	394	400	PF00018	0.697
LIG_SH3_3	422	428	PF00018	0.734
LIG_SUMO_SIM_anti_2	299	305	PF11976	0.355
LIG_SUMO_SIM_par_1	279	284	PF11976	0.382
LIG_SUMO_SIM_par_1	303	314	PF11976	0.443
LIG_SUMO_SIM_par_1	657	663	PF11976	0.646
LIG_TRAF2_1	492	495	PF00917	0.761
LIG_TRAF2_1	553	556	PF00917	0.553
LIG_TRAF2_1	77	80	PF00917	0.394
LIG_TYR_ITIM	324	329	PF00017	0.315
LIG_UBA3_1	639	644	PF00899	0.547
LIG_WRC_WIRS_1	275	280	PF05994	0.455
MOD_CK1_1	223	229	PF00069	0.622
MOD_CK1_1	279	285	PF00069	0.452
MOD_CK1_1	311	317	PF00069	0.602
MOD_CK1_1	421	427	PF00069	0.732
MOD_CK1_1	431	437	PF00069	0.662
MOD_CK1_1	660	666	PF00069	0.658
MOD_CK1_1	677	683	PF00069	0.439
MOD_CK1_1	9	15	PF00069	0.491
MOD_CK2_1	370	376	PF00069	0.606
MOD_CK2_1	445	451	PF00069	0.804
MOD_CK2_1	549	555	PF00069	0.600
MOD_CK2_1	561	567	PF00069	0.389
MOD_CK2_1	599	605	PF00069	0.533
MOD_GlcNHglycan	157	160	PF01048	0.405
MOD_GlcNHglycan	227	230	PF01048	0.582
MOD_GlcNHglycan	379	382	PF01048	0.386
MOD_GlcNHglycan	504	507	PF01048	0.659
MOD_GlcNHglycan	551	554	PF01048	0.561
MOD_GlcNHglycan	563	566	PF01048	0.574
MOD_GlcNHglycan	591	594	PF01048	0.530
MOD_GlcNHglycan	662	665	PF01048	0.621
MOD_GlcNHglycan	691	694	PF01048	0.530
MOD_GlcNHglycan	713	716	PF01048	0.736
MOD_GlcNHglycan	718	721	PF01048	0.768
MOD_GlcNHglycan	724	727	PF01048	0.576
MOD_GSK3_1	155	162	PF00069	0.288
MOD_GSK3_1	218	225	PF00069	0.563
MOD_GSK3_1	292	299	PF00069	0.413
MOD_GSK3_1	307	314	PF00069	0.586
MOD_GSK3_1	328	335	PF00069	0.365
MOD_GSK3_1	349	356	PF00069	0.391
MOD_GSK3_1	427	434	PF00069	0.653
MOD_GSK3_1	443	450	PF00069	0.774
MOD_GSK3_1	625	632	PF00069	0.483
MOD_GSK3_1	650	657	PF00069	0.466
MOD_GSK3_1	660	667	PF00069	0.484
MOD_GSK3_1	711	718	PF00069	0.632
MOD_N-GLC_1	250	255	PF02516	0.438
MOD_N-GLC_1	502	507	PF02516	0.616
MOD_N-GLC_2	155	157	PF02516	0.406
MOD_N-GLC_2	38	40	PF02516	0.439
MOD_NEK2_1	112	117	PF00069	0.350
MOD_NEK2_1	224	229	PF00069	0.599
MOD_NEK2_1	262	267	PF00069	0.346
MOD_NEK2_1	365	370	PF00069	0.367
MOD_NEK2_1	377	382	PF00069	0.397
MOD_NEK2_1	444	449	PF00069	0.684
MOD_NEK2_1	589	594	PF00069	0.515
MOD_NEK2_1	625	630	PF00069	0.497
MOD_PIKK_1	112	118	PF00454	0.292
MOD_PIKK_1	164	170	PF00454	0.467
MOD_PIKK_1	461	467	PF00454	0.631
MOD_PKA_1	389	395	PF00069	0.532
MOD_PKA_2	164	170	PF00069	0.360
MOD_PKA_2	207	213	PF00069	0.395
MOD_PKA_2	291	297	PF00069	0.464
MOD_PKA_2	370	376	PF00069	0.425
MOD_PKA_2	377	383	PF00069	0.365
MOD_PKA_2	395	401	PF00069	0.564
MOD_PKA_2	405	411	PF00069	0.653
MOD_PKA_2	44	50	PF00069	0.343
MOD_PKA_2	561	567	PF00069	0.488
MOD_PKA_2	582	588	PF00069	0.448
MOD_PKA_2	702	708	PF00069	0.696
MOD_PKA_2	720	726	PF00069	0.755
MOD_Plk_1	250	256	PF00069	0.486
MOD_Plk_1	286	292	PF00069	0.553
MOD_Plk_1	654	660	PF00069	0.541
MOD_Plk_4	207	213	PF00069	0.489
MOD_Plk_4	251	257	PF00069	0.388
MOD_Plk_4	292	298	PF00069	0.367
MOD_Plk_4	54	60	PF00069	0.429
MOD_Plk_4	654	660	PF00069	0.524
MOD_ProDKin_1	296	302	PF00069	0.350
MOD_ProDKin_1	421	427	PF00069	0.753
MOD_ProDKin_1	7	13	PF00069	0.477
MOD_SUMO_for_1	553	556	PF00179	0.537
MOD_SUMO_for_1	614	617	PF00179	0.405
MOD_SUMO_rev_2	331	340	PF00179	0.390
MOD_SUMO_rev_2	384	392	PF00179	0.449
TRG_DiLeu_BaEn_4	555	561	PF01217	0.448
TRG_DiLeu_BaLyEn_6	297	302	PF01217	0.328
TRG_DiLeu_BaLyEn_6	440	445	PF01217	0.555
TRG_ENDOCYTIC_2	321	324	PF00928	0.367
TRG_ENDOCYTIC_2	326	329	PF00928	0.320
TRG_ER_diArg_1	394	396	PF00400	0.534
TRG_ER_diArg_1	405	407	PF00400	0.699
TRG_ER_diArg_1	44	46	PF00400	0.371
TRG_ER_diArg_1	582	584	PF00400	0.449
TRG_ER_diArg_1	743	745	PF00400	0.691
TRG_NES_CRM1_1	134	149	PF08389	0.358
TRG_Pf-PMV_PEXEL_1	598	603	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6N7	Leptomonas seymouri	60%	100%
A0A1X0P2P6	Trypanosomatidae	37%	100%
A0A422NY96	Trypanosoma rangeli	37%	100%
A0A451EJ92	Leishmania donovani	99%	100%
A4H361	Leishmania braziliensis	76%	99%
C9ZXI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AC26	Leishmania major	93%	100%
E9AJC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	98%
V5D5U6	Trypanosoma cruzi	37%	100%