Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HRF7_LEIIN

TriTrypDb:

LINF_010008500

Length:

258

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HRF7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRF7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.378
CLV_NRD_NRD_1	213	215	PF00675	0.459
CLV_NRD_NRD_1	39	41	PF00675	0.440
CLV_PCSK_FUR_1	10	14	PF00082	0.391
CLV_PCSK_KEX2_1	12	14	PF00082	0.390
CLV_PCSK_KEX2_1	212	214	PF00082	0.427
CLV_PCSK_SKI1_1	154	158	PF00082	0.349
DOC_CDC14_PxL_1	226	234	PF14671	0.444
DOC_CKS1_1	189	194	PF01111	0.414
DOC_CYCLIN_yClb5_NLxxxL_5	236	245	PF00134	0.542
DOC_CYCLIN_yCln2_LP_2	215	221	PF00134	0.654
DOC_MAPK_gen_1	212	221	PF00069	0.566
DOC_MAPK_MEF2A_6	135	144	PF00069	0.645
DOC_MAPK_MEF2A_6	213	222	PF00069	0.567
DOC_PP2B_LxvP_1	215	218	PF13499	0.658
DOC_USP7_MATH_1	123	127	PF00917	0.678
DOC_USP7_MATH_1	228	232	PF00917	0.444
DOC_USP7_MATH_1	78	82	PF00917	0.758
DOC_USP7_MATH_1	88	92	PF00917	0.773
DOC_USP7_UBL2_3	41	45	PF12436	0.640
DOC_WW_Pin1_4	188	193	PF00397	0.352
DOC_WW_Pin1_4	50	55	PF00397	0.768
DOC_WW_Pin1_4	86	91	PF00397	0.750
DOC_WW_Pin1_4	94	99	PF00397	0.734
LIG_14-3-3_CanoR_1	212	218	PF00244	0.607
LIG_APCC_ABBA_1	145	150	PF00400	0.645
LIG_BIR_II_1	1	5	PF00653	0.715
LIG_BIR_III_2	227	231	PF00653	0.444
LIG_FHA_1	105	111	PF00498	0.730
LIG_FHA_1	3	9	PF00498	0.676
LIG_FHA_2	176	182	PF00498	0.406
LIG_FHA_2	71	77	PF00498	0.751
LIG_GBD_Chelix_1	237	245	PF00786	0.541
LIG_LIR_Gen_1	43	54	PF02991	0.672
LIG_LIR_LC3C_4	235	238	PF02991	0.447
LIG_LIR_Nem_3	43	49	PF02991	0.604
LIG_PDZ_Class_2	253	258	PF00595	0.456
LIG_Pex14_2	144	148	PF04695	0.667
LIG_REV1ctd_RIR_1	141	150	PF16727	0.673
LIG_SH2_CRK	15	19	PF00017	0.594
LIG_SH2_PTP2	223	226	PF00017	0.408
LIG_SH2_STAT5	208	211	PF00017	0.604
LIG_SH2_STAT5	223	226	PF00017	0.270
LIG_SH3_3	176	182	PF00018	0.379
LIG_SH3_3	48	54	PF00018	0.662
LIG_SH3_3	64	70	PF00018	0.743
LIG_SH3_3	74	80	PF00018	0.801
LIG_SH3_3	95	101	PF00018	0.768
LIG_SUMO_SIM_anti_2	242	247	PF11976	0.427
LIG_SUMO_SIM_par_1	164	169	PF11976	0.361
LIG_TRAF2_1	73	76	PF00917	0.784
LIG_TRFH_1	249	253	PF08558	0.313
LIG_TYR_ITIM	221	226	PF00017	0.369
LIG_WW_2	55	58	PF00397	0.688
MOD_CK1_1	188	194	PF00069	0.424
MOD_CK1_1	2	8	PF00069	0.665
MOD_CK1_1	206	212	PF00069	0.592
MOD_CK1_1	24	30	PF00069	0.698
MOD_CK1_1	71	77	PF00069	0.761
MOD_CK1_1	89	95	PF00069	0.798
MOD_CK2_1	1	7	PF00069	0.740
MOD_CK2_1	70	76	PF00069	0.779
MOD_GlcNHglycan	215	218	PF01048	0.426
MOD_GlcNHglycan	27	30	PF01048	0.496
MOD_GlcNHglycan	64	67	PF01048	0.555
MOD_GlcNHglycan	70	73	PF01048	0.600
MOD_GlcNHglycan	86	89	PF01048	0.367
MOD_GSK3_1	148	155	PF00069	0.611
MOD_GSK3_1	181	188	PF00069	0.446
MOD_GSK3_1	199	206	PF00069	0.188
MOD_GSK3_1	21	28	PF00069	0.696
MOD_GSK3_1	80	87	PF00069	0.721
MOD_LATS_1	211	217	PF00433	0.529
MOD_N-GLC_1	148	153	PF02516	0.411
MOD_N-GLC_1	239	244	PF02516	0.599
MOD_NEK2_1	1	6	PF00069	0.691
MOD_NEK2_1	148	153	PF00069	0.657
MOD_NEK2_1	175	180	PF00069	0.437
MOD_NEK2_1	241	246	PF00069	0.370
MOD_NEK2_1	25	30	PF00069	0.718
MOD_PIKK_1	206	212	PF00454	0.596
MOD_PKA_1	213	219	PF00069	0.605
MOD_PKA_2	21	27	PF00069	0.685
MOD_PKA_2	213	219	PF00069	0.522
MOD_Plk_1	239	245	PF00069	0.401
MOD_Plk_4	152	158	PF00069	0.528
MOD_Plk_4	166	172	PF00069	0.305
MOD_Plk_4	175	181	PF00069	0.374
MOD_Plk_4	185	191	PF00069	0.301
MOD_Plk_4	203	209	PF00069	0.243
MOD_Plk_4	241	247	PF00069	0.398
MOD_Plk_4	252	258	PF00069	0.477
MOD_ProDKin_1	188	194	PF00069	0.352
MOD_ProDKin_1	50	56	PF00069	0.773
MOD_ProDKin_1	86	92	PF00069	0.751
MOD_ProDKin_1	94	100	PF00069	0.734
MOD_SUMO_rev_2	37	47	PF00179	0.637
TRG_DiLeu_BaEn_4	37	43	PF01217	0.625
TRG_ENDOCYTIC_2	15	18	PF00928	0.576
TRG_ENDOCYTIC_2	223	226	PF00928	0.344
TRG_ENDOCYTIC_2	46	49	PF00928	0.604
TRG_ER_diArg_1	10	13	PF00400	0.593
TRG_ER_diArg_1	212	214	PF00400	0.669
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8C0	Leptomonas seymouri	40%	97%
A0A1X0P2R1	Trypanosomatidae	30%	100%
A0A3R7NR92	Trypanosoma rangeli	28%	95%
A0A3S5H4U7	Leishmania donovani	98%	100%
A4H360	Leishmania braziliensis	66%	100%
E9AC25	Leishmania major	91%	100%
E9AJC2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5AQ19	Trypanosoma cruzi	29%	88%